Article
Cell Biology
Maaike Schilperoort, Jan Kroon, Sander Kooijman, Annelies E. Smit, Max Gentenaar, Kathrin Mletzko, Felix N. Schmidt, Leo van Ruijven, Bjoern Busse, Alberto M. Pereira, Natasha M. Appelman-Dijkstra, Nathalie Bravenboer, Patrick C. N. Rensen, Onno C. Meijer, Elizabeth M. Winter
Summary: The flattening of the GC rhythm disrupts the circadian clock in bone, resulting in an osteoporotic phenotype in mice with reduced bone strength and stiffness. This suggests that the fracture risk associated with GC therapy may be partly due to a disturbed GC rhythm rather than just excess GC exposure, and that a dampened GC rhythm may contribute to age-related osteoporosis risk.
Article
Biochemistry & Molecular Biology
Sin-Yu Chen, Yi-Zhen Chen, Yi-Jing Lee, Chung-Lin Jiang, Shao-Chun Lu, Fu-Jung Lin
Summary: Maternal hypercholesterolemia exacerbates atherosclerosis in offspring by altering macrophage development and polarization, contributing to increased macrophage burden within lesions. This study highlights the importance of epigenetic modifications in the offspring's macrophage genome as a potential mechanism for the inheritance of cardiovascular disease susceptibility from hypercholesterolemic mothers.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Oncology
Ashley M. Mello, Tenzin Ngodup, Yusoo Lee, Katelyn L. Donahue, Jinju Li, Arvind Rao, Eileen S. Carpenter, Howard C. Crawford, Marina Pasca di Magliano, Kyoung Eun Lee
Summary: Hypoxia plays a crucial role in promoting the inflammatory phenotype in cancer-associated fibroblasts (CAF) in pancreatic ductal adenocarcinoma (PDAC).
Article
Medicine, Research & Experimental
Laura Lecce, Yang Xu, Bhargavi V'Gangula, Nirupama Chandel, Venu Pothula, Axelle Caudrillier, Maria Paola Santini, Valentina D'Escamard, Delaine K. Ceholski, Przemek A. Gorski, Lijiang Ma, Simon Koplev, Martin Maeng Bjorklund, Johan L. M. Bjorkegren, Manfred Boehm, Jacob Fog Bentzon, Valentin Fuster, Ha Won Kim, Neal L. Weintraub, Andrew H. Baker, Emily Bernstein, Jason C. Kovacic
Summary: The study identified the importance of HDAC9 in promoting EndMT in atherosclerosis, suggesting that targeting HDAC9 may be beneficial for stabilizing plaques or slowing the progression of atherosclerotic disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Celso M. Queiroz-Junior, Anna C. P. M. Santos, Matheus R. Goncalves, Camila B. Brito, Breno Barrioni, Pedro J. Almeida, Marcela H. Goncalves-Pereira, Tarcilia Silva, Sicilia R. Oliveira, Marivalda M. Pereira, Helton C. Santiago, Mauro M. Teixeira, Vivian V. Costa
Summary: The aim of this study was to investigate the impact of acute coronavirus infection on bone metabolism. The study found that patients with acute COVID-19 had decreased OPG and increased RANKL/OPG ratio in their serum. In vitro experiments showed that coronavirus infection increased the differentiation of macrophages and osteoclasts, as well as TNF release. In vivo experiments in mice showed that coronavirus infection triggered bone resorption and increased the number of osteoclasts, but this effect was not observed in TNFRp55- mice.
Article
Biotechnology & Applied Microbiology
Tengyu Geng, Yiru Wang, Kaili Lin, Cheng Zhang, Jing Wang, Ya Liu, Changyong Yuan, Penglai Wang
Summary: The hydrothermal treatment of Sr-doped nanocoating significantly promotes bone integration in the osteoporosis environment, providing an effective approach for improving implant surface osseointegration in this context.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Zhengmeng Yang, Lu Feng, Ming Wang, Yucong Li, Shanshan Bai, Xuan Lu, Haixing Wang, Xiaoting Zhang, Yaofeng Wang, Sien Lin, Micky D. Tortorella, Gang Li
Summary: Sesamin has been found to promote osteoporotic fracture healing by activating the BMP2 signaling pathway and enhancing chondrogenesis and angiogenesis activities.
