Article
Pharmacology & Pharmacy
Barbara Hutka, Bernadette Lazar, Andras S. Toth, Bence Agg, Szilvia B. Laszlo, Nora Makra, Balazs Ligeti, Balint Scheich, Kornel Kiraly, Mahmoud Al-Khrasani, Dora Szabo, Peter Ferdinandy, Klara Gyires, Zoltan S. Zadori
Summary: Low-dose ketorolac disrupts the delicate balance between small intestinal bacteria and bile acids without significant effects on intestinal mucosal integrity and peristalsis. Other factors besides mucosal inflammation may contribute to ketorolac-induced dysbiosis and bile dysmetabolism.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vanessa D'Antongiovanni, Luca Antonioli, Laura Benvenuti, Carolina Pellegrini, Clelia Di Salvo, Marco Calvigioni, Adelaide Panattoni, Larisa Ryskalin, Gianfranco Natale, Sebastiano Banni, Gianfranca Carta, Emilia Ghelardi, Matteo Fornai
Summary: Treatment with Saccharomyces boulardii CNCM I-745 prevents diclofenac-induced enteropathy through anti-inflammatory and antioxidant activities, likely by improving butyrate uptake by the enteric mucosa.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Minji Cho, Youngmin Bu, Jae-Woo Park, Hasanur Rahman, Seok-Jae Ko
Summary: NSIs caused by NSAIDs have been overlooked for decades, but with the advancement of video capsule endoscopy, their frequency and severity have become more apparent. CAMs, including various natural substances, have shown potential in treating and preventing NSIs, but more research on their efficacy is needed to fully understand their mechanisms of action.
Article
Environmental Sciences
Xiangju Li, Xue Xue, Jia Jia, Xiaocui Zou, Yongjing Guan, Long Zhu, Zaizhao Wang
Summary: The overuse of antimicrobial agents is a key factor in the emergence of antibiotic resistance bacteria (ARB), but it is unclear whether non-antibiotic chemicals like nonsteroidal anti-inflammatory drug (NSAID) can induce ARB. This study investigated whether NSAID diclofenac (DCF) promotes the emergence of antibiotic resistance in Escherichia coli K12 MG1655. The results showed that DCF induced hereditary stable ARB and caused gene variation on the chromosome. DCF also triggered bacterial oxidative stress and SOS response, leading to enhanced expression of antioxidant and SOS system-related genes. However, high-dosage DCF reduced mutation frequency but enhanced mutant resistance.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Allergy
Lily Li, Jillian Bensko, Kathleen Buchheit, Rebecca R. Saff, Tanya M. Laidlaw
Summary: This study investigated the safety and outcomes of two-step outpatient NSAID challenges for patients with non-aspirin-exacerbated respiratory disease (AERD)-related NSAID hypersensitivity. The results showed that more than 85% of the challenges were negative, allowing patients to use clinically indicated NSAIDs. The challenge reactions were generally mild.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Agriculture, Dairy & Animal Science
Wen Yang Chuang, Li Jen Lin, Hsin Der Shih, Yih Min Shy, Shang Chang Chang, Tzu Tai Lee
Summary: This study investigated the effects of Pennisetum purpureum waste mushroom compost supplementation on broiler chickens, finding that a 5% replacement of soybean meal with PWMC can enhance chicken health by maintaining intestinal microbiota balance, improving antioxidant capacities, and reducing inflammatory responses. It was observed that supplementation also increased the chickens' appetite and growth performances, while influencing gene expression and microbiota composition. Based on these results, a 5% replacement of soybean meal with PWMC is recommended for broiler chickens' diet.
Article
Pharmacology & Pharmacy
Els Mehuys, Tine De Backer, Filip De Keyser, Thierry Christiaens, Thierry Van Hees, Sophie Demarche, Inge Van Tongelen, Koen Boussery
Summary: The concomitant use of NSAIDs and antithrombotic agents increases the risk of bleeding and thromboembolism. In this intervention study, community pharmacists screened for and managed interactions between these drugs. The results showed that most interactions did not result in a change of pharmacotherapy, but in some cases, changes in medication were made.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Barbara Hutka, Anett Varallyay, Szilvia B. Laszlo, Andras S. Toth, Balint Scheich, Sandor Paku, Imre Voros, Zoltan Pos, Zoltan V. Varga, Derek D. Norman, Andrea Balogh, Zoltan Benyo, Gabor Tigyi, Klara Gyires, Zoltan S. Zadori
Summary: Lysophosphatidic acid (LPA) plays an important role in both NSAID-induced gastric injury and small intestinal injury. The signaling pathway of LPAR2 receptor is involved in the development of small intestinal injury, as well as the inflammatory responses associated with ulceration.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Zhongwei Zhao, Manqing Sun, Xinmu Cui, Jiaxin Chen, Chunhong Liu, Xuewu Zhang
Summary: Bacillus coagulans MZY531 has a protective effect on intestinal mucosal injury in immunosuppressed mice induced by cyclophosphamide. It promotes the expression of immune proteins, regulates intestinal inflammation and cellular repair. Furthermore, it can modulate the gut microbiota by increasing the abundance of beneficial bacteria. In conclusion, B. coagulans MZY531 has potential immunomodulatory activity.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Ruijuan Zheng, Yingchen Yang, Chang Yang, Yan Xia
Summary: A core-shell material (UiO@TapbTp) has been developed for detecting nonsteroidal anti-inflammatory drugs by MALDI-TOF MS, showing improved enrichment ability and matrix performance. Pre-enrichment under optimized conditions significantly reduces the detection limits of drugs, with good recoveries in complex samples like saliva and environmental water.
