期刊
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 294, 期 4, 页码 C869-C878出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00154.2007
关键词
cytoskeleton; force development; vimentin; and desmin
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL075388] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL075388, R01 HL075388-03, HL-75388, R01 HL075388-05, R01 HL075388-02, R01 HL075388-04, R01 HL075388-01A1] Funding Source: Medline
The intermediate filament ( IF) network is one of the three cytoskeletal systems in smooth muscle. The type III IF proteins vimentin and desmin are major constituents of the network in smooth muscle cells and tissues. Lack of vimentin or desmin impairs contractile ability of various smooth muscle preparations, implying their important role for smooth muscle force development. The IF framework has long been viewed as a fixed cytostructure that solely provides mechanical integrity for the cell. However, recent studies suggest that the IF cytoskeleton is dynamic in mammalian cells in response to various external stimulation. In this review, the structure and biological properties of IF proteins in smooth muscle are summarized. The role of IF proteins in the modulation of smooth muscle force development and redistribution/ translocation of signaling partners ( such as p130 Crk- associated substrate, CAS) is depicted. This review also summarizes our latest understanding on how the IF network may be regulated in smooth muscle.
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