Article
Biochemistry & Molecular Biology
Xie Peng, Xuelin Cai, Jian Li, Yingyan Huang, Hao Liu, Jiaqi He, Zhengfeng Fang, Bin Feng, Jiayong Tang, Yan Lin, Xuemei Jiang, Liang Hu, Shengyu Xu, Yong Zhuo, Lianqiang Che, De Wu
Summary: The study found that dietary supplementation of melatonin during pregnancy can increase placental weight, reduce the proportion of piglets born with lower birth weight, and improve maternal-placental-fetal redox status and reproductive performance. Additionally, dietary melatonin can enhance placental antioxidant status, inflammatory response, and mitochondrial function.
Article
Reproductive Biology
Esteban Salazar-Petres, Daniela Pereira Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri
Summary: In normal mouse pregnancy, placental structure, function, and mitochondrial phenotype respond differently to the growth of female and male fetuses. This study may provide design references for sex-specific therapies for placental insufficiency and fetal growth abnormalities, which could benefit the offspring throughout their lives.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Man Mohan Shrestha, Sanne Wermelin, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
Summary: Adiponectin deficiency affects fetal growth and placental function, particularly in obese individuals. Low levels of adiponectin lead to placental dysfunction and increased fetal triglyceride load, which could have long-term effects on the offspring's metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jing Long, Yan Huang, Gang Wang, Zhengshan Tang, Yali Shan, Shiping Shen, Xin Ni
Summary: In this study, it was found that increased maternal glucocorticoid levels were a risk factor for the development of preeclampsia (PE). Pregnant rats exposed to dexamethasone (DEX) exhibited features of PE, impaired spiral artery remodeling, and elevated levels of certain circulatory markers. Abnormal mitochondrial morphology and dysfunction were observed in placentas of DEX rats. The use of a mitochondria-targeted antioxidant alleviated maternal hypertension and renal damage in the DEX-induced PE model. However, scavenging excess ROS did not improve intrauterine growth retardation (IUGR) and elevated levels of certain markers in DEX rats. These findings suggest that excess mitochondrial ROS contributes to trophoblast dysfunction, impaired spiral artery remodeling, reduced uteroplacental blood flow, and maternal hypertension in the DEX-induced PE model, while inflammation and impaired energy metabolism and IGF system may be associated with elevated levels of certain markers and IUGR.
Article
Peripheral Vascular Disease
Francesca Gaccioli, Ulla Sovio, Sungsam Gong, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to investigate the relationship between protein levels of sFLT1 and PlGF in maternal serum and placental tissue lysates. The findings showed that the sFLT1:PlGF ratio is increased in both preeclampsia and FGR, but in preeclampsia, it is primarily driven by increased placental sFLT1 levels, while in FGR, it is primarily driven by decreased placental PlGF levels.
Article
Biochemistry & Molecular Biology
Dayuan Shi, Xinyao Zhou, Luyao Cai, Xing Wei, Luye Zhang, Qianqian Sun, Fenhe Zhou, Luming Sun
Summary: Changes in placental DNA methylation patterns in sFGR may have functional implications for differentially methylated genes and regulatory regions. The study validates the presence of abnormally methylated CYP11A1 gene in the placenta of sFGR.
Article
Pharmacology & Pharmacy
Lewis J. Renshall, Frances Beards, Angelos Evangelinos, Susan L. Greenwood, Paul Brownbill, Adam Stevens, Colin P. Sibley, John D. Aplin, Edward D. Johnstone, Tambet Teesalu, Lynda K. Harris
Summary: This study demonstrates the potential of using EGF-loaded, peptide-decorated liposomes to improve placental function. GPS-decorated liposomes containing EGF significantly increased amino acid transporter activity in healthy placental tissues, but were ineffective in those from pregnancies with FGR. Targeted liposomes represent a safe and useful tool for developing new therapies for placental dysfunction.
