Article
Nutrition & Dietetics
Joeri De Cloet, Ine Simal, Karel Benoot, Linde Goossens
Summary: In this retrospective study, the authors analyzed the adherence to the ESPGHAN 2018 PN guidelines and growth of 86 neonates admitted to the NICU. The study found that the guidelines were mostly followed for carbohydrate provisions, but lipid provisions often exceeded the recommended maximum. Protein provisions tended to fall below the recommended minimum. Overall, adherence to the ESPGHAN 2018 PN guidelines had a positive impact on the stable growth of neonates during their NICU stays.
Review
Nutrition & Dietetics
Edoardo Muratore, Davide Leardini, Francesco Baccelli, Francesco Venturelli, Arcangelo Prete, Riccardo Masetti
Summary: Allogeneic hematopoietic stem cell transplantation is a potentially curative strategy, but it is associated with complications and mortality. The disruption of gut microbiota has been linked to these complications, and nutritional strategies are being considered as effective methods of modulating the gut microbiota and improving clinical outcomes.
FRONTIERS IN NUTRITION
(2022)
Article
Pediatrics
Cornelia Wiechers, Jan-Niklas Doll, Christoph Maas, Kerstin Grundler, Katja Buchner, Christian F. Poets, Axel R. Franz
Summary: In this study, rapid advancement of enteral feeds did not significantly impact infants' growth up to age 5. Weight and BMI standard deviation scores at age 5 remained lower than the reference population, suggesting that accelerated feeding may not contribute to increased childhood adiposity risk.
Article
Nutrition & Dietetics
Justyna Romanska, Tomasz Wawrzoniak, Pawel Krajewski, Joanna Seliga-Siwecka, Natalia Brunets, Izabela Lehman, Renata Bokiniec, Ewa Adamska, Barbara Krolak-Olejnik, Jan Modzelewski, Tomasz Szczapa
Summary: This study evaluated the impact of central line discontinuation time on the short-term growth outcomes of preterm infants. The results showed that early discontinuation of central lines was non-inferior to the standard type for short-term growth outcomes in very low birth weight infants.
Article
Pediatrics
Na Wang, Jia Zhang, Bo Wang, Zhangbin Yu, Shuping Han, Huaiyan Wang, Rongrong Chen, Li Gu, Yan Gao, Weiwei Hou, Xingxing Lu
Summary: By analyzing the nutrition practices of very preterm infants during the transition phase, it was found that increasing the total protein intake during this phase can reduce the incidence of postnatal growth failure.
FRONTIERS IN PEDIATRICS
(2022)
Article
Food Science & Technology
Sara Bazrafshan, Maryam Mizani, Gholamreza Pazuki, Shahla Shahriari
Summary: Enteral nutrition, which provides energy and protein sources for patients with dysphagia, chronic disease, and loss of appetite, can be achieved using a gelatin-maltodextrin binary biopolymer system incorporated into a semi-solid formula. The rheological properties, dynamic laser scattering, and zeta potential responses of this formula were evaluated during storage. The study found that the optimal ratio of gelatin to maltodextrin in the formula was 4.35:3.64% w/w on day 17.4, which exhibited the best rheological stability and suitability for tube feeding.
JOURNAL OF TEXTURE STUDIES
(2023)
Review
Nutrition & Dietetics
John K. DiBaise, James S. Scolapio
Summary: This article highlights the importance of home parenteral and enteral nutrition in clinical nutrition and the development of these therapies to support patients. It emphasizes the need for healthcare providers to understand all aspects of HPEN in order to provide safe, effective, and cost-effective support to patients.
Review
Nutrition & Dietetics
Antonella Diamanti, Giacomo Calvitti, Diego Martinelli, Emma Santariga, Teresa Capriati, Giulia Bolasco, Lorenzo Iughetti, Arturo Pujia, Daniela Knafelz, Giuseppe Maggiore
Summary: Intestinal failure (IF) results from a reduction in gut mass, leading to inadequate digestion and absorption. Most cases are caused by intrinsic diseases of the gastrointestinal tract, while a few arise from other sources. Improved diagnostic and therapeutic tools have increased prevalence and life expectancy of IF, expanding knowledge on the pathophysiological mechanisms.
