Review
Medicine, Research & Experimental
Fan Ding, Qili Hu, Yixing Wang, Min Jiang, Zhengyu Cui, Run Guo, Liping Liu, Fang Chen, Hai Hu, Gang Zhao
Summary: The motility of the gallbladder involves the storage, concentration, and delivery of bile. Multiple factors control gallbladder motor functions, such as innervation, humoral factors, and neuropeptides. Gallbladder emptying is the result of coordinated contractions of the muscular layers of the gallbladder wall, mediated by rhythmic contractions of smooth muscle cells, GB neurons, telocytes, and interstitial cells of Cajal. This article introduces the STIN syncytium as a new motor unit in the gallbladder, providing pacemaker activity and propagation pathways for contractions.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yoshihiro Otsuka, Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa
Summary: The interstitial cells of Cajal (ICCs) play a central role in DMPP-induced relaxation through membrane hyperpolarization via the activation of anoctamin-1. ATP may serve as a neurotransmitter for inhibitory enteric neurons that stimulate ICCs. ICCs act as the interface for neurotransmission of nicotinic acetylcholine receptor to induce LES relaxation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Tasuku Hiroshige, Kei-Ichiro Uemura, Shingo Hirashima, Akinobu Togo, Keisuke Ohta, Kei-Ichiro Nakamura, Tsukasa Igawa
Summary: This study explored the three-dimensional ultrastructure of interstitial cells within the lamina propria of the murine vas deferens, as well as their spatial relationships with surrounding cells. The results revealed the presence of sheet-like interstitial cells with multiple cellular processes, forming a complex three-dimensional network. These cells were in parallel alignment with the epithelium and connected to each other via gap junctions or adherens junctions. The study also observed the presence of extracellular vesicle-like structures around the interstitial cells.
SCIENTIFIC REPORTS
(2022)
Review
Physiology
Bernard T. Drumm, Keith D. Thornbury, Mark A. Hollywood, Gerard P. Sergeant
Summary: Urinary continence is maintained by the contracture of urethral sphincters, including the role of Ano1 channels expressed in urethral ICC in increasing smooth muscle excitability. However, the specific role of urethral Ano1 channels remains unclear due to differences in species and experimental approaches. Clarifying this situation is crucial for developing new treatments for urinary incontinence.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Qi-Cheng Chen, Zhi Jiang, Jun-Hong Zhang, Li-Xing Cao, Zhi-Qiang Chen
Summary: The study found that ICC-IM participates in the regulation of gastric antrum MMC in mice, and XBF induces MMC III-like contractions that enhance gastric antrum motility via ICC-IM.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Egan L. Choi, Negar Taheri, Elijah Tan, Kenjiro Matsumoto, Yujiro Hayashi
Summary: This article discusses the role of interstitial cells of Cajal (ICC) in neurointestinal diseases and their association with various gastrointestinal disorders. Understanding the functions of ICC could provide new perspectives on modulating gastrointestinal motility and could lead to innovative therapeutic paradigms, enhancing efforts to combat neurointestinal diseases.
Article
Chemistry, Multidisciplinary
Lai-liu Luo, Jing-xuan Han, Shou-rong Wu, Vivi Kasim
Summary: This study suggests that SGLT2 inhibitor sotagliflozin may serve as a potential therapeutic angiogenesis agent for diabetic hindlimb ischemia (HLI). The results demonstrate that sotagliflozin can reverse the detrimental effects of high glucose and hypoxia on skeletal muscle cells, increase the expression and secretion of angiogenic factors, enhance the migration and proliferation capabilities of vascular endothelial and smooth muscle cells, and promote the formation of functional blood vessels. In vivo experiments show that intramuscular injection of sotagliflozin effectively restores blood perfusion in diabetic HLI mice.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Pediatrics
Fatima Safira Alatas, Kouji Masumoto, Kouji Nagata, Antonius Hocky Pudjiadi, Muzal Kadim, Tomoaki Taguchi, Tatsuro Tajiri
Summary: This study evaluated the diagnostic criteria of hypoganglionosis using immunohistochemistry and described its morphological features. The results showed variations in the muscular layers and a reduction in nerve fibers in the intestinal segments of hypoganglionosis patients. Further research on the definition, etiology, diagnosis, and treatment of this disease is needed to improve prognosis.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Nathan Grainger, Kenton M. Sanders, Bernard T. Drumm
Summary: This paper describes a new method for preparing intact segments of mouse PKJ to more accurately study the mechanisms responsible for normal urine transport contractions, overcoming limitations of previous research.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Medicine, General & Internal
Min Su Jung, Man-Hoon Han, Tae In Park, Min Kyu Jung
Summary: This study investigated the relationship among ICC number, gallbladder contractibility, and gallstones in patients undergoing cholecystectomy. Results showed that male participants had a higher number of ICC in the mucosal layer compared to females, and larger gallbladder size was associated with decreased ICC in the muscular layer. The number of ICC in the muscular layer decreased with an increase in gallbladder stone number, but there was no significant correlation with other factors.
Article
Biology
Moriya Shushan, Michal Shoshkes-Carmel
Summary: Researchers have identified a FOXL1+ intestinal subepithelial network of telocytes (TCs) that play a crucial role in the proliferation and regeneration of epithelial stem and progenitor cells. These FOXL1+ lineage cells are found not only along the intestinal epithelium, but also within the muscle layers. The study suggests that there is a mutual origin for TCs and smooth muscle cells (SMCs).
Article
Materials Science, Multidisciplinary
Hang Yu, Yangquan Liu, Meng Chu, Yu Si, Yaqiong Ye, Tingting Ge, Haiquan Zhao, Hui Zhang
Summary: This study identified the presence of ICC in the gastric muscularis mucosae of the Chinese giant salamander, showing distinctive morphological characteristics and close interactions with SMC and nerve fibers.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Na-Yeon Kim, Kyung-Ah Kim, Hee-Jong Yang, Su-Ji Jeong, Anna Han, Youn-Soo Cha
Summary: Gochujang, a traditional Korean fermented paste, alleviates constipation by increasing defecation frequency and water content, and reducing AQP3 mRNA expression. It also improves GI motility and neurotransmitter levels, regulates the enteric nervous system, and influences gut microbiota composition.
Article
Multidisciplinary Sciences
Tae Sik Sung, Suk Bae Moon, Brian A. Perrino, Kenton M. Sanders, Sang Don Koh
Summary: The response of protease-activated receptor-1 (PAR1) is altered in the inflamed colon, leading to changes in colonic smooth muscle function and expression.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Vy Truong Thuy Nguyen, Negar Taheri, Egan L. Choi, Todd A. Kellogg, David R. Linden, Yujiro Hayashi
Summary: The impaired gastric motor function in the elderly can be improved by IGF1, which activates ERK signaling and mitigates the loss of interstitial cells of Cajal (ICC) and pacemaker cells. This study also found that IGF1 can improve gastric function and reduce food intake in aging mice.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)