Article
Biochemistry & Molecular Biology
Yunjia Li, Mengchen Qin, Weichao Zhong, Chang Liu, Guanghui Deng, Menghan Yang, Junjie Li, Haixin Ye, Hao Shi, Chaofeng Wu, Haiyan Lin, Yuyao Chen, Shaohui Huang, Chuying Zhou, Zhiping Lv, Lei Gao
Summary: The study indicates the important role of RAGE in alcoholic liver disease (ALD). Deficiency or inhibition of RAGE can alleviate hepatic inflammation and oxidative stress, as well as affect iron metabolism pathways, thereby improving liver injury.
Article
Biochemistry & Molecular Biology
Vesna Sredoja Tisma, Stela Bulimbasic, Danica Galesic Ljubanovic, Kresimir Galesic, Jadranka Morovic-Vergles, Josko Mitrovic, Koji Uchida, Franz Tatzber, Neven Zarkovic, Morana Jaganjac
Summary: This study investigated the implication of oxidative stress in small-vessel vasculitis, focusing on acrolein immunohistochemistry in affected skin vessels and systemic stress response. It was found that systemic redox homeostasis and iron metabolism are altered in SVV patients, with possible biomarkers identified for evaluating oxidative status, disease activity, and prevalence. Furthermore, a strong correlation between the accumulation of acrolein-protein adducts in the skin and disease progression was revealed.
Review
Biochemistry & Molecular Biology
Zahra Najafi Arab, Danial Khayatan, Seyed Mehrad Razavi, Kimia Zare, Elnaz Kheradkhah, Saeideh Momtaz, Gianna Ferretti, Tiziana Bacchetti, Thozhukat Sathyapalan, Seyed Ahmad Emami, Amir Hossein Abdolghaffari, Amirhossein Sahebkar
Summary: Chronic diseases such as cardiovascular disease, atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality, with oxidative stress and free radicals playing important roles in their development. Antioxidants, including paraoxonases (PONs), can scavenge free radicals and mitigate their adverse effects. Modulating the expression of PON1, an important antioxidant enzyme, can have beneficial effects in various diseases by regulating inflammatory and oxidative stress signaling pathways. Dietary factors can influence PON1 expression and activity, making them important for disease prevention and treatment.
Article
Environmental Sciences
Kexin Zhu, Richard W. Browne, Rachael Hageman Blair, Matthew R. Bonner, Mingmei Tian, Zhongzheng Niu, Furong Deng, Zeinab Farhat, Lina Mu
Summary: This study found that hydroxy metabolites derived from AA and LA are associated with air pollution and may interact with systemic inflammation in response to air pollution exposure.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alvaro Aparisi, Marta Martin-Fernandez, Cristina Ybarra-Falcon, Jose Francisco Gil, Manuel Carrasco-Moraleja, Pedro Martinez-Paz, Ivan Cusacovich, Hugo Gonzalo-Benito, Raul Fuertes, Marta Marcos-Mangas, Carolina Iglesias-Echeverria, J. Alberto San Roman, Eduardo Tamayo, David Andaluz-Ojeda, Alvaro Tamayo-Velasco
Summary: A recent prospective study found that COVID-19 patients experience significant reductions in cholesterol levels and increased oxidative stress during the course of the disease. Lipid peroxidation was found to be associated with alterations in lipid profiles and inflammation. Survivors of COVID-19 showed recovery in their lipid profiles during long-term follow-up, but those with higher oxidative responses developed atherogenic lipid profiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Xiaoming Chen, Mingyu Bi, Jie Yang, Jingzeng Cai, Haoran Zhang, Yue Zhu, Yingying Zheng, Qi Liu, Guangliang Shi, Ziwei Zhang
Summary: The study revealed that cadmium induced toxic effects in pig intestines primarily through activating necroptosis and inflammation pathways, resulting in damage. Additionally, cadmium caused an imbalance in Th1/Th2 immunity, exacerbating inflammatory responses.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Cell Biology
Lei Lei, Jianan Zhang, Eric A. Decker, Guodong Zhang
Summary: This review discusses the common feature of redox stress in gut disorders and its impact on the development of inflammatory bowel disease (IBD) and colorectal cancer (CRC), emphasizing the critical role of lipid-derived electrophiles in the pathogenesis of these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Samukelisiwe C. Shabalala, Rabia Johnson, Albertus K. Basson, Khanyisani Ziqubu, Nokulunga Hlengwa, Sinenhlanhla X. H. Mthembu, Sihle E. Mabhida, Sithandiwe E. Mazibuko-Mbeje, Sidney Hanser, Ilenia Cirilli, Luca Tiano, Phiwayinkosi Dludla
Summary: This review investigates the pathological relevance of elevated lipid peroxidation products in type 2 diabetes (T2D), highlighting their potential role as biomarkers and therapeutic targets. It also briefly explains the significance of antioxidant enzymes/factors involved in blocking lipid peroxidation.
