Article
Engineering, Biomedical
Jens Lamsfuss, Swantje Bargmann
Summary: Skeletal muscle has high damage tolerance due to its high toughness, which allows it to withstand cracks while maintaining most of its strength. This study focuses on analyzing the damage behavior in muscle fibers and fascicles, where most serious muscle injuries occur. The results show that the endomysium does not transfer high strains, providing protection to adjacent undamaged fibers. Additionally, titin plays a significant role in stabilizing pre-damaged muscle fibers, resulting in minimal reduction in macroscopic strains of fascicles.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Morium Begam, Neha Narayan, Drew Mankowski, Robert Camaj, Nicholas Murphy, Kevin Roseni, Marie E. Pepin, Jacob M. Blackmer, Takako Jones, Joseph A. Roche
Summary: Progressive resistance training (PRT) can increase muscle mass and strength, and precision rehabilitation tools are needed for research. This article introduces a dosage-adjusted resistance training device (DART) that can objectively assess muscle contraction force in a mouse model. The study results suggest that DART causes less muscle damage compared to ISOM.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biochemistry & Molecular Biology
Enrico Pierantozzi, Peter Szentesi, Cecilia Paolini, Beatrix Dienes, Janos Fodor, Tamas Olah, Barbara Colombini, Dilson E. Rassier, Egidio Maria Rubino, Stephan Lange, Daniela Rossi, Laszlo Csernoch, Maria Angela Bagni, Carlo Reggiani, Vincenzo Sorrentino
Summary: Obscurin plays a significant role in skeletal muscle fibers, affecting muscle function and intracellular Ca2+ dynamics. The diaphragm of Obscn KO mice show prolonged TTP and HRT, decreased sarcoplasmic reticulum Ca2+ release and SERCA reuptake rates, as well as fiber damage, altered sarcomere ultrastructure and M-band disarray after intense exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zoltan Singlar, Peter Szentesi, Janos Fodor, Agnes Angyal, Laszlo Csernoch, Monika Sztretye
Summary: This study investigated the effects of nutraceutical supplementation in aging mice and found that AX diet limited weight gain without muscle tissue mass decline, while both AX and krill oil supplementation increased force production without affecting calcium homeostasis. Additionally, krill oil supplementation improved spatial memory and learning ability in aging mice, suggesting that antioxidant nutraceuticals can be beneficial for cognition and healthy aging.
Article
Medicine, Research & Experimental
Lei Wang, Cheng Peng, Jianwen Chen, Huaikang Li, Qilong Jiao, Zhou Zhang, Li Wang, Qing Yuan, Baojun Wang, Yan Huang, Xin Ma
Summary: The study compares the effects of intermittent hilar occlusion (IHO) and continuous hilar occlusion (CHO) on kidney injury and oxidative damage. The results show that IHO can attenuate kidney injury, prolong tolerable ischemia duration, and prevent renal ischemia-reperfusion injury. Proper application of IHO can be extremely efficient in avoiding renal ischemia-reperfusion injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Chien-Wen S. Kuo, Sara Dobi, Caglar Goek, Ana Da Silva Costa, Alice Main, Olivia Robertson-Gray, Daniel Baptista-Hon, Krzysztof J. Wypijewski, Hannah Costello, Tim G. Hales, Niall MacQuaide, Godfrey L. Smith, William Fuller
Summary: The α1C subunit of L-type Ca2+ channels, responsible for transmembrane Ca2+ fluxes, undergoes reversible palmitoylation in rat, rabbit, and human ventricular myocytes. The sites of palmitoylation are found in the N terminus and the linker between domains I and II of the channel. Unpalmitoylated α1C subunit leads to reduced voltage sensitivity of Ca2+ channels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Stefano Perni
Summary: Contraction of striated muscle is triggered by the release of calcium from the sarcoplasmic reticulum into the cytoplasm. This release is initiated by membrane depolarization, which is sensed by voltage-gated calcium channels. Junctophilin1 and Junctophilin2 play a crucial role in forming and stabilizing the junctions between the sarcoplasmic reticulum and the plasma membrane.
Article
Sport Sciences
Ralph J. F. H. Gordon, Christopher J. Tyler, Federico Castelli, Ceri E. Diss, Neale A. Tillin
Summary: The study investigates the impact of progressive whole-body hyperthermia on maximal and rapid voluntary torque production, indicating that late-phase voluntary rate of torque development is reduced under hyperthermic conditions, likely due to decreased neural drive and reduced maximum voluntary torque. In contrast, early-and middle-phase voluntary rate of torque development are unaffected by hyperthermia due to conflicting effects of reduced neural drive and faster intrinsic contractile properties.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Article
Orthopedics
Luyu Diao, Yundong Peng, Juan Wang, Jian Chen, Guanglan Wang, Shaohui Jia, Cheng Zheng
Summary: Eccentric contraction promotes better healing of the bone-tendon interface after rotator cuff repair in mice compared to other muscle contraction patterns.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yu Su, Bumsoo Ahn, Peter C. D. Macpherson, Rojina Ranjit, Dennis R. Claflin, Holly Van Remmen, Susan Brooks
Summary: Restoring CuZnSOD specifically in neurons of mice deficient in SOD can prevent muscle atrophy and loss of force, and restore mitochondrial function, ROS generation, and calcium handling levels. This suggests that intact neuronal function and innervation are key to maintaining excitation-contraction coupling and muscle mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zheng Fang Yang, Pankaj Panwar, Ciaran R. McFarlane, Wietske E. Tuinte, Marta Campiglio, Filip Van Petegem
Summary: Junctophilins (JPH) are proteins that connect the plasma membrane and the endoplasmic or sarcoplasmic reticulum, facilitating communication between proteins in different membranes. This study presents crystal structures of two JPH isoforms, revealing their importance in muscle excitation-contraction coupling. Various mutations in JPH2 and the L-type calcium channel affect their interaction and have been linked to cardiomyopathy and cardiac arrhythmia, respectively.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Xueyong Wang, Murad Nawaz, Chris DuPont, Jessica H. Myers, Steve Ra Burke, Roger A. Bannister, Brent D. Foy, Andrew A. Voss, Mark M. Rich
Summary: Excitation-contraction coupling is the process of converting electrical excitation of muscle into force generation. Depolarization of skeletal muscle can lead to failure of ECC, specifically the failure to generate calcium transients. Different AP properties, such as AP peak and AP integral, play important roles in different steps of ECC, including AP conduction and calcium release.
Article
Sport Sciences
Shigeru Sato, Riku Yoshida, Fu Murakoshi, Yuto Sasaki, Kaoru Yahata, Kazunori Nosaka, Masatoshi Nakamura
Summary: The study compared the effects of 3-s isometric maximal voluntary contraction (MVC), concentric MVC, and eccentric MVC on muscle strength and thickness. It found that performing one 3-s MVC a day can increase muscle strength, with eccentric MVC producing more potent effects than isometric or concentric MVC.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Sport Sciences
Pierre Clos, Adrien Mater, Davy Laroche, Romuald Lepers
Summary: The study found that eccentric cycling induced similar muscle pain compared to concentric cycling but resulted in a greater decrease in MVC torque.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Neurosciences
Martin Laasmaa, Jelena Branovets, Jekaterina Stolova, Xin Shen, Triinu Ratsepso, Mihkel Jaan Balodis, Caerolin Grahv, Eliise Hendrikson, William Edward Louch, Rikke Birkedal, Marko Vendelin
Summary: There are sex differences in the structural organization of transverse tubular network and ryanodine receptors in the heart, as well as in the response to adrenergic stimulation with isoprenaline.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)