Article
Chemistry, Medicinal
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Ruediger Gerstberger, Marita Meurer, Maren von Koeckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel
Summary: This study revealed the mechanisms of HMGB1 action in the brain during rat sepsis, finding that HMGB1 enhances brain inflammatory responses and is associated with sustained sepsis symptoms.
Article
Immunology
William A. Banks, Kim M. Hansen, Michelle A. Erickson, Fulton T. Crews
Summary: High-mobility group box 1 (HMGB1) is a protein that regulates transcription in the cell nucleus and activates the innate immune system. It can cross the blood-brain barrier (BBB) and affect neuroimmune signaling in the brain and periphery. In this study, the ability of radioactively labeled HMGB1 to cross the BBB was examined. The results showed that HMGB1 could bidirectionally cross the BBB and its transport rates were enhanced by inflammation. This finding suggests that HMGB1 levels have an impact on neuroimmune signaling in various conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Microbiology
Haoran Zhong, Xiang Gui, Ling Hou, Rongxue Lv, Yamei Jin
Summary: Schistosomiasis is a chronic parasitic disease that seriously damages the liver, and the current drugs cannot reverse the liver damage. Research has found that HMGB1 is a cytokine associated with schistosomiasis, and its inhibition can protect against liver fibrotic diseases. Therefore, HMGB1 may be a potential target for the treatment of schistosomiasis sequelae.
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Emilie Boissady, Yara Abi Zeid Daou, Estelle Faucher, Matthias Kohlhauer, Fanny Lidouren, Cynthia El Hedjaj, Sophie Chateau-Joubert, Hakim Hocini, Sophie Hue, Bijan Ghaleh, Renaud Tissier
Summary: The inhibition of the HMGB1-signaling pathway by glycyrrhizin improves neurological recovery and systemic immune response in rabbits after cardiac arrest. Glycyrrhizin reduces the levels of HMGB1, interleukin-6, and interleukin-10 in the blood. It also improves clinical recovery and histopathological damages associated with reduced cerebral CD4(+) and CD8(+) T-cell infiltration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Immunology
Jie Zhao, Fang Xu, Wanying Xu, Rong Lv, Juan Wang, Xufeng Yang
Summary: This study found an association between elevated HMGB1 levels and the severity of white matter lesions (WMLs) in stroke patients, particularly in the periventricular region.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Agronomy
Chuanbei Tian, Yaying Li, Yixia Wu, Wenqiang Chu, Huai Liu
Summary: In fluctuating climatic environments, heat acclimation in predatory mites is a superior adaptation strategy for effective agricultural pest management. The sustained accumulation of HSP70 proteins results in predatory mites with thermotolerance advantage, promoting their biological control function to pests. The divergent constitutive regulation of HSP70 to a thermal environment allows predators to adapt flexibly to extreme stress.
PEST MANAGEMENT SCIENCE
(2021)
Review
Critical Care Medicine
Yupei Li, Yu Chen, Tinghang Yang, Kaixi Chang, Ningyue Deng, Weifeng Zhao, Baihai Su
Summary: Both HMGB1 and histones play major roles in mediating inflammation, immune thrombosis, and organ dysfunction in critical illnesses. Targeting them with specific antibodies or inhibitors has shown promise in animal models, but their routine clinical use is not recommended. On the other hand, extracorporeal blood purification may remove these DAMPs and exert an immunomodulatory effect in critically ill patients. This review summarizes the immunopathological roles of HMGB1 and histones, discusses the rationale for using hemofilters to remove these DAMPs, and gathers the latest evidence for the use of extracorporeal blood purification to improve clinical outcomes in critically ill patients.
Article
Biochemistry & Molecular Biology
Precious Adedayo Adesina, Itsuki Saeki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Impaired integrity of the intestinal epithelium can lead to intestinal and extraintestinal diseases. Heat shock protein 70 (HSP70) plays a crucial role in maintaining intestinal homeostasis. This study investigates the molecular mechanisms behind the upregulation of HSP70 by n-butyrate, a major metabolite of the intestinal microbiota. The findings suggest that n-butyrate enhances HSP70 expression through the activation of heat shock factor 1 (HSF1) and AMP-activated protein kinase (AMPK) pathways.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Cell Biology
Sarah Saxena, Veronique Kruys, Raf De Jongh, Joseph Vamecq, Mervyn Maze
Summary: Aseptic surgical trauma induces the release of HMGB1, triggering the immune response and resulting in postoperative cognitive decline.
