A preferential p110α/γ PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-κB-dependent manner

NF-κB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65

(2009) Eriko Takeshima et al.   BMC MICROBIOLOGY

A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis

(2009) Nilesh M. Dagia et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis

(2009) Francesca Borrelli et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

(2009) T.-J. Liu et al.   MOLECULAR CANCER THERAPEUTICS

A novel mTOR inhibitor is efficacious in a murine model of colitis

(2008) Mandar R. Bhonde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

(2008) Minoru Fujimoto et al.   ARTHRITIS AND RHEUMATISM

A Vascular Targeted Pan Phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activity

(2008) J. R. Garlich et al.   CANCER RESEARCH

Cytokines: From Gut Inflammation to Colorectal Cancer

(2008) Massimo Fantini et al.   CURRENT DRUG TARGETS

Novel therapeutic targets in the treatment of IBD

(2008) Arthur Kaser et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics

(2008) Marc Feldmann et al.   IMMUNOLOGICAL REVIEWS

DNA-binding activity of NF-κB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase

(2008) Jiqin Liu et al.   MOLECULAR IMMUNOLOGY

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane–monocyte contact bioassay

(2007) Yi-Yang Yvonne Li et al.   IMMUNOLOGY LETTERS