Article
Anesthesiology
Claudius E. Degro, Nestor Nivardo Jimenez-Vargas, Quentin Tsang, Yang Yu, Mabel Guzman-Rodriguez, Elahe Alizadeh, David Hurlbut, David E. Reed, Alan E. Lomax, Christoph Stein, Nigel W. Bunnett, Stephen J. Vanner
Summary: This study found that repeated dosing of N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide can provide safe and effective analgesia for colitis by targeting the acidified layers of the inflamed colon. The drug is able to inhibit human colonic nociceptors and has minimal side effects.
Review
Neurosciences
Chanon Srihagulang, Jirapong Vongsfak, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, characterized by immediate neuronal destruction and secondary brain injury mechanisms. Vagus nerve stimulation (VNS) shows potential for neuroprotection in TBI through various mechanisms, providing beneficial effects in animal models and patients. Further research is needed to fully understand the therapeutic potential of VNS in treating TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Neurosciences
Erin Trifilio, Destin Shortell, Sarah Olshan, Alexandria O'Neal, Jozee Coyne, Damon Lamb, Eric Porges, John Williamson
Summary: Evidence has been accumulating over the past 15 years on the clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS). This novel non-invasive brain stimulation technique has been applied to various neuropsychiatric disorders and more recently, in healthy aging populations. This review discusses the possible mechanisms, considerations for older adults, and the use of non-invasive VNS in conjunction with existing behavioral interventions to promote healthy aging.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Behavioral Sciences
Yue Wang, Gaofeng Zhan, Ziwen Cai, Bo Jiao, Yilin Zhao, Shiyong Li, Ailin Luo
Summary: With the development of medical technology, vagus nerve stimulation (VNS) has been approved by the FDA as an alternative treatment for refractory epilepsy, refractory depression, cluster headaches, and migraines. Although VNS has shown promising results for more brain diseases like Parkinson's disease, autistic spectrum disorder, and traumatic brain injury, the specific biological mechanisms underlying its beneficial effects remain incompletely understood.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Food Science & Technology
Wei Jia, Jian Peng, Yan Zhang, Jiying Zhu, Xin Qiang, Rong Zhang, Lin Shi
Summary: The roles of intestinal flora in the gut-brain axis response pathway and their impact on hormone regulation, appetite, and energy metabolism have attracted significant attention. The mechanisms by which intestinal flora-derived metabolites influence leptin, ghrelin, and insulin to regulate appetite and body weight were outlined in this review, with a focus on the importance of the paraventricular nucleus and ventromedial prefrontal cortex in food reward. The vagus nerve and mitochondria serve as essential pathways in gut-brain communications, modulating neurotransmitters, neural signaling, and neurotransmission.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Neurosciences
Jing Yang, Hong-Quan Dong, Yan-Hu Liu, Mu-Huo Ji, Xun Zhang, Hong-Yu Dai, Zhao-Chu Sun, Lu Liu, Jian Zhou, Huan-Huan Sha, Yan-Ning Qian, Qing-Guo Li, Hao Yao, Na-Na Li
Summary: This study highlights the role of the vagus nerve as a conduction highway in surgery-induced neuroinflammation. The findings suggest that vagotomy can partially block neuroinflammation caused by peripheral inflammation, and inhibition of NR2B receptor on BMCs can reduce glutamate-induced neuroinflammation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Fatemeh Hesampour, Charles N. Bernstein, Jean-Eric Ghia
Summary: Inflammatory bowel disease (IBD) is a chronic condition with no known cause. Vagus nerve stimulation (VNS) has shown potential as a therapeutic approach for IBD by reducing inflammation. Noninvasive techniques for VNS have been developed, making it a promising treatment option.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Physiology
Robert Behrens, Mathias Dutschmann, Matthew Trewella, Stuart B. Mazzone, Aung Aung Kywe Moe
Summary: Vagal sensory inputs can affect breathing by modulating respiratory circuits in the brainstem. This study aimed to investigate the specific effects of modulating lateral parabrachial nucleus (LPB) activity on vagally-evoked changes in breathing. The researchers found that muscimol microinjections into the LPB attenuated vagus nerve stimulation (eVNS)-evoked respiratory rate responses, with specific effects in different regions of the LPB.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anna Carolyna L. Gianlorenco, Paulo S. de Melo, Anna Marduy, Angela Yun Kim, Chi Kyung Kim, Hyuk Choi, Jae-Jun Song, Felipe Fregni
Summary: Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive stimulation method that shows potential therapeutic benefits. This study conducted a systematic review on the effects of taVNS on EEG measures, finding that it increases activity in lower frequency bands and alters early components related to inhibitory tasks. Further research is needed to establish specific effects and metrics.
