Article
Biochemistry & Molecular Biology
Jingjing Zhang, Lina Rong, Jinping Shao, Yidan Zhang, Yaping Liu, Sen Zhao, Lei Li, Wenli Yu, Mengya Zhang, Xiuhua Ren, Qingzan Zhao, Changlian Zhu, Huan Luo, Weidong Zang, Jing Cao
Summary: The study demonstrates that miR-137-mediated Kv1.2 impairment plays a crucial role in the pathogenesis of nerve injury-induced neuropathic pain, suggesting it as a novel potential therapeutic target for neuropathic pain management.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Anesthesiology
Yan-Yan Wu, Qian Wang, Ping-An Zhang, Cheng Zhu, Guang-Yin Xu
Summary: There is mounting evidence that microRNAs (miRNAs) have critical roles in various pathophysiological conditions and diseases. However, the physiological impact of extracellular miRNAs on disease-related ion channels is largely unknown. In this study, miR-1306-3p was found to stimulate action potentials and inward currents in rat dorsal root ganglion (DRG) neurons. These effects were inhibited by the P2X3 receptor inhibitor A317491 or after knocking down P2X3Rs in DRG neurons. Specific interaction sites on the extracellular domain of P2X3Rs were identified as the miR-1306-3p binding sites. Intrathecal injection of miR-1306-3p induced visceral pain in rats while intrathecal application of a miR-1306-3p inhibitor and A317491 alleviated chronic visceral pain in a rat model.
Article
Biochemistry & Molecular Biology
Lequan Wen, Lirui Tang, Mingming Zhang, Congrui Wang, Shujuan Li, Yuqing Wen, Hongcheng Tu, Haokun Tian, Jingyi Wei, Peiwen Liang, Changsen Yang, Guodong Li, Yun Gao
Summary: This study investigated whether gallic acid could alleviate comorbid visceral pain and depression by reducing the expression of the P2X7 receptor. The results demonstrated that gallic acid was able to relieve pain and depression, while also reducing the expressions of the P2X7 receptor and p-ERK1/2. Gallic acid treatment also decreased inflammatory cytokines IL-1 beta and TNF-alpha levels, while increasing IL-10 levels in the serum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Yucheng Xiao, Jonathan W. Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore R. Cummins
Summary: In this study, the authors demonstrate that I-NaR can be reconstituted in a heterologous system by coexpression of sodium channel alpha-subunits and A-type fibroblast growth factor homologous factors (FHFs). They also identify the N-terminus of FHF as the critical molecule responsible for A-type FHFs-mediated I-NaR. Moreover, knockdown of FHF4A significantly reduces I-NaR amplitude and suppresses excitability in nociceptive sensory neurons.
Article
Neurosciences
Alexandru-Florian Deftu, Paul Chu Sin Chung, Cedric J. Laedermann, Ludovic Gillet, Marie Pertin, Guylene Kirschmann, Isabelle Decosterd
Summary: The antidiabetic drug metformin reduces pain hypersensitivity by targeting the E3 ubiquitin ligase NEDD4-2 and modulating the expression of voltage-gated sodium channels. NEDD4-2 is critical for the effect of metformin on the excitability of nociceptive neurons, and this action may contribute to the relief of neuropathic pain.
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Anesthesiology
Xinyan Gao, Shu Han, Qian Huang, Shao-Qiu He, Neil C. Ford, Qin Zheng, Zhiyong Chen, Shaoyong Yu, Xinzhong Dong, Yun Guan
Summary: The mechanisms of visceral pain sensitization and referred somatic hypersensitivity are unclear. Through experiments, it was found that TNBS-induced colitis may lead to mechanical hypersensitivity, simultaneously stimulating the intestines and body surface, causing increased sensitivity in L6 and L4 DRG neurons to inputs.
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Chemistry, Multidisciplinary
Yingqiao Wang, Raghav Garg, Jane E. Hartung, Adam Goad, Dipna A. Patel, Flavia Vitale, Michael S. Gold, Yury Gogotsi, Tzahi Cohen-Karni
Summary: Utilizing nanomaterial-assisted photothermal stimulation, Ti3C2Tx (MXene) demonstrates excellent potential as a candidate for remote, non-genetic, optical modulation of neuronal electrical activity with high spatiotemporal resolution. The material's photothermal response, low cytotoxicity, and ease of large-scale synthesis make it a promising tool for modulating electrophysiology at various scales.
Article
Multidisciplinary Sciences
Haohao Wu, Charles Petitpre, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab, Francois Lallemend
Summary: The study identified three main types of proprioceptive neurons (Ia, Ib and II PNs) and found that they segregate into eight distinct subgroups. Importantly, Ia-PN subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Yingda Li, Michael Y. Wang
Summary: This study demonstrated the feasibility of direct intraoperative neuromonitoring within Kambin's triangle in transforaminal endoscopic surgery for the first time. The incidence of new onset symptoms increased with lower stimulation thresholds, and 8 milliampere seems to be a reasonable compromise between sensitivity and specificity for this monitoring technique.
Review
Cell Biology
Risa Domoto, Fumiko Sekiguchi, Maho Tsubota, Atsufumi Kawabata
Summary: Neuroimmune crosstalk plays a crucial role in both somatic and visceral pathological pain, with macrophages interacting with neurons to regulate pain signals in peripheral tissues; recent studies have uncovered different characteristics and mediators of macrophages from various sources, highlighting their multitasking abilities in homeostatic conditions.
Article
Neurosciences
Qin Li, Lu Qin, Jianhua Li
Summary: The study demonstrates that in patients with PAD, muscle afferent neurons are inhibited by the metabolite bradykinin (BK), leading to a decrease in activity of K(V)4 channels and possibly exaggerating the exercise pressor reflex in PAD.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Multidisciplinary Sciences
Isabelle A. M. van Thiel, Aimilia A. Stavrou, Auke de Jong, Bart Theelen, Mark Davids, Theodorus B. M. Hakvoort, Iris Admiraal-van den Berg, Isabelle C. M. Weert, Martine A. M. Hesselink-van de Kruijs, Duong Vu, Christine Moissl-Eichinger, Sigrid E. M. Heinsbroek, Daisy M. A. E. Jonkers, Ferry Hagen, Teun Boekhout, Wouter J. de Jonge, Rene M. van den Wijngaard
Summary: Irritable bowel syndrome (IBS) is a common disorder characterized by chronic abdominal pain and changes in bowel movements. Visceral hypersensitivity may be caused by intestinal fungi, but the diversity of fungal communities does not differ between IBS subgroups. The study highlights the importance of conducting strain-specific cause-and-effect studies in IBS research.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Adam J. Dourson, Zachary K. Ford, Kathryn J. Green, Carolyn E. McCrossan, Megan C. Hofmann, Renita C. Hudgins, Michael P. Jankowski
Summary: The study found that growth hormone (GH) plays an important regulatory role in neonatal pain processing, inhibiting peripheral hypersensitivity through GH receptor (GHr) signaling in primary afferents. After injury, a macrophage-dependent displacement of GH at the injury site was found to regulate neuronal transcription through SRF regulation.
JOURNAL OF NEUROSCIENCE
(2021)
