Review
Immunology
James W. Reinhardt, Christopher K. Breuer
Summary: This review details past studies on fibrocytes, their findings, and discusses their strengths and limitations, aiming to identify opportunities for further investigation and promote best practices in future study design.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhengxia Wang, Wei Liu, Huidi Hu, Jingxian Jiang, Chen Yang, Xijie Zhang, Qi Yuan, Xiaofan Yang, Mao Huang, Yanming Bao, Ningfei Ji, Mingshun Zhang
Summary: This study found that decreased expression of CD146 in pulmonary tissues is associated with increased inflammatory response in pulmonary cryptococcosis. Furthermore, CD146 deficiency worsens the infection by C. neoformans.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Immunology
Yun-Hong Hu, Yang Wang, Fei Wang, Yan-Ming Dong, Wan-Ling Jiang, Ya-Ping Wang, Xing Zhong, Li-Xin Ma
Summary: The study identified SPOP as an important regulator of MyD88 in TLR signaling pathways, highlighting its role in limiting inflammatory responses by controlling MyD88 aggregation and downstream signaling kinase recruitment.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Jingwen Tian, Hyo Kyun Chung, Ji Sun Moon, Ha Thi Nga, Ho Yeop Lee, Jung Tae Kim, Joon Young Chang, Seul Gi Kang, Dongryeol Ryu, Xiangguo Che, Je-Yong Choi, Masayuki Tsukasaki, Takayoshi Sasako, Sang-Hee Lee, Minho Shong, Hyon-Seung Yi
Summary: Defects in muscle mitochondrial OxPhos promote bone marrow inflammation in mice, leading to decreased bone mass. Muscle mitochondrial dysfunction is linked to bone marrow inflammatory cytokine secretion via the CXCL12-CXCR4 signaling axis, which is critical for inducing low bone mass.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Chemistry, Medicinal
Pan Chen, Ying Zhou, Xiaobo Li, Jun Yang, Zhiwei Zheng, Yu Zou, Xiang Li, Jing Liao, Jintian Dai, Yuye Xu, Lina Yin, Gaozhi Chen, Jing Gu, Qin Ouyang, Won-Jea Cho, Qidong Tang, Guang Liang
Summary: MyD88 is an important protein in immune cascade reactions mediated by Toll-like receptors and interleukin-1 receptors. Dysregulation of MyD88 is associated with various inflammatory diseases, making it a potential target for anti-inflammatory and cancer therapy. In this study, 46 compounds were designed and synthesized based on virtual screening hits, and c17 exhibited high binding affinity with MyD88. It inhibited the interaction between TLR4 and MyD88, suppressed the NF-KB pathway, and showed therapeutic potential for ALI treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Hua-Jun Wang, Chen-Jie Zhou
Summary: Bone marrow metastasis in colon cancer, especially with septic shock as the main manifestation, is rare and has not been reported in mainland China. In this case, a 71-year-old woman presented with sepsis, which was later identified as bone marrow metastasis from colon adenocarcinoma through bone marrow puncture smear and PET/CT examination. Advanced colon cancer patients may lack typical symptoms, and the possibility of bone marrow metastasis should be considered when severe thrombocytopenia cannot be explained by intestinal sepsis, especially in countries with limited access to PET/CT.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Cell Biology
Veronica Mendoza-Reinoso, Patricia M. Schnepp, Dah Youn Baek, John R. Rubin, Ernestina Schipani, Evan T. Keller, Laurie K. McCauley, Hernan Roca
Summary: This study reveals that the clearance of apoptotic cancer cells by bone marrow macrophages triggers a pro-inflammatory response through the p-STAT3/HIF-1 alpha/MIF signaling pathway, which promotes the growth of bone-metastatic prostate cancer cells.
