Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Brittany G. Durgin, Katherine C. Wood, Scott A. Hahn, Brenda McMahon, Jeffrey J. Baust, Adam C. Straub
Summary: The study demonstrates that under chronic hypoxia conditions, SMC CYB5R3 deficiency exacerbates bilateral ventricular hypertrophy and impairs NO-dependent vasodilation, suggesting potential early cardiac remodeling and functional changes in response to hypoxic stress.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose Britto-Junior, Rafael Campos, Matheus Peixoto, Antonio Tiago Lima, Felipe Fernandes Jacintho, Fabiola Z. Monica, Ronilson Agnaldo Moreno, Edson Antunes, Gilberto De Nucci
Summary: The release of dopamine, noradrenaline, adrenaline, and 6-nitrodopamine (6-ND) from Chelonoidis carbonaria aortic rings is coupled to nitric oxide (NO) synthesis. 6-ND acts as a selective dopamine D-2-like receptor antagonist and affects the vascular smooth muscle reactivity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna Bartakova, Marie Novakova
Summary: Cardiovascular diseases are a major cause of death globally, often involving endothelial dysfunction. Plants contain biologically active substances that can affect the endothelium, potentially contributing to the development of cardiovascular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Helen Christou, Zoe Michael, Fotios Spyropoulos, Yunfei Chen, Dan Rong, Raouf A. Khalil
Summary: The study showed that amelioration of pulmonary hypertension through carbonic anhydrase inhibition involves improved pulmonary artery reactivity and NO-mediated relaxation, potentially enhancing responsiveness to vasodilator therapies for PH.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Review
Cell Biology
Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli, Marco Racchi, Stefano Govoni, Cristina Lanni
Summary: Pin1 functions as a key regulator of vascular homeostasis by modulating nitric oxide bioavailability and influencing various pathways involved in vascular diseases. Understanding the role of Pin1 in vascular endothelium could provide new insights for potential therapeutic strategies in vascular pathologies and neurodegenerative diseases.
Article
Cell Biology
Loic Louvet, Gaelle Lenglet, A. Michaela Krautzberger, Romuald Mentaverri, Frederic Hague, Clara Kowalewski, Nassim Mahtal, Julie Lesieur, Anne-Laure Bonnet, Caroline Andrique, Celine Gaucher, Cathy Gomila, Heinrich Schrewe, Pierre-Louis Tharaux, Said Kamel, Catherine Chaussain, Isabelle Six
Summary: In this study, we investigated the role of Vasn expression in vascular function. Vasn knockout mice showed decreases in blood pressure, angiotensin II levels, and vessel contractibility. In vitro experiments revealed that Vasn deficiency resulted in SMC contractile phenotype switching, changes in intracellular calcium levels, and impaired NO signaling. These findings highlight the importance of Vasn SMC expression in maintaining vascular functions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Concetta Iside, Angela Nebbioso, Vincenzo Carafa, Antonio Damato, Sebastiano Sciarretta, Giacomo Frati, Flavio Di Nonno, Valentina Valenti, Michele Ciccarelli, Eleonora Venturini, Mariarosaria Scioli, Paola Di Pietro, Tommaso Bucci, Valentina Giudice, Marianna Storto, Bianca Serio, Annibale Alessandro Puca, Giuseppe Giugliano, Valentina Trimarco, Raffaele Izzo, Bruno Trimarco, Carmine Selleri, Lucia Altucci, Carmine Vecchione
Summary: In addition to well-known risk factors, cardiovascular events may also be associated with epigenetic and genetic alterations. This study found that the MTHFR C677T gene variant is related to increased cardiovascular risk. Interestingly, even with normal homocysteine levels, heterozygous carriers of this gene variant have an augmented risk of cardiovascular accidents, suggesting the presence of additional deregulated processes. The study suggests that targeting SIRT1 activation could be a new therapeutic strategy to control cardiovascular risk in MTHFR carriers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Arash Y. Tehrani, Marco A. Ciufolini, Pascal Bernatchez
Summary: Marfan syndrome is a connective tissue disorder caused by mutations in the FBN1 gene, with progressive aortic root widening being a serious manifestation. Our understanding of MFS-associated aortic remodeling remains fragmented, with nitric oxide synthase-related changes potentially playing a significant role in the pathogenesis.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Oguzhan Yildiz, Kemal Gokhan Ulusoy
Summary: This review summarizes the role of taurine in vascular tone and blood pressure modulation. Taurine supplementation prevents hypertension and reduces blood pressure in hypertensive patients. The mechanisms underlying taurine's vascular effects are still largely unknown.