Review
Biochemistry & Molecular Biology
Fahim Muhammad, Bufang Fan, Ruoxi Wang, Jiayan Ren, Shuhui Jia, Liping Wang, Zuxin Chen, Xin-An Liu
Summary: The gut and the brain are connected through millions of nerves, immune factors, and hormones in the circulatory system. The gut microbiota plays a crucial role in the bidirectional communication, regulating intestinal homeostasis and influencing brain activity. Changes in gut microbiota composition and function affect neurophysiological development and immune regulatory disorders, making it a potential therapeutic target for neurodevelopmental diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Masatomo Ishioh, Tsukasa Nozu, Sho Igarashi, Hiroki Tanabe, Shima Kumei, Masumi Ohhira, Kaoru Takakusaki, Toshikatsu Okumura
Summary: Through activating adenosine A2B receptors in the central nervous system, intestinal barrier function can be improved; these receptors may mediate the ghrelin-induced improvement of leaky gut in a vagal dependent fashion, which helps us understand the pathophysiology not only in gastrointestinal diseases but also in non-gastrointestinal diseases associated with altered intestinal permeability.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Psychology, Biological
Toshikatsu Okumura, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Takuya Funayama, Shima Kumei, Masumi Ohhira
Summary: Brain oxytocin plays an important role in regulating intestinal barrier function. It can reduce colonic hyperpermeability and this effect is mediated by the vagal cholinergic pathway or cannabinoid 1 receptor signaling. This finding suggests that activation of central oxytocin signaling may be beneficial for the treatment of leaky gut-related diseases such as irritable bowel syndrome and autism.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Janielle Richards, Sharon Miksys, Maria Novalen, Rachel F. Tyndale
Summary: Inhibition of CYP2D activity in the brain results in higher analgesia from oral hydrocodone, suggesting that variation in CYP2D in the brain may play a significant role in interindividual differences in response to CYP2D substrates, including oral hydrocodone.
Article
Neurosciences
Tiaosi Xing, Giorgia Nanni, Cameron R. Burkholder, Kirsteen N. Browning, R. Alberto Travagli
Summary: A monosynaptic pathway connecting the substantia nigra pars compacta (SNpc) to neurons of the dorsal motor nucleus of the vagus (DMV) modulates the tone and motility of the proximal colon, and impairment of this pathway may contribute to colonic transit reduction and constipation.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Clinical Neurology
Daniel H. Lench, Travis H. Turner, Colin McLeod, Heather A. Boger, Lilia Lovera, Lisa Heidelberg, Jordan Elm, Anh Phan, Bashar W. Badran, Vanessa K. Hinson
Summary: This study evaluated the feasibility, safety, and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in participants with mild to moderate Parkinson's disease. The results showed that taVNS treatment was safe and well-tolerated, but daily in-office visits were burdensome for participants. Although there were no significant differences in MDS-UPDRS scores or self-reported measures, verbal fluency decreased in the taVNS group. Future studies should explore at-home stimulation devices and optimize stimulation parameters.
