Article
Endocrinology & Metabolism
Brittany L. Moyce Gruber, Laura K. Cole, Bo Xiang, Mario A. Fonseca, Julianne Klein, Grant M. Hatch, Christine A. Doucette, Vernon W. Dolinsky
Summary: Adiponectin deficiency contributes to the development of fatty liver during pregnancy and is associated with GDM. Adiponectin knockout mice developed hepatic steatosis and exhibited glucose and pyruvate intolerance during pregnancy.
Article
Endocrinology & Metabolism
Ruben Rodriguez, Andrew Y. Lee, Jose A. Godoy-Lugo, Bridget Martinez, Hiroyuki Ohsaki, Daisuke Nakano, David G. Parkes, Akira Nishiyama, Jose Pablo Vazquez-Medina, Rudy M. Ortiz
Summary: The study demonstrates that chronic AT(1) blockade improves obesity-related hyperglycemia in rats by enhancing adipocyte function and reducing hepatic glucose production via gluconeogenesis. The results shed light on the therapeutic potential of chronic AT(1) blockade for hyperglycemia.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Froukje Vanweert, Michael Neinast, Edmundo Erazo Tapia, Tineke van de Weijer, Joris Hoeks, Vera B. Schrauwen-Hinderling, Megan C. Blair, Marc R. Bornstein, Matthijs K. C. Hesselink, Patrick Schrauwen, Zoltan Arany, Esther Phielix
Summary: This study used NaPB to lower plasma BCAA levels in patients with T2D and found that it improved peripheral insulin sensitivity, muscle mitochondrial oxidative capacity, and whole-body insulin-stimulated carbohydrate oxidation while reducing plasma BCAA and glucose levels.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Juan Wu, Rui-Bo Jia, Donghui Luo, Zhao-Rong Li, Lianzhu Lin, Qianwen Zheng, Mouming Zhao
Summary: Compared with metformin alone, LMET-SFP has better effects in managing diabetes by lowering fasting blood glucose levels, improving insulin resistance, and reducing serum cholesterol. It also improves liver function, increases fecal bile acids, and enhances beneficial intestinal microbiota. These results suggest that SFP may be used as an auxiliary hypoglycemic substance for metformin in the future.
Article
Food Science & Technology
Yuhan Zhao, Mengjie Li, Jingya Guo, Jingjing Fang, Ruixuan Geng, Yanan Wang, Tingting Liu, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: The study found that cedrol (CED) has excellent health-promoting effects, including anti-inflammatory, anti-arthritic, and antinociceptive effects. Adding CED to the high-fat diet (HFD) can prevent obesity and metabolic syndrome, and the underlying mechanism is revealed. The results show that CED effectively reduces HFD-induced body weight gain, decreases visceral fat pad weight, and significantly prevents adipocyte hypertrophy in mice. HFD-induced hepatic steatosis, glucose intolerance, insulin resistance, and gluconeogenesis are ameliorated by CED supplementation. Overall, incorporating CED into the diet can prevent HFD-induced obesity and related metabolic syndrome, highlighting its potential as a promising dietary component for obesity therapeutic intervention.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Laura Nickel, Annika Suenderhauf, Elias Rawish, Ines Stoelting, Stefanie Derer, Christoph Thorns, Urte Matschl, Alaa Othman, Christian Sina, Walter Raasch
Summary: The angiotensin II receptor blocker telmisartan has been found to decrease mucin thickness associated with obesity, independent of expression levels of Muc2 and goblet cells. It also decreases cell proliferation and increases necroptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Justine Vily-Petit, Maud Soty, Marine Silva, Manon Micoud, Clara Bron, Laetitia Guerin-Deremaux, Gilles Mithieux
Summary: The prevalence of obesity is increasing worldwide, accompanied by changes in sugar and dietary fiber consumption. This study investigates the mechanisms of NUTRIOSE (R), a plant-based food ingredient, and its effects on obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). It reveals that intestinal gluconeogenesis (IGN) plays a crucial role in mediating the benefits of NUTRIOSE (R), and its absence in mice abolishes the metabolic benefits observed.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Xiaoya Sun, Ziqiang Cao, Yuanyuan Ma, Yimin Shao, Junqing Zhang, Geheng Yuan, Xiaohui Guo
Summary: The study found that resveratrol can attenuate dapagliflozin-induced renal gluconeogenesis by activating the PI3K/Akt signaling pathway and suppressing FoxO1 activation. This discovery provides a new potential strategy for achieving better glucose-lowering effects with SGLT2 inhibitors in the treatment of type 2 diabetes.
