The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor

Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin

(2012) Noriyuki Hatano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

(2012) Qi-An Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release

(2012) Noriyuki Hatano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner

(2012) Tomoko Komatsu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Trimer hydroxylated quinone derived from apocynin targets cysteine residues of p47phox preventing the activation of human vascular NADPH oxidase

(2011) Mauricio Mora-Pale et al.   FREE RADICAL BIOLOGY AND MEDICINE

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

(2011) David A Andersson et al.   Nature Communications

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   ACS Chemical Biology

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

(2010) Elizabeth S. Fernandes et al.   ARTHRITIS AND RHEUMATISM

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPA1 channels: Novel targets of 1,4-dihydropyridines

(2010) Otto Fajardo et al.   Channels

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

(2010) Romina Nassini et al.   FASEB JOURNAL

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

Irritating channels: the case of TRPA1

(2010) Bernd Nilius et al.   JOURNAL OF PHYSIOLOGY-LONDON

The flavin inhibitor diphenyleneiodonium renders Trichomonas vaginalis resistant to metronidazole, inhibits thioredoxin reductase and flavin reductase, and shuts off hydrogenosomal enzymatic pathways

(2010) David Leitsch et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes

(2009) Yuka Itoh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca2+ pump

(2009) T Tazzeo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nicotine activates the chemosensory cation channel TRPA1

(2009) Karel Talavera et al.   NATURE NEUROSCIENCE

TRPA1 acts as a cold sensor in vitro and in vivo

(2009) Y. Karashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

(2008) Yuji Karashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

(2008) J. A. Matta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION