Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Lingchun Kong, Jingjing Li, Yuqin Yang, Huixin Tang, Hong Zou
Summary: This study found that Paeoniflorin (PF) can alleviate the progression of retinal vein occlusion (RVO) by inhibiting the HIF-1 alpha/VEGF/STAT3 pathway. The results of this study may provide theoretical knowledge for exploring novel treatments for RVO patients.
Article
Cardiac & Cardiovascular Systems
Zhiyu Dai, Jianding Cheng, Bin Liu, Dan Yi, Anlin Feng, Ting Wang, Lingling An, Chen Gao, Yibin Wang, Maggie M. Zhu, Xianming Zhang, You-Yang Zhao
Summary: The study reveals the unexpected role of endothelial PHD2 deficiency in inducing cardiac hypertrophy and fibrosis in an HIF-2 alpha-dependent manner, suggesting it as a potential novel therapeutic approach for treating pathological cardiac hypertrophy and heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Bo Zhang, Yan Chen, Lei Bao, Weibo Luo
Summary: This study demonstrates that hypoxia upregulates the expression of GPT2 in GBM cells through HIF-2 activation. GPT2 is localized in the nucleus and mitochondria and can decrease α-ketoglutarate levels in GBM cells. Inhibition of GPT2 can reduce GBM cell growth and migration, and knockout of GPT2 inhibits GBM tumor growth in mice.
Article
Hematology
Robert Eckenstaler, Anne Ripperger, Michael Hauke, Markus Petermann, Sandra A. Hemkemeyer, Edzard Schwedhelm, Sueleyman Erguen, Maike Frye, Oliver Werz, Andreas Koeberle, Heike Braun, Ralf A. Benndorf
Summary: This study reveals the direct link between upregulation of TP expression and angiostatic TP signaling in endothelial cells, leading to endothelial dysfunction, microvascular rarefaction, and systemic hypertension.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Dermatology
Kiran Preet Malhotra, Swastika Suvirya, Hardeep Singh Malhotra, Brajesh Kumar, Surendra Kumar, Nuzhat Husain
Summary: The study evaluated the expressions of Cyclooxygenase 2 and Vascular Endothelial Growth Factor in skin biopsies from leprosy patients, finding that their expressions were significantly higher in type 1 reaction compared to type 2 reaction. These results may guide the use of Cyclooxygenase 2 and Vascular Endothelial Growth Factor inhibitor drugs in treating reactive leprosy patients and preventing nerve damage and disability.
DERMATOLOGIC THERAPY
(2021)
Article
Immunology
Marie Goepp, Siobhan Crittenden, You Zhou, Adriano G. Rossi, Shuh Narumiya, Chengcan Yao
Summary: Research suggests that PGE(2) negatively regulates iTreg cell differentiation through a direct action on T cells, indicating the potential importance of targeting the PGE(2)-EP2/EP4 pathway to control T cell-mediated inflammation.
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Giorgia F. Camagni, Giovanni Minervini, Silvio C. E. Tosatto
Summary: The Prolyl Hydroxylases (PHDs) are a family of enzymes that regulate cell oxygen-sensing by hydroxylating hypoxia-inducible transcription factors alpha (HIFs-alpha) and promoting their degradation. Hypoxia inhibits PHDs activity, leading to HIFs-alpha stabilization and cell adaptation to low oxygen levels. The different isoforms of PHDs have varying effects on tumor progression. Molecular dynamics simulations, conservation analysis, and binding free energy calculations were used to study the binding properties and substrate affinity of PHD2 with HIF-1 alpha and HIF-2 alpha. The findings suggest that the PHD2 C-terminus may play a role in regulating PHD activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ryuta Tagawa, Hiroshi Soda, Yosuke Dotsu, Hiroaki Senju, Satoshi Irifune, Masataka Yoshida, Shota Nakashima, Asuka Umemura, Keisuke Iwasaki, Hirokazu Taniguchi, Shinnosuke Takemoto, Yuichi Fukuda, Hiroshi Mukae
Summary: This article presents the case of a 69-year-old man who developed intractably painful hypertrophic osteoarthropathy (HOA) secondary to lung cancer. Treatment with carboplatin, paclitaxel, and bevacizumab reduced tumor size and plasma vascular endothelial growth factor (VEGF) levels, relieving the patient's leg pain. The immunohistochemical examination showed that lung cancer cells were positive for VEGF, suggesting a potential role of hypoxia-inducible factor-1a in VEGF production. The findings of this study may lead to the development of novel management strategies for painful HOA.