Review
Cell Biology
Bram DeWulf, Laurens Minsart, Franck Verdonk, Veronique Kruys, Michael Piagnerelli, Mervyn Maze, Sarah Saxena
Summary: Targeting HMGB1 can be a strategy to reduce sepsis-induced encephalopathy and complement non-pharmacological interventions.
Article
Nutrition & Dietetics
Laura Kate Gadanec, Ulf Andersson, Vasso Apostolopoulos, Anthony Zulli
Summary: High levels of HMGB-1 have been found in patients with Hyperhomocysteinemia (HHcy), which worsens cardiovascular outcomes. Targeting HMGB-1 may be a potential therapy for improving HHcy-induced cardiovascular pathologies.
Article
Biochemistry & Molecular Biology
Bing Qu, Qinghong Zhao, Qinglian Ma, Tian Yang, Xueyao Li, Yu Chen, Jing Yang, Yan Zhang
Summary: This study reveals that miR-144-3p is downregulated in PCOS patients and rat models, while HSP-70 is upregulated. Overexpression of miR-144-3p promotes ovarian granulosa cell proliferation and inhibits apoptosis, whereas its loss shows the opposite effects. Furthermore, the expression levels of E2, T, and LH are associated with miR-144-3p, and HSP-70 is identified as a direct target of miR-144-3p. Increased expression of HSP-70 can rescue the effects of miR-144-3p on ovarian granulosa cell growth and apoptosis, while knockdown of HSP-70 can alleviate symptoms of PCOS.
Article
Cell Biology
Ke-Bing Chen, Min-Min Chang, Sheng-Li Wang, Yong-Xin Li, Yi-Xi Wang, Zhi-Guang Xu, Hong Wang, Bing-Cheng Zhao, Wei-Ying Ma
Summary: The study demonstrated the important role of HMGB1 in inflammation after spinal cord injury, with neutralizing HMGB1 significantly reducing SCI pathogenesis and hind limb paralysis. Additionally, blocking HMGB1 also led to a decrease in various pro-inflammatory cytokines levels at the SCI lesion site.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Shuhua Wu, Yangyang Yu, Zhong Zheng, Qi Cheng
Summary: This article elaborates on the role and mechanism of HMGB1 in allergic rhinitis (AR), highlighting its potential value as a new target for clinical research on AR treatment. AR is a prevalent chronic inflammatory disease and current management focuses on symptom control.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Surgery
Stanley G. Rockson, Pat W. Whitworth, Andrea Cooper, Sarah Kania, Heidi Karnofel, Michelle Nguyen, Kristin Shadduck, Phyllis Gingerich, Jane Armer
Summary: This study evaluated the safety and efficacy of a novel nonpneumatic compression device (NPCD) compared to a commercially available advanced pneumatic compression device (APCD) for treating lymphedema. The results showed that the NPCD was more effective than the APCD in reducing limb edema volume, improving quality of life, increasing adherence to treatment, and enhancing patient satisfaction.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2022)
Correction
Multidisciplinary Sciences
Stanley G. G. Rockson, Pinar Karaca-Mandic, Michelle Nguyen, Kristin Shadduck, Phyllis Gingerich, Elizabeth Campione, Heather Hetrrick
SCIENTIFIC REPORTS
(2023)
Review
Peripheral Vascular Disease
Sergio Gianesini, Yung-Wei Chi, Chantal Aguero, Deena Alqedrah, Miguel Amore, Mohammad Barbati, Adriana Baturone, Stephen Black, Denis Borsuk, Oscar Bottini, Joseph Caprini, Marylin Chamo, Meena Cherian, Larisa Chernuka, Marianne DE Maeseneer, Jose Diaz, Mark J. Garcia, Kathleen Gibson, Monika Gloviczki, Peter Gloviczki, Veronika Golovina, Elena Goranova, Lorena Grillo, Adam Gwozdz, Tobias Hirsch, Emad Hussein, Ernesto Intriago, Houman Jalaie, Aleksandra Jaworucka-kaczorowska, Ravul Jindal, Matthieu Josnin, Neil M. Khilnani, Dong-Ik Kim, Alejandro Latorre, Zaza Lazarashvili, Byung-Boong Lee, Luis Leon, Ngoh C. Liew, Kirill Lobastov, Fedor Lurie, Annalisa Maghetti, Erica Menegatti, Kasuo Miyake, M. O. Makoto, Sriram Narayanan, Diana Neuhardt, Felizitas Pannier, Alfredo Prego, Eberhard Rabe, Joseph Raffetto, Pauline Raymond-Martimbeau, Laura Redman, Lourdes Reina-Gutierrez, Rodrigo Rial, Stanley Rockson, Marco Romanelli, Fabricio R. Santiago, Raquel A. Santiago, Nuttawut Sermsathanasawadi, Evgeny Shaydakov, Carlos Simkin, Joel Sousa, Julianne Stoughton, Andrzej Szuba, Wassila Taha, Jorge Ulloa, Tomasz Urbanek, Marco Vitale, Marc Vuylsteke, Jinsong Wang, Janaina Weingartner, Spencer Wilson, Takashi Yamaki, N. G. Yeejia, Igor Zolotukhin, Armando Mansilha
