Article
Environmental Sciences
Quirino Ciampi, Antonello Russo, Caterina D'Alise, Anna Ballirano, Bruno Villari, Cristina Mangia, Eugenio Picano
Summary: The study found that NO2 concentration is weakly correlated with pulmonary congestion, with higher NO2 levels predicting the presence of B-lines. PM2.5 concentration is also associated with B-lines, suggesting that NO2 may increase permeability of the alveolar-capillary barrier leading to pulmonary congestion.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Critical Care Medicine
Franck F. Rahaghi, Nicholas A. Kolaitis, Ayodeji Adegunsoye, Joao A. de Andrade, Kevin R. Flaherty, Lisa H. Lancaster, Joyce S. Lee, Deborah J. Levine, Ioana R. Preston, Zeenat Safdar, Rajan Saggar, Sandeep Sahay, Mary Beth Scholand, Oksana A. Shlobin, David A. Zisman, Steven D. Nathan
Summary: This study identifies triggers and screening tools for pulmonary hypertension (PH) in patients with interstitial lung disease (ILD) through expert consensus. Due to the lack of standardized approaches, this consensus statement aims to aid physicians in the identification of ILD patients with possible PH and provide guidance for timely right heart catheterization.
Article
Veterinary Sciences
Carlotta Valente, Massimiliano Tursi, Helen Poser, Carlo Guglielmini
Summary: A five-month-old European shorthair female kitten was referred due to recurrent respiratory distress and was diagnosed with severe precapillary pulmonary hypertension and interstitial pneumonia associated with right-sided cardiac remodeling. The cat quickly died from respiratory insufficiency. Pathological findings revealed left pulmonary artery coarctation, severe right-sided cardiac hypertrophy, and bilateral pneumonia, making this the first reported case of pulmonary artery coarctation associated with pneumonia and PH in a cat.
VETERINARY SCIENCES
(2021)
Article
Medicine, General & Internal
Ragnhild Sorum Falk, Julian Eek Mariampillai, Erik Edvard Prestgaard, Trond Heir, Johan Bodegard, Trude Eid Robsahm, Irene Grundvold, Per Torger Skretteberg, Kristian Engeseth, Jorgen Vildershoj Bjornholt, Knut Stavem, Knut Liestol, Leiv Sandvik, Erik Thaulow, Gunnar Erikssen, Sverre E. Kjeldsen, Knut Gjesdal, Jan E. Erikssen
Summary: The Oslo Ischaemia Study aimed to investigate the prevalence and predictors of silent coronary disease in Norwegian middle-aged men. The study found that participants with higher physical fitness had a lower risk of cardiovascular disease, and the magnitude of blood pressure responses to moderate exercise was related to the risk of cardiovascular disease and mortality.
Article
Cardiac & Cardiovascular Systems
Elisa Merli, Quirino Ciampi, Maria Chiara Scali, Angela Zagatina, Pablo Martin Merlo, Rosina Arbucci, Clarissa Borguezan Daros, Jose Luis de Castro e Silva Pretto, Miguel Amor, Michael F. Salame, Hugo Mosto, Doralisa Morrone, Antonello D'Andrea, Barbara Reisenhofer, Hugo Rodriguez-Zanella, Karina Wierzbowska-Drabik, Jaroslaw D. Kasprzak, Gergely Agoston, Albert Varga, Jorge Lowenstein, Claudio Dodi, Lauro Cortigiani, Iana Simova, Martina Samardjieva, Rodolfo Citro, Jelena Celutkiene, Federica Re, Ines Monte, Suzana Gligorova, Francesco Antonini-Canterin, Mauro Pepi, Clara Carpeggiani, Patricia A. Pellikka, Eugenio Picano
Summary: Lung ultrasound can detect pulmonary congestion at rest and during exercise stress echocardiography. Stress B-lines and ejection fraction <50% are independent predictors of all-cause death.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
Jason Davidge, Awais Ashfaq, Kristina Malene Odegaard, Mattias Olsson, Madlaina Costa-Scharplatz, Bjoern Agvall
Summary: This study found that among heart failure patients, 57% had abnormal ejection fractions based on echocardiography results, with 35% having reduced EF, 27% having mildly reduced EF, and 38% having preserved EF. The 1-year all-cause mortality rate was 42% for those without confirmed EF, while it was 30% for those with conclusive EF.