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Article
Gastroenterology & Hepatology
Sang Pyo Lee, Jin Lee, Sea Hyub Kae, Hyun Joo Jang, Eun Suk Jung
Summary: This study aimed to investigate whether NSAIDs can cause damage to the small bowel mucosa. Among the 273 subjects, 125 (45.8%) had small bowel erosions or ulcers, with NSAIDs identified as an independent risk factor for these injuries. Antithrombotic agents were not found to cause or exacerbate damage to the small bowel in this study.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Editorial Material
Pharmacology & Pharmacy
Arik Dahan, Isabel Gonzalez-Alvarez
Summary: The environment and conditions of different regions in the gastrointestinal tract have a significant impact on drug absorption, leading to the importance of studying regional-dependent intestinal drug absorption and delivery. Factors such as pH, fluid composition, and transporter expression can alter drug solubility, intestinal permeability, and overall absorption.
Article
Agriculture, Dairy & Animal Science
Lu Lin, Liguang Xu, Hua Kuang, Jing Xiao, Chuanlai Xu
Summary: A monoclonal antibody selective for 6 oxicam NSAIDs was developed, along with a colloidal gold immunochromatographic strip for on-site detection in milk samples. Results can be obtained within 10 minutes, making it a promising tool for screening oxicam NSAIDs in milk.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Oncology
Hiroshi Imaoka, Mitsuhito Sasaki, Hideaki Takahashi, Yusuke Hashimoto, Izumi Ohno, Shuichi Mitsunaga, Kazuo Watanabe, Kumiko Umemoto, Gen Kimura, Yuko Suzuki, Masafumi Ikeda
ENDOCRINE-RELATED CANCER
(2017)
Article
Medicine, General & Internal
Tsukasa Yoshida, Masahiro Tajika, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Hiroshi Imaoka, Nobuhiro Hieda, Nozomi Okuno, Takashi Kinoshita, Vikram Bhatia, Yasuhiro Shimizu, Yasushi Yatabe, Kenji Yamao, Yasumasa Niwa
Editorial Material
Gastroenterology & Hepatology
Yusuke Hashimoto, Izumi Ohno, Hideaki Takahashi, Mitsuhito Sasaki, Hiroshi Imaoka, Kazuo Watanabe, Kumiko Umemoto, Gen Kimura, Shuichi Mitsunaga, Masafumi Ikeda
ENDOSCOPIC ULTRASOUND
(2019)
Article
Oncology
Hitoshi Shibuya, Susumu Hijioka, Yasunari Sakamoto, Tetsuhide Ito, Keijiro Ueda, Izumi Komoto, Noritoshi Kobayashi, Atsushi Kudo, Hiroaki Yasuda, Hayato Miyake, Junichi Arita, Sho Kiritani, Masafumi Ikeda, Hiroshi Imaoka, Makoto Ueno, Satoshi Kobayashi, Mitsuhiro Furuta, Yoshikuni Nagashio, Gou Murohisa, Taku Aoki, Shigemi Matsumoto, Masayo Motoya, Nobuaki Azemoto, Jun Itakura, Shigeru Horiguchi, Tatsuji Yogi, Tetsuro Kawagoe, Youichi Miyaoka, Fumito Imamura, Michio Senju, Hitoshi Arioka, Kazuo Hara, Masayuki Imamura, Takuji Okusaka
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2018)
Article
Oncology
Hiroshi Imaoka, Mitsuhito Sasaki, Hideaki Takahashi, Yusuke Hashimoto, Izumi Ohno, Shuichi Mitsunaga, Kazuo Watanabe, Kumiko Umemoto, Gen Kimura, Yuko Suzuki, Motoyasu Kan, Masafumi Ikeda
Article
Oncology
Satoshi Shiba, Hiroshi Imaoka, Kazuhiko Shioji, Eiichiro Suzuki, Shigeru Horiguchi, Takeshi Terashima, Yasushi Kojima, Tatsuya Okuno, Yasutaka Sukawa, Kunihiko Tsuji, Kumiko Umemoto, Akinori Asagi, Akiko Todaka, Makoto Ueno, Masafumi Ikeda, Chigusa Morizane, Junji Furuse
Article
Gastroenterology & Hepatology
Yuko Suzuki, Motoyasu Kan, Gen Kimura, Kumiko Umemoto, Kazuo Watanabe, Mitsuhito Sasaki, Hideaki Takahashi, Yusuke Hashimoto, Hiroshi Imaoka, Izumi Ohno, Shuichi Mitsunaga, Masafumi Ikeda
JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Shigetaka Yoshinaga, Takao Itoi, Kenji Yamao, Ichiro Yasuda, Atsushi Irisawa, Hiroshi Imaoka, Takayoshi Tsuchiya, Shinpei Doi, Akane Yamabe, Yoshitaka Murakami, Hideki Ishikawa, Yutaka Saito
DIGESTIVE ENDOSCOPY
(2020)
Article
Medicine, General & Internal
Sakura Iizumi, Aya Kuchiba, Takuji Okusaka, Masafumi Ikeda, Yasunari Sakamoto, Shunsuke Kondo, Chigusa Morizane, Hideki Ueno, Keiichiro Osame, Shuichi Mitsunaga, Izumi Ohno, Hiroshi Imaoka, Yusuke Hashimoto, Hideaki Takahashi, Mitsuhito Sasaki, Ken Ohashi
Review
Medicine, General & Internal
Hiroshi Imaoka, Mitsuhito Sasaki, Yusuke Hashimoto, Kazuo Watanabe, Masafumi Ikeda
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Oncology
Motoyasu Kan, Hiroshi Imaoka, Kazuo Watanabe, Mitsuhito Sasaki, Hideaki Takahashi, Yusuke Hashimoto, Izumi Ohno, Shuichi Mitsunaga, Kumiko Umemoto, Gen Kimura, Yuko Suzuki, Hiroki Eguchi, Toru Otsuru, Kyosuke Goda, Masafumi Ikeda
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2020)
Article
Oncology
Hiroshi Imaoka, Masafumi Ikeda, Kosuke Maehara, Kumiko Umemoto, Masato Ozaka, Satoshi Kobayashi, Takeshi Terashima, Hiroto Inoue, Chihiro Sakaguchi, Kunihiro Tsuji, Kazuhiko Shioji, Keiya Okamura, Yasuyuki Kawamoto, Rei Suzuki, Hirofumi Shirakawa, Hiroaki Nagano, Makoto Ueno, Chigusa Morizane, Junji Furuse
Article
Gastroenterology & Hepatology
Hiroshi Imaoka, Masafumi Ikeda, Kosuke Maehara, Kumiko Umemoto, Masato Ozaka, Satoshi Kobayashi, Takeshi Terashima, Hiroto Inoue, Chihiro Sakaguchi, Kunihiro Tsuji, Kazuhiko Shioji, Keiya Okamura, Akiko Tsujimoto, Ikuo Nakamura, Hirofumi Shirakawa, Masayuki Furukawa, Makoto Ueno, Chigusa Morizane, Junji Furuse
Summary: This study aimed to clarify the prognosis of patients with unresectable undifferentiated carcinoma (UC) of the pancreas and construct a prognostic model. Independent prognostic factors were identified through multivariate analysis and used to define a prognostic model that stratified patients into high-risk and low-risk groups with significant differences in overall survival.
Review
Medicine, General & Internal
Hiroshi Imaoka, Mitsuhito Sasaki, Yusuke Hashimoto, Kazuo Watanabe, Shoichi Miyazawa, Taro Shibuki, Shuichi Mitsunaga, Masafumi Ikeda
Summary: Precision medicine in cancer treatment involves targeted therapy based on biomarker evaluation. Despite the challenges in pancreatic cancer, novel biomarker-based therapies have emerged, identifying potential genetic alterations as therapeutic targets in patients with PC.
Review
Oncology
Hiroshi Imaoka, Masafumi Ikeda, Kumiko Umemoto, Yu Sunakawa, Makoto Ueno, Hideki Ueno, Masato Ozaka, Takamichi Kuwahara, Naohiro Okano, Masashi Kanai, Terumasa Hisano, Yuko Suzuki, Akinori Asagi, Kazuhiko Shioji, Akiko Todaka, Kunihiro Tsuji, Kenji Ikezawa, Ikuya Miki, Yoshito Komatsu, Noriyuki Akutsu, Tatsuya Yamashita, Hiroyuki Okuyama, Junji Furuse, Hiroaki Nagano
Summary: Undifferentiated carcinoma (UC) is an aggressive epithelial neoplasm with a poor prognosis, but recent advances in diagnostic modalities and genomic sequencing technologies are providing new possibilities for diagnosis and expanded treatments. UC of the pancreas is a rare subtype of pancreatic cancer with no definitive direction of differentiation. The World Health Organization (WHO) classifies UC into subtypes, and surgical resection is currently the only curative treatment, though there are promising results from paclitaxel-containing regimens for unresectable UC.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)