Review
Biochemistry & Molecular Biology
Iain L. O. Buxton, Hazik Asif, Scott D. D. Barnett
Summary: Preterm labor leading to preterm birth is currently not preventable. Beta 2 agonists and nitric oxide, which are effective in relaxing smooth muscles, have been ineffective in preventing preterm birth. However, recent studies suggest that the repurposing of approved medication, such as mirabegron, may advance the prevention of preterm birth.
Review
Physiology
Susan Wray, Sarah Arrowsmith
Summary: This article reviews the advances in the understanding of myometrial physiology, focusing on excitation and the effects of gestation on ion channels. It discusses the role of various ion channels in myometrium, their modulation by key hormones, and their integration throughout gestation.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Chemistry, Multidisciplinary
Wenjie Tao, Curtis E. Moore, Shiyu Zhang
Summary: A redox-neutral S-nitrosation of thiol has been achieved at a dicopper(I,I) center, providing new insights into the mechanism of S-nitrosation. The reaction yielded thiol and di-S-nitrosothiol complexes, indicating that S-nitrosation proceeds through similar intermediate species.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Physiology
Kelsi N. Dodds, Lee Travis, Elizabeth A. H. Beckett, Nick J. Spencer
Summary: This study reveals that myogenic motility patterns of the nonpregnant mouse uterus are sensitive to changes in intraluminal pressure and may be modulated by voltage-gated sodium channel activity.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Reproductive Biology
Nardhy Gomez-Lopez, Roberto Romero, Jose Galaz, Gaurav Bhatti, Bogdan Done, Derek Miller, Corina Ghita, Kenichiro Motomura, Marcelo Farias-Jofre, Eunjung Jung, Roger Pique-Regi, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Adi L. Tarca
Summary: By analyzing the transcriptomic data, it was found that women undergoing term labor exhibit labor-specific gene expression changes in their peripheral blood, which correlate with gene changes in the chorioamniotic membranes, myometrium, and cervix, partially overlapping with changes observed in asymptomatic women prior to preterm birth, potentially serving as a tool for assessing labor status and identifying preterm birth risk.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Tatiana Lapina, Vladislav Statinov, Roman Puzanskiy, Elena Ermilova
Summary: The study demonstrates that colorless alga Polytomella parva cells synthesize nitric oxide (NO) through L-arginine and proposes the existence of a nitric oxide synthase-like activity independent of nitrate reductase (NR). The NO generated causes S-nitrosation of protein cysteine thiol groups as an essential post-translational modification in P. parva.
Article
Multidisciplinary Sciences
Christopher H. Switzer, Hyun-Ju Cho, Thomas R. Eykyn, Paul Lavender, Philip Eaton
Summary: Inducible nitric oxide synthase (NOS2) and nitric oxide (NO) signaling lead to DNA hypomethylation and genomic instability through degradation of DNMT1 protein and retrotransposon activation. NOS2 expression levels are correlated with decreased DNA methylation and malignant cellular transformation in breast cancer patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Yali Shan, Shiping Shen, Jing Long, Zhengshan Tang, Cichun Wu, Xin Ni
Summary: The study reveals that there is an increase in inflammatory response, particularly from macrophages, during term and preterm labor. This inflammation plays a critical role in the initiation of parturition.
Review
Endocrinology & Metabolism
Melissa L. Kozakiewicz, Chad A. Grotegut, Allyn C. Howlett
Summary: The endocannabinoid system plays a crucial role in early pregnancy success, embryo development, and parturition, influencing uterine activation and maternal-fetal interaction, regulating pregnancy maintenance and timing of labor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Physiology
Manasi Malik, Michelle Roh, Sarah K. England
Summary: The review provides a summary of studies on uterine excitation and contractions in mice, rats, guinea pigs, and humans, aiming to help new researchers understand the field and provide assistance in experimental design and result interpretation in rodent models.
