期刊
AMERICAN JOURNAL OF PERINATOLOGY
卷 28, 期 10, 页码 747-751出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0031-1280855
关键词
Folic acid; preterm delivery; food folate; preconceptional intake; birth defects; preterm
资金
- Centers for Disease Control and Prevention
- Center of Excellence [U50/CCU913241]
- March of Dimes Prematurity Research Center at Stanford University School of Medicine
We investigated multiple sources of folate and folic acid to determine whether their periconceptional intakes were associated with preterm delivery. Studied were controls from the National Birth Defects Prevention Study delivered September 1998 to December 2005. Telephone interviews were conducted with 5952 (68% of eligible) mothers. Women were queried about intake of vitamin supplements in the 12 weeks before conception through delivery. A version of the Nurse's Health Study food frequency questionnaire was used to assess food sources. Eight percent of infants (n = 487) were preterm (< 37 weeks). Compared with women who began intake of supplements with folic acid before pregnancy, those who began any time during pregnancy had an similar to 20% lowered risk of preterm delivery. Lower dietary intakes showed a modest increased risk of preterm delivery: odds ratios were 1.44 (1.01 to 2.04) for lowest quartile intake of folate and 1.27 (0.95 to 1.69) for lowest quartile intake of folic acid compared with the highest. Findings suggest some evidence that folates influenced risks; however, an interpretation of results was also consistent with no association between intake of folates and preterm delivery.
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