Article
Nutrition & Dietetics
Erika Salciute-Simene, Raimundas Stasiunaitis, Eduardas Ambrasas, Jonas Tutkus, Ignas Milkevicius, Gintare Sostakaite, Andrius Klimasauskas, Gintautas Kekstas
Summary: The study shows that episodes of ENI in critically ill patients are frequent and prolonged, often leading to underfeeding. The proportion of underfeeding is higher on trial days with ENI, with lower caloric and protein intake.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Adriana del Pilar Montealegre-Pomar, Ana Maria Bertolotto-Cepeda, Yoliseth Romero-Marquez, Kelly Jose Munoz-Ramirez
Summary: This study compared fast enteral advancement with traditional advancement in premature infants and found that fast advancement decreases the days to reach total enteral nutrition and the days of parenteral nutrition and/or intravenous fluid, without causing greater feeding intolerance. Additional studies are needed for more evidence.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Erin E. Morris, Neely C. Miller, Nicholas A. Marka, Jennifer L. Super, Emily M. Nagel, Juan David Gonzalez, Ellen W. Demerath, Sara E. Ramel
Summary: Retrospective studies show that parenteral nutrition during the first week after birth, providing calories, proteins, and lipids, is associated with improved neurodevelopment. However, an enhanced parenteral nutrition protocol in the early stage did not lead to improved neurodevelopmental outcomes. Instead, higher enteral caloric and protein intake in the first week after birth were associated with improved processing speed.
Article
Multidisciplinary Sciences
Anita N. Agyare, Qi Liang, Xuemei Song, Yan Zhang, Jing Yang, Yongqi Shi
Summary: This study aimed to spray dry yak butter into powder form for better stability. The results showed that using 50%:50% NaCas:lactose and 25%:75% NaCas:maltodextrin formulations can achieve optimum physical properties and oxidative stability.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Allison L. Yang
Summary: Acute pancreatitis is an inflammatory process requiring early nutritional support to correct negative nitrogen balance. Early enteral nutrition is an important aspect of clinical management for AP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Stephan C. Bischoff, Peter Austin, Kurt Boeykens, Michael Chourdakis, Cristina Cuerda, Cora Jonkers-Schuitema, Marek Lichota, Ibolya Nyulasi, Stephane M. Schneider, Zeno Stanga, Loris Pironi
Summary: This practical guideline by ESPEN provides concise information on the indications, contraindications, implementation, and monitoring of home enteral nutrition (HEN). It also serves as a resource for patients in need of HEN.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Darja Urlep, Rok Orel, Patricija Kunstek, Evgen Benedik
Summary: This study evaluated the clinical and endoscopic rates of remission in children with active Crohn's disease (CD) treated with partial enteral nutrition (PEN) combined with a modified Crohn's disease exclusion diet (mCDED). The study found that PEN + mCDED could potentially induce clinical and endoscopic remission in pediatric CD patients. The results provide evidence for the use of PEN + mCDED in the treatment of pediatric CD.
Article
Nutrition & Dietetics
Karina Obelitz-Ryom, Stine Brandt Bering, Silja Hvid Overgaard, Simon Fristed Eskildsen, Steffen Ringgaard, Jonas Lynge Olesen, Kerstin Skovgaard, Stanislava Pankratova, Bing Wang, Anders Brunse, Anne Birgitte Heckmann, Martin Peter Rydal, Per Torp Sangild, Thomas Thymann
Article
Gastroenterology & Hepatology
Gregory Guthrie, Barbara Stoll, Shaji Chacko, Charlotte Lauridsen, Jogchum Plat, Douglas Burrin
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Article
Nutrition & Dietetics
Agnethe May Ahnfeldt, Ole Baek, Yan Hui, Charlotte Holme Nielsen, Karina Obelitz-Ryom, Tilla Busk-Anderson, Anne Ruge, Jens Juul Holst, Silvia Rudloff, Douglas Burrin, Duc Ninh Nguyen, Dennis Sandris Nielsen, Gitte Zachariassen, Stine Brandt Bering, Thomas Thymann, Per Torp Sangild
JOURNAL OF NUTRITION
(2020)
Article
Neurosciences
Daniel Chizhikov, Randal K. Buddington, Igor Y. Iskusnykh
Article
Gastroenterology & Hepatology
William Yakah, Pratibha Singh, Joanne Brown, Barbara Stoll, Doug Burrin, Muralidhar H. Premkumar, Hasan H. Otu, Xuesong Gu, Simon T. Dillon, Towia A. Libermann, Steven D. Freedman, Camilia R. Martin
Summary: Exposure to parenteral lipid emulsions does not affect the risk of necrotizing enterocolitis in preterm pigs. Metabolomic and proteomic analyses provide insights into the pathogenesis of NEC. Differences in tryptophan metabolism and arachidonic acid-containing glycerophospholipids are observed between NEC and non-NEC tissues. Proteomic analysis highlights tissue injury, glucose uptake, and chemokine signaling as potential factors in NEC development.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Microbiology
Marie van der Merwe, Damien Moore, Jessica L. Hill, Faith H. Keating, Randal K. Buddington, Richard J. Bloomer, Anyou Wang, Dale D. Bowman
Summary: The study found that supplementation with fruit and vegetable concentrates and high fiber components had an impact on the gut microbiome of overweight/obese females, improving glucose metabolism. However, there was no significant effect on blood lipids, glucose, and immune parameters.
