Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Megan Hansel, Camila Capurro, Danielle Kozlosky, Christina Wang, Cathleen L. Doherty, Brian Buckley, Pamela Ohman-Strickland, Richard K. Miller, Thomas G. O'Connor, Lauren M. Aleksunes, Emily S. Barrett
Summary: This study found that cadmium exposure during pregnancy may lead to lower testosterone levels in pregnant women, while estrogen levels remain unchanged. This effect may be stronger in pregnancies carrying female fetuses. Further research is needed to understand how alterations in gestational testosterone activity may impact pregnancy and child health.
Article
Biochemistry & Molecular Biology
Maya Barsky, Jamie Merkison, Pardis Hosseinzadeh, Liubin Yang, Janet Bruno-Gaston, Jay Dunn, William Gibbons, Chellakkan Selvanesan Blesson
Summary: Polycystic ovary syndrome (PCOS) is a common form of anovulatory infertility with a strong hereditary component. Research indicates that excessive prenatal androgens can affect ovarian development by altering gene expression and mitochondrial function. This programming may begin at birth and is influenced by androgens in utero.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Developmental Biology
A. C. Santos, A. J. Conley, M. F. Oliveira, A. C. Assis Neto
Summary: Spix's cavy may serve as a useful experimental model for studying reproductive biology and sexual development. This study evaluated the ontogeny of steroidogenic enzymes in the testes of Spix's cavy during prenatal development, showing an increase in androgenic enzymes in Leydig cells as gestational age progressed. Testicular parenchyma began organization on Day 25 of gestation, while androgen-synthesizing enzymes peaked at Days 30 and 40 and decreased at Day 50.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2021)
Article
Agriculture, Dairy & Animal Science
Fabiana Pecchia, Stefania Di Giorgio, Alessandra Sfacteria, Salvatore Monti, Cecilia Vullo, Giuseppe Catone, Gabriele Marino
Summary: This study focuses on the ultrasound diagnosis of twins in canine and feline species. The prevalence of monochorionic twins is found to be low, and this diagnosis is crucial for preventing complications during pregnancy and delivery.
Article
Agriculture, Dairy & Animal Science
Zihui Wang, Qian Wang, Nan Cui, Longfei Xiao, Huawei Wei, Jian Kang, Xihui Sheng, Xiaolong Qi, Kai Xing, Yong Guo, Hemin Ni, Xiangguo Wang
Summary: This study identified a novel pathogenesis of cryptorchidism and provided a new idea for therapeutics.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Behavioral Sciences
Stefania R. D'Arpa, Jaime Muriel, Raquel Monclus, Diego Gil, Lorenzo Perez-Rodriguez
Summary: This study investigated whether female birds exposed to high yolk androgen concentrations would reduce their maternal investment later in life. The results showed that females exposed to high egg androgen levels exhibited a steeper decrease in egg size along the laying order, potentially leading to a more unbalanced distribution of resources within the clutch. This research highlights the potential long-term effects of prenatal androgens on egg characteristics and calls for further study on the influence of androgens on reproductive investment.
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
(2021)
Review
Neurosciences
Adriene M. Beltz, Michael I. Demidenko, Stephen J. Wilson, Sheri A. Berenbaum
Summary: Sex hormones, especially androgens, play a crucial role in sex and gender differences in the brain and behavior, with organizational effects believed to be permanent. Studies on females with congenital adrenal hyperplasia have shown the influence of hormones on gender behavior, despite a lack of neural mechanisms explaining these links.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Microbiology
Aurelle Yondo, Allen A. Kalantari, Ingrid Fernandez-Marrero, Amy Mckinney, Hemant K. Naikare, Binu T. Velayudhan
Summary: Canine infectious respiratory disease complex (CIRDC) is caused by various viruses and bacteria. A study found that viral agents were detected in 34% of CIRDC cases, while bacterial agents were detected in 58% of cases. The most prevalent pathogens associated with CIRDC were CPIV, M. canis, and M. cynos.
Article
Agriculture, Dairy & Animal Science
Yan-Peng Li, Zhi-Pang Huang, Yin Yang, Xiao-Bin He, Ru-Liang Pan, Xin-Ming He, Gui-Wei Yang, Hua Wu, Liang-Wei Cui, Wen Xiao
Summary: Sexual dimorphism is widely observed in animals, with body mass dimorphism being the most prominent. Studying the developmental and adaptive mechanisms of sexual dimorphism in body mass can help us understand how animals adapt to their environment. This study explores the ontogenetic development pattern of sexual dimorphism in the body mass of Rhinopithecus bieti and investigates the causes of extreme sexual dimorphism. The results show that significant dimorphism appears when females enter the reproductive period and reaches its maximum when males are sexually mature. The study also reveals a longer growth period for males and explains the large sexual dimorphism in R. bieti through Bergmann's and Rensch's rules.
Article
Endocrinology & Metabolism
Elena Colicino, Whitney Cowell, Nicolo Foppa Pedretti, Anu Joshi, Lauren Petrick, Megan Niedzwiecki, Robert O. Wright, Rosalind J. Wright
Summary: This study aimed to assess the associations between prenatal maternal stress and psychological functioning measures and steroid profiles during pregnancy. The results showed that high prenatal perceived stress was independently associated with lower levels of androgens and estrogens in pregnant women, especially among those carrying male fetuses.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Clinical Neurology
M. Bekiesinska-Figatowska, P. Sobieraj, M. Pasieczna, J. Szymkiewicz-Dangel
Summary: There is a strong emphasis on early detection and treatment of tuberous sclerosis complex before seizure onset, which can be achieved through prenatal ultrasound and MR imaging. Cardiac rhabdomyomas can be detected during fetal ultrasound, while prenatal MR imaging can detect major cerebral manifestations.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Developmental Biology
Mingjie Xu, Jie Yao, Yingchao Shi, Huijuan Yi, Wukui Zhao, Xinhua Lin, Zhongzhou Yang
Summary: The study identified a crucial role of the SRCAP chromatin remodeling complex in mitochondrial maturation and oxidative metabolism during heart development in mice. The complex functions through H2A.Z deposition to activate transcription of metabolic genes, shedding new light on the transcriptional regulation of ubiquinone biosynthesis.
Article
Clinical Neurology
Terence K. Y. Lai, Andrew R. Abela, Ping Su, Paul J. Fletcher, Fang Liu
Summary: Research suggests that GABAergic interneurons play a crucial role in the central nervous system of mammals, and abnormalities in their development may lead to the onset of neurodevelopmental disorders such as schizophrenia and autism spectrum disorder. Disrupting the interaction between dopamine D1 receptor and synaptic Ras GTPaseactivating protein can negatively impact GABAergic interneuron migration, resulting in abnormal behavioral expression during adulthood.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemical Research Methods
Patrick Caron, Veronique Turcotte, Chantal Guillemette
Summary: Bioactive 11-oxygenated C 19 adrenal-derived steroids have potential significance in endocrine and metabolic contexts. A LC-ESI-MS/MS method for quantifying seven 11-oxy C 19 was developed and validated, demonstrating applicability in adult men and women with sex differences. However, detection of one steroid, 11KDHT, remained undetectable possibly due to interfering endogenous molecules.
JOURNAL OF CHROMATOGRAPHY A
(2021)