Article
Biochemistry & Molecular Biology
Anna Billeschou, Jenna Elizabeth Hunt, Aruna Ghimire, Jens J. Holst, Hannelouise Kissow
Summary: This study found that GLP-2 receptor activation does not have a major impact on acute intestinal injury, but it is crucial for the adaptive response in the small intestine.
Article
Endocrinology & Metabolism
Biao Wang, Yajuan Xu, Xiaofeng Hou, Jingjing Li, Yanjun Cai, Yingqi Hao, Qian Ouyang, Bo Wu, Zongzong Sun, Miao Zhang, Yanjie Ban
Summary: The study found that the prevalence of small intestinal bacterial overgrowth (SIBO) is higher in pregnant women with subclinical hypothyroidism compared to those with normal thyroid function. SIBO-positive patients are more likely to experience abdominal distension and constipation, and have lower body mass index. Additionally, SIBO-positive patients have higher levels of inflammatory markers and thyroid function indicators.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Changhao Dong, Guangxiang Wang, Rui Xian, Chao Li, Shaoxin Wang, Lihong Cui
Summary: Several recent studies have investigated the relationship between atherosclerosis and gut microbial imbalance, specifically small intestinal bacterial overgrowth (SIBO). This study aimed to explore the association between SIBO and subclinical atheromatous plaques. The results showed that SIBO was significantly associated with an increased frequency of plaques in various arterial territories.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Pawel Serek, Monika Oleksy-Wawrzyniak
Summary: The intestinal barrier, composed of cells, mucus, and microbiota, plays a crucial role in maintaining immune homeostasis. Disturbances in its tightness can lead to a range of issues, including systemic infections and autoimmune diseases. Zonulin, a protein found in epithelial cells, plays a key regulatory role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Hoang Thuy Linh, Yasunori Iwata, Yasuko Senda, Yukiko Sakai-Takemori, Yusuke Nakade, Megumi Oshima, Shiori Nakagawa-Yoneda, Hisayuki Ogura, Koichi Sato, Taichiro Minami, Shinji Kitajima, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Miho Shimizu, Kengo Furuichi, Norihiko Sakai, Hiroyuki Yamada, Katsuhiko Asanuma, Kouji Matsushima, Takashi Wada
Summary: Impairment of intestinal barrier function is associated with the progression of diabetic kidney disease, and abnormal MAVS signaling in the kidney and intestine contributes to disrupted intestinal homeostasis. Controlling intestinal homeostasis may offer a novel therapeutic approach for diabetic kidney disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Immunology
Yan-hua Wang
Summary: Bacterial translocation can lead to multiple organ dysfunction syndrome, and ensuring the integrity of the intestinal mucosal barrier is crucial for prevention. Early diagnosis, intervention, or prevention of bacterial translocation may be a new avenue in the treatment of various diseases. Elimination of the primary disease, maintaining blood and oxygen supply to the intestine, and selective digestive decontamination are key in treatment.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Irina Efremova, Roman Maslennikov, Aliya Alieva, Elena Poluektova, Vladimir Ivashkin
Summary: The aim of this study was to determine whether the presence of small intestinal bacterial overgrowth (SIBO) affects the prognosis in cirrhosis. A total of 50 patients were included in this prospective cohort study and underwent lactulose hydrogen breath test for SIBO. The results showed that SIBO is associated with poor prognosis in cirrhosis.
Article
Biology
Jacob A. Van Winkle, Stefan T. Peterson, Elizabeth A. Kennedy, Michael J. Wheadon, Harshad Ingle, Chandni Desai, Rachel Rodgers, David A. Constant, Austin P. Wright, Lena Li, Maxim N. Artyomov, Sanghyun Lee, Megan T. Baldridge, Timothy J. Nice
Summary: Bacterial microbiota stimulate the expression of antiviral genes in intestinal epithelial cells, enhancing host defense against enteric viruses.
