Article
Medicine, Legal
E. Doberentz, A. Wegner, L. Rochlitzer, B. Madea, J. Ulbricht
Summary: In cases of fatal hemorrhage, there is no induction of extensive Hsp27 or 70 expression, indicating that fatal blood loss does not cause cellular stress.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Immunology
Shakuntala Surender Kumar Saraswati, Ankush Kumar Rana, Aayushi Singh, Vandana Anang, Aarti Singh, Krishnamurthy Natarajan
Summary: Mycobacterium tuberculosis suppresses defence responses in alveolar macrophages to establish a favorable environment in the human lung during infection. Heat Shock Proteins (HSPs) show significantly higher expression in active TB patients compared to those with latent infection. Inhibiting HSP-27 and HSP-70 prior to mycobacterial infection leads to a significant decrease in mycobacterial growth within macrophages. Inhibiting HSPs also increases intracellular oxidative burst levels and enhances T cell activation while inhibiting T cell inhibitory molecules. Additionally, inhibiting HSPs promotes autophagy pathway and pro-inflammatory transcription factors. HSP-27 and HSP-70 are associated with anti-apoptotic proteins Bcl-2 and Beclin-1. These findings suggest a suppressive role of host HSP-27 and HSP-70 during mycobacterial infection.
MICROBES AND INFECTION
(2023)
Article
Medicine, Legal
Burkhard Madea, Elvira Ruppel, Julian Prangenberg, Michael Kramer, Elke Doberentz
Summary: The hearts of amphetamine and cocaine users show similar microscopic features, but there are differences in the expression of heat shock proteins (HSP). The hypothesis that amphetamines have a cytoprotective function in contrast to cocaine-related deaths could not be verified. Both cocaine and benzoylecgonine independently lead to increased expression of HSP 27 in the liver and heart.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Review
Plant Sciences
M. Ashraf
Summary: Improving thermotolerance in plants requires precise selection criteria based on physiological, biochemical, and molecular processes, rather than solely focusing on yield attributes. Understanding the specific genes involved in stress tolerance is crucial for successful breeding programs and gene editing using advanced techniques.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Agriculture, Dairy & Animal Science
Won Seob Kim, Jayasimha R. Daddam, Boon Hong Keng, Jaehwan Kim, Jongkyoo Kim
Summary: This study investigated the response of bovine satellite cells to different levels of heat stress and exposure times. The results showed that extreme heat exposure promotes the accumulation of heat shock proteins and modulates the expression of myogenic regulatory factors in satellite cells. HSP27 acts as a molecular chaperone by binding to Myf5, thereby regulating the division or differentiation of satellite cells in response to heat stress.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Yujing Du, Zhao Chen, Ping Yan, Chunli Zhang, Xiaojiang Duan, Xueqi Chen, Meng Liu, Lei Kang, Xing Yang, Yan Fan, Jianhua Zhang, Rongfu Wang
Summary: The study identified heat shock protein 70 (HSP70) as the binding target for RRL, revealing a potential interaction between RRL and the nucleotide-binding domain (NBD) of HSP70. Clathrin-dependent endocytosis and macropinocytosis were suggested as vital internalization mechanisms of RRL. In vivo, Tc-99m-MAG3-RRL demonstrated satisfactory tumor accumulation and targeting, providing a promising probe for visualizing overexpressed HSP70 tumor sections.
MOLECULAR PHARMACEUTICS
(2021)
Article
Oncology
Jan Hrudka, Karolina Jelinkova, Hana Fiserova, Radoslav Matej, Vaclav Mandys, Petr Waldauf
Summary: Heat shock proteins (HSPs) are cytoprotective chaperones that play a critical role in maintaining cellular homeostasis. Overexpression of HSPs in cancer cells is associated with shorter overall survival and poorer prognosis. However, only HSP70 expression was found to have a significant impact on colorectal cancer prognosis in this study, with stage dependency.
Article
Biochemistry & Molecular Biology
Marzieh Davoudi, Jinfeng Chen, Qunfeng Lou
Summary: This study comprehensively analyzed the HSP70s gene family in pumpkin, including phylogenetic relationship, gene structure, gene duplication, collinearity, and promoter analysis. The study found 21 HSP70s genes in pumpkin, classified into five groups, and identified their cellular localization. Promoter analysis indicated the potential role of this gene family in stress tolerance. The study also analyzed the expression patterns of HSP70s genes in pumpkin under progressive drought stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Li-rong Yan, Shi-xuan Shen, Ang Wang, Han-xi Ding, Ying-nan Liu, Yuan Yuan, Qian Xu
Summary: The study showed differential expression of heat shock proteins (HSPs) in various cancers, with HSP expression levels generally associated with prognosis in multiple cancer types. While HSP gene mutations were generally linked to poor prognosis in cancers, copy number variations of HSPs had varying impacts on survival status in different cancers. HSPs were found to be involved in the activation and inhibition of multiple cancer-related pathways and closely correlated with immune cell infiltrations in different cancer types.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Larissa Smulders, Rachel Altman, Carolina Briseno, Alireza Saatchi, Leslie Wallace, Maha AlSebaye, Robert Stahelin, Nikolas Nikolaidis
Summary: HSPA1A is a molecular chaperone that regulates the survival of stressed and cancer cells. It localizes to the plasma membrane of stressed and tumor cells and interacts with specific lipids, playing a role in immunomodulatory functions and rendering tumors resistant to treatment. This study reveals that the surface presentation of HSPA1A is a multifaceted lipid-driven phenomenon controlled by binding to endosomal and plasma membrane lipids.
