期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 294, 期 4, 页码 G839-G843出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00061.2008
关键词
Niemann-Pick C1-like 1 protein; scavenger receptors; ATP-binding; cassette proteins
资金
- NHLBI NIH HHS [HL-78900] Funding Source: Medline
- NIDDK NIH HHS [DK-76907, DK-67416] Funding Source: Medline
Intestinal cholesterol absorption is modulated by transport proteins in enterocytes. Cholesterol uptake from intestinal lumen requires several proteins on apical brush-border membranes, including Niemann-Pick C1-like 1 (NPC1L1), scavenger receptor B-I, and CD36, whereas two ATP-binding cassette half transporters, ABCG5 and ABCG8, on apical membranes work together for cholesterol efflux back to the intestinal lumen to limit cholesterol absorption. NPC1L1 is essential for cholesterol absorption, but its function as a cell surface transporter or an intracellular cholesterol transport protein needs clarification. Another ATP transporter, ABCA1, is present in the basolateral membrane to mediate HDL secretion from enterocytes.
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