Article
Medicine, Research & Experimental
Sarah M. Graff, Stephanie R. Johnson, Paul J. Leo, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Aideen M. McInerney-Leo, Mhairi Marshall, Karolina E. Zaborska, Charles M. Schaub, Matthew A. Brown, David A. Jacobson, Emma L. Duncan
Summary: Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders caused by impaired pancreatic beta cell function. A nonsynonymous coding variant in the KCNK16 gene has been linked to MODY, affecting potassium channel function and leading to reduced insulin secretion.
Article
Immunology
Soraya Sajadimajd, Niloofar Deravi, Kimia Forouhar, Roja Rahimi, Ali Kheirandish, Roodabeh Bahramsoltani
Summary: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and beta-cell dysfunction, and its incidence is increasing worldwide. Research has shown that long-term high blood sugar leads to beta-cell failure and death through endoplasmic reticulum (ER) stress. Herbal compounds such as ginsenoside compound K, baicalein, quercetin, and resveratrol have demonstrated significant improvement of T2DM through modulation of ER stress. These findings suggest that herbal constituents have the potential to prevent and treat various complications of T2DM.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Pengcheng Zhang, Daniels Konja, Yiwei Zhang, Yu Wang
Summary: MAM serves as a crucial hub for integrating cellular and organelle homeostasis, facilitating adaptation of energy metabolism. Abnormalities in MAM can lead to impaired insulin sensitivity and metabolic diseases.
Review
Biochemistry & Molecular Biology
Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi'u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar
Summary: The endoplasmic reticulum (ER) is vital for cellular functions, but disruptions in its homeostasis can lead to ER stress, linked to diseases like cancer, obesity, and diabetes. The mechanisms of ER stress related to chronic hyperglycemia and hyperlipidemia in type II diabetes remain unclear.
Article
Multidisciplinary Sciences
Ming Wang, Yan Yan, Zhengguo Zhang, Xiaohan Yao, Xixi Duan, Ziming Jiang, Junfeng An, Peiguo Zheng, Yijie Han, Hao Wu, Zhaoqing Wang, Rainer Glauben, Zhihai Qin
Summary: Inflammaging, associated with an increased risk of chronic disease, may be influenced by high levels of lipid droplets in monocytes and impaired fatty acid oxidation. Downregulation of PPAR-alpha and LD levels in monocytes may serve as novel biomarkers for inflammaging. Activation of PPAR-alpha in the elderly could potentially alleviate long-term inflammaging and prevent the development of life-limiting chronic diseases.
Article
Endocrinology & Metabolism
Maroof Alam, Anoop Arunagiri, Leena Haataja, Mauricio Torres, Dennis Larkin, John Kappler, Niyun Jin, Peter Arvan
Summary: This study demonstrates that mice carrying the proinsulin-R(B22)E heterozygous mutation do not develop diabetes at any age, but show subtle signs of proinsulin misfolding in isolated islets. Males with the mutation exhibit glucose intolerance and develop diabetes after exposure to a high-fat diet. The severity of diabetes is greater in homozygotes, and disease development is associated with beta-cell heterogeneity and increased proinsulin-rich/insulin-poor cells.
Article
Neurosciences
Alexandre Bouron
Summary: The endoplasmic reticulum (ER) is the primary storage compartment for calcium (Ca2+) in eukaryotic cells. Ca2+ is mobilized from the ER through store-operated Ca2+ channels (SOCCs), leading to a store-operated Ca2+ entry (SOCE) that has been extensively studied in non-excitable cells. The presence of this Ca2+ entry route in neurons has been a subject of debate, but experimental evidence suggests that SOCE can be generated by the recruitment of Ca2+ from neuronal ER Ca2+ stores. This review summarizes the main supporting studies and explores the molecular composition, expression, pharmacological properties, and physiological relevance of neuronal SOCCs.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengdie Luo, Emmanuel Opoku, C. Alicia Traughber, Qimin Hai, Peggy Robinet, Stela Berisha, Jonathan D. Smith
Summary: The study showed that AKR and DBA/2 mouse macrophages exhibit different levels of free cholesterol and CHOP expression after cholesterol loading due to variations in the Soat1 gene. Inhibition of ACAT enzyme revealed that differences in free cholesterol levels were responsible for the differential induction of CHOP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Multidisciplinary Sciences
Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simo, James S. Trimmer, Rose E. Dixon, Eamonn J. Dickson
Summary: The loss of NPC1 function alters the nanoscale distribution and function of ion channels, leading to abnormal calcium entry, mitochondrial dysfunction, and neurotoxicity. These findings provide insights into the molecular mechanisms connecting NPC1 loss to NPC-associated neuropathology.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Kouminin Kanwore, Piniel Alphayo Kambey, Xiao-Xiao Guo, Ayanlaja Abdulrahman Abiola, Ying Xia, Dianshuai Gao
Summary: The external and internal factors of the cell play a critical role in glioma initiation, with multiple factors and molecules implicated in brain cancer progression. Glioma stem cells have been identified as the origin, and oncogene overexpression is involved in tumorigenesis, maintenance, and progression. Additionally, defects in cell organelles contribute to cancer cell resistance to drugs, apoptosis, and immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Applied
Shane M. Hickey, Ian R. D. Johnson, Elena Dallerba, Mark J. Hackett, Massimiliano Massi, Joanna Lazniewska, Lauren A. Thurgood, Frederick M. Pfeffer, Douglas A. Brooks, Trent D. Ashton
Summary: We introduce a highly fluorescent, solvatochromic, 1,8-naphthalimide probe that enables the simultaneous imaging of lipid droplets and endoplasmic reticulum, with distinguishable emission maxima. By delineating organelles based on their emission profiles, we are able to visualize lipid droplet biogenesis and intercellular trafficking events. Furthermore, this probe demonstrates potential histochemical applications by staining myelin lipids in ex vivo brain tissue.
