Article
Cell Biology
Ya-Shuan Chou, Shu-Chun Chuang, Chung-Hwan Chen, Mei-Ling Ho, Je-Ken Chang
Summary: Estrogen enhances long bone growth during early puberty, with GPER-1 playing a crucial role in regulating growth plate chondrocyte function. Knocking out GPER-1 in chondrocytes led to decreased body length and bone growth, demonstrating GPER-1's positive regulation on chondrocyte proliferation and longitudinal bone growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Julien C. Marie, Edith Bonnelye
Summary: This review summarizes the impacts of estrogens on bone immune cells and their consequences on bone homeostasis, metastasis settlement into the bone, and tumor progression. The role of an orphan nuclear receptor ERRalpha on macrophages and T lymphocytes is also addressed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Nuria Lara-Castillo
Summary: Estrogen plays important roles in bone homeostasis, affecting bone growth, healing, and mechanical adaptation. Abrupt loss of estrogen can lead to osteoporosis. Understanding the mechanisms of estrogen action is crucial for bone health.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Lin-Yu Jin, Chen Guo, Shuai Xu, Hai-Ying Liu, Xin-Feng Li
Summary: The study revealed that ob/ob mice exhibit contrasting growth patterns in appendicular and axial bone growth, with ERα playing a key role in regulating these growth patterns. The absence of leptin seems to disrupt the regulatory effects of ER antagonists on bone growth in ob/ob mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Yuyou Yang, Naibo Feng, Li Liang, Rong Jiang, Yiming Pan, Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo
Summary: This study confirmed the important role of PGRN in regulating the estrogen signal, maintaining bone homeostasis. Our findings may provide a new strategy for the treatment of osteoporosis and maintaining bone homeostasis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemistry & Molecular Biology
Aoi Ikedo, Yuuki Imai
Summary: Estrogen deficiency impairs fracture healing by affecting the expression ratio of estrogen receptors, especially ERα, in callus during the process. The study clarified the significance of ERs during fracture healing using osteoblast-specific ER knockout mice, showing that ERα in osteocalcin-positive osteoblasts may contribute to the late stage of bone regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Karin L. Gustafsson, Sofia Moverare-Skrtic, Helen H. Farman, Cecilia Engdahl, Petra Henning, Karin H. Nilsson, Julia M. Scheffler, Edina Sehic, Ulrika Islander, Ellis Levin, Claes Ohlsson, Marie K. Lagerquist
Summary: Selective estrogen receptor modulators (SERMs) act on estrogen receptors (ERs) in a tissue-specific manner, exerting effects through nuclear actions and membrane-initiated signaling pathways. This study demonstrates that membrane-initiated ER alpha (mER alpha) signaling modulates the tissue-specific responses of SERMs.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Karin L. Gustafsson, Helen H. Farman, Karin H. Nilsson, Petra Henning, Sofia Moverare-Skrtic, Vikte Lionikaite, Lina Lawenius, Cecilia Engdahl, Claes Ohlsson, Marie K. Lagerquist
Summary: Mutation of arginine 264 in ER alpha has been shown to abolish rapid membrane ER alpha-mediated endothelial effects. The novel finding that mutation of R264 is dispensable for ER alpha-mediated skeletal effects supports the concept that R264 determines the tissue specificity of ER alpha.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
H. Mirzaei-Alamouti, R. Hadionnejad, A. Abdollahi, A. Bahari, F. Fatahnia, R. Masoumi, M. P. Green, M. Vazirigohar, M. Mansouryar
Summary: This study investigated the effects of varying the plane of nutrition on gene expression related to mammary gland development in a seasonal sheep breed. The findings showed a positive impact of high-nutrient diet on mammary gland development, and revealed a complex relationship between the expression of genes critical for mammary gland function and development. These findings provide valuable insights for future nutritional strategies to optimize animal liveweight gain and mammary gland development.
