Article
Food Science & Technology
Chih-Cheng Lin, Chih-Yu Hsieh, Li-Fen Chen, Yen-Chun Chen, Tien-Hwa Ho, Shao-Chin Chang, Jia-Feng Chang
Summary: A study found that consuming GABA-fortified oolong tea daily for 28 days can improve blood pressure, relax brain waves, and enhance quality of life.
Article
Biochemistry & Molecular Biology
Eun-Jin Kim, Oh-Sang Kwon, Chang-Gi Hur, Marie Merci Nyiramana, Dong-Kun Lee, Seong-Geun Hong, Jaehee Han, Dawon Kang
Summary: This study identified the effect of GABAR agonists on K-2P channel expression and activity in neuroblastic B35 cells. Muscimol, a GABA(A)R agonist, was found to significantly increase TREK-2 expression and activity, potentially reducing cellular excitability in GABAergic neurons through activating the TREK-2 channel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Multidisciplinary
Eun Namgung, Jungyoon Kim, Hyeonseok Jeong, Jiyoung Ma, Gahae Hong, Ilhyang Kang, Jinsol Kim, Yoonji Joo, Rye Young Kim, In Kyoon Lyoo
Summary: Computerized relaxation training was found to significantly improve stress-related symptoms in women with psychological distress by reducing prefrontal GABA levels and increasing relative CBF.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Electrochemistry
Yuanyuan Li, Hong Wei, Yan Chen, Jing Ma, Xinru Zhang-Peng, Wen Li, Fangdi Hu
Summary: In this study, a molecularly imprinted electrochemical sensor based on high-performance magnetically functionalized reduced graphene oxide (MRGO) was constructed for the sensitive detection of gamma-aminobutyric acid (GABA) in the serum of depressed mice. It provides a basis for the objective diagnosis of depression in clinic.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Plant Sciences
Zainab Waris, Zahra Noreen, Anis Ali Shah, Sheeraz Usman, Adnan Noor Shah, Muhammad Rizwan, Ryan Casini, Hosam O. O. Elansary
Summary: The research shows that cadmium can enter plants easily from the soil solution and cause harmful effects, even at low concentrations. The experiment conducted on lettuce (Lactuca sativa) demonstrates that the addition of γ-aminobutyric acid (GABA) can mitigate the toxicity of cadmium by promoting plant growth and enhancing antioxidant enzyme activity.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Pharmacology & Pharmacy
Kenji Muroya, Kenta Ueda, Keiichi Wada, Masakazu Kotoda, Takashi Matsukawa
Summary: The study explores the potential of remimazolam in preventing shivering in hypothermic rabbits. Remimazolam at 1 mg/kg/h significantly lowered the core temperature change during shivering, which may act through the GABA pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Zhen Wu, Pengyu Wang, Daodong Pan, Xiaoqun Zeng, Yuxing Guo, Guangsheng Zhao
Summary: The study demonstrated that GABA-enriched adzuki bean sprout fermented milk may alleviate and even prevent mild depression symptoms in mice by enhancing social interaction and pleasure derived from movement. The research also highlighted the involvement of the GABA(B)-cAMP-PKA-CREB signaling pathway and increased neurotransmitter levels in the hippocampus after treatment. This suggests a potential dietary therapy for chronic social stress.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Food Science & Technology
Weidan Guo, Zhengwen Li, Xiangjin Fu, Wenhua Zhou, Jiali Ren, Yue Wu
Summary: S. aureus contamination in sourdough has significant effects on metabolites, titratable acidity, and microbial diversity. It decreases the content of mannose, increases the content of sorbitol, reduces the number of lactic acid bacteria, decreases the acidity values, reduces the content of esters and acid flavor compounds, and increases the content of 2,4-decadienal. A PCA model using volatile metabolites data can be used to detect S. aureus contamination in sourdough.