Article
Biochemistry & Molecular Biology
Manjula Nandakumar, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin
Summary: Oxidative stress, heat shock proteins, and vitamin D levels may be associated with polycystic ovary syndrome (PCOS). In this study, the levels of oxidative stress proteins and heat shock proteins were measured in non-obese, non-insulin resistant women with PCOS and control women. The results showed that only esterase D was elevated in PCOS, while other oxidative stress proteins and heat shock proteins were not elevated. Vitamin D levels were not correlated with any of the proteins.
Article
Medicine, Research & Experimental
Jiao Ge, Yan Liu
Summary: This study investigated the serum expression of HSP-70 in children with ITP and healthy controls, and found that the expression of HSP-70 is associated with the progression and severity of childhood ITP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Immunology
Stefan Tukaj, Jagoda Mantej, Michal Sobala, Katarzyna Potrykus, Zbigniew Tukaj, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz
Summary: The study found that Hsp70 immunization and anti-Hsp70 antibody treatment can decrease disease severity in a psoriasis-like skin inflammation mouse model by affecting T cell populations. This suggests that Hsp70 may be a promising therapeutic target for psoriasis and other autoimmune dermatoses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Fatemeh Rezaei, Ali Namvar, Elahe Akbari, Fatemeh Heidarnejad, Azam Bolhassani
Summary: Heat shock proteins (HSPs) can improve the presentation of tumor antigens and have potential for use in therapeutic vaccine design. In this study, in silico analyses and molecular docking were performed to compare different vaccine constructs linking human papillomavirus (HPV)-16 E7 protein to Hsp27 or Hsp70. The results showed that the whole sequence of Hsp27 had a better interaction with receptors and higher immunogenicity than Hsp70, suggesting its potential as a vaccine candidate against HPV-related cancers.
Article
Environmental Sciences
B. Rangaswamy, W. -s. Kim, I. -S. Kwak
Summary: Heat shock proteins are natural biomarkers that play a vital role in genetic variability and adaptive survival in organisms under environmental stress. This study assessed the effect of stressors on Heat shock protein 70 in two fish species, Hemibarbus labeo and Lepomis macrochirus. The results showed that the expression of Heat shock protein 70 in fish was influenced by physicochemical factors in the lake ecosystem, indicating a stress-relieving effect.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Cell Biology
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
Article
Pathology
Motoko Sasaki, Yasunori Sato
Article
Pathology
Yasunori Sato, Minako Yamamura, Motoko Sasaki, Kenichi Harada
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Cell Biology
Motoko Sasaki, Fang-Ying Kuo, Chao-Cheng Huang, Paul E. Swanson, Chao-Long Chen, Jiin-Haur Chuang, Matthew M. Yeh
Article
Medicine, Research & Experimental
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
LABORATORY INVESTIGATION
(2018)
Article
Pathology
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2019)
Article
Cell Biology
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
Summary: The prevalence of bile duct adenomas in the background liver was significantly higher in small duct iCCA compared to other primary liver carcinomas, suggesting they may be precursor lesions. Alterations in ARID1A, p53, and PBRM1 genes may be involved in the carcinogenesis of small duct iCCA.
Article
Pathology
Motoko Sasaki, Yasunori Sato
Summary: The study examined 51 bile duct biopsy samples and found that IMP3, EZH2, and p53 have high sensitivity and accuracy in diagnosing malignancy. The conclusion is that the immunohistochemical markers of these three can increase the diagnostic sensitivity and accuracy of bile duct biopsy for the diagnosis of cholangiocarcinoma.
Article
Cell Biology
M. Sasaki, Y. Sato, Y. Nakanuma
Summary: Nestin may serve as a diagnostic marker for combined hepatocellular-cholangiocarcinoma (cHCC-CCA) and small duct-type intrahepatic cholangiocarcinoma (iCCA). Its expression is associated with NCAM and vimentin, and correlates with tumor size, CLC components, p53 overexpression, and multiple genetic alterations.
Article
Cell Biology
Sasaki Motoko, Sato Yasunori, Nakanuma Yasuni
Summary: By analyzing genetic alterations and other features, this study found that bile duct adenoma is not a precursor of small duct iCCA. Immunohistochemical staining for IMP3, EZH2, p53, ARID1A, and MTAP may help distinguish between bile duct adenomas and small duct iCCAs.
Review
Medicine, General & Internal
Soo Ryang Kim, Soo Ki Kim, Yu-ichiro Koma, Motoko Sasaki, Akira Asai, Hiroki Nishikawa
Summary: Hepatic inflammatory pseudotumors (IPTs) are benign tumors characterized by the presence of myofibroblastic spindle cells, inflammatory cells, fibrosis, and necrosis. The diagnosis of hepatic IPT remains challenging, as it can be confused with other benign diseases and malignant tumors. Histopathological findings are necessary to confirm the diagnosis. Once diagnosed, unnecessary surgery should be avoided.
Meeting Abstract
Gastroenterology & Hepatology
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
Meeting Abstract
Gastroenterology & Hepatology
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
Meeting Abstract
Gastroenterology & Hepatology
Motoko Sasaki, Yasunori Sato
Article
Gastroenterology & Hepatology
Motoko Sasaki, Yasuni Nakanuma
DIGESTIVE DISEASES
(2017)