ANIMAL BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Maki Fukami, Tsutomu Ogata
Summary: Estrogens play important roles in pubertal development, reproductive function, bone turnover, and metabolic conditions. Mutations in genes related to estrogen synthesis and action can lead to congenital disorders. Clinical studies on these disorders provide insights into the functions of estrogens in the human body.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Kaoru Sato, Ken-ichi Takayama, Satoshi Inoue
Summary: Estrogens play an important role in the female reproductive system and also regulate physiological processes associated with learning and memory in the brain. They have neuroprotective effects in the pathogenesis of Alzheimer's disease (AD), which has a higher incidence in older and postmenopausal women. Estrogens bind to estrogen receptors (ERs) and activate transcriptional machineries, and also stimulate signal transduction through membrane ERs (mERs). Estrogen-related receptors (ERRs), which lack estrogen-binding capabilities, are expressed in the human brain and implicated in AD pathogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kenta Yoh, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue
Summary: Estrogen is an essential hormone that primarily functions in the female reproductive system and has pleiotropic effects in various tissues and organs. Low estrogen levels, such as in postmenopausal women, can lead to disorders like cardiovascular disease, dementia, metabolic syndrome, osteoporosis, sarcopenia, and frailty. Estrogen receptors (ERs) and estrogen-related receptors (ERRs) play crucial roles in muscle physiology, including muscle mass maintenance, exercise physiology, and regeneration, particularly in relation to mitochondrial function and metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jeffrey T. McNamara, Kelsey E. Huntington, Samantha Borys, Chathuraka T. Jayasuriya, Laurent Brossay
Summary: The study shows that in the absence of SHP-2, uncontrolled proliferation of the BCSP subset may lead to the development of wrist cartilage tumors. These cells have a history of CD4 expression and wrist location tropism, explaining why the wrist is the main site of tumor development.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Zhenhua Li, Yaqiang Pan, Qinghua Liu, Jian Wang, Chang Liu, Laihao Qu, Dingbiao Li
Summary: The expression of GPER1 is associated with ER and EGFR mutations in lung adenocarcinoma. GPER1 regulates ER expression and MAPK signaling, and co-inhibition of GPER1 and ER can decrease phosphorylation of ERK1/2 and Akt in cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Gudmundur Vignir Sigurdsson, Susanne Schmidt, Dan Mellstrom, Claes Ohlsson, Robert Saalman, Mattias Lorentzon
Summary: Young adult men with childhood-onset IBD have decreased bone quality in both cortical and trabecular bone structures compared to age- and height-matched controls. This has implications for their skeletal health and quality of life.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Endocrinology & Metabolism
Xiaoyu Xu, Haisheng Yang, Whitney A. Bullock, Maxim A. Gallant, Claes Ohlsson, Teresita M. Bellido, Russell P. Main
Summary: Age-related bone loss is caused by imbalanced bone turnover and decreased skeletal mechanoadaptation. Estrogen receptors, ER alpha and ER beta, play crucial roles in osteoprotective regulation. Previous studies focused on ER alpha but the role of Ot-ER beta in bone mass regulation is still unknown. This study found that Ot-ER beta regulates bone (re)modeling and mechanical signal response differently in males and females.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Genetics & Heredity
Yiheng Chen, Tianyuan Lu, Ulrika Pettersson-Kymmer, Isobel D. Stewart, Guillaume Butler-Laporte, Tomoko Nakanishi, Agustin Cerani, Kevin Y. H. Liang, Satoshi Yoshiji, Julian Daniel Sunday Willett, Chen-Yang Su, Parminder Raina, Celia M. T. Greenwood, Yossi Farjoun, Vincenzo Forgetta, Claudia Langenberg, Sirui Zhou, Claes Ohlsson, J. Brent Richards
Summary: Through genome-wide association studies, this study identified associations between 690 metabolites and 248 loci, as well as associations between 143 metabolite ratios and 69 loci. The integration of metabolite-gene and gene expression information revealed 94 effector genes for 109 metabolites and 48 metabolite ratios. The use of Mendelian randomization identified 22 metabolites and 20 metabolite ratios with estimated causal effects on 12 traits and diseases.
