Physical Biology in Cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography

Correction: Impact of Tumor Cell Cytoskeleton Organization on Invasiveness and Migration: A Microchannel-Based Approach

(2014) Claudio G. Rolli et al.   PLoS One

Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model

(2013) Shawn P. Carey et al.   CLINICAL & EXPERIMENTAL METASTASIS

Networking galore: intermediate filaments and cell migration

(2013) Byung-Min Chung et al.   CURRENT OPINION IN CELL BIOLOGY

Noninvasive Bioluminescence Imaging in Small Animals

(2013) K. R. Zinn et al.   ILAR JOURNAL

Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D

(2013) Casey M. Kraning-Rush et al.   Integrative Biology

Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration

(2013) Amit Pathak et al.   Integrative Biology

Three-dimensional photolithographic micropatterning: a novel tool to probe the complexities of cell migration

(2013) Joseph C. Hoffmann et al.   Integrative Biology

Hutchinson–Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates

(2013) Elizabeth A. Booth-Gauthier et al.   Integrative Biology

Keratin 8 and 18 Loss in Epithelial Cancer Cells Increases Collective Cell Migration and Cisplatin Sensitivity through Claudin1 Up-regulation

(2013) Anne-Marie Fortier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Fabrication of 3D cell-laden hydrogel microstructures through photo-mold patterning

(2013) P Occhetta et al.   Biofabrication

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Cytoskeleton keratin regulation of FasR signaling through modulation of actin/ezrin interplay at lipid rafts in hepatocytes

(2012) Stéphane Gilbert et al.   APOPTOSIS

Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture

(2012) Shawn P. Carey et al.   BIOMATERIALS

Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness

(2012) Pranav Soman et al.   BIOMATERIALS

Force-Induced Changes in Subnuclear Movement and Rheology

(2012) Elizabeth A. Booth-Gauthier et al.   BIOPHYSICAL JOURNAL

Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices

(2012) Vanisri Raviraj et al.   BMC CELL BIOLOGY

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Individual versus collective fibroblast spreading and migration: Regulation by matrix composition in 3D culture

(2012) Miguel Miron-Mendoza et al.   EXPERIMENTAL EYE RESEARCH

Physical confinement alters tumor cell adhesion and migration phenotypes

(2012) Eric M. Balzer et al.   FASEB JOURNAL

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

(2012) Matthew Raab et al.   JOURNAL OF CELL BIOLOGY

Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells

(2012) T. Busch et al.   JOURNAL OF CELL SCIENCE

Constructing Three-Dimensional Models to Study Mammary Gland Branching Morphogenesis and Functional Differentiation

(2012) Alvin T. Lo et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device

(2012) Michael Mak et al.   LAB ON A CHIP

α3β1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments

(2012) T M E Scales et al.   ONCOGENE

Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution

(2012) ZiQiu Tong et al.   PLoS One

Cellular Traction Stresses Increase with Increasing Metastatic Potential

(2012) Casey M. Kraning-Rush et al.   PLoS One

Keratin 8/18 Regulation of Cell Stiffness-Extracellular Matrix Interplay through Modulation of Rho-Mediated Actin Cytoskeleton Dynamics

(2012) François Bordeleau et al.   PLoS One

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microtubule-associated protein EB1 maintains cell polarity through activation of protein kinase C

(2011) Joseph M. Schober et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function

(2011) Maria L. Lombardi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Engineering extracellular matrix structure in 3D multiphase tissues

(2011) Brian M. Gillette et al.   BIOMATERIALS

A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration

(2011) Gregory F. Weber et al.   DEVELOPMENTAL CELL

Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning

(2011) Ana Sala et al.   Integrative Biology

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

(2011) Amit Pathak et al.   Integrative Biology

Measuring integrated cellular mechanical stress response at focal adhesions by optical tweezers

(2011) François Bordeleau et al.   JOURNAL OF BIOMEDICAL OPTICS

Integrin  5 1 facilitates cancer cell invasion through enhanced contractile forces

(2011) C. T. Mierke et al.   JOURNAL OF CELL SCIENCE

Loss of keratins 8 and 18 leads to alterations in  6 4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line