Article
Cardiac & Cardiovascular Systems
Zijing Zhou, Weijie Tang, Xiaokang Tu, Feng Li, Zhonghua Huang, Wancun Jin, Qin Wu, Feng Liu, Chengming Fan
Summary: Rheumatic heart disease is prevalent in developing countries and mainly affects the mitral and aortic valves. This case presents a rare occurrence of severe pulmonary valve contracture and regurgitation in a patient with rheumatic right-sided valve disease. Surgical valvular reconstruction with a bovine pericardial patch was successfully performed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Sanna A. Borg, Michael Rene Skjelbo Nielsen, Peter Sogaard, Soren Lundbye-Christensen, Jan Joanesarson, Tomas Zaremba, Rudi Kollslid, Erik Berg Schmidt, Albert Marni Joensen, Christian Sorensen Bork
Summary: This study aims to assess the prevalence, genetic and clinical characteristics, and potential causes of familial hypercholesterolaemia (FH) in the Faroe Islands. The research methods include estimating the prevalence of FH using a nationwide laboratory database, inviting eligible subjects for detailed evaluation, collecting samples for genetic testing and storage, and conducting cardiovascular examinations. The project has been approved by the ethical committee and data protection agency, and is expected to provide important information that will be published in international peer-reviewed journals.
Article
Medicine, General & Internal
Guangxiao Li, Tan Li, Yanli Chen, Xiaofan Guo, Zhao Li, Ying Zhou, Hongmei Yang, Shasha Yu, Guozhe Sun, Liqiang Zheng, Yingxian Sun
Summary: The study found that compared with patients without AR, those with moderate/severe AR had a significantly higher risk of MI and MI mortality, but there was no significant association between AR and the risk of stroke or stroke mortality.
Review
Medicine, General & Internal
G. E. Mandoli, G. De Carli, M. C. Pastore, P. Cameli, F. Contorni, M. D'Alessandro, E. Bargagli, S. Mondillo, M. Cameli
Summary: Lung diseases are a major healthcare concern with high morbidity and mortality rates, and the cardiovascular system, specifically the right ventricle, plays a crucial role in mitigating impaired lung function. Echocardiography is a valuable tool for assessing right ventricular function, especially in chronic obstructive and restrictive lung disease. Understanding the cardiac involvement in lung diseases and utilizing multimodality imaging techniques are essential for diagnosis and prognosis.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Rong Jiang, Lan Wang, Qin-Hua Zhao, Cheng Wu, Ping Yuan, Shang Wang, Rui Zhang, Su-Gang Gong, Wen-Hui Wu, Jing He, Hong-Ling Qiu, Ci-Jun Luo, Jin-Ming Liu, Zhi-Cheng Jing
Summary: We established and validated a novel nomogram using echocardiographic parameters to predict all-cause death in patients with severe CLD-PH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Theodore K. Marras, Paul Nelson, Adriana Peci, Melissa Richard-Greenblatt, Sarah Brode, Ashleigh Sullivan, Frances B. Jamieson, Julianne V. Kus
Summary: We assessed the annual prevalence of microbiologically defined nontuberculous mycobacterial lung disease in Ontario, Canada. The prevalence of Mycobacterium avium was 13 cases/100,000 persons in 2020, showing a 2.5-fold increase from 2010, indicating a significant rise in actual M. avium lung disease. Meanwhile, M. xenopi decreased by almost 50% to 0.84 cases/100,000 persons during the same period.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Leo F. Buckley, Brian L. Claggett, Kunihiro Matsushita, Gearoid M. McMahon, Hicham Skali, Josef Coresh, Aaron R. Folsom, Suma H. Konety, Lynne E. Wagenknecht, Thomas H. Mosley, Amil M. Shah
Summary: This study aimed to investigate the associations between kidney dysfunction and damage and heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), as well as adverse cardiac remodeling in late-life. The results showed that mild to moderate kidney dysfunction and damage were associated with incident HF and adverse cardiac remodeling in late-life.
