Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hye Min, Seong Hyun Kim, Jeong Ah Hwang, Seung Hyup Hyun, Sang Yun Ha, Seo-Youn Choi, Seon Woo Kim, Hye Seung Kim
Summary: Both LI-RADS category on MRI and TLR on PET-CT are associated with the postoperative prognosis of PLCs. The prognosis of PLCs classified as LR-M can be further stratified according to the TLR group, but not for the PLCs classified as LR-4/5.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Lohmeier, Helena Radbruch, Winfried Brenner, Bernd Hamm, Brian Hansen, Anna Tietze, Marcus R. Makowski
Summary: The study aims to investigate the diagnostic potential of a multimodal PET/DKI approach for the detection of glioma recurrence and IDH genotyping. The results showed that compared to post-treatment-related effects (PTRE), recurrent high-grade glioma (HGG) had increased amino acid uptake and diffusivity, but lower mean kurtosis tensor and fractional anisotropy. Diffusion metrics from the metabolic periphery improved the diagnostic performance and were negatively correlated with amino acid uptake. The combination of PET and DKI metrics showed the highest diagnostic accuracy for the detection of relapse and could distinguish IDH genotypes in the post-treatment setting.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Eleni Rebelos, Andrea Mari, Miikka-Juhani Honka, Laura Pekkarinen, Aino Latva-Rasku, Sanna Laurila, Johan Rajander, Paulina Salminen, Hidehiro Iida, Ele Ferrannini, Pirjo Nuutila
Summary: This study confirms differences in renal cortical glucose uptake rates between people with obesity and healthy non-obese controls. Moreover, the negative correlations between renal cortical glucose uptake and free fatty acids, ketone bodies, and citrate suggest substrate competition in the renal cortex.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Se Jin Choi, Sang Hyun Choi, Dong Yun Lee, Ji Sung Lee, Dong Wook Kim, Jong Keon Jang
Summary: [(68)Ga]Ga-DOTA-SSA PET/MRI has good overall performance in detecting liver metastasis in patients with NET and has a higher detection rate than PET/CT.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Grazia Daniela Femminella, Nicholas R. Livingston, Sanara Raza, Thalia van der Doef, Eleni Frangou, Sharon Love, Gail Busza, Valeria Calsolaro, Stefan Carver, Clive Holmes, Craig W. Ritchie, Robert M. Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Anthony Peter Passmore, Ramin Nilforooshan, Ajayverma Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, Tricia Tan, Christian Holscher, John Harrison, David J. Brooks, Clive Ballard, Paul Edison
Summary: In non-diabetic Alzheimer's disease patients, peripheral insulin resistance is independently associated with reduced hippocampal glucose metabolism and lower grey matter volume, suggesting a potential influence of insulin resistance on AD pathology through its effects on cerebral glucose metabolism and neurodegeneration.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Oncology
Isabel Theresa Schobert, Lynn Jeanette Savic
Summary: Deregulated tumor metabolism in liver cancer leads to heterogeneous response rates to treatments, making personalized therapy selection crucial. Non-invasive imaging techniques focusing on the crosstalk between tumor cells and their microenvironment aim to improve tumor detection and guide personalized treatment regimens. Understanding tumor metabolism through imaging technologies may help identify suitable therapies and design targeted treatments to overcome resistance mechanisms in liver cancer.
Review
Medicine, Research & Experimental
Shen Pan, Lu Wang, Jun Xin
Summary: The study evaluated the diagnostic performance of combining F-18-FDG PET and Gd-EOB-DTPA enhanced MRI for liver fibrosis staging, finding that combining SUVmean and RE provides high accuracy for grading liver fibrosis, especially in distinguishing between F1-2 and F3-4.
Review
Radiology, Nuclear Medicine & Medical Imaging
Valeria Romeo, Thomas H. Helbich, Katja Pinker
Summary: The recent introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) as a promising imaging modality for breast cancer assessment has sparked extensive research on its clinical applications. This state-of-the-art review provides an overview of advanced MRI techniques, PET tracers, and the use of radiomics and artificial intelligence techniques in hybrid breast PET/MRI. The strengths and limitations of hybrid PET/MRI in the real world are also discussed.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Valeria Romeo, Panagiotis Kapetas, Paola Clauser, Sazan Rasul, Renato Cuocolo, Martina Caruso, Thomas H. Helbich, Pascal A. T. Baltzer, Katja Pinker
Summary: A machine learning-based radiomics approach using hybrid 18F-FDG PET/MRI can predict axillary lymph node involvement in breast cancer. By analyzing primary cancer lesions, this approach can assess tumor heterogeneity, aggressiveness, and propensity to invade. This method can improve preoperative stratification and make PET/MRI a comprehensive tool for local and node staging in breast cancer.