Review
Endocrinology & Metabolism
Nicole Aaron, Samantha Costa, Clifford J. Rosen, Li Qiang
Summary: BMAT is now recognized as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis, and metabolism. Age-related inflammatory changes associated with BMAT accrual and the downstream effect on endocrine function, energy expenditure, and metabolism are discussed, with potential therapeutic strategies addressed to prevent dysfunction during aging. Further research is needed to fully understand the explicit characterization of BMAT in aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Chika Iwamoto, Kenoki Ohuchida, Tomohiko Shinkawa, Sho Okuda, Yoshiki Otsubo, Takashi Okumura, Akiko Sagara, Kazuhiro Koikawa, Yohei Ando, Koji Shindo, Naoki Ikenaga, Kohei Nakata, Taiki Moriyama, Yoshihiro Miyasaka, Takao Ohtsuka, Masatoshi Eto, Koichi Akashi, Masafumi Nakamura
Summary: This study found that in PDAC, macrophages derived from bone marrow can partially convert into CAF-like cells, acting as a specific subtype that promotes pancreatic cancer growth and invasion. This conversion may represent a novel therapeutic strategy.
Editorial Material
Oncology
Song Chen, Andrew D. Luster
Summary: The study identifies that histamine released during allergic reactions and from tumor cells weakens the response to immunotherapy. Histamine H-1-receptor signaling induces a suppressive phenotype in tumor-associated macrophages and increases VISTA expression, thereby suppressing CD8(+) T cell function. Anti-histamines can reverse these effects and improve the efficacy of immunotherapy.
Article
Cardiac & Cardiovascular Systems
Christina Kassiteridi, Jennifer E. Cole, Thibault Griseri, Mika Falck-Hansen, Michael E. Goddard, Anusha N. Seneviratne, Patricia A. Green, Inhye Park, Annelie G. Shami, Tanyaporn Pattarabanjird, Aditi Upadhye, Angela M. Taylor, Ashok Handa, Keith M. Channon, Esther Lutgens, Coleen A. McNamara, Richard O. Williams, Claudia Monaco
Summary: The study demonstrates the significant role of CD200 in atherosclerosis, where CD200 deficiency increases atherosclerotic lesion formation. The CD200/CD200R pathway restrains macrophage activation and monocyte recruitment, limiting the progression of atherosclerosis.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Zheng Gong, Qing Li, Jiayuan Shi, Peishan Li, Li Hua, Leonard D. Shultz, Guangwen Ren
Summary: Neutrophils, the most abundant innate immune cells, play a crucial role in regulating the adaptive immune system in various pathological conditions, including metastatic cancer. The immunosuppressive effects of neutrophils in the lungs are induced by lung-resident stroma and reinforced by tumor-associated inflammation. This immunosuppressive capacity is largely mediated by CD140a+ mesenchymal cells (MCs) and prostaglandin-endoperoxide synthase 2 (PTGS2), which is the rate-limiting enzyme for prostaglandin E2 (PGE2) biosynthesis. Targeting lung stromal factors can enhance tissue-resident immunity against metastatic disease.
SCIENCE IMMUNOLOGY
(2023)
Article
Hematology
Joseph H. Oved, Andrew J. Paris, Kandace Gollomp, Ning Dai, Kathryn Rubey, Ping Wang, Lynn A. Spruce, Steven H. Seeholzer, Mortimer Poncz, G. Scott Worthen
Summary: Neutrophils play a critical role in sterile inflammation, engulfing and degrading extracellular DNA fragments to facilitate optimal organ repair.
Review
Biochemistry & Molecular Biology
Hammad Ahmed, Mahtab Ahmad Khan, Ulf Dietrich Kahlert, Mika Niemela, Daniel Haenggi, Shafqat Rasul Chaudhry, Sajjad Muhammad
Summary: MyD88 is an inflammatory adaptor protein in the Toll-like receptor 4 signaling pathway, playing a crucial role in SAH-related neuroinflammation. Research suggests that inhibition of MyD88 can reduce inflammation caused by SAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jasmine Nour, Annalisa Moregola, Monika Svecla, Lorenzo Da Dalt, Rossella Bellini, Olivier Neyrolles, Gian Paolo Fadini, Yoann Rombouts, Mattia Albiero, Fabrizia Bonacina, Giuseppe Danilo Norata
Summary: Research has shown that during a high-fat diet, deficiency of the mannose receptor affects bone marrow and circulating immune cell subsets, leading to reduced systemic inflammation and resistance to obesity development.
Article
Critical Care Medicine
Aoife N. McElroy, Rachele Invernizzi, Joanna W. Laskowska, Andrew O'Neill, Mohammad Doroudian, Mohsen Moghoofei, Shayan Mostafaei, Feng Li, Alexander A. Przybylski, David N. O'Dwyer, Andrew G. Bowie, Padraic G. Fallon, Toby M. Maher, Cory M. Hogaboam, Philip L. Molyneaux, Nik Hirani, Michelle E. Armstrong, Seamas C. Donnelly
Summary: The study on the association between TLR3 L412F polymorphism and acute exacerbation-related death in idiopathic pulmonary fibrosis (IPF) reveals that this polymorphism attenuates the immune responses of IPF lung cells to bacteria and dysregulates the lung microbiome in IPF patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Otorhinolaryngology
Laura Beth O'Neill, Matthew Magyar, Brian Reilly, Tamara Gayle
Summary: The article described a case of idiopathic cricopharyngeal achalasia in a pediatric patient with acute onset of dysphagia, managed conservatively with supportive care. The patient showed improvement over 3 months follow-up after discharge. Conservative management with supportive care is a reasonable approach in similar cases with acute onset in otherwise healthy children.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2022)
Article
Immunology
Gemma Leon, Yasmina E. Hernandez Santana, Naoise Irwin, Eirini Giannoudaki, Sadhbh O'Neill, Ilona Csizmadia, Martina Gogarty, Tae J. Lee, Darren Ruane, Aideen Long, Padraic G. Fallon, Seamus Hussey, Patrick T. Walsh
Summary: IL-36 cytokines play a crucial role in intestinal inflammation and may be involved in the pathogenesis of inflammatory bowel diseases. The study found that IL-36 alpha is specifically elevated in the serum of newly diagnosed pediatric IBD patients, while IL-36 beta and IL-36 gamma are not. T cells were identified as the primary mediators of IL-36 responses in the inflamed gut.
MUCOSAL IMMUNOLOGY
(2022)
Article
Cell Biology
Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, Maria A. Argiriadi, Anne F. McGettrick, Rui Santalla Mendez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayamaran, Kamal Dua, Alexandra C. Brown, Richard Y. Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke A. J. O'Neill
Summary: Itaconate and 4-octyl itaconate inhibit M2 macrophage polarization and metabolic remodeling by suppressing JAK1 phosphorylation and kinase activity. This discovery provides a new strategy to inhibit JAK1 in M2 macrophage-driven diseases.
Article
Biochemistry & Molecular Biology
Laura Matarazzo, Yasmina E. Hernandez Santana, Patrick T. Walsh, Padraic G. Fallon
Summary: The interleukin-1 (IL-1) family of cytokines and receptors are involved in innate and adaptive immunity and inflammation. They are widely expressed in structural and immune cells, particularly within barrier mucosal surfaces. In the lung, gut, and skin, they play important roles in maintaining the integrity of the barrier and regulating innate and adaptive immunity in response to insult and infections. Dysregulation of IL-1 cytokines is associated with abnormal tissue inflammation and inflammatory diseases.
Article
Cell Biology
Christian Schwartz, Viviane Schmidt, Andrea Deinzer, Heike C. Hawerkamp, Emily Hams, Jasmin Bayerlein, Ole Roeger, Moritz Bailer, Christian Krautz, Amr El Gendy, Moustafa Elshafei, Helen M. Heneghan, Andrew E. Hogan, Donal O'Shea, Padraic G. Fallon
Summary: Obesity is a major health problem in the industrialized world. Immune regulation plays an important role in adipose tissue homeostasis. A recent study found that the costimulatory molecule programmed death-ligand 1 (PD-L1) plays a role in limiting diet-induced obesity. PD-L1 expression on dendritic cells (DCs) is essential for obesity control.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Elaine Dempsey, Sinead C. Corr
Summary: This paper reviews the current understanding of how Lactobacillus species can benefit our gastrointestinal health. It emphasizes the need for further research to determine the mechanisms of action of probiotics and the impact of individual differences on health.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mohamed S. Hasim, Marie Marotel, Jonathan J. Hodgins, Elisabetta Vulpis, Olivia J. Makinson, Sara Asif, Han-Yun Shih, Amit K. Scheer, Olivia MacMillan, Felipe G. Alonso, Kelly P. Burke, David P. Cook, Rui Li, Maria Teresa Petrucci, Angela Santoni, Padraic G. Fallon, Arlene H. Sharpe, Giuseppe Sciume, Andre Veillette, Alessandra Zingoni, Douglas A. Gray, Arleigh McCurdy, Michele Ardolino
Summary: This study reveals that lymphocytes can acquire PD-1 and other checkpoint receptors through trogocytosis from leukemia cells, leading to immunoregulation.