Article
Biochemistry & Molecular Biology
Hyesook Lee, Seon Yeong Ji, Hyun Hwangbo, Min Yeong Kim, Da Hye Kim, Beom Su Park, Joung-Hyun Park, Bae-Jin Lee, Gi-Young Kim, You-Jin Jeon, Yung Hyun Choi
Summary: GABA-enriched salt has a protective effect against renal injury caused by high salt intake in cisplatin-induced nephrotoxicity mice, reducing hematological and biochemical toxicity, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yunshi Liang, Yi Wu, Jianping Li, Ruibing Peng, Maowang Jiang, Xiamin Jiang, Siqing Chen, Jianyuan Lin
Summary: This study examined the effect of gamma-aminobutyric acid (GABA) as a supplement on the ammonia stress resistance of S. pharaonis. The results showed that the application of GABA significantly alleviated the adverse effects of ammonia poisoning, with the best effect observed at a dosage of 80-100 mg/kg.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Plant Sciences
Chujiang Zhou, Wanqi Dong, Shuwan Jin, Qingli Liu, Liyu Shi, Shifeng Cao, Saisai Li, Wei Chen, Zhenfeng Yang
Summary: The treatment of peach fruit with GABA can reduce chilling injury during cold storage by up-regulating the biosynthetic genes and candidate transcription factors related to ascorbic acid and glutathione.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Clinical Neurology
James Fasham, Antje K. Huebner, Lutz Liebmann, Reham Khalaf-Nazzal, Reza Maroofian, Nderim Kryeziu, Saskia B. Wortmann, Joseph S. Leslie, Nishanka Ubeyratna, Grazia M. S. Mancini, Marjon van Slegtenhorst, Martina Wilke, Tobias B. Haack, Hanan E. Shamseldin, Joseph G. Gleeson, Mohamed Almuhaizea, Imad Dweikat, Bassam Abu-Libdeh, Muhannad Daana, Maha S. Zaki, Matthew N. Wakeling, Lucy McGavin, Peter D. Turnpenny, Fowzan S. Alkuraya, Henry Houlden, Peter Schlattmann, Kai Kaila, Andrew H. Crosby, Emma L. Baple, Christian A. Huebner
Summary: A novel neurodevelopmental disorder associated with biallelic pathogenic variants in SLC4A10 has been identified, which exhibits learning difficulties, seizures, and characteristic brain imaging features. Dysfunction of GABAergic transmission may contribute to the disorder.
Article
Behavioral Sciences
Sum Yi Ma, Kin Ming Kwan
Summary: The study found that early prenatal exposure to VPA in mice led to tail deformation and decreased cerebellar weight and size, with reduced expression of GAD 65 and GAD 67 in the cerebellum of adult mice showing autistic behavior. Additionally, protein expressions of GAT-1 and GABAT were reduced in VPA mice, suggesting alterations in GABA production, recycling, and metabolism that could disrupt the excitatory-inhibitory balance in the autistic cerebellum.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Applied
Zahra Sadat Asgarian, Rouhollah Karimi, Mehdi Ghabooli, Masoomeh Maleki
Summary: The study found that using 40 mM concentration of GABA can effectively reduce weight loss, rachis browning, and decay incident in grapes during storage, while increasing antioxidant enzyme activity and decreasing membrane electrolyte leakage, leading to higher soluble sugars, organic acids, and phenolic compounds.
Article
Food Science & Technology
Wee Yin Koh, Xiao Xian Lim, Eva Sheue Wen Teoh, Rovina Kobun, Babak Rasti
Summary: This study aimed to develop GABA-enriched dark chocolate by partially replacing sugar syrup with pure GABA powder. The addition of 0.15% GABA significantly increased the GABA content and ACE inhibitory effect of chocolate. The quality of GABA-enriched chocolate was similar to regular chocolate in terms of nutritional, physical, shelf-life, and sensorial properties.
Article
Cardiac & Cardiovascular Systems
Mazher Mohammed, Dominique N. Johnson, Lei A. Wang, Scott W. Harden, Wanhui Sheng, Eliot A. Spector, Khalid Elsaafien, Michael Bader, U. Muscha Steckelings, Karen A. Scott, Charles J. Frazier, Colin Sumners, Eric G. Krause, Annette D. de Kloet
Summary: These studies use advanced techniques to investigate the role of AT2R-expressing neurons in the NTS in blood pressure regulation. Optogenetic stimulation of these neurons increases GABA release and blood pressure. Central activation of AT2R also reduces GABA-related gene expression and blunts pressor responses.
CARDIOVASCULAR RESEARCH
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Sayeman Islam Niloy, Yagna Jarajapu, Stephen O'Rourke, Chengwen Sun
Meeting Abstract
Biochemistry & Molecular Biology
Santo K. Anto, Chengwen Sun, Stephen T. O'Rourke
Article
Cardiac & Cardiovascular Systems
Santo Anto, Venkatachalem Sathish, Chengwen Sun, Stephen T. O'Rourke
Summary: This study found that exposure to cigarette smoke extract (CSE) impairs the vasorelaxant effect of apelin in coronary arteries and reduces its ability to inhibit endothelium-dependent relaxation to acetylcholine (ACh).
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Cheng-Wen Sun, Bojan Obrenovic, Hai-Ting Li
Summary: The study found that virtual CSR co-creation can promote customers' willingness to purchase green products. Virtual CSR co-creation and self-construal have an interactive effect on green product purchase intention, and environmental involvement plays a moderating role in this interaction. Virtual community identity partially mediates this interactive effect.
Review
Biochemistry & Molecular Biology
Richard Nii Lante Lamptey, Chengwen Sun, Buddhadev Layek, Jagdish Singh
Summary: Hypertension is a global health concern, and neurogenic hypertension (NH) accounts for almost half of all hypertension cases. The increased sympathetic nervous system activity mediated by angiotensin II in the brain is known to be the main cause of NH. However, traditional antihypertensive drugs lack the ability to effectively penetrate the blood-brain barrier, making it challenging to manage NH. Therefore, developing strategies for targeted delivery of antihypertensives to the brain is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Caitlin Baumer-Harrison, Joseph M. Breza, Colin Sumners, Eric G. Krause, Annette D. de Kloet
Summary: Sodium (Na+) is crucial for body homeostasis and its levels are tightly regulated by multiple organ systems. Sodium is acquired from diet and substances containing sodium taste salty and are palatable. Sodium appetite is a response involving the brain and organ systems to increase sodium intake. Dysregulation of sodium intake can lead to diseases. This article focuses on how stress-related and cardiometabolic diseases influence sodium intake and proposes a reciprocal relationship between neural control of sodium intake and blood pressure.
Article
Urology & Nephrology
Chengwen Sun, Dongrong Yang, Jin Zhu, Yibin Zhou, Congming Xiang, Sheng Wu
Summary: This study suggests that the modified staging system may be more effective in predicting prognosis for patients with advanced prostate cancer compared to the AJCC 8th staging system, indicating a need for further optimization.
Article
Pharmacology & Pharmacy
Richard Nii Lante Lamptey, Chengwen Sun, Jagdish Singh
Summary: Functionalized liposomes can safely deliver losartan potassium to the brain, blocking angiotensin receptor type 1 activity and preventing the occurrence of hypertension in spontaneously hypertensive rats.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Weicheng Kong, Detao Liu, Chengwen Sun, Dejun Kong
Summary: A CuCMnNiTi coating was prepared on Ti6Al4V alloy using laser cladding technique. The coating's corrosion resistance was improved by tempering at 450 and 500℃.
MATERIALS CHARACTERIZATION
(2023)
Article
Chemistry, Medicinal
Qi Zhang, Yue Shen, Sayeman Islam Niloy, Stephen T. O'Rourke, Chengwen Sun
Summary: This study found that chronic infusion of apelin-13 does not change blood pressure or heart rate, and does not alter Ang II-induced hypertension and cardiac hypertrophy. These findings suggest that an APJ receptor biased agonist could be a better therapeutic alternative for treatment of hypertension.
Article
Biochemistry & Molecular Biology
Fanrong Yao, Sayeman Islam Niloy, Yue Shen, Qi Zhang, Stephen T. O'Rourke, Chengwen Sun
Summary: Intravenous administration of apelin-13 causes a significant decrease in blood pressure, while not affecting heart rate and contractility. Furthermore, the plasma from apelin-treated rats induces relaxation of blood vessels through a NO-independent mechanism involving an unidentified substance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
A. Augusto Peluso, Igor M. Souza-Silva, Daniel C. Villela, Pernille B. L. Hansen, Anders Hallberg, Michael Bader, Robson Santos, Colin Sumners, U. Muscha Steckelings
Summary: The discovery of the protective arm of the renin-angiotensin system (RAS) and the angiotensin AT2-receptor (AT2R) as a potential new drug target has sparked interest in developing drugs that target this receptor. However, the lack of standard assays to test the agonistic or antagonistic properties of AT2R ligands has hindered the development of such drugs. In this study, the researchers developed a reliable assay based on the measurement of NO release in cells to characterize AT2R ligands. They made several novel findings during the testing of the assay.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sayeman Islam Niloy, Yue Shen, Lirong Guo, Stephen T. O'Rourke, Chengwen Sun
Summary: This study reveals that dysfunction of BKCa channels in vascular smooth muscle cells (VSMCs) is related to abnormal proliferation and morphological changes in hypertension, possibly due to decoupling of IP3R-BKCa. Genetic disruption of IP3R-BKCa coupling increases VSMC proliferation, while infusion of the BKCa opener NS1619 attenuates vascular hypertrophy in hypertensive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Physiology
Debora S. A. Colombari, Colin Sumners, Khalid Elsaafien
FRONTIERS IN PHYSIOLOGY
(2023)