期刊
AMERICAN JOURNAL OF PATHOLOGY
卷 177, 期 2, 页码 525-531出版社
ELSEVIER SCIENCE INC
DOI: 10.2353/ajpath.2010.090936
关键词
-
类别
资金
- National Institutes of Health [RC146576A]
Allergic diseases and asthma are caused by dysregulated Th2-type immune responses, which drive disease development in susceptible individuals. Immune tolerance to allergens prevents inflammatory symptoms in the respiratory mucosa and provides protection against inflammation in the airways. Increasing evidence indicates that Foxp3+ regulatory T cells (Tregs) play a critical role in immune tolerance and control Th2-biased responses. Tregs develop in the thymus from CD4(+) T cells (natural Tregs) and also in the periphery by the conversion of naive CD4(+) T cells (induced Tregs). Increased susceptibility to allergy and airway inflammation is hypothesized to result from impaired development and function of Tregs. Thus, strategies to induce allergen-specific Tregs hold great promise for treatment and prevention of asthma. (Am J Pathol 2010, 177:525-531; DOI: 10.2353/ajpath.2010.090936)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据