Article
Pharmacology & Pharmacy
Hongxue Li, Qian Xu, Chengye Xu, Yuxin Hu, Xingyang Yu, Kangqi Zhao, Mingqing Li, Meng Li, Junfang Xu, Hongyu Kuang
Summary: Hepatic gluconeogenesis is crucial in maintaining glucose metabolism homeostasis, particularly in cases of type 2 diabetes mellitus combined with non-alcoholic fatty liver disease (T2DM-NAFLD). Inhibiting liver inflammation has been shown to improve glucose metabolism disorders. Studies suggest that Bicyclol may be an effective drug for treating T2DM-NAFLD and other metabolic disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Nesrin M. Hasan, Kelli F. Johnson, Jianyi Yin, Nicholas W. Baetz, Lea Fayad, Vadim Sherman, Sarah E. Blutt, Mary K. Estes, Vivek Kumbhari, Nicholas C. Zachos, Olga Kovbasnjuk
Summary: This study investigated the mechanisms underlying carbohydrate absorption and metabolism abnormalities in obese patients using human enteroids. Different phenotypes were found among obese patients, and elevated glucose absorption and gluconeogenesis in enteroids from obese patients were associated with specific transporter and enzyme expression. Human enteroids can be used as a preclinical platform to study obesity pathophysiology and identify novel therapeutics.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Victoria E. R. Parker, Darren Robertson, Edmundo Erazo-Tapia, Bas Havekes, Esther Phielix, Marlies de Ligt, Kay H. M. Roumans, Julian Mevenkamp, Folke Sjoberg, Vera B. Schrauwen-Hinderling, Edvin Johansson, Yi-Ting Chang, Russell Esterline, Kenneth Smith, Daniel J. Wilkinson, Lars Hansen, Lars Johansson, Philip Ambery, Lutz Jermutus, Patrick Schrauwen
Summary: In a two-part randomized phase 2a trial in men and women with overweight or obesity and type 2 diabetes mellitus, cotadutide promoted greater reductions in liver glycogen and fat than placebo and liraglutide.
Article
Urology & Nephrology
Camille Ansermet, Gabriel Centeno, Yohan Bignon, Daniel Ortiz, Sylvain Pradervand, Andy Garcia, Laure Menin, Frederic Gachon, Hikari Ai Yoshihara, Dmitri Firsov
Summary: This study aims to investigate the pathophysiological role of intrinsic circadian clocks in the kidney of diabetics. By inducing type I diabetes in mice, the researchers found that mice with diabetes exhibited exacerbated hyperglycemia, increased polyuria, and enhanced expression of the gluconeogenic pathway in the kidneys.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Kellen Cristina da Cruz Rodrigues, Rodrigo Martins Pereira, Guilherme Francisco Peruca, Lucas Wesley Torres Barbosa, Marcella Ramos Sant'Ana, Vitor Rosetto Munoz, Ana Paula Morelli, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Leandro Pereira de Moura
Summary: This study found that short-term strength exercise can improve hepatic insulin sensitivity in obese mice by reducing PTP1B content, thereby improving glucose homeostasis in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Li Gu, Yahui Zhu, Kosuke Watari, Maiya Lee, Junlai Liu, Sofia Perez, Melinda Thai, Joshua E. Mayfield, Bichen Zhang, Karina Cunha e Rocha, Fuming Li, Laura C. Kim, Alexander C. Jones, Igor H. Wierzbicki, Xiao Liu, Alexandra C. Newton, Tatiana Kisseleva, Jun Hee Lee, Wei Ying, David J. Gonzalez, Alan R. Saltiel, M. Celeste Simon, Michael Karin
Summary: Insulin coordinates the activities of inhibiting gluconeogenesis and stimulating glucose conversion to prevent hypoglycemia and hepatosteatosis. Fructose-1,6-bisphosphatase (FBP1) is crucial for gluconeogenesis, and its deficiency leads to fasting-induced liver pathologies. FBP1 forms a complex with AKT, PP2A-C, and ALDOB to prevent insulin hyperresponsiveness and maintain lipid and glucose homeostasis.
Article
Immunology
Maria A. Pedrosa, Carmen M. Labandeira, Rita Valenzuela, Aloia Quijano, Marina Sanchez-Andrade, Juan A. Suarez-Quintanilla, Jose L. Lanciego, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez
Summary: Metabolic syndrome is associated with chronic inflammation and neurodegeneration in Parkinson's disease. The activation of renin-angiotensin system and the presence of AT1 autoantibodies play a critical role in this process. Inhibition of AT1 receptor or strategies against autoantibody production may be potential therapeutic approaches for Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2023)