Article
Developmental Biology
Akaljot Singh, Holly M. Poling, Praneet Chaturvedi, Konrad Thorner, Nambirajan Sundaram, Daniel O. Kechele, Charlie J. Childs, Heather A. McCauley, Garrett W. Fisher, Nicole E. Brown, Jason R. Spence, James M. Wells, Michael A. Helmrath
Summary: The in vitro differentiation of pluripotent stem cells into human intestinal organoids (HIOs) is an effective method for creating complex three-dimensional intestinal structures. This study analyzed the developmental stages of HIO engraftment and found that HIO maturation closely resembles fetal human intestinal development. The use of single-nuclear RNA sequencing further validated these findings and solidified the value of transplanted HIOs as a human intestinal model system.
Review
Medicine, Research & Experimental
David Dahlgren, Hans Lennernas
Summary: Chemotherapy damages the intestinal barrier by killing gut stem cells, leading to increased bacterial translocation and altered permeability. The mucus layer and epithelium are also affected by chemotherapy, making the barrier more permeable. However, the exact sequence of events and contributions of different barrier components are still unclear, and further research is needed to understand the development of chemotherapy-induced gut toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Surgery
Affonso Flavio Jorge Mussolino, Ana Cristina Aoun Tannuri, Josiane de Oliveira Goncalves, Suellen Serafini, Uenis Tannuri
Summary: The adaptation processes of the remaining jejunum or ileum after extensive intestinal resection in a growing animal model showed that adaptive responses seemed to be more effective in the ileum than in the jejunum.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Nutrition & Dietetics
Katia Anunciacao Costa, Marina Chaves de Oliveira, Leticia Maria de Souza Cordeiro, Cynthia Honorato Val, Fabiana Simao Machado, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Mauro Martins Teixeira, Ana Leticia Malheiros Silveira, Adaliene Versiani Matos Ferreira
Summary: This study aims to evaluate the effects of a high-refined carbohydrate (HC) diet on small intestine changes. Male BALB/c mice were fed an HC diet for 8 weeks, and it was found that although there were no significant differences in body weight gain, mice fed the HC diet exhibited adiposity and metabolic alterations. However, there were no significant changes observed in intestinal integrity, tight junction protein expression, intestinal permeability, and bacterial translocation.
Article
Pharmacology & Pharmacy
Kaifan Bao, Meiling Wang, Li Liu, Dongya Zhang, Cuiyuan Jin, Junfeng Zhang, Liyun Shi
Summary: This study demonstrates that Jinhong Decoction can significantly improve the survival rate of septic mice and alleviate infection-related lung inflammation and injury. The protective role of JHD is mediated through the regulation of gut microbiota and restoration of intestinal barrier function. This research reveals the mechanism of gut bacteria migration leading to sepsis-associated acute lung injury and highlights the potential of JHD as an effective treatment strategy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Yingqi Hao, Yajuan Xu, Yanjie Ban, Jingjing Li, Bo Wu, Qian Ouyang, Zongzong Sun, Miao Zhang, Yanjun Cai, Mengqi Wang, Wentao Wang
Summary: The study suggests that probiotics combined with prebiotics are effective in treating clinical hypothyroidism complicated with small intestinal bacterial overgrowth (SIBO) during pregnancy, improving intestinal bacterial overgrowth, gastrointestinal symptoms, thyroid function, and inflammatory factors.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Food Science & Technology
Shengnan Huang, Yanan Gao, Ziwei Wang, Xue Yang, Jiaqi Wang, Nan Zheng
Summary: This study investigated the anti-inflammatory effects of short-chain fatty acids (SCFAs) in the immature intestine and found that SCFAs can reduce the inflammatory response induced by IL-1 beta. Furthermore, SCFAs improved the inflammation by inhibiting multiple signaling pathways. These findings suggest that SCFAs may serve as a new therapeutic agent for NEC.
