Review
Plant Sciences
Norbert Andrasi, Aladar Pettko-Szandtner, Laszlo Szabados
Summary: Plant heat shock factors (HSFs) are encoded by large gene families and are involved in responses to high temperatures and various abiotic stresses. They are regulated primarily at the transcript level, with alternative splicing and post-translational modifications providing additional variability. Plant HSFs participate in a complex network of protein-protein interactions and play crucial roles in transcriptional control.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Cell Biology
Jian Deng, Shao-Hua Wang, Xue-Mei Zheng, Zan-Mei Tang
Summary: The study showed that CGRP can promote cell viability and inhibit hyperoxia-induced transdifferentiation of AECII, reducing oxidative injury and inflammation. Additionally, CGRP activates the Notch signaling pathway, promoting structural and functional regeneration.
Article
Biochemistry & Molecular Biology
Rupesh Kumar, Maged Mostafa Mahmoud, Hanaa M. Tashkandi, Shafiul Haque, Steve Harakeh, Kalaiarasan Ponnusamy, Shazia Haider
Summary: This study aimed to identify key molecules in colorectal cancer using a computational systems biology approach. A protein-protein interaction network was constructed, and TP53, CTNBB1, AKT1, EGFR, HRAS, JUN, RHOA, and EGF were identified as key molecules. Regulatory networks of these key molecules were also constructed, revealing important regulatory factors. Biochemical investigation of these key regulators could provide further understanding of their role in the pathophysiology of colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Que Kong, Pui Man Low, Audrey R. Q. Lim, Yuzhou Yang, Ling Yuan, Wei Ma
Summary: WRI1 interacts with TCP20 to regulate GH3.3 expression, thereby contributing to auxin homeostasis.
Article
Chemistry, Multidisciplinary
Chao Zhang, Shuyuan Chen, Qunying Li, Jiao Wu, Fuqiang Qiu, Zhiyi Chen, Yang Sun, Jieli Luo, Raul A. Bastarrachea, Paul A. Grayburn, Ralph A. DeFronzo, Yajing Liu, Kun Qian, Pintong Huang
Summary: The study demonstrated successful gene delivery of GLP-1 in macaques using UTMD, leading to enhanced GLP-1 expression and improvement in pancreatic beta cell regeneration and plasma glucose regulation. This approach shows promising alternatives for treating type 2 diabetes.
Review
Plant Sciences
Yanlei Zhai, Zhiyi Fan, Yuanyuan Cui, Xiaojiao Gu, Shangwu Chen, Huiqin Ma
Summary: Fruit ripening involves a series of physiological and biochemical changes, and AP2/ERF family transcription factors have been shown to play a crucial role in this process. Research focuses on their regulatory mechanisms in fruit ripening, including target genes and co-regulators.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Polymer Science
Zheng Huang, Ya-Ping Xiao, Yu Guo, Hui-Zhen Yang, Rui-Mo Zhao, Ji Zhang, Xiao-Qi Yu
Summary: Gene and protein therapy have great potential in treating severe human diseases. A novel polymer that combines zinc coordination and a fluorinated backbone has been designed and synthesized for efficient gene and protein delivery. Experimental results demonstrate its versatility and potential in gene and protein therapy.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Alzbeta Ressnerova, Filip Novotny, Hana Michalkova, Martin Pumera, Vojtech Adam, Zbynek Heger
Summary: Transfection involves nonviral delivery of nucleic acids or proteins into cells, with nanotechnology surpassing viral methods due to safety concerns. Nanorobots, particularly chemically powered rectangular nanorobots, show enhanced efficiency in protein transfection by fast internalization and subcellular localization, challenging the field of nanomedicine with potential in translational medical research.
Article
Plant Sciences
Jinjin Ding, Hassan Karim, Yulong Li, Wendy Harwood, Carlos Guzman, Na Lin, Qiang Xu, Yazhou Zhang, Huaping Tang, Yunfeng Jiang, Pengfei Qi, Mei Deng, Jian Ma, Jirui Wang, Guoyue Chen, Xiujin Lan, Yuming Wei, Youliang Zheng, Qiantao Jiang
Summary: The AP2/ERF gene family plays important roles in regulating starch synthesis in barley, with HvAP2-18 identified as a potential negative regulator of starch synthesis and a candidate gene for further exploration of the regulatory mechanisms involved.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Agronomy
Juanying Zhao, Lei Zheng, Jitong Wei, Yixuan Wang, Jun Chen, Yongbin Zhou, Ming Chen, Fengzhi Wang, Youzhi Ma, Zhao-Shi Xu
Summary: In this study, 31 GmPLATZ genes were identified in soybean, and it was found that GmPLATZ17 can inhibit drought tolerance in plants through interaction with GmDREB5.