Article
Biochemistry & Molecular Biology
Anberitha T. Matthews, Hitesh Soni, Katherine E. Robinson-Freeman, Theresa A. John, Randal K. Buddington, Adebowale Adebiyi
Summary: Doxorubicin (DOX), a chemotherapeutic agent, can induce fetal nephrotoxicity by inhibiting proliferation and inducing death of fetal pig glomerular mesangial cells (GMCs). DOX treatment reduces TRPC6 protein expression, leading to mitochondrial ROS generation and cell death in GMCs. The DOX-induced fetal pig GMC apoptosis is independent of TRPC6 upregulation but requires mtROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Marko Rudar, Jane K. Naberhuis, Agus Suryawan, Hanh Nguyen, Barbara Stoll, Candace C. Style, Mariatu A. Verla, Oluyinka O. Olutoye, Douglas G. Burrin, Marta L. Fiorotto, Teresa A. Davis
Summary: It was found that intermittent bolus feeding does not increase skeletal muscle protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in preterm pigs. This suggests that premature birth attenuates the capacity of skeletal muscle to respond to cyclical surges in insulin and amino acids with intermittent feeding in early postnatal life. This attenuated anabolic response of muscle to intermittent bolus feeding in preterm pigs compared with those born at term may contribute to deficits in lean mass.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Caitlin Vonderohe, Greg Guthrie, Barbara Stoll, Shaji Chacko, Harry Dawson, Douglas G. Burrin
Summary: The molecular mechanisms and tissue-specific differences in FXR-FGF19 signaling pathway in perinatal pigs were studied, indicating that preterm pigs have smaller, hydrophobic bile acid pools, lower plasma FGF19 levels, and blunted ileal response to bile acids compared to term pigs. It was also found that GATA-4 expression in the jejunum and ileum differed between preterm and term pigs, suggesting developmental patterning effects. These results may have implications for disturbances in bile acid homeostasis and metabolism in preterm infants.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Marko Rudar, Agus Suryawan, Hanh Nguyen, Shaji K. Chacko, Caitlin Vonderohe, Barbara Stoll, Douglas G. Burrin, Marta L. Fiorotto, Teresa A. Davis
Summary: The study aimed to investigate the impact of intermittent intravenous pulses of leucine (Leu) on muscle protein anabolism in preterm neonatal pigs administered continuous parenteral nutrition. The results showed that intermittent Leu pulses do not enhance muscle protein anabolism in preterm pigs supplied continuous parenteral nutrition.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Caitlin Vonderohe, Gregory Guthrie, Douglas G. Burrin
Summary: Limited work has focused on the secretion and function of fibroblast growth factor-19 (FGF19) during the perinatal period. FGF19 plays a role in embryological development of various organs but transitions to be an endocrine regulator of liver bile acid synthesis after birth. It has been implicated in metabolism, insulin sensitivity, and skeletal muscle growth, and research suggests that it could improve growth and nutritional outcomes in preterm infants.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Caitlin Vonderohe, Gregory Guthrie, Barbara Stoll, Valeria Melendez Hebib, Harry Dawson, Douglas Burrin
Summary: The impact of birth modality and gestational age on hormone levels, gene expression, and plasma levels of FGF19 in neonatal pigs was investigated. Vaginally born piglets had significantly higher plasma FGF19 levels at birth compared to cesarean and preterm piglets. However, FGF19 gene expression in the distal ileum was similar among all groups. Plasma FGF19 was positively correlated with plasma cortisol, and dexamethasone treatment increased FGF19 expression in pig tissue and human enteroids.
Article
Social Sciences, Interdisciplinary
Mie S. Dam, Per T. Sangild, Mette N. Svendsen
PALGRAVE COMMUNICATIONS
(2020)
Article
Physiology
Mahmoud A. Mohammad, Inka C. Didelija, Xiaoying Wang, Barbara Stoll, Douglas G. Burrin, Juan C. Marini
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)
Article
Nutrition & Dietetics
Rebecca J. Welch-Jernigan, Evan Abrahamse, Barbara Stoll, OBrian Smith, Peter A. Wierenga, Bert J. M. van de Heijning, Ingrid B. Renes, Douglas G. Burrin
CURRENT DEVELOPMENTS IN NUTRITION
(2019)