Article
Multidisciplinary Sciences
Chongyang Zhang, Hongmei Zhao, Yujun Cai, Jian Xiong, Amy Mohan, Danfei Lou, Hangchuan Shi, Yishuai Zhang, Xiaochun Long, Jing Wang, Chen Yan
Summary: Abdominal aortic aneurysm (AAA) is a common vascular pathology in elderly males characterized by aorta dilation, with cyclic nucleotide phosphodiesterase 1C (PDE1C) playing a critical role in its development. PDE1C elevation contributes to SMC senescence and AAA progression, potentially serving as a therapeutic target against aortic aneurysms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Guojun Zhang, Guoliang Zheng, Fengli Jiang, Tianyi Wu, Lizhao Wu
Summary: ST-4 activates specific types of T cells to produce high levels of granzyme B and perforin, which exhibit anticancer effects. Inhibition of granzyme B and perforin weakens the anticancer effect of ST-4, indicating its potential in cancer immunotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cardiac & Cardiovascular Systems
Tan Li, Chao Yang, Jingjing Jing, Liping Sun, Yuan Yuan
Summary: Elevated levels of GZMK were found to be associated with the presence of AAA and its rupture risk, suggesting that serum GZMK could serve as a potential non-invasive marker for identifying AAA and assessing its risk of rupture.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Immunology
Zhen Yuan, Yi Lu, Jia Wei, Jiaqi Wu, Jin Yang, Zhejun Cai
Summary: Abdominal aortic aneurysms (AAAs) are local dilations of the infrarenal segment of aortas, with inflammation playing a central role in their development. In addition to inflammatory cells like T cells, macrophages, and neutrophils, special structures such as inflammasomes and neutrophil extracellular traps are investigated for their roles in aneurysm formation. Understanding the impacts and interactions of these inflammatory cells and structures is crucial for developing new screening and pharmacological interventions for AAA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Shan Lu, Ruihan Wang, Weiguo Fu, Yi Si
Summary: This article introduces the pathological process of abdominal aortic aneurysm (AAA) and the crucial role of extracellular vesicles (EVs), highlighting their potential applications as biomarkers, therapeutic agents, and drug delivery carriers. However, there are still challenges to overcome, such as poor targeting effect, low accumulation rate, and rapid clearance by the mononuclear phagocyte system.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Bartosz Pilecki, Paulo V. S. D. de Carvalho, Katrine L. Kirketerp-Moller, Anders Schlosser, Karin Kejling, Magdalena Dubik, Nicklas P. Madsen, Jane Stubbe, Pernille B. L. Hansen, Thomas L. Andersen, Jesper B. Moeller, Niels Marcussen, Vasco Azevedo, Svend Hvidsten, Christina Baun, Guo-Ping Shi, Jes S. Lindholt, Grith L. Sorensen
Summary: MFAP4 plays a crucial role in promoting the development of AAA by inducing macrophage-rich inflammation and MMP activity within the vessel wall. Its deficiency leads to reduced AAA incidence and ameliorates pathological changes in AAA, implicating regulation of monocyte influx and MMP production as key mechanisms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Azar Hosseini, Toktam Sahranavard, Zeljko Reiner, Tannaz Jamialahmadi, Yusra Al Dhaheri, Ali H. Eid, Amirhossein Sahebkar
Summary: This article reviews different studies and summarizes potential mechanisms by which statins can have an effect on abdominal aortic aneurysm (AAA). The evidence suggests an association between treatment with statins and improvement of AAA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biology
Violeta Soljic, Maja Barbaric, Martina Vukoja, Marina Curlin, Martina Orlovic Vlaho, Edita Cerni Obrdalj, Lidija Lasic Arapovic, Daniela Bevanda Glibo, Katarina Vukojevic
Summary: The study indicates that the expression of cytotoxic CD8(+) T cells in decidual tissue of patients with preeclampsia is altered, suggesting their potential role in the pathophysiology of preeclampsia and fetal-maternal immune tolerance.
Article
Medical Laboratory Technology
Likun Sun, Xin Li, Zhongchen Luo, Maohua Li, Hongyu Liu, Zhaowei Zhu, Junwei Wang, Peng Lu, Lunchang Wang, Chenzi Yang, Tun Wang, Hao He, Ming Li, Chang Shu, Jiehua Li
Summary: The purinergic receptor P2X7 plays a crucial role in abdominal aortic aneurysm (AAA) development by modulating macrophage pyroptosis and inflammation. P2X7 is highly expressed in human AAA specimens and experimental murine AAA lesions. Inhibition or deficiency of P2X7 attenuates aneurysm formation in experimental murine models, while its activation promotes AAA development. Mechanistically, macrophage P2X7 activates the NLRP3 inflammasome and its downstream caspase-1 to initiate the pyroptosis pathway.
TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Jakub Toczek, Parnaz Boodagh, Nowshin Sanzida, Mean Ghim, Mani Salarian, Kiran Gona, Gunjan Kukreja, Saranya Rajendran, Linyan Wei, Jinah Han, Jiasheng Zhang, Jae-Joon Jung, Morven Graham, Xinran Liu, Mehran M. Sadeghi
Summary: This study demonstrates the potential of using nanoparticle-enhanced CT imaging to predict AAA outcomes by evaluating phagocytic activity. The uptake of nanoparticles can predict AAA outcomes and is related to vascular wall inflammatory responses.
