Article
Oncology
Ya Xie, Haoran Duan, Dong Wang, Huiqing Li, Jia Jia, Jialin Zhang, Linlin Li
Summary: GnRH agonist co-therapy is effective in preserving ovarian function during platinum-based chemotherapy in patients with ovarian malignancy, reducing the risk of low AMH levels post-chemotherapy and improving menstrual resumption and quality of life. It provides a therapeutic reference for gynecologists, especially in economically and medically underdeveloped areas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Hui Ji, Yan Su, Mianqiu Zhang, Xin Li, Xiuling Li, Hui Ding, Li Dong, Shanren Cao, Chun Zhao, Junqiang Zhang, Rong Shen, Xiufeng Ling
Summary: This study aimed to investigate the incidence of functional ovarian cysts, their influence on clinical outcomes, and proper management in the context of assisted reproductive technology. The study found that there was no need to cancel cycles with functional ovarian cyst formation. Both conservative management and continued use of agonist treatment yielded similar pregnancy rates, but the conservative approach was recommended due to its lower cost and fewer side effects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Carsten Gruendker, Guenter Emons
Summary: The HPG axis regulates the female menstrual cycle through GnRH, which can impact ovarian cancer either indirectly through the HPG axis or directly through receptors on the surface of tumor cells.
Article
Multidisciplinary Sciences
Lisa-Marie Sattler, Hanna A. Schniewind, Waldemar B. Minich, Christoph W. Haudum, Petra Niklowitz, Julia Muenzker, Gabor L. Kovacs, Thomas Reinehr, Barbara Obermayer-Pietsch, Lutz Schomburg
Summary: In European adult control groups and PCOS patients, only a very small fraction have natural GnRH-R-aAb. Our results do not support the hypothesis that GnRH-R is a significant autoantigen in PCOS.
Article
Obstetrics & Gynecology
Xin Mu, He Cai, Juan-zi Shi
Summary: This study compares the outcomes of two different hormonal protocols for IVF in young patients with low BMI. The prolonged protocol required more medication and stimulation time, but the live birth rate was similar to that of the long protocol. However, the prolonged protocol had a higher incidence of ovarian hyperstimulation syndrome.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Andrology
Hiroshi Sasaki, Kenta Miki, Kojiro Tashiro, Keiichiro Mori, Fumihiko Urabe, Wataru Fukuokaya, Takahiro Kimura, Shun Sato, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa
Summary: The recovery patterns of hormonal profiles after short-term (12 weeks) neoadjuvant ADT differ between GnRH antagonists and GnRH agonists. The choice between these drugs matters and may have a clinical impact depending on the primary objective of ADT.
Article
Biology
Yanlong Song, Yinjun Jiang, Ji Chen, Binbin Tao, Wen Xu, Yang Huang, Guangli Li, Chunhua Zhu, Wei Hu
Summary: This study analyzed the key regulatory factors in greater amberjack and found that the injection of SNa and GnRHa could elevate hormone levels and promote spawning in fish, suggesting their potential as stimulators of reproduction in marine species.
Article
Obstetrics & Gynecology
Xiaoyan Ding, Jingwei Yang, Lan Li, Na Yang, Ling Lan, Guoning Huang, Hong Ye
Summary: Under the GnRH-a long protocol, fresh embryo transfer (ET) was associated with higher implantation and live birth rates compared to frozen embryo transfer (FET). The study found no significant differences in clinical pregnancy rate, ectopic pregnancy rate, and pregnancy loss rate between the two groups. The freeze all strategy should be individualized and approached with caution, especially when using the GnRH-a long protocol.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Medicine, General & Internal
Mia Park, Min Soon Song, Byung Hun Kang, Soo Youn Song, Geon Woo Lee, Ye Won Jung, Won Kyo Shin, Young Bok Ko, Ki Hwan Lee, Heon Jong Yoo
Summary: This study evaluated the efficacy and safety of using a gonadotropin-releasing hormone (GnRH) agonist for treating large-sized submucosal leiomyoma before hysteroscopic myomectomy. The results showed that pretreatment with GnRH agonist led to a decrease in leiomyoma volume, shorter operation time, and reduced amount of uterine-distension media used, without an increase in surgical complications.
Article
Obstetrics & Gynecology
Tetsuro Hanada, Fuminori Kimura, Jun Kitazawa, Aina Morimune, Takashi Murakami
Summary: In a breast cancer patient undergoing a change from hormone therapy to chemotherapy, controlled ovarian stimulation and embryo freezing were performed for fertility preservation. Despite developing severe ovarian hyperstimulation syndrome post oocyte retrieval, the patient’s symptoms improved after treatment with an oral gonadotropin-releasing hormone antagonist, allowing her to proceed with chemotherapy on schedule.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Huan Wu, Xiaoyan Xu, Cong Ma, Yiran Zhou, Shanai Pei, Hao Geng, Ye He, Qianhua Xu, Yuping Xu, Xiaojin He, Ping Zhou, Zhaolian Wei, Xiaofeng Xu, Yunxia Cao
Summary: Retrospective analysis of obstetric and repregnancy outcomes in women receiving GnRH-a during early pregnancy showed that accidental exposure to GnRH-a in early pregnancy might be safe. Suggestions for reproductive treatment for repregnancy should consider the outcomes of the previously GnRH-a-exposed spontaneous pregnancy.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Aijun Ti, Ting Zhang, Lili Jia, Mingli Chen
Summary: This study evaluates the therapeutic efficacy of gonadotropin-releasing hormone agonist (GnRHa) plus levonorgestrel-releasing intrauterine system (LNG-IUS) for moderate and severe endometriosis (EMS). The results show that LNG-IUS + GnRHa has better efficacy against moderate and severe EMS and higher efficacy in improving patients' ovarian function.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
H. Wang, Y. W. Zhu, J. Yang, X. Y. Wang, Y. C. Zhan, W. C. Wang, L. Yang
Summary: This study aimed to investigate the developmental changes in glucose metabolism and insulin signaling in goose embryos. The results showed that there were linear and quadratic decreases in relative body weight, relative liver weight, and relative body length, as well as a linear decrease in relative yolk weight. Serum glucose, insulin, and free triiodothyronine levels increased linearly with incubation time. The hepatic mRNA expression related to glucose catabolism and insulin signaling increased quadratically from embryonic day 19 to day of hatchment, while the expression of citrate synthase and isocitrate dehydrogenase mRNA decreased linearly and quadratically respectively. Serum glucose levels were positively related to serum insulin and free triiodothyronine levels, as well as the hepatic mRNA expression of insulin receptor, insulin receptor substrate protein, extracellular signal-regulated kinase, and ribosomal protein S6 kinase, 70 ku, related to insulin signaling.
Article
Obstetrics & Gynecology
Min Xia, Jie Zheng
Summary: In normal ovarian responders, the GnRH antagonist protocol showed lower clinical pregnancy rates and lower incidences of moderate and severe ovarian hyperstimulation syndrome in fresh transfer cycles compared to the depot GnRH agonist protocol. However, in frozen-thawed transfer cycles, both protocols had similar clinical pregnancy rates. Further large-sample, prospective, randomized, and controlled studies are needed to confirm these results.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.