Article
Biochemistry & Molecular Biology
Esra Aktas Senocak, Necati Utlu, Seyda Kurt, Sefa Kucukler, Fatih Mehmet Kandemir
Summary: The research aims to investigate the protective effects of boron against APAP-induced toxicity in rats. Oral administration of boron reduced the harmful effects of APAP on the liver and kidneys, and exerted anti-inflammatory, antioxidant, and anti-apoptotic effects.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Ahmed Abdelraouf Salem, Kira Trares, Matthias Kohl, Eugene Jansen, Hermann Brenner, Ben Schottker
Summary: The study found a significant association between current smoking and increased levels of oxidative stress biomarker D-ROM, while there was no association with TTP levels. There is a dose-response relationship between smoking amount and D-ROM concentrations, indicating long-term effects of smoking on redox balance.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Victor Arroyo, Carmen Carnicero, Rebeca Siguenza, Reyes Busta, Natalia Mora, Beatriz Antolin, Eduardo Tamayo, Patricia Aspichueta, Irene Carnicero-Frutos, Hugo Gonzalo-Benito, Rocio Aller
Summary: This study found that elevated levels of lipid peroxidation (LPO) are significantly associated with a NASH score of >= 4 in NAFLD patients. LPO levels above 315.39 μM were identified as an independent risk factor. The model showed good discrimination ability in distinguishing NASH patients. Therefore, understanding the molecular mechanisms of basal inflammation may help identify biomarkers and therapeutic targets for NASH.
Review
Biochemistry & Molecular Biology
Heshu Chen, Chenyu Wang, Zemin Liu, Xinmiao He, Wenjie Tang, Liuqin He, Yanzhong Feng, Di Liu, Yulong Yin, Tiejun Li
Summary: Ferroptosis is a novel type of non-apoptotic cell death that can be triggered by specific modulators. It has potential implications in preventing inflammatory storms and cancer development. Ferroptosis may mediate biological processes such as oxidative stress and iron overload to treat cancer.
Review
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras, Lorraine M. Sordillo
Summary: Oxidative stress is associated with the generation of oxidized products such as IsoP, which are highly specific biomarkers of lipid peroxidation. Despite advancements in their detection and use, there is still limited knowledge about the biological activity and potential roles of IsoP in oxidative stress pathology, especially in veterinary medicine.
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Marlena Rademacher, Hartmut Kuhn, Astrid Borchert
Summary: GPX4, as the only enzyme capable of reducing complex lipid peroxides to the corresponding alcohols, plays a role in erythroid differentiation of mouse erythroleukemia cells, but heterozygous expression of a catalytically inactive Gpx4 is not sufficient to compromise erythropoiesis in vivo and ex vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Vitor Teixeira, Clemence Guiraut, Ibrahim Mohamed, Jean-Claude Lavoie
Summary: Premature birth and PN have significant impacts on energy metabolism and glutathione metabolism. Glutathione supplementation can mitigate the effects of PN, but early PN may involve other factors in altering metabolic pathways.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Review
Physiology
Emile Levy, Jean Francois Beaulieu, Schohraya Spahis
Summary: Over the past two decades, extensive research has been carried out on the digestion and absorption of intestinal fat, with a focus on the critical players and mechanisms involved in the process. Through experiments and animal models, the relationship between disease-causing factors and clinical manifestations has been revealed, contributing to a better understanding and treatment of the pathological condition.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elisa Gnodi, Clara Mancuso, Luca Elli, Elisa Ballarini, Raffaella Meneveri, Jean Francois Beaulieu, Donatella Barisani
Summary: The study found that in patients with celiac disease, the expression of NEAT1 and TUG1 is downregulated at diagnosis, but increases in patients' intestinal biopsies after exposure to gluten on a gluten-free diet. Through gel shift assays, it was demonstrated that the increase in NEAT1 expression after gluten exposure is mediated by IL-15 and STAT3 activation, binding to the NEAT1 promoter. NEAT1 is primarily localized in the nucleus and can regulate gene expression by sequestering transcription factors, and has been implicated in immune regulation and control of cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Elizabeth Herring, Eric Tremblay, Nathalie McFadden, Shigeru Kanaoka, Jean-Francois Beaulieu
Summary: Colorectal cancer remains one of the deadliest cancers, with early detection being crucial for reducing mortality. Using targeted mRNA assay in stools can optimize the identification of precancerous lesions and curable colorectal cancers. Host mRNA stool testing shows potential in improving colorectal cancer screening efficacy.
Article
Pediatrics
Marie-Pier Thibault, Eric Tremblay, Chantal Horth, Aube Fournier-Morin, David Grynspan, Corentin Babakissa, Emile Levy, Emanuela Ferretti, Valerie Bertelle, Jean-Francois Beaulieu
Summary: Stool biomarkers such as lipocalin-2 and calprotectin can effectively predict the development of NEC in very low birth weight infants over a 10-day period before clinical diagnosis. The combination of LCN2 and CALPRO presents a significant biomarker signature for predicting NEC development, with potential to further improve prediction algorithms by incorporating additional stool markers like PGE2.