JACC-HEART FAILURE
(2023)
Article
Physiology
Mona Lichtblau, Tsogyal D. Latshang, Sayaka S. Aeschbacher, Fabienne Huber, Philipp M. Scheiwiller, Stefanie Ulrich, Simon R. Schneider, Elisabeth D. Hasler, Michael Furian, Konrad E. Bloch, Stephanie Saxer, Silvia Ulrich
Summary: The study investigated whether nocturnal oxygen therapy helps mitigate the increase of pulmonary artery pressure in COPD patients traveling to altitude during the day. The results showed that changes in daytime pulmonary hemodynamics at high altitude were minor and not significantly affected by nocturnal oxygen therapy. Additionally, some patients experienced adverse health effects during their time at high altitude.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Shiro Hoshida, Shungo Hikoso, Yukinori Shinoda, Koichi Tachibana, Tomoko Minamisaka, Tamaki Shunsuke, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Takahisa Yamada, Yoshio Yasumura, Daisaku Nakatani, Yasushi Sakata
Summary: This study aimed to investigate the association between changes in the afterload-integrated diastolic index (Ed/Ea) and prognosis in patients with heart failure with preserved ejection fraction (HFpEF). The results showed that high Ed/Ea was significantly associated with increased mortality and re-admission for heart failure during the second year after discharge. This finding suggests that Ed/Ea has time-sensitive prognostic performance in older patients with HFpEF.
Article
Peripheral Vascular Disease
Daniel A. Duprez, David R. Jacobs, Leah I. B. Andrews, Lyndia C. Brumback, Julie O. Denenberg, Robyn L. Mcclelland, Isac C. Thomas, Michael H. Criqui, Matthew A. Allison
Summary: This study investigated the difference, reproducibility, and incidence of cardiovascular disease (CVD) in inter-arm systolic blood pressure (sIAD). It found that high absolute sIAD values were not persistent over time, but were associated with increased risk for stroke and peripheral arterial disease (PAD). Measuring systolic blood pressure between arms can help identify individuals at higher risk for CVD.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Kazuki Shiina, Hirofumi Tomiyama, Atsushi Tanaka, Takumi Imai, Itaru Hisauchi, Isao Taguchi, Akira Sezai, Shigeru Toyoda, Kaoru Dohi, Haruo Kamiya, Keisuke Kida, Toshihisa Anzai, Taishiro Chikamori, Koichi Node
Summary: SGLT2 inhibitors have been found to reduce the risk of heart failure progression and mortality rates. This study shows that SGLT2 inhibitors can chronically reduce estimated plasma volume and improve heart failure prognosis in patients with type 2 diabetes and chronic heart failure, especially in those with preserved ejection fraction. The subanalysis of the CANDLE trial indicates that canagliflozin significantly reduces estimated plasma volume without worsening renal function and lowers serum uric acid without causing major electrolyte abnormalities.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yuni Choi, David R. R. Jacobs Jr, Michael Patrick Bancks, Cora E. E. Lewis, EunSeok Cha, Fengxia Yan, Mercedes R. R. Carnethon, Pamela J. J. Schreiner, Daniel A. A. Duprez
Summary: The study found that the American Heart Association's cardiovascular health (CVH) score is closely associated with early-onset diabetes, later-onset diabetes, and subsequent complications of diabetes. Higher CVH score is associated with lower risk of both early- and later-onset diabetes, as well as diabetic complications. This study highlights the importance of maintaining good cardiovascular health in preventing diabetes and its complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Respiratory System
Motahareh Vameghestahbanati, Coralynn Sack, Artur Wysoczanski, Eric A. Hoffman, Elsa Angelini, Norrina B. Allen, Alain G. Bertoni, Junfeng Guo, David R. Jacobs Jr, Joel D. Kaufman, Andrew Laine, Ching-Long Lin, Daniel Malinsky, Erin D. Michos, Elizabeth C. Oelsner, Steven J. Shea, Karol E. Watson, Andrea Benedetti, R. Graham Barr, Benjamin M. Smith
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Daisaku Nakatani, Tomoharu Dohi, Shungo Hikoso, Atsushi Tanaka, Mamoru Nanasato, Wataru Shimizu, Koichi Node, Yasushi Sakata
Summary: There were limited clinical studies on the relationship between SGLT2 inhibitors and hematopoiesis in patients with diabetes and heart failure. In the CANDLE trial, 226 patients were studied, and it was found that canagliflozin was associated with increased hematocrit and hemoglobin levels compared to glimepiride. In conclusion, canagliflozin improved hematologic parameters in patients with diabetes and heart failure.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Sport Sciences
Tyler D. Quinn, Abbi Lane, Kelley Pettee Gabriel, Barbara Sternfeld, David R. Jacobs, Peter Smith, Bethany Barone Gibbs
Summary: This study examined the associations between fitness and leisure-time physical activity (LTPA) and occupational physical activity (OPA). The results showed a positive correlation between LTPA and fitness, while OPA was negatively correlated with fitness. These findings are important for physical activity research and public health promotion.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Medicine, General & Internal
Kelley Pettee Gabriel, Byron C. Jaeger, Cora E. Lewis, Stephen Sidney, Erin E. Dooley, Mercedes R. Carnethon, David R. Jacobs, Bjoern Hornikel, Jared P. Reis, Pamela J. Schreiner, JamesM. Shikany, Kara M. Whitaker, Alexander Arynchyn, Barbara Sternfeld
Summary: This study found that higher early-adulthood cardiorespiratory fitness and greater retention of early-adulthood cardiorespiratory fitness throughout midlife were associated with a lower risk of premature death and CVD events.