Review
Radiology, Nuclear Medicine & Medical Imaging
Seyed Ali Mirshahvalad, Andres Kohan, Ur Metser, Ricarda Hinzpeter, Claudia Ortega, Adam Farag, Patrick Veit-Haibach
Summary: This study conducted a diagnostic meta-analysis to evaluate the performance of [F-18]FDG PET/MR in M staging of [F-18]FDG-avid cancer entities. The results showed that [F-18]FDG PET/MR is highly accurate in detecting distant metastasis and has high sensitivity and specificity in various malignancy types. These findings provide clinicians and patients with confidence in the performance of [F-18]FDG PET/MR in clinical practice.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kai Jannusch, Maike E. Lindemann, Nils Martin Bruckmann, Janna Morawitz, Frederic Dietzel, Kelsey L. Pomykala, Ken Herrmann, Ann-Kathrin Bittner, Oliver Hoffmann, Svjetlana Mohrmann, Lale Umutlu, Gerald Antoch, Harald H. Quick, Julian Kirchner
Summary: Breast PET/MRI protocols can be shortened from 20 to below 10 minutes without losing essential diagnostic information.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhen-Ming Wang, Peng-Hu Wei, Chunxiu Wang, Yaqin Hou, Kun Guo, Bixiao Cui, Yongzhi Shan, Guo-Guang Zhao, Jie Lu
Summary: The combination of PET and structural patterns is helpful in predicting post-surgical seizure outcomes and worse outcomes of Engel III/IV. This reduces unnecessary surgical injuries to patients who may not be suitable for surgery.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun Guo, Jingjuan Wang, Bixiao Cui, Yihe Wang, Yaqin Hou, Guoguang Zhao, Jie Lu
Summary: The combination of [F-18]FDG PET/MRI and MEG in localizing the EZ in TLE patients showed higher concordance with surgical resection compared to PET/MRI or MEG alone. Lobar localization was clearly defined in majority of patients by [F-18]FDG PET/MRI/MEG. The results of PET/MRI/MEG in concordance with surgical outcome were found to be superior to PET/MRI or MEG alone.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun Guo, Bixiao Cui, Kun Shang, Yaqin Hou, Xiaotong Fan, Hongwei Yang, Guoguang Zhao, Jie Lu
Summary: This study evaluated the accuracy of [F-18]-FDG PET/MRI in preoperative localization and postsurgical prediction for refractory epilepsy patients. The results showed significant structural abnormalities in the MR portion and hypometabolism in the PET portion of the PET/MRI, suggesting a high sensitivity for detecting possible epileptic foci.
EUROPEAN RADIOLOGY
(2021)
Review
Health Care Sciences & Services
Igino Simonetti, Piero Trovato, Vincenza Granata, Carmine Picone, Roberta Fusco, Sergio Venanzio Setola, Mauro Mattace Raso, Corrado Caraco, Paolo A. Ascierto, Fabio Sandomenico, Antonella Petrillo
Summary: Interval metastasis is a specific type of lymph node metastasis in patients with melanoma. Imaging techniques such as ultrasound, CT, MRI, lymphoscintigraphy, and PET are used for evaluation. Understanding these methods and collaborating with clinicians are essential for treatment and survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Richard Aarnio, Erika Atencio Herre, Salli Karna, Senthil Palani, Helena Virtanen, Heidi Liljenback, Jenni Virta, Aake Honkaniemi, Vesa Oikonen, Chunlei Han, Sanna Laurila, Marco Bucci, Semi Helin, Emrah Yatkin, Lauri Nummenmaa, Pirjo Nuutila, Jing Tang, Anne Roivainen
Summary: Photoperiod affects the availability of mu-opioid receptors (MOR) in brown adipose tissue (BAT), and sympathetic innervation may regulate thermogenesis via the peripheral MOR system.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jurrien H. Kuneman, Sophie E. van Rosendael, Pieter van der Bijl, Alexander R. van Rosendael, Pieter H. Kitslaar, Johan H. C. Reiber, J. Wouter Jukema, Martin B. Leon, Nina Ajmone Marsan, Juhani Knuuti, Jeroen J. Bax