FOOD SCIENCE & NUTRITION
(2022)
Article
Immunology
D. Rios, M. B. Wood, J. Li, B. Chassaing, A. T. Gewirtz, I. R. Williams
MUCOSAL IMMUNOLOGY
(2016)
Article
Nanoscience & Nanotechnology
Jonathan J. Powell, Emma Thomas-McKay, Vinay Thoree, Jack Robertson, Rachel E. Hewitt, Jeremy N. Skepper, Andy Brown, Juan Carlos Hernandez-Garrido, Paul A. Midgley, Inmaculada Gomez-Morilla, Geoffrey W. Grime, Karen J. Kirkby, Neil A. Mabbott, David S. Donaldson, Ifor R. Williams, Daniel Rios, Stephen E. Girardin, Carolin T. Haas, Sylvaine F. A. Bruggraber, Jon D. Laman, Yakup Tanriver, Giovanna Lombardi, Robert Lechler, Richard P. H. Thompson, Laetitia C. Pele
NATURE NANOTECHNOLOGY
(2015)
Article
Multidisciplinary Sciences
Ighovwerha Ofotokun, Kehmia Titanji, Tatyana Vikulina, Susanne Roser-Page, Masayoshi Yamaguchi, Majd Zayzafoon, Ifor R. Williams, M. Neale Weitzmann
NATURE COMMUNICATIONS
(2015)
Article
Cell Biology
Megan B. Wood, Daniel Rios, Ifor R. Williams
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2016)
Article
Immunology
Melanie Chypre, Jonathan Seaman, Olga G. Cordeiro, Laure Willen, Kathryn A. Knoop, Andrew Buchanan, Richard C. A. Sainson, Ifor R. Williams, Hideo Yagita, Pascal Schneider, Christopher G. Mueller
IMMUNOLOGY LETTERS
(2016)
Article
Microbiology
David S. Donaldson, Anuj Sehgal, Daniel Rios, Ifor R. Williams, Neil A. Mabbott
Review
Nutrition & Dietetics
Huifeng Jin, Haojie Cheng, Wei Chen, Xiaoming Sheng, Mark A. Levy, Mark J. Brown, Junqiang Tian
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2018)
Article
Cell Biology
Beatrice A. Nyagode, Ifor R. Williams, Edward T. Morgan
Article
Multidisciplinary Sciences
Aimee L. Cunningham, M. Neal Guentzel, Jieh-Juen Yu, Chiung-Yu Hung, Thomas G. Forsthuber, Christopher S. Navara, Hideo Yagita, Ifor R. Williams, Karl E. Klose, Tonyia D. Eaves-Pyles, Bernard P. Arulanandam
Article
Cell Biology
Yi Huang, Yan Chen, Amanda Marie Shaw, Howard Goldfine, Junqiang Tian, Jiyang Cai
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Integrative & Complementary Medicine
Junrong Wu, Haojie Cheng, Jianpin Shi, Weidong Yin, Jun Wang, Xuanqiao Ou, Jin Li Chen, Ira Bernstein, Mark Levy, Rolando Maddela, Robert Sinnott, Junqiang Tian
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2020)
Article
Integrative & Complementary Medicine
Mark Levy, Wu Jun-rong, Shi Jian-pin, Cheng Hao-jie, Qu Xuan-qiao, Ira Bernstein, Robert Sinnott, Tian Jun-qiang
Summary: The study developed a preliminary diagnostic risk score for protective qi deficiency (PQD) using a multivariate logistic model, and showed that beta-glucan had a positive impact on improving PQD. The research indicated the feasibility of utilizing therapies from mainstream biomedicine to enhance treatment guided by traditional Chinese medicine principles.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Jun-rong Wu, Hao-jie Cheng, Jian-pin Shi, Wei-dong Yin, Jun Wang, Xuan-qiao Ou, Jin-li Chen, Ira Bernstein, Mark Levy, Rolando Maddela, Robert Sinnott, Jun-qiang Tian
Summary: The study demonstrated that beta-glucan can improve the protective qi status of PQD individuals, enhancing the body's defense against external harmful influences. Additionally, beta-glucan also improves symptoms of upper respiratory tract infections, levels of saliva secretory IgA, and physical and mental health status.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Letter
Pharmacology & Pharmacy
Junqiang J. Tian, Mark Levy, Robert Sinnott
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Junqiang J. Tian, Mark Levy, Xuekai Zhang, Robert Sinnott, Rolando Maddela
Summary: Homeostasis is a steady state of physiological parameters that vary within a certain range and are maintained by negative feedback mechanisms. This concept applies to both whole-body and cellular levels, and is crucial for adaptation to stress. However, chronic stress can lead to collateral damages.
PHARMACOLOGICAL RESEARCH
(2022)