Article
Cardiac & Cardiovascular Systems
Alessandro Menotti, Paolo Emilio Puddu, Anthony G. Kafatos, Hanna Tolonen, Hisashi Adachi, David R. Jacobs
Summary: This study aimed to investigate mortality rates from three major cardiovascular diseases (coronary heart disease, cerebrovascular diseases, and other heart diseases of uncertain etiology) in a pooled cohort over a 60-year follow-up period. The results showed that countries with high serum cholesterol levels had higher death rates from coronary heart disease, while countries with low cholesterol levels had higher death rates from stroke and other heart diseases. Differences in lifelong cardiovascular disease mortalities across different countries were smaller than expected.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Respiratory System
Gabrielle Y. Liu, Laura A. Colangelo, Samuel Y. Ash, Raul San Jose Estepar, David R. Jacobs, Bharat Thyagarajan, J. Michael Wells, Rachel K. Putman, Bina Choi, Christopher S. Stevenson, Mercedes Carnethon, George R. Washko, Ravi Kalhan
Summary: This epidemiological study found that CT lung injury is associated with future interstitial features and restrictive spirometry abnormality. Among 2213 participants, a 10% higher amount of CT lung injury at mean age 40 years was associated with a 4.37% higher amount of lung tissue characterised as interstitial features at mean age 50 years. Compared to those with the lowest quartile of CT lung injury at mean age 40 years, there were higher odds of incident restrictive spirometry at mean age 55 years in quartile 2, quartile 3, and quartile 4.
Letter
Critical Care Medicine
Gabrielle Y. Liu, Laura A. Colangelo, Raul San Jose Estepar, Anthony J. Esposito, Samuel Y. Ash, Bina Choi, David R. Jacobs, Mercedes R. Carnethon, George R. Washko, Ravi Kalhan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniel A. Duprez, David R. Jacobs Jr
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Junia N. de Brito, Daniel J. McDonough, Mahesh Mathew, Lisa B. VanWagner, Pamela J. Schreiner, Kelley Pettee Gabriel, David R. Jacobs Jr, James G. Terry, John Jeffrey Carr, Mark A. Pereira
Summary: This study found that higher levels of vigorous-intensity physical activity (VPA) throughout young to middle adulthood were associated with a reduced risk of nonalcoholic fatty liver disease (NAFLD) in middle age.
Article
Peripheral Vascular Disease
Gabor Szalo, Margareta I. Hellgren, Matthew Allison, Ying Li, Lennart Rastam, Karin Radholm, Entela Bollano, Daniel A. Duprez, David R. Jacobs, Ulf Lindblad, Bledar Daka
Summary: The association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) was investigated. The study found a significant increase in the risk for incident CVD with each quartile decrease in arterial elasticity.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Paolo Emilio Puddu, Alessandro Menotti, David R. Jacobs, Hisashi Adachi, Antony Kafatos, Hanna Tolonen
Summary: This study examined the age at death and its determinants in cohorts of middle-aged men. The results showed that cardiovascular disease risk factors were strongly associated with age at death. Other factors such as age, physical activity, and smoking status were also related to age at death.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