Summary: This study compared the pericoronary adipose tissue (PCAT) attenuation between acute coronary syndrome and stable coronary artery disease patients. The results showed that the PCAT attenuation in culprit lesion precursors of acute coronary syndrome patients was significantly higher than nonculprit lesions and lesions of stable coronary artery disease patients. Therefore, PCAT attenuation may be a novel marker for identifying high-risk plaques.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Sanna Laurila, Minna Lahesmaa, Eleni Rebelos, Kirsi A. Virtanen, Katharina Schnabl, Martin Klingenspor, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study reveals that secretin can induce satiation by modulating the metabolic communication between brown adipose tissue and the brain. Secretin regulates the brain response to appetite-inducing stimuli and improves inhibitory control, leading to increased feelings of fullness.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Sport Sciences
Jooa Norha, Tanja Sjoros, Taru Garthwaite, Saara Laine, Maria Saarenhovi, Petri Kallio, Kirsi Laitinen, Noora Houttu, Henri Vaha-Ypya, Harri Sievanen, Eliisa Loyttyniemi, Tommi Vasankari, Juhani Knuuti, Kari K. Kalliokoski, Ilkka H. A. Heinonen
Summary: A study on adults with metabolic syndrome found that reducing sedentary behavior without adding exercise training did not significantly improve maximal oxygen uptake (VO2max). However, increasing daily step count may increase VO2max.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas H. Schindler, William F. Fearon, Matthieu Pelletier-Galarneau, Giuseppe Ambrosio, Udo Sechtem, Terrence D. Ruddy, Krishna K. Patel, Deepak L. Bhatt, Timothy M. Bateman, Henry Gewirtz, Jamshid Shirani, Juhani Knuuti, Robert J. Gropler, Panithaya Chareonthaitawee, Riemer H. J. A. Slart, Stephan Windecker, Philipp A. Kaufmann, Maria R. Abraham, Viviany R. Taqueti, Thomas J. Ford, Paolo G. Camici, Heinrich R. Schelbert, Vasken Dilsizian
Summary: Diagnosing angina pectoris and dyspnea in patients with normal or nonobstructive coronary vessels is challenging. Invasive coronary angiography can identify nonobstructive coronary artery disease, but coronary microvascular dysfunction may actually be the cause of symptoms. Positron emission tomography (PET) allows noninvasive detection and delineation of coronary microvascular dysfunction by quantifying myocardial blood flow at rest and during vasodilation. Individualized or intensified medical therapies may improve symptoms, quality of life, and outcomes. Standardized diagnosis and reporting criteria for ischemic symptoms caused by coronary microvascular dysfunction are crucial for treatment decisions. A consensus document proposes standardized diagnosis, nomenclature, and reporting criteria for coronary microvascular dysfunction. It aims to provide an overview of its pathophysiology, assessment, and classification, which are essential for diagnosis, patient care, and clinical trials. (J Am Coll Cardiol Img 2023;16:536-548) (c) 2023 by the American College of Cardiology Foundation.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Arghavan Jahandideh, Jenni Virta, Xiang-Guo Li, Heidi Liljenback, Olli Moisio, Jesse Ponkamo, Noora Rajala, Marion Alix, Jukka Lehtonen, Mikko I. Mayranpaa, Tiina A. Salminen, Juhani Knuuti, Sirpa Jalkanen, Antti Saraste, Anne Roivainen
Summary: This study successfully demonstrated the feasibility of using [Ga-68]Ga-DOTA-Siglec-9 PET imaging to detect myocardial lesions in rats with autoimmune myocarditis, suggesting its potential as a novel technique.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jamshid Maddahi, Denis Agostini, Timothy M. Bateman, Jeroen J. Bax, Rob S. B. Beanlands, Daniel S. Berman, Sharmila Dorbala, Ernest V. Garcia, James Feldman, Gary V. Heller, Juhani M. Knuuti, Pedro Martinez-Clark, Matthieu Pelletier-Galarneau, Benjamin Shepple, Nagara Tamaki, Francois Tranquart, James E. Udelson
Summary: This study demonstrates that Flurpiridaz F-18 is a novel PET tracer with high diagnostic efficacy and safety for detecting coronary artery disease. It has higher sensitivity and specificity compared to traditional SPECT technique, especially in women and obese patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Takeru Nabeta, Maria Chiara Meucci, Jos J. M. Westenberg, Johan H. C. Reiber, Juhani Knuuti, Pieter van der Bijl, Nina Ajmone Marsan, Jeroen J. J. Bax