Article
Environmental Sciences
Yingya Zhao, Pengpeng Wang, Yuhan Zhou, Bin Xia, Qingyang Zhu, Wenzhen Ge, Jialin Li, Huijing Shi, Xirong Xiao, Yunhui Zhang
Summary: This study examined the impact of prenatal PM2.5 exposure on fetal growth and placental epigenetic mechanisms in Chinese women. Results showed that increased PM2.5 exposure was associated with reduced fetal growth characteristics and aberrant changes in placental DNA methylation.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Hua-Long Zhu, Xue-Ting Shi, Xiao-Feng Xu, Yong-Wei Xiong, Song-Jia Yi, Guo-Xiang Zhou, Wei-Bo Liu, Miao-Miao Huang, Lan Gao, Cheng Zhang, Ling-Li Zhao, De-Xiang Xu, Hua Wang
Summary: The study found that environmental cadmium exposure can lead to fetal growth restriction by activating PERK-regulated placental mitophagy and inhibiting P4 synthesis. Additionally, placental mitophagy is associated with reduced progesterone levels and all-cause fetal growth restriction.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Sinisa Cikic, Partha K. Chandra, Jarrod C. Harman, Ibolya Rutkai, Prasad V. G. Katakam, Jessie J. Guidry, Jeffrey M. Gidday, David W. Busija
Summary: The study identified sexual dimorphism in mitochondrial metabolic protein profiles of cerebral microvessels, with females expressing more proteins involved in energy production, antioxidant defense, and fatty acid oxidation, while males had higher expression levels of mitochondria-destructive proteins. These differences may contribute to sex-dependent cerebrovascular and neurological pathologies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Environmental Sciences
Guangquan Chen, Shiyi Xiong, Qiao Jing, Cornelis A. M. van Gestel, Nico M. van Straalen, Dick Roelofs, Luming Sun, Hao Qiu
Summary: This study investigated the effects of polystyrene nanoplastics (PS-NPs) on fetal development and cholesterol metabolism in mice. The exposure to PS-NPs led to a decline in fetal weights and abnormal cell morphologies in the placenta and fetus. Transcriptomic and metabolomic analyses revealed disturbances in cholesterol metabolism and other pathways, offering new insights into the mechanisms underlying the detrimental effects of PS-NPs on placenta and fetus.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Leonardo Ermini, Maurizio Mandala, Laura Cresti, Sofia Passaponti, Laura Patrussi, Luana Paulesu, Kent Thornburg, Francesca Ietta
Summary: Dietary exposure to Bisphenol A affects nutrient metabolism in fetal hearts, leading to decreased expression of glucose transporter-1 and increased expression of fatty acid transporter. Placenta-derived exosomes may contribute to the stabilization of fetal heart metabolism by increasing glucose transporter expression.
Article
Environmental Sciences
Hao Zhang, Yi Zheng, Xiaoyun Liu, Xia Zha, Mabrouk Elsabagh, Yi Ma, Honghua Jiang, Hongrong Wang, Mengzhi Wang
Summary: This study investigated the potential relationship between oxidative stress, autophagy, and apoptosis in pregnant ewes exposed to BPA. The results showed that BPA exposure led to placental insufficiency, fetal growth restriction, autophagy, endoplasmic reticulum stress, mitochondrial dysfunction, oxidative stress, and apoptosis. Additionally, the study revealed that autophagy could alleviate BPA-induced apoptosis, mitochondrial dysfunction, and oxidative stress.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Immunology
Huan Yang, Jie He, Shuai Huang, Hongbing Yang, Qingjie Yi, Yuelan Tao, Miaomiao Chen, Xuemei Zhang, Hongbo Qi
Summary: The study identified a large number of eccDNAs/ecDNAs in FGR, highlighting their potential association with factors such as gestational age. These molecules were found to be mainly enriched in immune-related functions and pathways, overlapping with non-coding RNAs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Hannah Ee Juen Yong, Katarzyna Maksym, Muhammad Ashraf Bin Yusoff, Esteban Salazar-Petres, Tatiana Nazarenko, Alexey Zaikin, Anna L. David, Sara L. Hillman, Amanda N. Sferruzzi-Perri
Summary: Fetal growth restriction (FGR) is a major cause of perinatal morbidity and mortality. This study explores the relationship between placental structure and function in healthy and FGR pregnancies through predictive modeling. The findings provide new insights into the etiology of FGR.