PEDIATRIC RESEARCH
(2022)
Article
Medicine, General & Internal
Melanie Henderson, Matthias Friedrich, Andraea Van Hulst, Catherine Pelletier, Tracie A. Barnett, Andrea Benedetti, Jean-Luc Bigras, Vicky Drapeau, Jean-Claude Lavoie, Emile Levy, Marie-Eve Mathieu, Anne-Monique Nuyt
Summary: This study aims to compare early markers of cardiovascular disease between adolescents with T1D and healthy controls, examine their associations with lifestyle habits, inflammatory markers, and oxidative stress indicators, and explore the relationships between CVD markers and residential neighborhood features.
Article
Biochemistry & Molecular Biology
Vitor Teixeira, Ibrahim Mohamed, Jean-Claude Lavoie
Summary: The study evaluated the short- and long-term effects of neonatal vitamin C (VC) and cysteine deficient diets on redox and energy metabolism, showing that these deficiencies may permanently affect liver metabolism. Early-life deficiencies of VC and cysteine induce oxidative stress and predispose to increased lipogenic rates during adulthood.
Meeting Abstract
Biochemistry & Molecular Biology
Angela Mungala Lengo, Jean-Claude lavoie, Ibrahim Mohamed
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Nadine El Raichani, Clemence Guiraut, Guillaume Morin, Ibrahim Mohamed, Jean-Claude Lavoie
Summary: The addition of GSSG to parenteral nutrition can potentially provide a precursor for glutathione synthesis and prevent oxidative stress and alveolar loss in premature infants. Cysteine and multivitamins are important factors contributing to the loss of GSSG.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Review
Anatomy & Morphology
Sepideh Fallah, Jean-Francois Beaulieu
Summary: The Hippo pathway regulates intestinal epithelial proliferation and regeneration, and YAP1 is involved in inhibiting differentiation of certain intestinal cell types, while the role of TAZ in this process is unclear.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Immunology
Amira Seltana, Gabriel Cloutier, Vilcy Reyes Nicolas, Taoufik Khalfaoui, Inga C. Teller, Nathalie Perreault, Jean-Francois Beaulieu
Summary: Fibrinogen plays an important role in wound healing and tissue inflammation, acting as a substrate in the basement membrane of intestinal cells. It has a promoting effect on cell healing, especially under pathological conditions that require rapid epithelial repair.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
David Gagne, Elmira Shajari, Marie-Pier Thibault, Jean-Francois Noel, Francois-Michel Boisvert, Corentin Babakissa, Emile Levy, Hugo Gagnon, Marie A. Brunet, David Grynspan, Emanuela Ferretti, Valerie Bertelle, Jean-Francois Beaulieu
Summary: This study investigates the potential of fecal biomarkers using proteomics technology to predict the development of necrotizing enterocolitis (NEC) in premature infants. The analysis of 36 proteins showed the ability to predict all NEC infants at least a week in advance. This study provides a promising approach for early detection of NEC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jean-Claude Lavoie, Ibrahim Mohamed, Vitor Teixeira
Summary: Glutathione deficiency in premature infants leads to increased oxidative stress, which is a major contributor to bronchopulmonary dysplasia (BPD) development. Animal studies have shown that supplementation of parenteral nutrition (PN) with glutathione can prevent pulmonary oxidative stress and hypoalveolarization characteristic of BPD. In a clinical setting, improving low-plasma glutathione levels may be effective in preventing the development of BPD.
Article
Cell Biology
Blanche Senicourt, Gabriel Cloutier, Nuria Basora, Sepideh Fallah, Andreanne Laniel, Christine Lavoie, Jean-Francois Beaulieu
Summary: Primary cilia are sensory antennae on the cell surface that mediate extracellular signals involved in development, tissue homeostasis, stem cells, and cancer. They are found in various vertebrate cells but are only generated when cells become quiescent. In this study, it was discovered that a subset of cells located deep in the crypts of the small intestine contains primary cilia, indicating the presence of a quiescent cell population. These findings provide further evidence of a quiescent cell population in the human small intestine and suggest new modes of regulation in stem cell dynamics.
Article
Oncology
Gabriel Cloutier, Amira Seltana, Sepideh Fallah, Jean-Francois Beaulieu
Summary: Intestinal epithelial cell differentiation occurs in the crypt and is controlled by various mechanisms. Absorptive cell precursors undergo amplification and then reach the terminal differentiation compartment. The interaction between laminin and integrin plays a role in inhibiting early stages of differentiation. Knocking down ITGA7 in Caco-2/15 cells resulted in increased differentiation markers and morphological features of intestinal cells. The integrin & alpha;7 is a major repressor of absorptive cell terminal differentiation.
EXPERIMENTAL CELL RESEARCH
(2023)