Article
Biology
Zdravka Daneva, Matteo Ottolini, Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A. Shah, Richard D. Minshall, Cheikh Seye, Victor E. Laubach, Brant E. Isakson, Swapnil K. Sonkusare
Summary: The study showed that endothelial Panx1 signaling pathway contributes to vasodilation and reduces pulmonary arterial pressure through ATP-TRPV4 channel signaling. By regulating ATP efflux and TRPV4 channel activity, Panx1 could potentially be targeted for the treatment of pulmonary arterial hypertension and related diseases.
Article
Peripheral Vascular Disease
Yifei Zhu, Yuan Chu, Sheng Wang, Junjian Tang, Hu Li, Lei Feng, Fan Yu, Xin Ma
Summary: Smooth muscle cell TRPV4 plays a significant role in vascular contraction and blood pressure regulation, and its expression level may be associated with obesity. The study found that TRPV4(SMC) has different effects on vasomotor tone regulation compared to endothelial TRPV4, and the loss of TRPV4(SMC) can protect obese mice from vasoconstriction and hypertension.
Article
Cell Biology
Hui Sun, Omkar Paudel, James S. K. Sham
Summary: This study provides evidence for altered intracellular Cl- homeostasis in PA smooth muscle cells associated with chronic hypoxic pulmonary hypertension, suggesting the important role of chloride transporters in regulating the Cl- concentration in pulmonary arterial smooth muscle cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zdravka Daneva, Corina Marziano, Matteo Ottolini, Yen-Lin Chen, Thomas M. Baker, Maniselvan Kuppusamy, Aimee Zhang, Huy Q. Ta, Claire E. Reagan, Andrew D. Mihalek, Ramesh B. Kasetti, Yuanjun Shen, Brant E. Isakson, Richard D. Minshall, Gulab S. Zode, Elena A. Goncharova, Victor E. Laubach, Swapnil K. Sonkusare
Summary: Recent studies have found that the activity of TRPV4 channels in endothelial cell caveolae is impaired in patients with pulmonary hypertension and mouse models. Up-regulation of iNOS and NOX1 enzymes leads to the formation of the oxidant molecule peroxynitrite, which targets the structural protein caveolin-1 and reduces the activity of TRPV4 channels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Benjamin Grimmer, Adrienn Krauszman, Xudong Hu, Golam Kabir, Kim A. Connelly, Mei Li, Jana Grune, Christian Madry, Brant E. Isakson, Wolfgang M. Kuebler
Summary: This study identifies Panx1 as a novel regulator of HPV, but its role is not necessarily linked to ATP release and downstream signaling via P2Y receptors or TRPV4 activation. Instead, Panx1 appears to modulate the Ca2+ response of PASMC to hypoxia. Furthermore, Panx1 does not affect the development of chronic hypoxic PH.
CARDIOVASCULAR RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Armin Frille, Michael Rullmann, Georg-Alexander Becker, Marianne Patt, Julia Luthardt, Solveig Tiepolt, Hubert Wirtz, Osama Sabri, Swen Hesse, Hans-Juergen Seyfarth
Summary: This study investigated the in vivo availability of serotonin transporter in the lungs of patients with COPD and PH for the first time. The findings suggest that pulmonary SERT may be involved in the development of PH in COPD patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Pharmacology & Pharmacy
Florian Dilasser, Marc Rio, Lindsay Rose, Angela Tesse, Christophe Guignabert, Gervaise Loirand, Vincent Sauzeau
Summary: This study demonstrates the protective effect of SMC Rac1 deletion against hypoxic PH. Rac1 activity in PASMCs plays a causal role in PH by promoting ROS-dependent PA remodeling and endothelial dysfunction induced by chronic hypoxia.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaofei Zhou, Yuanqing Jiang, Yuewen Wang, Linge Fan, Yunhui Zhu, Yefeng Chen, Yiran Wang, Yingyi Zhu, Hongkun Wang, Zihang Pan, Zhoubin Li, Xiaolong Zhu, Ruizhe Ren, Zhen Ge, Dongwu Lai, En Yin Lai, Ting Chen, Kai Wang, Ping Liang, Lingfeng Qin, Cuiqing Liu, Cong Qiu, Michael Simons, Luyang Yu
Summary: This study found that the FIS1 protein in endothelial mitochondria undergoes a transition between SUMOylation and deSUMOylation in hypoxia-induced pulmonary hypertension (PH). Short-term hypoxia promotes the translocation of SENP1 to endothelial mitochondria and deSUMOylation of FIS1, maintaining mitochondrial integrity and calcium communication. Prolonged hypoxia inhibits this process, leading to mitochondrial dysfunction and metabolic reprogramming.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jamie L. Archambault, Cassidy A. Delaney
Summary: This article discusses the impact of 5-HT on fetal and neonatal pulmonary circulation and summarizes the existing preclinical and clinical literature on 5-HT in neonatal PH.
Review
Cardiac & Cardiovascular Systems
Miranda K. Culley, Stephen Y. Chan
Summary: This review discusses emerging concepts centered on endothelial senescence in pulmonary vascular disease. It proposes that endothelial senescence may serve as a unifying mechanism for pulmonary hypertension and highlights the link between aging and this disease. Additionally, it presents potential opportunities and barriers for targeting senescence in the diagnosis and treatment of pulmonary hypertension.
CIRCULATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Heba Abdelazeem, Ly Tu, Raphael Thuillet, Mina Ottaviani, Achraf Boulfrad, Thomas Beck, Amira Senbel, Salma Mani, Yves Castier, Alice Guyard, Alexy Tran-Dinh, Jamel El-Benna, Dan Longrois, Adam M. Silverstein, Christophe Guignabert, Xavier Norel
Summary: The study found that metformin treatment can slow down the progression of monocrotaline-induced pulmonary hypertension in rats and protect lung tissue by increasing endothelial nitric oxide synthase activity and protein kinase G-1 expression. In addition, AMPK activation can reduce vasoconstriction in patients with pulmonary hypertension. This study suggests that AMPK activation can enhance the nitric oxide pathway, alleviate vasoconstriction through direct effects on smooth muscles, and reverse pulmonary hypertension in rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Karen Flores, Patricia Siques, Julio Brito, Silvia M. Arribas
Summary: AMP-activated protein kinase (AMPK) plays an important role in hypoxic pulmonary hypertension by participating in cardiovascular protection and inhibiting pulmonary artery wall overgrowth pathways, potentially serving as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yi Ye, Qiying Xu, Tana Wuren
Summary: Hypoxic pulmonary hypertension (HPH) is a complex vascular disorder characterized by elevated blood pressure in the lungs. It is driven by the reprogramming of gene expression patterns, leading to cellular metabolism, inflammation, and proliferation. Hypoxia plays a key role in HPH by promoting immune/inflammatory processes that control vascular remodeling. However, many animal models used to study HPH may not accurately represent the human disease state and are not suitable for testing new therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyu Fang, Min Xie, Xiansheng Liu, Yuanzhou He
Summary: High expression of CENPE is observed in PH patients and hypoxia-induced PH animals, and its deficiency inhibits pulmonary vascular remodeling and right ventricular hypertrophy. CENPE may exert its biological effect by targeting the transcription of CDK1 proteins.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Physiology
Tyler Kelly, Courtney Brown, Mohini Bryant-Ekstrand, Rachel Lord, Tony Dawkins, Aimee Drane, Joel E. Futral, Otto Barak, Tanja Dragun, Michael Stembridge, Boris Spajic, Ivan Drvis, Joseph W. Duke, Philip N. Ainslie, Glen E. Foster, Zeljko Dujic, Andrew T. Lovering
Summary: This study aimed to investigate the pulmonary vasoreactivity and right heart work in apnoea divers under the stress of hyperbaric, hypercapnic, acidotic, and hypoxic conditions. The findings showed that divers experienced less change in total pulmonary resistance compared to the control group during short-duration isocapnic hypoxia. The administration of sildenafil had a similar effect on reducing pulmonary resistance in both divers and controls. This suggests that divers can maintain normal pulmonary artery tone in hypoxic conditions, which might be a beneficial adaptation for apnoea diving.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Paulo W. Pires, Michelle N. Sullivan, Harry A. T. Pritchard, Jennifer J. Robinson, Scott Earley
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2015)
Editorial Material
Cardiac & Cardiovascular Systems
Paulo Wagner Pires, Scott Earley
CARDIOVASCULAR RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Michelle N. Sullivan, Albert L. Gonzales, Paulo W. Pires, Allison Bruhl, M. Dennis Leo, Wencheng Li, Agathe Oulidi, Frederick A. Boop, Yumei Feng, Jonathan H. Jaggar, Donald G. Welsh, Scott Earley
Article
Biochemistry & Molecular Biology
Michelle N. Sullivan, Albert L. Gonzales, Paulo W. Pires, Allison Bruhl, M. Dennis Leo, Wencheng Li, Agathe Oulidi, Frederick A. Boop, Yumei Feng, Jonathan H. Jaggar, Donald G. Welsh, Scott Earley
Editorial Material
Cardiac & Cardiovascular Systems
Paulo W. Pires, Scott Earley
CIRCULATION RESEARCH
(2016)
Article
Multidisciplinary Sciences
Paulo W. Pires, Fabrice Dabertrand, Scott Earley
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Neurosciences
Paulo W. Pires, Eun-A. Ko, Harry A. T. Pritchard, Michael Rudokas, Evan Yamasaki, Scott Earley
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Biochemistry & Molecular Biology
Harry A. T. Pritchard, Albert L. Gonzales, Paulo W. Pires, Bernard T. Drumm, Eun A. Ko, Kenton M. Sanders, Grant W. Hennig, Scott Earley
Article
Biochemistry & Molecular Biology
Harry A. T. Pritchard, Albert L. Gonzales, Paulo W. Pires, Bernard T. Drumm, Eun A. Ko, Kenton M. Sanders, Grant W. Hennig, Scott Earley
Editorial Material
Physiology
P. W. Pires, S. Earley
Article
Multidisciplinary Sciences
Harry A. T. Pritchard, Paulo W. Pires, Evan Yamasaki, Pratish Thakore, Scott Earley
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biology
Paulo Wagner Pires, Scott Earley
Meeting Abstract
Physiology
Scott Earley
JOURNAL OF GENERAL PHYSIOLOGY
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
Michelle Sullivan, Paulo Pires, Jennifer Robinson, Eun Ko, Scott Earley
Meeting Abstract
Biochemistry & Molecular Biology
Michelle Sullivan, Jennifer Robinson, Wencheng Li, Yumei Feng, Scott Earley
