Article
Plant Sciences
Kaili Ren, Weiping Kong, Taoxia Tang, Hong Cheng
Summary: In this study, the structure and phylogenetics of CmACL genes in melon were analyzed, and their important roles in sugar and acid accumulation were demonstrated. Four CmACL genes were identified and members within the same subfamily shared similar biological functions. The CmACL proteins were closely related to tricarboxylic acid cycle, glyoxylic acid cycle, and glycolytic pathway, indicating their involvement in sugar and acid metabolism.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Medicinal
Yongjun Zang, Luyang Tai, Yuanyang Hu, Yu Wang, Hongbin Sun, Xiaoan Wen, Haoliang Yuan, Liang Dai
Summary: A novel macrocyclic compound 2 with potent ACLY inhibitory activity and improved metabolic stability has been identified, highlighting its potential as a lead compound worthy of further study.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Immunology
Monica Dominguez, Verena Truemper, Ana Carolina Mota, Bernhard Bruene, Dmitry Namgaladze
Summary: ATP-citrate lyase (ACLY) is a key enzyme involved in metabolic and epigenetic gene regulation. This study investigated the impact of ACLY phosphorylation on its function in human myeloid cells and found that phosphorylation at serine 455 does not affect the enzymatic activity of ACLY. Additionally, loss of ACLY activity may trigger long-term adaptive mechanisms that increase inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Meng Zhang, Ruyi Peng, Haizhou Wang, Zhenwei Yang, Hailin Zhang, Yangyang Zhang, Meng Wang, Hongling Wang, Jun Lin, Qiu Zhao, Jing Liu
Summary: This study discovered that Nanog can induce cellular dormancy in colorectal cancer cells through the FAO/ACLY-dependent pathway. This finding reveals a specific mechanism governing cellular dormancy in colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche
Summary: Research indicates that despite enhanced inflammatory responses in vitro, deficiency of macrophage Acly does not worsen acute and chronic inflammatory responses in vivo. Myeloid-specific Acly deletion has limited impact on inflammation and overall metabolic homeostasis in inflammatory disorders like multiple sclerosis and obesity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Snehanshu Chowdhury, Anwesha Kar, Debaleena Bhowmik, Anupam Gautam, Debashree Basak, Ishita Sarkar, Puspendu Ghosh, Deborpita Sarkar, Alvina Deka, Paramita Chakraborty, Asima Mukhopadhyay, Shikhar Mehrotra, Soumen Basak, Sandip Paul, Shilpak Chatterjee
Summary: IL-12 stimulation increases intracellular acetyl CoA levels in CD8(+) T cells, allowing them to maintain effector function in nutrient-deprived tumor microenvironments. Inhibition of ATP-citrate lyase, an enzyme involved in the glucose-citrate-acetyl CoA pathway, impairs IFN gamma production and viability of CD8(+) T cells in nutrient-restricted conditions. CD8(+) T cells cultured in high pyruvate-containing media acquire metabolic features of IL-12-stimulated CD8(+) T cells and display improved antitumor potential.
Article
Medicine, Research & Experimental
Mohamed M. Elseweidy, Alaa S. Elawady, Mohammed S. Sobh, Gehad M. Elnagar
Summary: The study aimed to investigate the metabolic effects of lycopene (LYC) and atorvastatin (ATOR) in a diabetic hyperlipidemic rat model. The results showed that LYC had better effects on the studied biomarkers, indicating its potential as a natural therapeutic agent for hyperlipidemia.
Article
Cell Biology
Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong
Summary: Hyperglycemia-induced aberrant glucose metabolism is a causative factor of neurodegeneration and cognitive impairment in diabetes mellitus (DM) patients. The pyruvate dehydrogenase kinase (PDK)-lactic acid axis and histone acetylation modification play important roles in the regulation of PDK1 expression under high glucose conditions. Overexpression of PDK1 can protect against hyperglycemia-induced neuronal injury and cognitive impairment in diabetic mice.
CELL DEATH & DISEASE
(2023)
Review
Immunology
Monica Dominguez, Bernhard Bruene, Dmitry Namgaladze
Summary: Recent studies have shown the profound influence of metabolism on immune responses, particularly through epigenetic regulation of gene expression. ACLY plays a crucial role in the formation of cytosolic acetyl-CoA, supporting de novo lipogenesis and contributing to epigenetic regulation through histone acetylation. Alternative sources of acetyl-CoA also play a role in metabolic and epigenetic regulation in immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Christoph Trautwein, Laimdota Zizmare, Irina Maurer, Benjamin Bender, Bjorn Bayer, Ulrike Ernemann, Marcos Tatagiba, Stefan J. Grau, Bernd J. Pichler, Marco Skardelly, Ghazaleh Tabatabai
Summary: This study presents a valuable resource for analyzing tissue metabolites in diffuse glioma patients, revealing the modulations of metabolites by IDH1 mutation, histology, and tumor treatments. Furthermore, tissue metabolites were found to correlate with patient survival, potentially serving as prognostic and surrogate biomarkers in future clinical studies.
Article
Medicine, Research & Experimental
Mohamed M. Elseweidy, Ahmed E. Elesawy, Mohammed S. Sobh, Gehad M. Elnagar
Summary: High-fructose intake can induce non-alcoholic fatty liver disease (NAFLD) and hyperuricemia. Ellagic acid can alleviate these conditions through the activation of CTRP3 and inhibition of ACL activities, showing more remarkable effects than allopurinol.
Article
Biochemistry & Molecular Biology
Ying Zhan, Wei Qiao, Bolong Yi, Xinyu Yang, Miaomiao Li, Lu Sun, Lian Ji, Peng Su, Xin Wang, Furong Zhang, Rui Zhang, Mingjun Gao, Wujun Zhao, Yichen Song
Summary: This study found that TMEM198B promotes the malignant progression of glioma by regulating lipid metabolism reprogramming and remodeling immune microenvironment. TMEM198B increases PLAGL2 expression, which activates ACLY and ELOVL6, influencing the behavior of glioma cells. Additionally, TMEM198B promotes M2 polarization of macrophages via glioma-derived exosomes, further facilitating immune escape of glioma cells.
Article
Cell Biology
Chong Zhang, Xiang-Yu Wang, Peng Zhang, Tao-Chen He, Jia-Hao Han, Rui Zhang, Jing Lin, Jie Fan, Lu Lu, Wen-Wei Zhu, Hu-Liang Jia, Ju-Bo Zhang, Jin-Hong Chen
Summary: This study identified HSPC111 as a key gene in promoting pre-metastatic niche formation and colorectal cancer liver metastasis (CRLM). HSPC111 altered the lipid metabolism of cancer-associated fibroblasts (CAFs), leading to the formation of a favorable microenvironment for cancer metastasis. This study suggests that targeting HSPC111 may be a potential therapeutic strategy for preventing CRLM.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Medicinal
Carlotta Granchi
Summary: ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, involved in fatty acid synthesis and cancer occurrence. This review focuses on ACLY inhibitors and alternative strategies to modulate ACLY activity for potential therapeutic applications. Currently, effective ACLY inhibitors are limited due to low cell penetration and affinity. Further research on new ACLY inhibitors is of great significance for lipid-related pathologies and cancer treatment.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2022)
Article
Plant Sciences
Fujie Liu, Zhifeng Ma, Sheng Cai, Lingjun Dai, Jianbo Gao, Baoliang Zhou
Summary: This study reveals the important regulatory role of ACL genes in immune response and cell death in cotton, providing a theoretical guidance for developing cotton varieties resistant to Verticillium wilt.