Article
Immunology
Varsha Potdar, Megha Brijwal, Rakesh Lodha, Pragya Yadav, Santosh Jadhav, Manohar Lal Choudhary, Aashish Choudhary, Veena Vipat, Nivedita Gupta, Ashok Kumar Deorari, Lalit Dar, Priya Abraham
Summary: An 11-year-old boy with acute myeloid leukemia in New Delhi, India, was treated for severe acute respiratory infection caused by avian influenza A(H5N1). The strain belonged to hemagglutinin gene clade 2.3.2.1a and was found to be susceptible to amantadine and neuraminidase inhibitors.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Mariana Leguia, Alejandra Garcia-Glaessner, Breno Munoz-Saavedra, Diana Juarez, Patricia Barrera, Carlos Calvo-Mac, Javier Jara, Walter Silva, Karl Ploog, Lady Amaro, Paulo Colchao-Claux, Christine K. Johnson, Marcela M. Uhart, Martha I. Nelson, Jesus Lescano
Summary: Highly pathogenic avian influenza A/H5N1 viruses have invaded the Americas and pose a threat to wildlife, poultry, and humans. The HPAI/H5N1 viruses in Peru have genetic reassortment between Eurasian and American lineages, emphasizing the need for surveillance and control measures.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Wendy Puryear, Kaitlin Sawatzki, Nichola Hill, Alexa Foss, Jonathon J. Stone, Lynda Doughty, Dominique Walk, Katie Gilbert, Maureen Murray, Elena Cox, Priya Patel, Zak Mertz, Stephanie Ellis, Jennifer Taylor, Deborah Fauquier, Ainsley Smith, Robert A. DiGiovanni Jr, Adriana van de Guchte, Ana Silvia Gonzalez-Reiche, Zain Khalil, Harm van Bakel, Mia K. Torchetti, Kristina Lantz, Julianna B. Lenoch, Jonathan Runstadler
Summary: We report the spread of highly pathogenic avian influenza A(H5N1) in marine mammals in the northeastern United States, which is concurrent with the presence of H5N1 in wild birds in the same area. Our findings highlight the importance of monitoring both wild coastal birds and marine mammals in assessing the potential for an influenza A virus pandemic.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Fisheries
Yeojin Hong, Anh Duc Truong, Thi Hao Vu, Sooyeon Lee, Jubi Heo, Suyeon Kang, Hyun S. Lillehoj, Yeong Ho Hong
Summary: This study demonstrates the immunomodulatory effects of exosomes from HPAIV H5N1-infected chickens on immune-related cells, showing that these exosomes induce pro-inflammatory cytokine expression and stimulate the MAPK signaling pathway. Moreover, viral proteins from H5N1 are packaged in exosomes and transferred to non-infected immune-related cells.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Infectious Diseases
Ariful Islam, Tasnim Ara, Emama Amin, Shariful Islam, Md. Abu Sayeed, Tahmina Shirin, Mohammad Mahmudul Hassan, Marcel Klaassen, Jonathan H. Epstein
Summary: Understanding the characteristics, dynamics, and evolution of H5N1 outbreaks in Bangladesh is crucial for the prevention and control of High Pathogenicity Avian Influenza (HPAI). Our study revealed nine waves of HPAI H5N1 outbreaks between 2007 and 2020, with peak incidences during the winter season. Despite vaccination efforts, the virus continued to circulate in Bangladesh, with significant clustering and hotspots of H5N1 outbreaks in and around Dhaka district. Four H5N1 clades have been detected, with clade 2.3.2.1a persisting since 2011 and reassortment occurring in 2012. Our findings emphasize the importance of spatiotemporal analysis and phylodynamics in developing targeted control measures.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Immunology
Honglei Sun, Fangtao Li, Qingzhi Liu, Jianyong Du, Litao Liu, Haoran Sun, Chong Li, Jiyu Liu, Xin Zhang, Jizhe Yang, Yuhong Duan, Yuhai Bi, Juan Pu, Yipeng Sun, Qi Tong, Yongqiang Wang, Xiangjun Du, Yuelong Shu, Kin-Chow Chang, Jinhua Liu
Summary: The study found that farmed minks are commonly infected with both human and avian influenza viruses. Human influenza viruses may be transmitted from humans to minks, while avian influenza viruses may be transmitted through feed to farmed minks. Therefore, feeding minks with raw poultry by-products should be prohibited to reduce the risk of novel pandemic virus emergence.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Multidisciplinary Sciences
Natalie Moyen, Md. Ahasanul Hoque, Rashed Mahmud, Mahmudul Hasan, Sudipta Sarkar, Paritosh Kumar Biswas, Hossain Mehedi, Joerg Henning, Punam Mangtani, Meerjady Sabrina Flora, Mahmudur Rahman, Nitish C. Debnath, Mohammad Giasuddin, Tony Barnett, Dirk U. Pfeiffer, Guillaume Fournie
Summary: Live animal markets are known hotspots for zoonotic disease emergence, and trading networks play a crucial role in disease spread dynamics. In Bangladesh, live poultry trading networks promote viral strain co-circulation, with upstream transmission nodes significantly impacting viral prevalence in markets. Disease control interventions should target network structures, tailored to local characteristics for effectiveness.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Olivier Duriez, Yohan Sassi, Chloe Le Gall-Ladeveze, Lea Giraud, Robert Straughan, Lise Dauverne, Anna Terras, Thierry Boulinier, Remi Choquet, Anne van de Wiele, Julien Hirschinger, Jean-Luc Guerin, Guillaume Le Loc'h
Summary: A study found that terrestrial birds infected with highly pathogenic avian influenza (HPAI) virus exhibit immobility behavior during the breeding season, which may reduce the risk of virus transmission. However, these infections pose a threat to endangered vulture species, raising concerns about their resistance to the virus.
Article
Microbiology
Pei Zhou, Bo Chen, Xinkai Hu, Xiangyu Xiao, Ruohan Liu, Shoujun Li
Summary: The study evaluated the transmissibility of the first- and last-isolated Chinese H3N2 CIV strains to birds, and the results demonstrated that avian species are unsusceptible to H3N2 CIV, indicating unidirectional evolution of the mammalian host tropism of H3N2 CIV.
VETERINARY MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Jiao Hu, Peipei Peng, Jun Li, Qi Zhang, Rumeng Li, Xiaoquan Wang, Min Gu, Zenglei Hu, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: The bivalent H5+H7 VLP vaccine candidate shows promising results in protecting poultry against highly pathogenic H5N1 and H7N9 avian influenza viruses, and may serve as a critical alternative to traditional egg-based inactivated vaccines.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
V Caliendo, N. S. Lewis, A. Pohlmann, S. R. Baillie, A. C. Banyard, M. Beer, I. H. Brown, R. A. M. Fouchier, R. D. E. Hansen, T. K. Lameris, A. S. Lang, S. Laurendeau, O. Lung, G. Robertson, H. van der Jeugd, T. N. Alkie, K. Thorup, M. L. van Toor, J. Waldenstrom, C. Yason, T. Kuiken, Y. Berhane
Summary: Recent detection of highly pathogenic avian influenza viruses in North America, closely related to the viruses in Europe, raises concerns about further spread across the Americas through wild bird migration.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Nichola J. Hill, Mary Anne Bishop, Nidia S. Trovao, Katherine M. Ineson, Anne L. Schaefer, Wendy B. Puryear, Katherine Zhou, Alexa D. Foss, Daniel E. Clark, Kenneth G. MacKenzie, Jonathon D. Gass, Laura K. Borkenhagen, Jeffrey S. Hall, Jonathan A. Runstadler
Summary: The study provides insights into how a variety of avian hosts contribute to viral spread and spillover, potentially enhancing surveillance in a rapidly changing global environment.
Article
Immunology
Sarah N. Bevins, Susan A. Shriner, James C. Cumbee, Krista E. Dilione, Kelly E. Douglass, Jeremy W. Ellis, Mary Lea Killian, Mia K. Torchetti, Julianna B. Lenoch
Summary: Eurasian-origin highly pathogenic avian influenza A(H5N1) virus belonging to the Gs/GD lineage, clade 2.3.4.4b, was detected in wild waterfowl in 2 Atlantic coastal states in the United States. Bird banding data revealed widespread movement of waterfowl within the Atlantic Flyway and between neighboring flyways and northern breeding grounds.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Microbiology
Haixiang Zhang, Jingying Sun, Yangmeng Feng, Jingli Li, Nana Wang, Xiangrong Zhao, Yan Li, Jun Hu, Lijun Sun, Cuixiang Xu
Summary: By investigating monoclonal antibodies against avian influenza virus (AIV), this study revealed their cross-reactivity with human kidney tissue and identified a potential mechanism of AIV-related kidney injury involving the binding of H5N1 AIV to human renal tubular epithelial cells.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Infectious Diseases
Leo Loth, Long Thanh Pham, Mark Anthony Stevenson
Summary: The study revealed statistically significant spatio-temporal clustering of HPAI-H5N1 outbreaks in poultry in Vietnam, with frequent outbreaks in the southern region. Shortcomings in control measures led to difficulties in effectively controlling the outbreaks, highlighting the need for a better understanding of the relative impact of various control measures on spatio-temporal interactions in order to focus efforts on the most effective measures.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)