期刊
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 303, 期 5, 页码 C475-C485出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00125.2012
关键词
AMPK; autophagy; Ulk1; metabolism; ubiquitin-proteasome; FoxO
资金
- INRA's PHASE division
- Universite de Montpellier 1, Faculte des Sciences du Sport
- Ministere de la Recherche et de la Technologie (MRT)
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H. The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis. Am J Physiol Cell Physiol 303: C475-C485, 2012. First published June 13, 2012; doi:10.1152/ajpcell.00125.2012.-The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activity and increasing protein degradation through regulation of ubiquitin-proteasome and autophagy pathways. In this review, we give an overview of the central role of AMPK in the control of skeletal muscle plasticity. We detail particularly its implication in the control of the hypertrophic and atrophic signaling pathways. In the light of these cumulative and attractive results, AMPK appears as a key player in regulating muscle homeostasis and the modulation of its activity may constitute a therapeutic potential in treating muscle wasting syndromes in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据