Therapeutic targets in liver fibrosis

Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis

(2010) Yury Popov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells

(2010) Jonel Trebicka et al.   JOURNAL OF HEPATOLOGY

Antifibrotic therapies—emerging biomarkers as treatment end points

(2010) Jayant A. Talwalkar   Nature Reviews Gastroenterology & Hepatology

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal Myofibroblasts

(2009) Peter Fickert et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C

(2009) Jordi Colmenero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis

(2009) Fiona Oakley et al.   GASTROENTEROLOGY

Farglitazar Lacks Antifibrotic Activity in Patients With Chronic Hepatitis C Infection

(2009) John McHutchison et al.   GASTROENTEROLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans

(2009) Montserrat Moreno et al.   HEPATOLOGY

Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis

(2009) Xiaoming Tang et al.   LIFE SCIENCES

Current and Future Anti-Fibrotic Therapies for Chronic Liver Disease

(2008) Don C. Rockey   Clinics in Liver Disease

Current status of autologous bone marrow cell infusion therapy for liver cirrhosis patients

(2008) Shuji Terai et al.   HEPATOLOGY RESEARCH

Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury

(2008) Angela Douglass et al.   JOURNAL OF HEPATOLOGY

Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

(2008) Yury Popov et al.   JOURNAL OF HEPATOLOGY