Article
Nutrition & Dietetics
Lucie Marousez, Norbert Sprenger, Marie De Lamballerie, Sarahi Jaramillo-Ortiz, Lea Tran, Edwina Micours, Frederic Gottrand, Michael Howsam, Frederic J. Tessier, Delphine Ley, Jean Lesage
Summary: This study evaluated the impact of HHP processing on human milk components and found that HHP treatment preserves HMOs and avoids the formation of Maillard reaction products. In contrast, Holder pasteurization significantly increased the levels of Maillard reaction products.
CLINICAL NUTRITION
(2022)
Article
Neurosciences
Marie-Helene Canu, Valerie Montel, Julie Dereumetz, Tanguy Marqueste, Tanguy Decherchi, Jacques-Olivier Coq, Erwan Dupont, Bruno Bastide
Summary: Research indicates that early movement restriction can lead to severe atrophy and functional disorganization in the soleus muscle of rats, resulting in issues such as sensorimotor restriction and increased neuromuscular excitability. However, some of these changes can be reversed when typical activity is resumed, suggesting the importance of proprioceptive feedback in promoting typical motor function development.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Eve Wemelle, Lucie Marousez, Marie de Lamballerie, Claude Knauf, Jean Lesage
Summary: This study found that high hydrostatic pressure (HHP) processing preserves apelin and glucagon-like peptide 1 (GLP-1) in breast milk (BM) compared to Holder pasteurization (HoP). It also improves glucose tolerance by acting on gut contractions.
Article
Nutrition & Dietetics
Camille Dugardin, Lea Fleury, Veronique Touche, Farah Ahdach, Jean Lesage, Mathie Tenenbaum, Nadia Everaert, Olivier Briand, Sophie Lestavel, Rozenn Ravallec, Benoit Cudennec
Summary: High protein diets have been shown to improve glucose homeostasis. This study investigates the acute effects of proteins from different sources on intestinal glucose absorption. The digested proteins were found to decrease intestinal glucose absorption and ingestion of certain proteins improved glucose tolerance without affecting insulin secretion. These results suggest that protein-derived peptides and amino acids play a key role in regulating glucose homeostasis and intestinal glucose absorption.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Victoriane Peugnet, Maggy Chwastyniak, Paul Mulder, Steve Lancel, Laurent Bultot, Natacha Fourny, Edith Renguet, Heiko Bugger, Olivia Beseme, Anne Loyens, Wilfried Heyse, Vincent Richard, Philippe Amouyel, Luc Bertrand, Florence Pinet, Emilie Dubois-Deruy
Summary: This study investigated the impact of mitochondria-targeted therapy on cardiac hypertrophy and found that MitoQ can reduce mitochondrial ROS and hypertrophy, but it may also affect mitochondrial structure and function by impairing mitochondrial respiration and mitophagy, particularly showing deleterious effects in cardiomyocytes.
Article
Multidisciplinary Sciences
Charlotte Claeyssen, Bruno Bastide, Caroline Cieniewski-Bernard
Summary: Desmin plays a crucial role in maintaining muscle integrity and cell homeostasis. Post-translational modifications and O-GlcNAcylation regulate Desmin, and their interplay affects Desmin's behavior, phosphorylation level, and partition towards the cytoskeleton.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Alexis Boulinguiez, Christian Duhem, Alicia Mayeuf-Louchart, Benoit Pourcet, Yasmine Sebti, Kateryna Kondratska, Valerie Montel, Stephane Delhaye, Quentin Thorel, Justine Beauchamp, Aurore Hebras, Marion Gimenez, Marie Couvelaere, Mathilde Zecchin, Lise Ferri, Natalia Prevarskaya, Anne Forand, Christel Gentil, Jessica Ohana, France Pietri-Rouxel, Bruno Bastide, Bart Staels, Helene Duez, Steve Lancel
Summary: The study shows that NR1D1 plays a crucial role in regulating skeletal muscle SR calcium homeostasis by repressing the expression of the SERCA inhibitor myoregulin. Lower NR1D1 expression is observed in patients with Duchenne muscular dystrophy, while pharmacological activation of NR1D1 improves calcium homeostasis and muscle structure and function.