Article
Medicine, Research & Experimental
Changju Hou, Xuepeng Wang, Wu Jiang, Zhenyu Bian, Liulong Zhu, Maoqiang Li
Summary: The study found that 11R-VIVIT promotes bone formation, accelerates fracture healing, and enhances osteogenic differentiation of osteoporotic BMSCs into osteoblasts rather than adipocytes. Mechanistic analysis revealed that 11R-VIVIT promotes autophagy by blocking the AKT/NFATc1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Emily Anderson-Baucum, Annie R. Pineros, Abhishek Kulkarni, Bobbie-Jo Webb-Robertson, Bernhard Maier, Ryan M. Anderson, Wenting Wu, Sarah A. Tersey, Teresa L. Mastracci, Isabel Casimiro, Donalyn Scheuner, Thomas O. Metz, Ernesto S. Nakayasu, Carmella Evans-Molina, Raghavendra G. Mirmira
Summary: The study showed that deficiency of DHPS in macrophages alters the abundance of proteins involved in NF-kappa B signaling, likely through translational control of their respective mRNAs. DHPS deficiency in myeloid cells of obese mice suppressed M1 macrophage accumulation in adipose tissue and improved glucose tolerance. These findings indicate that DHPS plays a role in post-transcriptional regulation of inflammation-related mRNAs in macrophages, contributing to a proinflammatory M1-like phenotype.
Article
Dentistry, Oral Surgery & Medicine
An Song, Feng Jiang, Yi Wang, Ming Wang, Yanhui Wu, Yang Zheng, Xiaomeng Song, Wei Zhang, Junbo Zhou
Summary: The study aims to evaluate the role of Sema3A in osteointegration of titanium implants in osteoporotic rabbits through in vivo and in vitro experiments. The results showed that Sema3A significantly improved the bone-implant contact and mechanical properties of the implants in the animals.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Multidisciplinary Sciences
Jingting Li, Xiaojun Xu, Manisha Tiwari, Yifang Chen, Mackenzie Fuller, Varun Bansal, Pablo Tamayo, Soumita Das, Pradipta Ghosh, George L. Sen
Summary: The research found that in epidermal stem and progenitor cells, some induced differentiation genes already contain stalled transcription complexes. SPT6 and PAF1 are necessary factors for the effective elongation of these differentiation genes. However, loss of SPT6 can lead to the spontaneous transdifferentiation of epidermal cells into other cell types.
NATURE COMMUNICATIONS
(2021)
Review
Genetics & Heredity
Amina Kamar, Athar Khalil, Georges Nemer
Summary: More than 10 million individuals worldwide are affected by genetically inherited defects in lipoprotein metabolism, with consanguinity playing a major role in establishing founder mutations. Mutations in four genes have been linked to the disease, with single or compound mutations in these genes accounting for a range of phenotypes. Studying digenic mutations and potential protective effects of single nucleotide polymorphisms is important for understanding the biology of the disease.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Sabrina D'Agosto, Francesco Pezzini, Lisa Veghini, Pietro Delfino, Claudia Fiorini, Gael D. Temgue Tane, Anais Del Curatolo, Caterina Vicentini, Giorgia Ferrari, Davide Pasini, Silvia Andreani, Francesca Lupo, Elena Fiorini, Giulia Lorenzon, Rita T. Lawlor, Borislav Rusev, Antonia Malinova, Claudio Luchini, Michele Milella, Elisabetta Sereni, Antonio Pea, Claudio Bassi, Peter Bailey, Aldo Scarpa, Emilio Bria, Vincenzo Corbo
Summary: Transcriptomic analysis has shown that FGFR1 and FGFR4 play distinct roles in determining the aggressive phenotype of pancreatic ductal adenocarcinoma (PDAC). FGFR4 expression is elevated in the classical PDAC subtype and associated with better outcomes, while FGFR1 expression is associated with the EMT phenotype. Downregulation of FGFR4 leads to increased proliferation and phenotype switch in PDAC cells.
Article
Hematology
Asier Benito-Vicente, Kepa B. Uribe, Asier Larrea-Sebal, Lourdes Palacios, Ana Cenarro, Xabier Calle, Unai Galicia-Garcia, Shifa Jebari-Benslaiman, Rosa M. Sanchez-Hernandez, Marianne Stef, Gilles Lambert, Fernando Civeira, Cesar Martin
Summary: This study extensively characterized the activities of L8 and L11 variants located in the signal peptide through in vitro experiments. It was found that the L11 variant enhances intracellular degradation of LDLr, which may lead to inefficient LDLr transport and LDLr degradation, resulting in mild hypercholesterolemia.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Liang Chen, Ri-Yan Zhang, Jun Xie, Jia-Yi Yang, Kang-Hao Fang, Chen-Xuan Hong, Rong-Bo Yang, Najeeb Bsoul, Lei Yang
Summary: The study found that catalpol can enhance the osteogenic ability of bone marrow mesenchymal stem cells and promote BMSC-mediated angiogenesis by activating the JAK2/STAT3 signaling pathway. This suggests that catalpol may be an ideal therapeutic agent for the clinical treatment of osteoporotic bone fractures.
STEM CELL RESEARCH & THERAPY
(2021)