Article
Plant Sciences
Cicero Andre Ferreira Macedo, Gabriela Olinda de Paiva, Pedro Modesto Nascimento Menezes, Tiago Feitosa Ribeiro, Mariana Coelho Brito, Deisy Azevedo Dourado Vilela, Luiz Antonio Miranda de Souza Duarte Filho, Fernanda Pires Rodrigues de Almeida Ribeiro, Angelica Maria Lucchese, Julianeli Tolentino de Lima, Fabricio Souza Silva
Summary: The essential oil of L. origanoides has shown to have tocolytic activity in experimental models, possibly by opening potassium channels, increasing cAMP, and reducing intracellular calcium levels. This relaxing effect may help reduce pain in animal dysmenorrhea models, and can be potentiated by the drugs nifedipine or mefenamic acid.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Jason Phung, Carol A. Wang, Jocelyn Reeders, Eng-Cheng Chan, Carlos Riveros, Tamas Zakar, Jonathan W. Paul, Craig E. Pennell, Roger Smith
Summary: The study found that gene expression patterns in preterm uterine contractions are different from term labor, suggesting preterm labor may have different initiation processes compared to term labor.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Jing Yang, Zhengyong Chen, Shuang Li, Yingchun Yang, Yuan Liao
Summary: This study found that bone marrow mesenchymal stem cells (BMSCs) and TGF-133 have therapeutic effects in regenerative injuries in the myometrium of the uterus in rats, promoting scar healing and tissue repair.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2022)
Review
Developmental Biology
Nawrah Khader, Virlana M. Shchuka, Oksana Shynlova, Jennifer A. Mitchell
Summary: The onset of labour involves a transition of smooth muscle cells in the muscular layer of the uterus from quiescent to contractile phenotypes, facilitated by various transcription factors. Understanding the role of transcription factors in labour-associated gene expression changes may lead to new therapeutic treatments for preventing preterm labour.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Oksana Shynlova, Lubna Nadeem, Anna Dorogin, Sam Mesiano, Stephen J. Lye
Summary: This study demonstrates that the selective progesterone receptor modulator, promegestone, can effectively prevent term labor and bacterial endotoxin-induced preterm birth in mice.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Reproductive Biology
Chad L. Cowles, Yi-Ying Wu, Scott D. Barnett, Michael T. Lee, Heather R. Burkin, Iain L. O. Buxton
BIOLOGY OF REPRODUCTION
(2015)
Meeting Abstract
Oncology
Senny Nordmeier, Suzann Duan, Iain L. O. Buxton
Meeting Abstract
Oncology
Suzann Duan, Senny Nordmeier, Iain Lo. Buxton
Article
Biophysics
Christian Copley Salem, Craig Ulrich, David Quilici, Karen Schlauch, Iain L. O. Buxton, Heather Burkin
JOURNAL OF BIOMECHANICS
(2018)
Article
Multidisciplinary Sciences
Scott D. Barnett, Christina R. Smith, Craig C. Ulrich, Josh E. Baker, Iain L. O. Buxton
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Samantha S. Romanick, Craig Ulrich, Karen Schlauch, Andrew Hostler, Jordanna Payne, Rebekah Woolsey, David Quilici, Yumei Feng, Bradley S. Ferguson
BIOSCIENCE REPORTS
(2018)
Article
Cell Biology
Scott D. Barnett, Iain L. O. Buxton
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Reproductive Biology
Craig C. Ulrich, Veronica Arinze, Carolina Bueno Wandscheer, Christian Copley Salem, Camellia Nabati, Neda Etezadi-Amoli, Heather R. Burkin
BIOLOGY OF REPRODUCTION
(2019)
Meeting Abstract
Oncology
Senny Nordmeier, Jon Evasovic, Suzann Duan, Ryan Wuebbles, Dean J. Burkin, Iain L. Buxton
Meeting Abstract
Oncology
Suzann Duan, Senny Nordmeier, Iain L. Buxton
Meeting Abstract
Obstetrics & Gynecology
Craig Ulrich, Christian Copley-Salem, Kyle VonSchimmelmann, Iain Buxton, Heather Burkin
REPRODUCTIVE SCIENCES
(2016)
Meeting Abstract
Obstetrics & Gynecology
Chad L. Cowles, Heather R. Burkin, Craig C. Ulrich, Michael T. Lee, Iain L. O. Buxton
REPRODUCTIVE SCIENCES
(2016)
Article
Multidisciplinary Sciences
Craig C. Ulrich, David R. Quilici, Karen A. Schlauch, Heather R. Burkin, Iain L. O. Buxton
Meeting Abstract
Obstetrics & Gynecology
Craig C. Ulrich, David R. Quilici, Karen Schlauch, Heather R. Burkin, Iain L. O. Buxton
REPRODUCTIVE SCIENCES
(2014)