Article
Multidisciplinary Sciences
Hyunwoo Kim, Seowhang Lee, Youngsoo Jun, Changwook Lee
Summary: This study reveals the molecular mechanism and structural basis of how MIGA2 regulates ERMCS formation and facilitates lipid trafficking at ERMCS.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yating Li, Siqian Gong, Meng Li, Xiaoling Cai, Wei Liu, Simin Zhang, Yumin Ma, Yingying Luo, Lingli Zhou, Xiuying Zhang, Xiuting Huang, Xueying Gao, Mengdie Hu, Yufeng Li, Qian Ren, Yanai Wang, Xianghai Zhou, Xueyao Han, Linong Ji
Summary: This study aimed to explore the prevalence and clinical characteristics of WFS1-related diabetes (WFS1-DM) in a Chinese population with early-onset type 2 diabetes (EOD). Through sequencing the exons of the WFS1 gene in 690 EOD patients, 33 rare variants were identified, and 6 patients were found to have pathogenic or likely pathogenic variants associated with WFS1-DM. These patients exhibited lower C-peptide levels and the need for insulin treatment. WFS1-DM is often misdiagnosed as type 2 diabetes, and genetic testing is helpful for personalized treatment.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Decio L. Eizirik, Florian Szymczak, Maria Ines Alvelos, Frank Martin
Summary: This article discusses the importance of focusing on beta-cells in type 1 diabetes, proposing the design of therapies by defining regulatory networks rather than solely targeting the immune system.
Article
Multidisciplinary Sciences
Ehud Haimov, Michael Urbakh, Michael M. Kozlov
Summary: For 2D networks with mobile three-way junctions, a negative tension is necessary for network stability. The presence of symmetric junctions and the balance between tension and junction energy determine the optimal density of the network.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Leonid E. Fridlyand, Natalia A. Tamarina, Andrew V. Schally, Louis H. Philipson
FRONTIERS IN ENDOCRINOLOGY
(2016)
Article
Biophysics
L. E. Fridlyand, D. A. Jacobson, A. Kuznetsov, L. H. Philipson
BIOPHYSICAL JOURNAL
(2009)
Article
Multidisciplinary Sciences
Leonid E. Fridlyand, Louis H. Philipson
Review
Biochemistry & Molecular Biology
Leonid E. Fridlyand, Louis H. Philipson
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2011)
Article
Mathematical & Computational Biology
Leonid E. Fridlyand, Louis H. Philipson
THEORETICAL BIOLOGY AND MEDICAL MODELLING
(2010)
Review
Endocrinology & Metabolism
Leonid E. Fridlyand, Louis H. Philipson
Review
Endocrinology & Metabolism
Leonid E. Fridlyand, Louis H. Philipson
Review
Endocrinology & Metabolism
Leonid E. Fridlyand, David A. Jacobson, L. H. Philipson
Article
Cell Biology
Leonid E. Fridlyand, Mark C. Harbeck, Michael W. Roe, Louis H. Philipson
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2007)
Article
Endocrinology & Metabolism
LE Fridlyand, LH Philipson
DIABETES OBESITY & METABOLISM
(2006)
Article
Endocrinology & Metabolism
LE Fridlyand, L Ma, LH Philipson
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2005)
Article
Endocrinology & Metabolism
NA Tamarina, A Kuznetsov, LE Fridlyand, LH Philipson
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2005)
Article
Medicine, Research & Experimental
Leonid E. Fridlyand, Louis H. Philipson
MEDICAL HYPOTHESES
(2006)
Review
Endocrinology & Metabolism
Leonid E. Fridlyand, Louis H. Philipson
CURRENT DIABETES REVIEWS
(2006)