Article
Endocrinology & Metabolism
Yuan Fu, Ruochen Du, Yufei Wang, Yitong Yuan, Yujuan Zhang, Chunfang Wang, Xuanping Zhang
Summary: MiR-31 can improve vascular endothelial cell damage caused by diabetes and promote cell proliferation, while also providing protection against vascular damage associated with type 2 diabetes by increasing the levels of HIF-1α and VEGF-A.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Review
Physiology
Karim Ullah, Rongxue Wu
Summary: Endothelial cells play a crucial role in maintaining cardiovascular homeostasis, tissue growth, and repair, relying on glycolysis to resist hypoxic damage and promote angiogenesis in ischemic regions. Hypoxia-inducible factors (HIFs) are key regulators of endothelial cell metabolism and angiogenesis, with varying effects on cardiovascular dysfunction in different disease settings.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuan Fu, Ruochen Du, Yufei Wang, Yitong Yuan, Yujuan Zhang, Chunfang Wang, Xuanping Zhang
Summary: This study investigates the effect of miR-31 on type 2 diabetes and its associated vascular injury. The results show that miR-31 improves cell proliferation and has a protective effect on type 2 diabetes and vascular damage.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Oncology
Chao Fang, Lei Dai, Cun Wang, Chuanwen Fan, Yongyang Yu, Lie Yang, Hongxin Deng, Zongguang Zhou
Summary: Research showed that SCG2 expression was associated with the survival of CRC patients, and it exhibited anti-tumor and anti-angiogenesis effects by inhibiting HIF-1 alpha/VEGF activity.
MOLECULAR ONCOLOGY
(2021)
Article
Hematology
Tatsuya Akiyama, Taketaro Sadahiro, Yu Yamada, Ryo Fujita, Yuto Abe, Koji Nakano, Seiichiro Honda, Masatsugu Ema, Yoshiaki Kubota, Satoshi Sakai, Nobuyuki Hizawa, Masaki Ieda
Summary: In this study, the differential expression patterns of Flk1 and Flt1 in pulmonary endothelial cells were investigated. Deficiency of Flk1 and hypoxia jointly dysregulated arteriolar endothelial cells, promoting vascular remodeling. Therefore, dysfunctional Flk1+ endothelial cells may contribute to the pathogenesis of vascular remodeling in pulmonary arterioles.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jun Hee Lee, Yeo Min Yoon, Sang Hun Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Chul Won Yun, Sang Hun Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Physical
Xuan-Hung Pham, Eunil Hahm, Eunji Kang, Yu Na Ha, Sang Hun Lee, Won-Yeop Rho, Yoon-Sik Lee, Dae Hong Jeong, Bong-Hyun Jun
JOURNAL OF ALLOYS AND COMPOUNDS
(2019)
Article
Cell Biology
Jae Ryong Lim, Hyun Jik Lee, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Seo Yihl Kim, Ho Jae Han
CELL COMMUNICATION AND SIGNALING
(2020)
Review
Medicine, General & Internal
Jong Hwa Lee, Hyun Jin Roh, Jun Woo Ahn, Jeong Sook Kim, Jin Young Choi, Soo-Jeong Lee, Sang Hun Lee
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Gee Euhn Choi, Hyun Jik Lee, Chang Woo Chae, Ji Hyeon Cho, Young Hyun Jung, Jun Sung Kim, Seo Yihl Kim, Jae Ryong Lim, Ho Jae Han
Summary: The study found that glucocorticoids inhibit NIX-dependent basal mitophagy, leading to reduced synaptic density and neurodegeneration, which can be reversed in a mouse model by pretreatment with a NIX enhancer.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Jin-Young Choi, Song-Soo Yang, Jong-Hwa Lee, Hyun-Jin Roh, Jun-Woo Ahn, Jeong-Sook Kim, Soo-Jeong Lee, Sang-Hun Lee
Summary: Congenital diaphragmatic hernia, especially Bochdalek hernia, during pregnancy is rare but can lead to high morbidity and mortality. Early diagnosis and surgical intervention are crucial, with multidisciplinary care and individualized treatment being key to optimal results for both the mother and fetus.