Summary: The inward displacement of the left ventricle, measured through cardiac magnetic resonance imaging, can independently predict the prognosis of patients with ischemic heart disease and prior myocardial infarction, and provides additional prognostic value in addition to left ventricular ejection fraction and global radial strain.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Nozomi Kotoku, Bjarne L. Norgaard, Scot Garg, Koen Nieman, Marc R. Dweck, Jeroen J. Bax, Juhani Knuuti, Jagat Narula, Divaka Perera, Charles A. Taylor, Jonathon A. Leipsic, Edward D. Nicol, Nicolo Piazza, Carl J. Schultz, Kakuya Kitagawa, Bernard De Bruyne, Carlos Collet, Kaoru Tanaka, Saima Mushtaq, Marta Belmonte, Darius Dudek, Adriana Zlahoda-Huzior, Shengxian Tu, William Wijns, Faisal Sharif, Matthew J. Budoff, Johan de Mey, Daniele Andreini, Yoshinobu Onuma
Summary: Coronary computed tomographic angiography (CCTA) has become the preferred investigation for determining the presence and haemodynamic significance of coronary artery disease. It can rule out atherosclerosis or detect subclinical plaque in patients without significant epicardial obstruction, and provide risk classification. For ischaemic non-obstructive coronary arteries, non-invasive imaging, including CCTA, is also expected. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining disease complexity, vessel size, lesion length, tissue composition of the atherosclerotic plaque, and the best fluoroscopic viewing angle.
Article
Radiology, Nuclear Medicine & Medical Imaging
Oona Rainio, Chunlei Han, Jarmo Teuho, Sergey V. Nesterov, Vesa Oikonen, Sauli Piirola, Timo Laitinen, Marko Tattalainen, Juhani Knuuti, Riku Klen
Summary: Carimas is a versatile tool for processing medical imaging data, allowing visualization, analysis, and modeling of various medical images in research. Originally designed for positron emission tomography data, it has expanded to include other tomography imaging modalities like computed tomography and magnetic resonance imaging. Carimas excels in analyzing three- and four-dimensional image data and creating polar maps for cardiac perfusion modeling.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Eleni Rebelos, Andrea Mari, Miikka-Juhani Honka, Laura Pekkarinen, Aino Latva-Rasku, Sanna Laurila, Johan Rajander, Paulina Salminen, Hidehiro Iida, Ele Ferrannini, Pirjo Nuutila
Summary: This study confirms differences in renal cortical glucose uptake rates between people with obesity and healthy non-obese controls. Moreover, the negative correlations between renal cortical glucose uptake and free fatty acids, ketone bodies, and citrate suggest substrate competition in the renal cortex.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Lihua Sun, Pirjo Nuutila
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Haitham Ballo, Fatma Doghman, Juha Hartikainen, Antti Saraste, Juhani Knuuti
Summary: This meta-analysis evaluated the diagnostic accuracy of 2DSTE strain in detecting myocardial viability at rest and during low-dose dobutamine stress. The results showed that LS and CS during LDD stress accurately identify reversible ischemic myocardial dysfunction in patients with chronic ischemic LV dysfunction or after MI. LS and CS had lower sensitivity and specificity at rest compared to LDD stress.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jussi Schultz, Inge J. van den Hoogen, Jurrien H. Kuneman, Michiel A. de Graaf, Vasileios Kamperidis, Alexander Broersen, J. Wouter Jukema, Antonis Sakellarios, Sotirios Nikopoulos, Konstantina Tsarapatsani, Katerina Naka, Lampros Michalis, Dimitrios Fotiadis, Teemu Maaniitty, Antti Saraste, Jeroen J. Bax, Juhani Knuuti
Summary: This study evaluated CCTA-based ESS values in coronary arteries without atherosclerosis and identified factors affecting ESS values. The findings showed that ESS was highest in the left anterior descending artery and lower in men compared to women, even after adjusting for lumen diameter. ESS values were also highest in small segments and had a correlation with the distance from the ostium.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)