Review
Immunology
Viviane Schmidt, Andrew E. Hogan, Padraic G. Fallon, Christian Schwartz
Summary: In recent decades, the relationship between the immune system and metabolism has become a major research focus. The secretion of immunomodulatory molecules by adipose tissue during obesity, along with underlying low-grade inflammation, has brought attention to the impact obesity has on the immune system. Adipokines and nutrient availability play crucial roles in the differentiation and activation of T cells. The influence of obesity on the immune system is particularly evident in Th2-dominated immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Celine Maquet, Jerome Baiwir, Pauline Loos, Lucia Rodriguez-Rodriguez, Justine Javaux, Remy Sandor, Fabienne Perin, Padraic G. Fallon, Matthias Mack, Didier Cataldo, Laurent Gillet, Benedicte Machiels
Summary: Gammaherpesviruses have evolved together with their hosts, shaping host immunity. Infection with Murid herpesvirus 4 drives the recruitment of specific monocytes into the airway, suppressing immune response and reducing host damage.
SCIENCE IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Kevin McCarthy, Eamon Laird, Aisling M. O'Halloran, Padraic Fallon, Roman Romero Ortuno, Rose Anne Kenny
Summary: This study aimed to examine the association between metabolic syndrome (MetS) and prevalent and incident frailty in the elderly. The results showed that MetS was associated with an increased likelihood of both prevalent and incident frailty. MetS should be considered as a risk factor for frailty and be taken into consideration in geriatric assessments.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Medicine, General & Internal
Kevin McCarthy, Eamon Laird, Aisling M. O. 'Halloran, Cathal Walsh, Martin Healy, Annette L. Fitzpatrick, James B. Walsh, Belinda Hern, Padraic Fallon, Anne M. Molloy, Rose Anne Kenny
Summary: The study suggests that low vitamin D concentrations are associated with an increased risk of diabetes and prediabetes. Optimizing vitamin D levels at a population level may significantly reduce the incidence of diabetes.
Article
Cell Biology
Stephanie Lavazais, Manja Jargosch, Sonia Dupont, Frederic Labeguere, Christel Menet, Catherine Jagerschmidt, Frenz Ohm, Laszlo Kupcsik, Isabelle Parent, Celine Cottereaux, Florence Marsais, Line Oste, An Van de Water, Thierry Christophe, Steve De Vos, Padraic Fallon, Felix Lauffer, Philippe Clement-Lacroix, Kilian Eyerich, Reginald Brys
Summary: Innate immunity plays an important role in both environmental cue interpretation and adaptive responses, making modulators of innate immune responses potentially useful in treating immune-mediated inflammatory diseases. A selective IRAK4 inhibitor, GLPG2534, has been evaluated in various in vitro and in vivo models of inflammatory skin diseases, demonstrating inhibition of TLR and IL-1 responses in multiple cell types and dampening disease activity in murine models. Additionally, inhibiting IRAK4 reversed pathogenic molecular signatures in human lesional psoriasis and atopic dermatitis biopsies, highlighting its potential therapeutic strategy in chronic inflammatory skin diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Dermatology
H. Buruno, D. Johnston, D. Tobin
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Meeting Abstract
Medicine, General & Internal
S. O'Donohoe, C. Leahy, D. G. W. Johnston, D. J. Tobin
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