Article
Orthopedics
Henrik Damm, Anette Jonsson, Bjorn E. Rosengren, Lars Jehpsson, Claes Ohlsson, Eva Ribom, Dan Mellstrom, Magnus K. Karlsson
Summary: The purpose of this study was to determine the prevalence and morbidity of neck pain, cervical rhizopathy, upper extremity motor deficit, and/or thoracolumbar pain in elderly men. A cross-sectional questionnaire study of 3,000 community-dwelling older men was conducted, and the results showed that 29% of the participants reported experiencing neck pain and 54% reported thoracolumbar pain. Among those with neck pain, 13% had severe morbidity for those with only neck pain, while 46% had severe morbidity for those with neck pain, rhizopathy, and motor deficit.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Geriatrics & Gerontology
Leo D. Westbury, Charlotte Beaudart, Olivier Bruyere, Jane A. Cauley, Peggy Cawthon, Alfonso J. Cruz-Jentoft, Elizabeth M. Curtis, Kristine Ensrud, Roger A. Fielding, Helena Johansson, John A. Kanis, Magnus K. Karlsson, Nancy E. Lane, Laetitia Lengele, Mattias Lorentzon, Eugene McCloskey, Dan Mellstrom, Anne B. Newman, Claes Ohlsson, Eric Orwoll, Jean-Yves Reginster, Eva Ribom, Bjorn E. Rosengren, John T. Schousboe, Eric J. Shiroma, Nicholas C. Harvey, Elaine M. Dennison, Cyrus Cooper
Summary: The performance of recent sarcopenia definitions in terms of thresholds employed, concordance in individuals, and prediction of important health-related outcomes such as death is limited. This study addressed these limitations in a large multinational cohort study.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Dominyka Batkovskyte, Fiona McKenzie, Fulya Taylan, Pelin Ozlem Simsek-Kiper, Sarah M. Nikkel, Hirofumi Ohashi, Roger E. Stevenson, Thuong Ha, Denise P. Cavalcanti, Hiroyuki Miyahara, Steven A. Skinner, Miguel A. Aguirre, Zuehal Akcoeren, Gulen Eda Utine, Tillie Chiu, Kenji Shimizu, Anna Hammarsjoe, Koray Boduroglu, Hannah W. Moore, Raymond J. Louie, Peer Arts, Allie N. Merrihew, Milena Babic, Matilda R. Jackson, Nikos Papadogiannakis, Anna Lindstrand, Ann Nordgren, Christopher P. Barnett, Hamish S. Scott, Andrei S. Chagin, Gen Nishimura, Giedre Grigelioniene
Summary: Lethal short-limb skeletal dysplasia Al-Gazali type is a rare disorder with unknown genetic etiology. A study involving nine patients with clinical features consistent with this disorder identified disease-causing variants in ADAMTSL2, shedding light on the genetic cause and highlighting the importance of analyzing the pseudogene region. This study enhances our understanding of Al-Gazali skeletal dysplasia and its association with ADAMTSL2-related disorders.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Sebastian Rohrich, Paul Saenger, Reiko Horikawa
Summary: This study aimed to assess the efficacy and safety of somapacitan in treating growth hormone deficiency (GHD) in children, as well as the burden of treatment. The results showed that weekly injections of somapacitan could reduce the burden for patients and their parents/guardians compared to daily GH injections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Louise Grahnemo, Anna L. Eriksson, Maria Nethander, Robert Johansson, Mattias Lorentzon, Dan Mellstroem, Ulrika Pettersson-Kymmer, Claes Ohlsson
Summary: This study found a robust association between circulating valine and hip fractures, which was confirmed in a replication study. Further analysis showed that high circulating valine levels were associated with increased cortical bone area and trabecular thickness. Therefore, circulating valine may be an important marker for predicting hip fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Lina Lilja, Maria Bygdell, Jari Martikainen, Annika Rosengren, Jenny M. Kindblom, Claes Ohlsson
Summary: The study found that high BMI during childhood and puberty is associated with an increased risk of venous and arterial thromboembolic events in adult men. Young adult overweight is a strong determinant, while childhood overweight is a moderate determinant, of VTE in adult life.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Anastasiia D. Kurenkova, Lei Li, Anna P. Usanova, Xiaogang Feng, Baoyi Zhou, Andrei A. Nedorubov, Alexey Lychagin, Andrei S. Chagin
Summary: Articular cartilage has limited ability to self-repair, and clinical approaches to cartilage regeneration are necessary. The current method involves expansion of autologous chondrocytes followed by reimplantation, but the outcome is often unsatisfactory due to dedifferentiation. In recent years, articular stem/progenitor cells (artSPCs) have been discovered, which have the potential to repair damaged cartilage. This study found that modulation of the Notch pathway during expansion facilitated chondrogenic potential of artSPCs and chondrocytes, while activation of the pathway abrogated this potential.