Article
Developmental Biology
Sandy Hanssens, Lucie Marousez, Oceane Pecheux, Capucine Besengez, Laurent Storme, Philippe Deruelle, Delphine Eberle, Jean Lesage
Summary: This study found that obesity reduces the levels of apelin in cord blood, but has no effect on maternal and cord blood levels of elabela or placental gene expression of this system.
Article
Nutrition & Dietetics
Lucie Marousez, Lea Chantal Tran, Edwina Micours, Matthieu Antoine, Frederic Gottrand, Jean Lesage, Delphine Ley
Summary: Inadequate perinatal nutrition can affect the maturity of the intestinal barrier and the development of the intestinal microbiota in mice. Supplementing with prebiotic fiber appears to improve gut microbiota establishment in postnatal-growth-restricted mice and can lead to changes in intestinal morphology and microbial composition.
Article
Cell Biology
Camille Menaceur, Johan Hachani, Shiraz Dib, Sophie Duban-Deweer, Yannis Karamanos, Fumitaka Shimizu, Takashi Kanda, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol
Summary: This study investigates the proteome differences between brain pericytes (BPs) cultured alone (hBP-solo) and in co-culture with brain microvessel endothelial cells (ECs) (hBP-coc) to model the human blood-brain barrier (BBB) in vitro. The results show that hBP-solo has 51 proteins related to cell proliferation, contractility, adhesion, and extracellular matrix elements, indicating an immature cell state. On the other hand, hBP-coc has 90 proteins associated with reduced contractile activities and enhanced metabolic functions, particularly in mitochondrial activities and sterol metabolism, suggesting mature pericytes. This study highlights the role of ECs in promoting the maturation and metabolic switch of BPs during barriergenesis.
Article
Biology
Alexandre Pierre, Claire Bourel, Raphael Favory, Benoit Brassart, Frederic Wallet, Frederic N. N. Daussin, Sylvain Normandin, Michael Howsam, Raphael Romien, Jeremy Lemaire, Gaelle Grolaux, Arthur Durand, Marie Frimat, Bruno Bastide, Philippe Amouyel, Eric Boulanger, Sebastien Preau, Steve Lancel
Summary: Sepsis is a life-threatening infection that leads to muscle weakness, which impairs short- and long-term prognoses. This study investigated the impact of an energy deficit on skeletal muscle during the early stages of sepsis. The results showed that a sepsis-like energy deficit did not explain the muscle fiber atrophy and mitochondrial dysfunction observed in sepsis, but led to specific metabolic adaptations not found in sepsis.
Article
Virology
Peggy Bouquet, Virginie Alexandre, Marie De Lamballerie, Delphine Ley, Jean Lesage, Anne Goffard, Laurence Cocquerel
Summary: In this study, the efficacy of high hydrostatic pressure (HHP) processing and Holder pasteurization method (HoP) in inactivating surrogate virus models in donor milk were compared. It was demonstrated that HCoV-229E can be inactivated by both HHP and HoP treatment, with the 4xHP350 protocol being highly effective. However, the milk matrix has a matrix effect on HCoV-229E inactivation. HEV is stable to moderate pressure HHP treatment, but the milk matrix does not protect it from high-pressure HHP treatment.
Article
Nutrition & Dietetics
Lionel Carneiro, Lucie Marousez, Matthias Van Hul, Lea Chantal Tran, Marie De Lamballerie, Delphine Ley, Patrice D. Cani, Claude Knauf, Jean Lesage
Summary: This study demonstrates that high hydrostatic pressure processing can reinforce intestinal barrier integrity without affecting gut microbiota composition and short chain fatty acid production.