Article
Multidisciplinary Sciences
Christopher W. Murray, Jennifer J. Brady, Mingqi Han, Hongchen Cai, Min K. Tsai, Sarah E. Pierce, Ran Cheng, Janos Demeter, David M. Feldser, Peter K. Jackson, David B. Shackelford, Monte M. Winslow
Summary: LKB1 restoration inhibits cell proliferation and drives neoplastic cells towards a more differentiated and less proliferative state in lung tumors through C/EBP-mediated reprogramming, according to a study using mouse models of lung cancer.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zhilei Mao, Xuxu Wei, Ling Li, Peng Xu, Jingyi Zhang, Wenxiu Wang, Tongtong Guo, Shuang Kou, Wanting Wang, Langxi Miao, Xiaoli Cao, Jiachen Zhao, Guangqiong Yang, Shilong Zhang, Hongli Lian, Hong-Quan Yang
Summary: Light is a key environmental cue regulating plant growth and development, with CRY1 promoting H2A.Z deposition through enhancing SWR1 complex activity and HY5 recruitment, thereby regulating photomorphogenesis.
Article
Biochemistry & Molecular Biology
Takashi Fukaya
Summary: Expression of gap and pair-rule genes is crucial for body segmentation in Drosophila embryogenesis, and the length of the transcription period plays a major role in determining spatial patterning of gene expression in early embryos. Enhancer interference can influence transcriptional activation and impact the refinement of gene expression patterns during animal development.
Article
Plant Sciences
Zhengxiu Ye, Lu Qiao, Xiangyin Luo, Xinyuan Chen, Xianlong Zhang, Lili Tu
Summary: The study identified 164 genes encoding GRAM domain proteins in four cotton species. Experimental results showed that GhGRAM31 may control fiber length, interact with other GRAM domain proteins, and participate in the regulation of multiple transcription factors.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Anthony Birnie, Audrey Plat, Cemil Korkmaz, Jacques P. Bothma
Summary: In this study, the regulation of the Fushi tarazu (Ftz) gene in Drosophila melanogaster embryos was dissected using single-cell live imaging tools. It was found that the autoregulatory enhancer does not determine cell fate, but rather maintains the fate determined by the zebra enhancer. Additionally, activation of the autoregulatory enhancer is based on a timing mechanism rather than a concentration threshold. This research provides new insights into how precisely timed enhancer activity can directly regulate gene regulatory network dynamics.
Article
Multidisciplinary Sciences
Marcelo A. Catalan, Yusuke Kondo, Gaspar Pena-Munzenmayer, Yasna Jaramillo, Frances Liu, Sooji Choi, Edward Crandall, Zea Borok, Per Flodby, Gary E. Shull, James E. Melvin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Cell & Tissue Engineering
Changgong Li, Min Li, Sha Li, Yiming Xing, Chang-Yo Yang, Aimin Li, Zea Borok, Stijn De langhe, Parviz Minoo
Article
Biochemistry & Molecular Biology
Per Flodby, Yong Ho Kim, LaMonta L. Beard, Danping Gao, Yanbin Ji, Hidenori Kage, Janice M. Liebler, Parviz Minoo, Kwang-Jin Kim, Zea Borok, Edward D. Crandall
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Hovhannes J. Gukasyan, Tomomi Uchiyama, Kwang-Jin Kim, Carsten Ehrhardt, Sharon K. Wu, Zea Borok, Edward D. Crandall, Vincent H. L. Lee
PHARMACEUTICAL RESEARCH
(2017)
Article
Physiology
Arnold Sipos, Kwang-Jin Kim, Robert H. Chow, Per Flodby, Zea Borok, Edward D. Crandall
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Danielle R. Little, Kamryn N. Gerner-Mauro, Per Flodby, Edward D. Crandall, Zea Borok, Haruhiko Akiyama, Shioko Kimura, Edwin J. Ostrin, Jichao Chen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Critical Care Medicine
Zea Borok, Masafumi Horie, Per Flodby, Hongjun Wang, Yixin Liu, Sivagini Ganesh, Amy L. Firth, Parviz Minoo, Changgong Li, Michael F. Beers, Amy S. Lee, Beiyun Zhou
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Physiology
Alessandra Castaldi, Masafumi Horie, Megan E. Rieger, Mickael Dubourd, Mitsuhiro Sunohara, Kusum Pandit, Beiyun Zhou, Ite A. Offringa, Crystal N. Marconett, Zea Borok
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Genetics & Heredity
Daniel J. Mullen, Chunli Yan, Diane S. Kang, Beiyun Zhou, Zea Borok, Crystal N. Marconett, Peggy J. Farnham, Ite A. Offringa, Suhn Kyong Rhie
Article
Biochemistry & Molecular Biology
Daisy Flores Rangel, Louis Dubeau, Ryan Park, Priscilla Chan, Dat P. Ha, Mario A. Pulido, Daniel J. Mullen, Ivetta Vorobyova, Beiyun Zhou, Zea Borok, Ite A. Offringa, Amy S. Lee
Summary: Lung cancer is the leading cause of cancer mortality worldwide, with KRAS being the most commonly mutated gene in lung adenocarcinoma. Research has shown that elevated expression of the protein GRP78/BiP in human lung cancers can be suppressed to inhibit KRAS mutation-mediated lung tumor progression. This study provides evidence that targeting GRP78 represents a novel therapeutic approach to suppress mutant KRAS-mediated lung tumorigenesis.