Article
Endocrinology & Metabolism
Suchita Desai, Jianyao Wu, Karin Horkeby, Maria Norgard, Claes Ohlsson, Sara H. Windahl, Cecilia Engdahl
Summary: Mechanical loading enhances bone strength and counteracts arthritis-induced inflammation-mediated bone loss in female mice. It is unknown whether nonsteroidal anti-inflammatory drugs (NSAIDs; eg, COX-2 inhibitors) can reduce inflammation without affecting the loading-associated bone formation in male mice. The aim of this study was to investigate if loading combined with a COX-2 inhibitor (NS-398) could prevent arthritis-induced bone loss and inflammation in male mice. The results showed that loading prevented arthritis-induced bone loss and NS-398 reduced knee swelling without affecting the bone-protective effects of loading.
Article
Endocrinology & Metabolism
Claes Ohlsson, Maria Nethander, Anna-Karin Norlen, Matti Poutanen, Elias Freyr Gudmundsson, Thor Aspelund, Sigurdur Sigurdsson, Henrik Ryberg, Vilmundur Gudnason, Asa Tivesten
Summary: This study found an inverse association between serum levels of DHEA and testosterone and coronary artery calcification in elderly men, partially independently from each other. These results raise the question whether androgens produced by both the adrenals and the testes may contribute to male cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Johan Svensson, Klara Sjogren, Lina Lawenius, Antti Koskela, Juha Tuukkanen, Karin H. Nilsson, Sofia Moverare-Skrtic, Claes Ohlsson
Summary: Insulin-like growth factor-I (IGF-I) levels and cortical bone dimensions play important roles in determining fracture risk in elderly people. Inactivation of liver-derived circulating IGF-I reduces periosteal bone expansion in young and older mice. This study investigates the effect of inducible inactivation of IGF-I specifically in bone on the bone phenotype in adult/old mice, finding that it results in reduced radial growth of cortical bone, suggesting the importance of locally derived IGF-I in regulating the cortical bone phenotype in older mice.
Article
Endocrinology & Metabolism
Hannah Collden, Malin Hagberg Thulin, Andreas Landin, Karin Horkeby, Marie Lagerquist, Jianyao Wu, Karin H. Nilsson, Louise Grahnemo, Matti Poutanen, Henrik Ryberg, Liesbeth Vandenput, Claes Ohlsson
Summary: Progesterone levels in males with advanced prostate cancer have been identified as a potential predictor for treatment effect. This study found that progesterone levels remained high in orchiectomized male mice, with the highest levels observed in white adipose tissue and the gastrointestinal tract. Additionally, dietary intake of progesterone, particularly from female animals of reproductive age, was found to contribute to tissue levels of progesterone in male mice. These findings suggest that food containing high levels of progesterone may be a significant source of progesterone in males, possibly affecting men undergoing androgen deprivation therapy for prostate cancer.