Review
Biochemistry & Molecular Biology
Justine Bonetti, Alessandro Corti, Lucie Lerouge, Alfonso Pompella, Caroline Gaucher
Summary: Monocytes/macrophages and vascular smooth muscle cells (vSMCs) play key roles in atherosclerosis development and exhibit plasticity in response to environmental changes; vSMCs can switch from a contractile to a secretory phenotype and display macrophage characteristics, contributing to foam cell formation in atherosclerotic plaques. Nitric oxide levels impact molecular pathways involved in these processes, suggesting potential therapeutic targets for further exploration.
Article
Biochemistry & Molecular Biology
Anastasia A. Shvetsova, Anna A. Borzykh, Ekaterina K. Selivanova, Oxana O. Kiryukhina, Dina K. Gaynullina, Olga S. Tarasova
Summary: Nitric oxide (NO) deficiency during pregnancy is a key factor in the development of preeclampsia, affecting the expression of specific genes in arterial smooth muscle of newborn offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Eric H. Mace, Melissa J. Kimlinger, Tom J. No, Sergey Dikalov, Cassandra Hennessy, Matthew S. Shotwell, Frederic T. Billings, Marcos G. Lopez
Summary: Hyperoxia impairs endothelium-dependent and endothelium-independent vasodilation, but has no effect on the response to heme-independent soluble guanylyl cyclase activation. It increases vascular superoxide production.
Article
Critical Care Medicine
Ashley E. Walker, Jazmin A. Cole, Sahana Krishna Kumaran, Jonathan I. Kato, Xinhao Zhuang, Julia R. Wolf, Grant D. Henson, Belinda H. McCully
Summary: Obesity increases the risk of complications and mortality after trauma, which are associated with vascular damage. The impact of obesity on vascular dysfunction after traumatic hemorrhage is unclear. This study suggests that obesity may potentiate trauma-induced vascular inflammation and dysfunction.
Article
Biochemistry & Molecular Biology
Rocio Salsoso, Alfonso Mate, Fernando Toledo, Carmen M. Vazquez, Luis Sobrevia
Summary: Late-onset preeclampsia is associated with altered endothelial function in the fetoplacental vasculature, causing an imbalance in the L-arginine/NO signaling pathway and reducing umbilical vein dilation to insulin, which requires A(2B)AR activation in HUVECs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Baoyi Zhu, Fataima Daoud, Shaohua Zeng, Ljubica Matic, Ulf Hedin, Bengt Uvelius, Catarina Rippe, Sebastian Albinsson, Karl Sward
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Alicia Gil-Ramirez, Oskar Rosmark, Peter Spegel, Karl Sward, Gunilla Westergren-Thorsson, Anna-Karin Larsson-Callerfelt, Irene Rodriguez-Meizoso
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Susan Lan, Sebastian Albinsson
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Gastroenterology & Hepatology
Fatima Daoud, Johan Holmberg, Azra Alajbegovic, Mario Grossi, Catarina Rippe, Karl Sward, Sebastian Albinsson
Summary: YAP and TAZ in smooth muscle cells play crucial roles in maintaining colonic contractility and controlling the expression of contractile proteins and muscarinic receptors. The knockout model exhibits features of human chronic intestinal pseudo-obstruction and may serve as a valuable tool for studying this disease.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Azra Alajbegovic, Johan Holmberg, Fatima Daoud, Catarina Rippe, Gabriella Kalliokoski, Mari Ekman, Sebastien Daudi, Sigurdur Ragnarsson, Karl Sward, Sebastian Albinsson
Summary: This study reveals that the transcriptional co-activator MRTFA promotes lipid accumulation in smooth muscle cells through various mechanisms, and plays an important role in vascular remodeling in humans. Thus, MRTFA could potentially be a new therapeutic target for inhibiting vascular lipid accumulation.