Summary: Published scientific evidence reveals the widespread dissemination of healthcare misinformation in popular social networks and unofficial communication channels. A significant percentage (up to 40%) of medical websites were found to provide inappropriate information, which was shared over 450,000 times in just a five-year period. The issue is particularly prevalent in the fields of infectious diseases, oncology, and cardiovascular medicine. This document represents a collaborative effort by top experts to address these issues, providing evidence-based facts on vein and lymphatic management while also aiming to improve public awareness and fulfill research needs in the field.
INTERNATIONAL ANGIOLOGY
(2023)
Article
Surgery
Dimitrios Dionyssiou, Dung Nguyen, Anastasios Topalis, Peter Deptula, Michael Paukshto, Tatiana Zaitseva, Efterpi Demiri, Angeliki Cheva, Stanley Rockson
Summary: The combination of a propeller vascularized lymphatic tissue flap and aligned nanofibrillar collagen scaffolds was effective in reducing lymphedema in rats, with significant volume reduction and restoration of lymphatic function.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Rosie Friedman, Anna Rose Johnson, Kathy Shillue, Aaron Fleishman, Chris Mistretta, Leo Magrini, Bao Ngoc N. Tran, Stanley G. Rockson, Weidong Lu, Gloria Y. Yeh, Dhruv Singhal
Summary: This pilot study examined the safety and feasibility of acupuncture treatment for breast cancer-related lymphedema (BCRL). The results showed that acupuncture intervention improved patients' functional quality of life and had no safety concerns in a small sample. This suggests the need for further investigation of acupuncture treatment for BCRL.
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
S. Gianesini, E. Rimondi, J. D. Raffetto, E. Melloni, A. Pellati, E. Menegatti, G. P. Avruscio, F. Bassetto, A. L. Costa, S. Rockson
Summary: Blood flow is translated into biochemical signals in response to shear stress, which is recognized by sensitive endothelial receptors and plays a vital role in understanding vascular remodeling. While the role of glycocalyx structures in veins and arteries is known, the presence of such structures in the lymphatic system has not been identified in humans.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dung Nguyen, Dimitrios Dionyssiou, Tatiana S. Zaitseva, Anna T. Zhou, Gloria Sue, Peter Deptula, Maxim A. Moroz, Peter Tabada, Stanley G. Rockson, Michael V. Paukshto, Ming-Huei Cheng, Ngan F. Huang
Summary: Secondary lymphedema is a common condition among cancer survivors and there is high demand for treatment strategies. A preclinical rat hindlimb model of lymphedema has been developed and characterized to aid in the development and testing of novel diagnostic and therapeutic strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Health Policy & Services
Pinar Karaca-Mandic, Craig A. Solid, Jane M. Armer, Roman Skoracki, Elizabeth Campione, Stanley G. Rockson
Summary: Breast cancer-related lymphedema (BCRL) imposes a significant economic burden on patients, providers, and society, mainly due to adverse events, productivity reduction, and burden on caregivers. Self-care regimens can effectively manage BCRL, but poor adherence reduces their effectiveness and leads to costly complications.
COST EFFECTIVENESS AND RESOURCE ALLOCATION
(2023)
Meeting Abstract
Surgery
Stanley G. Rockson, Roman Skoracki, Jane Armer
JOURNAL OF VASCULAR SURGERY
(2023)
Meeting Abstract
Peripheral Vascular Disease
Catharine Bowman, Stanley G. Rockson