Review
Medicine, General & Internal
Ok Ju Kang, Ji Hye Koh, Ji Eun Yoo, So Yeon Park, Jeong-Ik Park, Songsoo Yang, Sang-Hun Lee, Soo-Jeong Lee, Jun-Woo Ahn, Hyun-Jin Roh, Jeong Sook Kim
Summary: Non-tubal ectopic pregnancies with abdominal hemorrhaging have significantly higher mortality and morbidity rates compared to tubal pregnancies. Prompt diagnosis and management through laparoscopic surgery are crucial for improving prognosis in cases of primary diaphragmatic ectopic pregnancy with hemorrhage.
Article
Pharmacology & Pharmacy
Chang Woo Chae, Gee Euhn Choi, Young Hyun Jung, Jae Ryong Lim, Ji Hyeon Cho, Jee Hyeon Yoon, Ho Jae Han
Summary: The study investigates the relationship between hyperglycemia-induced retromer dysfunction and Alzheimer's disease (AD). The researchers found that high glucose down-regulated the vacuolar protein sorting-associated protein 26a (VPS26a) through a methylation pathway, leading to impaired intracellular trafficking and increased AD-like pathology. Restoring VPS26a levels improved cellular transport and decreased levels of amyloid beta (A beta) and phosphorylated tau (p-tau), suggesting that VPS26a plays a role in inhibiting DM-associated AD pathogenesis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gee Euhn Choi, Chang Woo Chae, Mo Ran Park, Jee Hyeon Yoon, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han
Summary: Exposure to prenatal stress has irreversible effects on neurogenesis and can lead to cognitive and neuropsychiatric abnormalities in adulthood. This study identified glucocorticoid as a key factor impairing neurogenesis and inducing abnormal behaviors. The researchers also discovered that astrocytes derived from neural stem cells exhibited neurotoxic properties after glucocorticoid treatment. Additionally, the study revealed that cortisol-treated astrocytic conditioned media inhibited glutamatergic synaptic formation and transmission in differentiating neurons. Restoring the expression of neuroligin 1 and neuronal FGFR1 through FGF2 treatment improved glutamatergic synaptogenesis and overall neurogenesis. The findings highlight the importance of understanding the impact of prenatal stress on brain development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Medicine, General & Internal
Hyoeun Kim, Ji Hye Koh, Jihee Lee, Yeongeun Sim, Sang-Hun Lee, Soo-Jeong Lee, Jun-Woo Ahn, Hyun-Jin Roh, Jeong Sook Kim
Summary: This case report presents a successful treatment for heterotopic cesarean scar pregnancy, using selective potassium chloride injection into the scar pregnancy and uterine cerclage to control vaginal bleeding, resulting in the preservation of the intrauterine pregnancy and full-term delivery.
Review
Medicine, General & Internal
Sang Hun Lee, Songsoo Yang, Inkyu Park, Yeong Cheol Im, Gyu Yeol Kim
Summary: This case report describes a 33-year-old pregnant woman who experienced a sudden onset of epigastric pain at 18 weeks of pregnancy due to a ruptured SAA. After emergent intervention and surgery, the woman recovered without complications and was discharged 15 days postoperatively, even though the fetus was found to be dead during resuscitation.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Cell Biology
Min Jeong Kim, Gee Euhn Choi, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Han
Summary: Carrots can decrease the likelihood of rabbits developing nearsightedness.
CELL DEATH & DISEASE
(2023)
Article
Urology & Nephrology
Seong Cheol Kim, Won Hyeok Lee, Song Hee Kim, Abdumadjidov Alisher Abdulkhayevich, Jeong Woo Park, Young Min Kim, Kyung Hyun Moon, Sang Hun Lee, Sungchan Park
Summary: This study confirms the association between DRG2 expression and docetaxel-induced apoptosis in prostate cancer cells. Knockdown of DRG2 increases docetaxel-induced apoptosis without G2/M arrest, showing potential to enhance treatment outcomes in castration-resistant prostate cancer.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Article
Oncology
Jeong-Yeol Park, Sang-Hun Lee, Kyu-Rae Kim, Young-Tak Kim, Joo-Hyun Nam
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)