Article
Microbiology
Mariana C. de Alba Alvarado, Elia Torres Gutierrez, Margarita Cabrera Bravo, Edgar Zenteno Galindo, Jose Antonio Villarreal Munoz, Paz Maria Salazar Schettino, Martha Irene Bucio Torres
Summary: Symptoms in the acute phase of Chagas disease are usually mild and nonspecific. This study analyzed the cardiac histopathology in a mouse model during the acute phase to determine its involvement in the development of lesions in the cardiac tissue. The results revealed the presence of parasitism, fibrotic damage, and a cellular infiltrate, suggesting their role in the pathogenesis of Chagas disease.
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Chien-Te Lee, Hwee-Yeong Ng, Hua-Rong Zhong, Yi Wang, Chih-Han Liu, Yuai-Ting Lee
Summary: This study found that as aging progressed, the abundance of renal glucose transporters and blood sugar levels increased, along with the increase in diabetes-related indicators. GYY4137 partially improved these conditions, reduced glomerulosclerosis, and reversed the expression of glucose transporters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Michele Spinicci, Carlo Fumagalli, Niccolo Maurizi, Enrico Guglielmi, Mimmo Roselli, Herlan Gamboa, Marianne Strohmeyer, Veronica Poma, Roberto Vargas, Iacopo Olivotto, Alessandro Bartoloni
Summary: The study conducted rapid diagnostic test and electrocardiographic screening in a remote rural village in Bolivia, showing high prevalence of Trypanosoma cruzi infection and ECG abnormalities. Following screening, some individuals required further clinical evaluation.
Article
Chemistry, Medicinal
Minerva Arce-Fonseca, Rodolfo Andres Gutierrez-Ocejo, Jose Luis Rosales-Encina, Alberto Aranda-Fraustro, Juan Jose Cabrera-Mata, Olivia Rodriguez-Morales
Summary: This study aimed to evaluate the efficacy of nitazoxanide against the Mexican T. cruzi Ninoa strain in mice. The results showed that nitazoxanide can reduce parasitemia, indirectly induce IgG antibody production, and partially prevent histopathological damage.
Review
Nutrition & Dietetics
Saioa Gomez-Zorita, Inaki Milton-Laskibar, Itziar Eseberri, Pauline Beaumont, Arnaud Courtois, Stephanie Krisa, Maria P. Portillo
Summary: Viniferin is a phenolic compound that belongs to the group of stilbenoids. In particular, epsilon-viniferin is a dimer of resveratrol and is found in various plant genders, with grapes being a primary source. Research suggests that epsilon-viniferin has the potential to reduce fat accumulation and prevent obesity-related co-morbidities.
Article
Parasitology
Marcela S. Rial, Chantal Reigada, Nilda Prado, Jacqueline Bua, Monica Esteva, Claudio A. Pereira, Laura E. Fichera
Summary: The study found that a drug containing isotretinoin as the main ingredient can effectively treat congestive heart failure and improve cardiac function.
Article
Chemistry, Multidisciplinary
Maiara M. Romanelli, Maiara Amaral, Fernanda Thevenard, Lucas M. Santa Cruz, Luis O. Regasini, Alvaro E. Migotto, Joao Henrique G. Lago, Andre G. Tempone
Summary: In this study, a new compound BMA was isolated and characterized from a marine coral. It was found that BMA exhibited inhibitory effects against T. cruzi without cytotoxicity to mammalian cells. The mechanism of action of BMA involved the depolarization of mitochondrial membrane potential and reduction of intracellular calcium levels, leading to decreased ATP levels and growth inhibition of T. cruzi.
Article
Multidisciplinary Sciences
E. Garcia-Escobar, S. Valdes, F. Soriguer, J. Vendrell, I. M. Urrutia-Etxebarria, C. Maldonado-Araque, E. Ortega, P. Ocon, E. Montanya, E. Menendez, A. Lago-Sampedro, T. Gonzalez-Frutos, R. Gomis, A. Goday, S. Garcia-Serrano, J. L. Galan-Garcia, C. Castell, E. Bordiu, R. Badia, G. Aguilera-Venegas, J. Girbes, S. Gaztambide, E. Delgado, F. J. Chaves, L. Castano, A. Calle-Pascual, G. Rojo-Martinez, J. Franch-Nadal
Summary: The study found that a high FLI category was a significant independent risk factor for developing diabetes, even under normal blood sugar conditions. Additionally, including FLI categories in prediction models based on traditional T2DM risk factors significantly increased the predictive power of the models in the overall population.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Haozhe Qi, Felix Schmoehl, Xiaogang Li, Xin Qian, Christoph T. Tabler, Katrin Bennewitz, Carsten Sticht, Jakob Morgenstern, Thomas Fleming, Nadine Volk, Ingrid Hausser, Elena Heidenreich, Ruediger Hell, Peter Paul Nawroth, Jens Kroll
Summary: The study revealed that acrolein plays a critical role in glucose homeostasis and diabetes development, with impaired acrolein detoxification and elevated ACR concentration serving as biomarkers and inducers for diabetes and diabetic complications.
Review
Biochemistry & Molecular Biology
Md Saidur Rahman, Khandkar Shaharina Hossain, Sharnali Das, Sushmita Kundu, Elikanah Olusayo Adegoke, Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Myung-Geol Pang
Summary: Insulin, a polypeptide hormone secreted mainly by pancreatic beta cells, coordinates with glucagon to regulate blood glucose levels. It induces glucose storage in the liver, muscles, and adipose tissue, leading to overall weight gain. The modulation of physiological processes by insulin is crucial in the onset and progression of various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Jumana Abuqwider, Mohammad Altamimi, Gianluigi Mauriello
Summary: Limosilactobacillus reuteri, a beneficial probiotic, exerts its health benefits through the production of various metabolites, such as anti-inflammatory cytokines and antimicrobial molecules. It plays a role in controlling body weight, improving insulin sensitivity, and modulating the gut microbiota. Ingestion of this strain has the potential for prevention and treatment of various diseases and disorders through the modulation of the gut microbiota.
Review
Immunology
Eduardo G. Bruneto, Miguel M. Fernandes-Silva, Cristina Toledo-Cornell, Silvia Martins, Joao M. B. Ferreira, Valeria R. Correa, Joicely M. da Costa, Ana Yece das N. Pinto, Dilma do S. M. de Souza, Maria Carmelinda G. Pinto, Jose Albuquerque de F Neto, Alberto N. Ramos, James H. Maguire, Odilson M. Silvestre
Summary: Orally-transmitted acute Chagas disease is emerging as a significant public health problem, with considerable lethality in the first year after infection but a declining mortality rate over the years. Symptomatic cases have a similar lethality rate to those from other routes of infection.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Yashan Bu, Yau-Kei Chan, Ho-Lam Wong, Stephanie Hiu-Ling Poon, Amy Cheuk-Yin Lo, Kendrick Co Shih, Louis Tong
Summary: Recent studies have found a link between ocular diseases and microbiota profiles in the host's intestinal tract and oral cavity, forming a 'gut-eye axis'. Changes in gut microbiome can affect host immunity and have significant implications for ocular health and disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Immunology
Katherine R. McAleese, Janitzio J. Guzman, Lauren Thumm, Thomas B. Nutman, Adrienne Showler, Elise M. O'Connell
Summary: In a cohort of mostly Central American immigrants with neurocysticercosis (NCC), 3.1% were also diagnosed with Chagas disease (CD). The majority of patients were diagnosed with CD before the age of 50. The treatment of NCC provides an opportunity for early detection and potential treatment of CD in individuals from endemic areas.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Pollyana Maria de Oliveira Pimentel, Diego Rodney Rodrigues de Assis, Melisa Gualdron-Lopez, Andreia Barroso, Fatima Brant, Paulo Gaio Leite, Bruno Cabral de Lima Oliveira, Lisia Esper, Shaun M. K. McKinnie, John C. Vederas, Marta do Nascimento Cordeiro, Pablo Victor Mendes dos Reis, Mauro Martins Teixeira, Adriano Monteiro de Castro Pimenta, Marcia Helena Borges, Maria Elena de Lima, Fabiana Simao Machado
Summary: The study found that components of Tityus serrulatus venom have therapeutic effects on Trypanosoma cruzi infection, increasing nitric oxide and proinflammatory cytokine production while decreasing parasite replication and release, with a positive effect on p38 activation. This research opens up new perspectives for finding new strategies for Chagas Disease treatment.
CLINICAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francesca De Santis, Giovanni Fuca, Dirk Schadendorf, Alberto Mantovani, Luca Magnani, Michael Lisanti, Stephen Pettitt, Matteo Bellone, Giannino Del Sal, Saverio Minucci, Alexander Eggermont, Paolo Bruzzi, Silvio Bicciato, Pierfranco Conte, Roberta Noberini, John Hiscott, Filippo De Braud, Michele Del Vecchio, Massimo Di Nicola
Summary: Experts at the Tenth Edition of the Annual Congress on Anticancer Innovative Therapy shared the latest knowledge and novel therapeutic approaches in fields such as immuno-oncology, epigenetics, cancer metabolism, cancer stem cells, tumor cell signaling, and the immune system. The conference also discussed possible mechanisms of resistance to these innovative therapies, particularly with respect to immune checkpoint blockers (ICB), providing a broad overview of future challenges and hopes for improving cancer treatment in the medium-short term.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Multidisciplinary Sciences
Cristian Scatena, Giovanni Fanelli, Giuseppe Nicolo Fanelli, Michele Menicagli, Paolo Aretini, Valerio Ortenzi, Sara Piera Civitelli, Lorenzo Innocenti, Federica Sotgia, Michael P. Lisanti, Antonio Giuseppe Naccarato
Summary: Recent evidence indicates that loss of caveolin expression in the stromal compartment of human invasive breast carcinoma may be predictive of disease recurrence, metastasis, and poor prognosis. Additionally, a study on sCav-1 expression in breast cancer and axillary lymph nodes suggests that the loss of Cav-1 in lymph nodes may contribute to metastatic spread in breast cancer.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Marco Fiorillo, Cristian Scatena, Antonio Giuseppe Naccarato, Federica Sotgia, Michael P. Lisanti
Summary: This study identifies high ATP production by the mitochondrial ATP-synthase as a new therapeutic target for anticancer therapy, particularly for inhibiting tumor progression. ATP-high cancer cells exhibit aggressive phenotypes with increased proliferation, stemness, anchorage-independence, cell migration, invasion, and multi-drug resistance, along with high antioxidant capacity. ATP depletion through targeting ATP5F1C may serve as a promising strategy for preventing metastasis and avoiding treatment failure, making ATP5F1C a potential biomarker and molecular target for future drug development to prevent metastatic disease progression.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Diego Rodney Rodrigues de Assis, Alexandre Almeida Oliveira, Samuel Luiz Porto, Rayane Aparecida Nonato Rabelo, Eduardo Burgarelli Lages, Viviane Correa Santos, Matheus Marques Milagre, Stenio Perdigao Fragoso, Mauro Martins Teixeira, Rafaela Salgado Ferreira, Carlos Renato Machado, Lucas Antonio Miranda Ferreira, Nivaldo Lucio Speziali, Heloisa Beraldo, Fabiana Simao Machado
Summary: (English Summary:)
This study investigated the potential antichagasic activities of thiosemicarbazones and hydrazones as new anti-T. cruzi drug candidates. Compounds C1 and C3 showed anti-parasitic activity in macrophages without toxicity to host cells, and were also effective in directly killing trypomastigotes. Moreover, C1 and C3 attenuated parasitemia in T. cruzi-infected mice and maintained anti-T. cruzi activity in vivo when loaded in a lipid nanocarrier system.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Camillo Sargiacomo, Sophie Stonehouse, Zahra Moftakhar, Federica Sotgia, Michael P. Lisanti
Summary: MTDR can be used to target and eradicate cancer stem cells by selectively interfering with mitochondrial metabolism in breast cancer cells. It significantly inhibits tumor growth and metastasis with little to no toxicity observed in a preclinical animal model.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Filippo Di Pisa, Elisa Pesenti, Maria Bono, Andrea N. Mazzarello, Cinzia Bernardi, Michael P. Lisanti, Giovanni Renzone, Andrea Scaloni, Ermanno Ciccone, Franco Fais, Silvia Bruno, Paolo Scartezzini, Fabio Ghiotto
Summary: This study sheds light on the potential role of SH3BGRL3 in regulating myosin-cytoskeleton interaction and cell migration. It was found that SH3BGRL3 specifically interacts with Myo1c in a Ca2+-dependent manner, suggesting a potential regulatory mechanism for cytoskeleton dynamics involving SH3BGRL3 and Myo1c.
BMC MOLECULAR AND CELL BIOLOGY
(2021)
Article
Cell Biology
Allysson Cramer, Izabela Galvao, Nathalia Venturini de Sa, Paulo Gaio, Natalia Fernanda de Melo Oliveira, Mariana Rates Gonzaga Santos, Gabriel Henrique Campolina-Silva, Bruno Vinicius Santos Valiate, Fernanda Rezende Souza, Geovanni Dantas Cassali, Mauro Martins Teixeira, Flavio Almeida Amaral, Fabiana Sima Machado
Summary: This study investigated the role of SOCS2 in the development and resolution of experimental antigen-induced arthritis. The results showed that SOCS2 expression decreased during arthritis development, leading to reduced cell infiltration at the peak of inflammation. However, in the late phase, there was an increase in neutrophils, macrophages, and T cells infiltration, as well as joint damage and nociception. SOCS2 deficiency also resulted in lower apoptosis of neutrophils and reduced efferocytosis.
CELLULAR IMMUNOLOGY
(2022)
Article
Immunology
Paulo Gaio, Melisa Gualdron-Lopez, Allysson Cramer, Lisia Esper, Jose Evaldo Rodrigues de Menezes Filho, Jader Santos Cruz, Mauro Martins Teixeira, Fabiana Simao Machado
Summary: This study found that SOCS2 plays a crucial role in regulating the immune response during Trypanosoma cruzi infection and maintaining the balance between inflammatory cells and immune tolerogenic cells.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Mila B. Ortigoza, Hyunah Yoon, Keith S. Goldfeld, Andrea B. Troxel, Johanna P. Daily, Yinxiang Wu, Yi Li, Danni Wu, Gia F. Cobb, Gillian Baptiste, Mary O'Keeffe, Marilou O. Corpuz, Luis Ostrosky-Zeichner, Amee Amin, Ioannis M. Zacharioudakis, Dushyantha T. Jayaweera, Yanyun Wu, Julie Philley, Megan S. Devine, Mahalia S. Desruisseaux, Alessandro D. Santin, Shweta Anjan, Reeba Mathew, Bela Patel, Masayuki Nigo, Rabi Upadhyay, Tania Kupferman, Andrew N. Dentino, Rahul Nanchal, Christian A. Merlo, David N. Hager, Kartik Chandran, Jonathan R. Lai, Johanna Rivera, Chowdhury R. Bikash, Gorka Lasso, Timothy P. Hilbert, Monika Paroder, Andrea A. Asencio, Mengling Liu, Eva Petkova, Alexander Bragat, Reza Shaker, David D. McPherson, Ralph L. Sacco, Marla J. Keller, Corita R. Grudzen, Judith S. Hochman, Liise-anne Pirofski
Summary: The randomized clinical trial did not show significant benefits of COVID-19 convalescent plasma (CCP) in hospitalized patients compared to placebo. However, exploratory analyses suggested that high-titer CCP may have benefits for early participants in the pandemic when other treatments were not in use. This indicates a heterogeneous treatment effect of CCP over time.
JAMA INTERNAL MEDICINE
(2022)
Review
Oncology
Marco Fiorillo, Bela Ozsvari, Federica Sotgia, Michael P. Lisanti
Summary: The study suggests that high mitochondrial ATP production is a new therapeutic target for cancer treatment, isolating metabolically fit cancer cells with enhanced stem-like properties and invasive abilities. By regulating mitochondrial ATP-synthase, prevention of metastasis in cancer cells is possible.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Matteo Brindisi, Luca Frattaruolo, Marco Fiorillo, Vincenza Dolce, Federica Sotgia, Michael P. Lisanti, Anna Rita Cappello
Summary: This study found that elevated cholesterol levels increase the aggressiveness of breast cancer cells and promote the release of pro-inflammatory factors. Furthermore, there is a close symbiotic relationship between breast cancer cells and the microenvironment. These findings highlight the potential of targeting the cholesterol-ERR alpha synergy for breast cancer treatment.
Article
Cell Biology
Mariana Rates Gonzaga Santos, Ian de Meira Chaves, Celso Martins Queiroz-Junior, Allysson Thiago Cramer, Thales Augusto Anestino, Anna Clara Paiva Menezes dos Santos, Paulo Gaio Leite, Soraia Macari, Breno Rocha Barrioni, Marivalda de Magalhaes Pereira, Mauro Martins Teixeira, Danielle da Gloria de Souza, Mila Fernandes Moreira Madeira, Fabiana Simao Machado
Summary: This study investigated the role of SOCS2 in Aa-induced alveolar bone loss. Alveolar bone loss was induced by infecting mice with Aa and bone parameters, cell counts, and cytokine profile were evaluated. Results showed that SOCS2 deficiency increased alveolar bone loss despite decreased proinflammatory cytokine production. Therefore, SOCS2 is a regulator of Aa-induced bone loss and an important target for preventing alveolar bone loss in periodontal inflammatory conditions.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Oscar B. Akide Ndunge, Henry J. Shikani, Minxian Dai, Brandi D. Freeman, Mahalia S. Desruisseaux
Summary: This study suggests that immunotherapy with PHF-1 mAB may prevent neural cell injury and neuroinflammation during cerebral malaria, improving cognitive function.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Infectious Diseases
Katherine Hill, Irene Kuo, Sheela V. Shenoi, Mahalia S. Desruisseaux, Sandra A. Springer
Summary: This review explores the negative impact of behaviors and practices associated with substance use on HIV virologic suppression and transmission. It provides an overview and evaluation of initiatives for integrated care aimed at serving individuals at risk for and living with HIV and substance use disorder. The review identifies that integrated care services can improve health outcomes and suggests various strategies such as brick-and-mortar facilities, mobile healthcare clinics, and technology incorporation for delivering integrated care.
CURRENT HIV/AIDS REPORTS
(2023)