Article
Multidisciplinary Sciences
Shane Shahrestani, Tzu-Chieh Chou, Kuang-Ming Shang, Gabriel Zada, Zea Borok, Adupa P. Rao, Yu-Chong Tai
Summary: The article discusses the development of a non-contact wearable pulmonary sensor for pulmonary waveform analysis, volume quantification, and thoracic imaging. Statistical regression analysis confirms the predictive validity of the sensor, with data continuously digitally stored at a high sampling rate, facilitating rapid monitoring for high-risk individuals during the COVID-19 pandemic.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Laertis Ikonomou, Mattias Magnusson, Ruben Dries, Erica L. Herzog, Robert E. Hynds, Zea Borok, Jin-Ah Park, Steven Skolasinski, Janette K. Burgess, Leigh Turner, Sarah M. Mojarad, John E. Mahoney, Thomas Lynch, Mareike Lehmann, Victor J. Thannickal, Jamie L. Hook, Andrew E. Vaughan, Evan T. Hoffman, Daniel J. Weiss, Amy L. Ryan
Summary: The 9th biennial conference focused on the application of stem cells, cell therapies, and bioengineering in lung biology and diseases. The virtual event provided a platform for researchers to discuss advancements in the field, including technological innovations, stem cell signaling, airway engineering, viral infection response, and ethical considerations in cell-based treatments for lung diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Biology
Feng Gao, Changgong Li, Susan M. Smith, Neil Peinado, Golenaz Kohbodi, Evelyn Tran, Yong-Hwee Eddie Loh, Wei Li, Zea Borok, Parviz Minoo
Summary: Lung development is controlled by gene regulatory networks (GRN), and disruption of these networks can cause diseases like BPD. This study used a transgenic mouse model to construct an IGF1 signaling network associated with BPD, providing insights into the regulatory mechanisms. The findings have important implications for understanding and treating BPD, and further research on the full signaling network is needed.
Article
Respiratory System
Bethany B. Moore, Megan N. Ballinger, Natalie N. Bauer, Timothy S. Blackwell, Zea Borok, G. R. Scott Budinger, Blanca Camoretti-Mercado, Serpil C. Erzurum, Blanca E. Himes, Venkateshwar G. Keshamouni, Hrishikesh S. Kulkarni, Rama K. Mallampalli, Thomas J. Mariani, Fernando J. Martinez, Janet E. McCombs, Dawn C. Newcomb, Richard A. Johnston, Michael A. O'Reilly, Y. S. Prakash, Karen M. Ridge, Patricia J. Sime, Anne I. Sperling, Shelia Violette, David S. Wilkes, Melanie Konigshoff
Summary: The American Thoracic Society established an ad hoc committee to identify barriers and opportunities for non-clinically practicing basic and translational scientists to integrate into clinical units. Based on surveys of division chiefs and workshop participants, it was found that hiring Ph.D. scientists into clinical units often resulted in non-tenure track positions without the same support as basic science units. These barriers are primarily financial. The recommendation is for academic medical centers to consider strategies to integrate basic and translational scientists into clinical units in a meaningful way.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Genetics & Heredity
Crystal N. Marconett, Beiyun Zhou, Kimberly D. Siegmund, Zea Borok, Ite A. Laird-Offringa