FRONTIERS IN NEUROLOGY
(2023)
Article
Cell Biology
Juan Ji An, Guey-Ying Liao, Clint E. Kinney, Niaz Sahibzada, Baoji Xu
Article
Endocrinology & Metabolism
Guey-Ying Liao, Karine Bouyer, Anna Kamitakahara, Niaz Sahibzada, Chien-Hua Wang, Michael Rutlin, Richard B. Simerly, Baoji Xu
MOLECULAR METABOLISM
(2015)
Article
Neurosciences
Amanda E. Lewin, Stefano Vicini, Janell Richardson, Kenneth L. Dretchen, Richard A. Gillis, Niaz Sahibzada
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Article
Neurosciences
Ghazaul Dezfuli, Kenneth J. Kellar, Kenneth L. Dretchen, Yousef Tizabi, Niaz Sahibzada, Richard A. Gillis
Article
Pharmacology & Pharmacy
Kristen E. DeDominicis, Niaz Sahibzada, Thao T. Olson, Yingxian Xiao, Barry B. Wolfe, Kenneth J. Kellar, Robert P. Yasuda
MOLECULAR PHARMACOLOGY
(2017)
Article
Neurosciences
Ghazaul Dezfuli, Richard A. Gillis, Jaclyn E. Tatge, Kimbell R. Duncan, Kenneth L. Dretchen, Patrick G. Jackson, Joseph G. Verbalis, Niaz Sahibzada
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Chemistry, Medicinal
Venkata M. Yenugonda, Yingxian Xiao, Edward D. Levin, Amir H. Rezvani, Thao Tran, Nour Al-Muhtasib, Niaz Sahibzada, Teresa Xie, Corinne Wells, Susan Slade, Joshua E. Johnson, Sivanesan Dakshanamurthy, Hye-Sik Kong, York Tomita, Yong Liu, Mikell Paige, Kenneth J. Kellar, Milton L. Brown
JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Yong Liu, Janell Richardson, Thao Tran, Nour Al-Muhtasib, Teresa Xie, Venkata Mahidhar Yenugonda, Hannah G. Sexton, Amir H. Rezvani, Edward D. Levin, Niaz Sahibzada, Kenneth J. Kellar, Milton L. Brown, Yingxian Xiao, Mikell Paige
JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
G. Patrick Hussmann, Kristen E. DeDominicis, Jill R. Turner, Robert P. Yasuda, Jacquelyn Klehm, Patrick A. Forcelli, Yingxian Xiao, Janell R. Richardson, Niaz Sahibzada, Barry B. Wolfe, Jon Lindstrom, Julie A. Blendy, Kenneth J. Kellar
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Neurosciences
Janell Richardson, Maureen T. Cruz, Usnish Majumdar, Amanda Lewin, Kathryn A. Kingsbury, Ghazaul Dezfuli, Stefano Vicini, Joseph G. Verbalis, Kenneth L. Dretchen, Richard A. Gillis, Niaz Sahibzada
JOURNAL OF NEUROSCIENCE
(2013)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew G. Horti, Yongjun Gao, Hiroto Kuwabara, Yuchuan Wang, Sofya Abazyan, Robert P. Yasuda, Thao Tran, Yingxian Xiao, Niaz Sahibzada, Daniel P. Holt, Kenneth J. Kellar, Mikhail V. Pletnikov, Martin G. Pomper, Dean F. Wong, Robert F. Dannals
JOURNAL OF NUCLEAR MEDICINE
(2014)
Article
Multidisciplinary Sciences
Niaz Sahibzada, Allen W. Mangel, Jaclyn E. Tatge, Kenneth L. Dretchen, Michael R. Franz, Renu Virmani, Richard A. Gillis
Article
Neurosciences
Maureen T. Cruz, Ghazaul Dezfuli, Erin C. Murphy, Stefano Vicini, Niaz Sahibzada, Richard A. Gillis
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Neurosciences
Ghazaul Dezfuli, Thao T. Olson, Lukas M. Martin, Youngshin Keum, Byron A. Siegars, Anushka Desai, Mia Uitz, Niaz Sahibzada, Richard A. Gillis, Kenneth J. Kellar
Article
Pharmacology & Pharmacy
Edward W. Tuan, Andrew G. Horti, Thao T. Olson, Yongiun Gao, Craig A. Stockmeier, Nour Al-Muhtasib, Carrie Bowman Dalley, Amanda E. Lewin, Barry B. Wolfe, Niaz Sahibzada, Yingxian Xiao, Kenneth J. Kellar
MOLECULAR PHARMACOLOGY
(2015)