VASCULAR PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Marycarmen Arevalo-Martinez, Pilar Cidad, Sara Moreno-Estar, Mirella Fernandez, Sebastian Albinsson, Irene Cozar-Castellano, Jose R. Lopez-Lopez, M. Teresa Perez-Garcia
Summary: The study found that miR-126 plays a crucial role in the metabolic memory of T2DM patients' VSMCs, enhancing the efficacy of Kv1.3 blockers in preventing restenosis by activating the MEK/ERK pathway.
MOLECULAR METABOLISM
(2021)
Article
Hematology
Fatima Daoud, Marycarmen Arevalo Martinez, Johan Holmberg, Azra Alajbegovic, Neserin Ali, Catarina Rippe, Karl Sward, Sebastian Albinsson
Summary: This study investigates the role of YAP/TAZ in vascular smooth muscle cell mechanotransduction and demonstrates their protective role against hypertensive vasculopathy. YAP/TAZ deficiency leads to decreased contractile function and attenuated transcriptional regulation in smooth muscle cells, resulting in severe vascular lesions in established hypertension.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Li Liu, Dmytro Kryvokhyzha, Catarina Rippe, Aishwarya Jacob, Andrea Borreguero-Munoz, Karin G. Stenkula, Ola Hansson, Christopher W. J. Smith, Steven A. Fisher, Karl Sward
Summary: The study reveals the association between MYOCD and four splicing factors, which are involved in the control of SMC-specific alternative exon usage and splicing. RNA-sequencing and analysis demonstrate that MYOCD contributes to the regulation of transcript diversity through alternative exon usage and splicing, playing a critical role in SMC differentiation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Fatima Daoud, Marycarmen Arevalo Martinez, Jan Holst, Johan Holmberg, Sebastian Albinsson, Karl Sward
Summary: Ruptured arterial aneurysm is a serious condition that requires screening and treatment. Maintaining nuclear integrity can prevent aneurysm development, providing a new direction for treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Physiology
Azra Alajbegovic, Fatima Daoud, Neserin Ali, Katarzyna Kawka, Johan Holmberg, Sebastian Albinsson
Summary: The study found that GATA6 promotes cell migration in human coronary artery smooth muscle cells and silencing GATA6 reduces cellular motility. Microarray screening and pathway enrichment analysis revealed the involvement of the transforming growth factor beta signaling and MAPK pathway in GATA6-sensitive gene transcription. These findings provide important insights into the functional role of GATA6 in vascular smooth muscle.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Michelle Kha, Krzysztof Krawczyk, Oi Kuan Choong, Francesco De Luca, Gulay Altiparmak, Eva Kallberg, Helen Nilsson, Karin Leandersson, Karl Sward, Martin E. Johansson
Summary: Activation of the SOX9 transcription factor promotes cell proliferation and regeneration in the injured kidney. It is expressed in scattered tubular cells in the uninjured kidney and is increased in response to injury. SOX9 also regulates the differentiation of nephron segments in the kidney.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Meeting Abstract
Physiology
M. Arevalo Martinez, J. Holmberg, F. Daoud, K. Sward, K. Kawka, C. Rippe, S. Albinsson
Meeting Abstract
Hematology
Cheng Zhang, Yuanyuan Zhang, Jennifer Lucitti, Andrea Palos-Jasso, Sebastian Albinsson, Yuan Gao, Yaru Cui, Takahisa Murata, James E. Faber, William C. Sessa, Jun Yu
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Meeting Abstract
Urology & Nephrology
Baoyi Zhu, Catarina Rippe, Johan Holmberg, Shoahua Zeng, Ljubica Perisic, Sebastian Albinsson, Jianwen Zeng, Ulf Hedin, Bengt Uvelius, Karl Sward
JOURNAL OF UROLOGY
(2020)