(2011) H. Alam et al.   JOURNAL OF CELL SCIENCE

Fabrication of Substrates with Defined Mechanical Properties and Topographical Features for the Study of Cell Migration

(2011) Jonathan M. Charest et al.   MACROMOLECULAR BIOSCIENCE

Cell-matrix adhesions in 3D

(2011) Jill S. Harunaga et al.   MATRIX BIOLOGY

Vimentin organization modulates the formation of lamellipodia

(2011) Brian T. Helfand et al.   MOLECULAR BIOLOGY OF THE CELL

Microfabricated Physical Spatial Gradients for Investigating Cell Migration and Invasion Dynamics

(2011) Michael Mak et al.   PLoS One

Loss of Keratin 8 Phosphorylation Leads to Increased Tumor Progression and Correlates with Clinico-Pathological Parameters of OSCC Patients

(2011) Hunain Alam et al.   PLoS One

Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel

(2011) Renaud Poincloux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cell migration by dynamic microtubules

(2011) Irina Kaverina et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices

(2010) Miguel Miron-Mendoza et al.   BIOMATERIALS

Study of matrix metalloproteinases and their inhibitors in prostate cancer

(2010) S Escaff et al.   BRITISH JOURNAL OF CANCER

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

(2010) Marie Schoumacher et al.   JOURNAL OF CELL BIOLOGY

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

(2010) Rebecca W. Scott et al.   JOURNAL OF CELL BIOLOGY

Keratin 8/18 Modulation of Protein Kinase C-mediated Integrin-dependent Adhesion and Migration of Liver Epithelial Cells

(2010) François Bordeleau et al.   MOLECULAR BIOLOGY OF THE CELL

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Reducing background fluorescence reveals adhesions in 3D matrices

(2010) Kristopher E. Kubow et al.   NATURE CELL BIOLOGY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Keratins in health and cancer: more than mere epithelial cell markers

(2010) V Karantza   ONCOGENE

EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching the timescale of intravital imaging in tumors

(2010) Bojana Gligorijevic et al.   Cell Adhesion & Migration

Filamin A is required for vimentin-mediated cell adhesion and spreading

(2009) Hugh Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells

(2009) Leena P. Desai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Spontaneous migration of cancer cells under conditions of mechanical confinement

(2009) Daniel Irimia et al.   Integrative Biology

Tissue Transglutaminase Is an Essential Participant in the Epidermal Growth Factor-stimulated Signaling Pathway Leading to Cancer Cell Migration and Invasion

(2009) Marc A. Antonyak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Integrins in cell migration - the actin connection

(2009) M. Vicente-Manzanares et al.   JOURNAL OF CELL SCIENCE

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Recruitment of vimentin to the cell surface by  3 integrin and plectin mediates adhesion strength

(2009) R. Bhattacharya et al.   JOURNAL OF CELL SCIENCE

Introducing intermediate filaments: from discovery to disease

(2009) John E. Eriksson et al.   JOURNAL OF CLINICAL INVESTIGATION

Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility

(2009) Pierre A. Coulombe et al.   JOURNAL OF CLINICAL INVESTIGATION

Toward unraveling the complexity of simple epithelial keratins in human disease

(2009) M. Bishr Omary et al.   JOURNAL OF CLINICAL INVESTIGATION

Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

(2009) Silvia Giampieri et al.   NATURE CELL BIOLOGY

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Collagen-based cell migration models in vitro and in vivo

(2009) Katarina Wolf et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Mechanosensing machinery for cells under low substratum rigidity

(2008) Wei-Chun Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Switch in Fas-activated death signaling pathway as result of keratin 8/18-intermediate filament loss

(2008) Stéphane Gilbert et al.   APOPTOSIS

Keratin contribution to cellular mechanical stress response at focal adhesions as assayed by laser tweezers

(2008) François Bordeleau et al.   Biochemistry and Cell Biology

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Cell Stiffening in Response to External Stress is Correlated to Actin Recruitment

(2008) Delphine Icard-Arcizet et al.   BIOPHYSICAL JOURNAL

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH

Mapping proteolytic cancer cell-extracellular matrix interfaces

(2008) Katarina Wolf et al.   CLINICAL & EXPERIMENTAL METASTASIS

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS