期刊
AMERICAN JOURNAL OF PATHOLOGY
卷 182, 期 3, 页码 875-885出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2012.11.031
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资金
- National Health and Medical Research Council of Australia
- Lions Eye Institute
- University of Western Australia
Microglial cells are the resident macrophages of the central nervous system and participate in both innate and adaptive immune responses but can also lead to exacerbation of neurodegenerative pathologies after viral infections. Microglia in the outer layers of the retina and the subretinal space are thought to be involved in retinal diseases where Low-grade chronic inflammation and oxidative stress play a role. This study investigated the effect of systemic infection with murine cytomegalovirus on the distribution and dynamics of retinal microglia cells. Systemic infection with murine cytomegalovirus elicited a significant increase in the number of microglia in the subretinal space and an accumulation of iris macrophages, along with morphological signs of activation. Interferon gamma (IFN-gamma) deficient mice failed to induce changes in microglia distribution. Bone marrow chimera experiments confirmed that microgtial cells in the subretinal space were not recruited from the circulating monocyte pool, but rather represented an accumulation of resident microgtial cells from within the retina. Our results demonstrate that a systemic viral infection can lead to IFN-gamma-mediated accumulation of microglia into the outer retinal layers and offer proof of concept that systemic viral infections alter the ocular microenvironment and therefore, may influence the course of diseases such as macular degeneration, diabetic retinopathy, or autoimmune uveitis, where tow-grade inflammation is implicated. (Am 3 Pathol 2013, 182:875-885; http://dx.doLorg/10.1016/j.ajpath.2012.11.031)
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