Review
Biochemistry & Molecular Biology
Karolina L. Stepien, Karolina Bajdak-Rusinek, Agnieszka Fus-Kujawa, Waclaw Kuczmik, Katarzyna Gawron
Summary: Abdominal aortic aneurysm (AAA) is a dangerous cardiovascular disease that mainly occurs in men over the age of 55. There is no pharmacological treatment available, so early diagnosis is crucial. Biomarkers play a key role in evaluating disease progression and timely diagnosis of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Tyler W. Benson, Kelsey A. Conrad, Xinmin S. Li, Zeneng Wang, Robert N. Helsley, Rebecca. C. Schugar, Taylor M. Coughlin, Caris Wadding-Lee, Salma Fleifil, Hannah M. Russell, Timothy Stone, Michael Brooks, Jennifer A. Buffa, Kevin Mani, Martin Bjorck, Anders Wanhainen, Naseer Sangwan, Sudha Biddinger, Rohan Bhandari, Akiirayi Ademoya, Crystal Pascual, W. H. Wilson Tang, Michael Tranter, Scott J. Cameron, J. Mark Brown, Stanley L. Hazen, A. Phillip Owens
Summary: Large-scale human and mechanistic mouse studies have found a strong relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) and cardiometabolic diseases. This study investigates the role of TMAO in abdominal aortic aneurysm (AAA) and targets TMAO's parent microbes for potential pharmacological intervention. The study examines TMAO and choline metabolites in plasma samples from patient cohorts and uses murine AAA models to observe the effects of TMAO. The results suggest that inhibition of microbiome-derived TMAO could serve as a novel therapeutic approach for AAA treatment.
Article
Multidisciplinary Sciences
Shizhi Wang, Qingwen Yuan, Wenpeng Zhao, Weimin Zhou
Summary: This study identified 65 differentially expressed circular RNAs in AAA tissues compared to normal tissues, with circRBM33 being significantly increased in AAA tissues and Ang II-induced VSMCs. The findings suggest that circRBM33 may play a role in AAA progression by regulating ECM degradation via the miR-4268/EPHB2 axis.
Article
Hematology
Ming-Tsai Chiang, I-Ming Chen, Fu-Fei Hsu, Yen-Hui Chen, Min-Shao Tsai, Yaw-Wen Hsu, Hsin-Bang Leu, Po-Hsun Huang, Jaw-Wen Chen, Fu-Tong Liu, Ying-Hwa Chen, Lee-Young Chau
Summary: Abdominal aortic aneurysm (AAA) is a vascular degenerative disease with high mortality in elders, lacking prognostic and therapeutic targets. Gal-1, a lectin expressed in vasculature, has been identified as a key player in the progression of AAA. Experimental and clinical studies suggest that Gal-1 may serve as a potential disease biomarker and therapeutic target for AAA.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ming Xue, Dan Li, Zhu Wang, Lei Mi, Shuwei Cao, Lijun Zhang, Xiangqian Kong
Summary: Increased expression of IFI16 was found in AAA specimens and Ang-II-treated VSMCs. Silencing IFI16 and ASC suppressed apoptosis and migration ability of VSMCs, reduced elasticity damage and MMP expression. Thus, IFI16 and ASC may play important roles in the progression of AAA.
Review
Biochemistry & Molecular Biology
A. Hendel, P. R. Hiebert, W. A. Boivin, S. J. Williams, D. J. Granville
CELL DEATH AND DIFFERENTIATION
(2010)
Article
Geriatrics & Gerontology
Paul R. Hiebert, Wendy A. Boivin, Thomas Abraham, Sara Pazooki, Hongyan Zhao, David J. Granville
EXPERIMENTAL GERONTOLOGY
(2011)
Review
Medicine, Research & Experimental
Wendy Anne Boivin, Dawn Michelle Cooper, Paul Ryan Hiebert, David James Granville
LABORATORY INVESTIGATION
(2009)
Article
Multidisciplinary Sciences
Wendy A. Boivin, Marlo Shackleford, Amanda Vanden Hoek, Hongyan Zhao, Tillie L. Hackett, Darryl A. Knight, David J. Granville
Article
Multidisciplinary Sciences
Paul R. Hiebert, Wendy A. Boivin, Hongyan Zhao, Bruce M. McManus, David J. Granville
Article
Cell Biology
L. S. Ang, W. A. Boivin, S. J. Williams, H. Zhao, T. Abraham, K. Carmine-Simmen, B. M. McManus, R. C. Bleackley, D. J. Granville
CELL DEATH & DISEASE
(2011)
Article
Dermatology
Christopher T. Turner, Matthew R. Zeglinski, Wendy Boivin, Hongyan Zhao, Megan A. Pawluk, Katlyn C. Richardson, Arundhasa Chandrabalan, Phillip Bird, Rithwik Ramachandran, Roma Sehmi, Hermenio Lima, Gail Gauvreau, David J. Granville
Summary: This study found that GzmK plays an important role in atopic dermatitis and may serve as a potential therapeutic target for skin conditions associated with persistent inflammation, vasculitis, and pathological angiogenesis.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Gideon Obasanmi, Matthew R. Zeglinski, Ella Hardie, Anna-Catharina Wilhelm, Christopher T. Turner, Sho Hiroyasu, Wendy A. Boivin, Yuan Tian, Hongyan Zhao, Eleanor To, Jing Z. Cui, Jeanne Xi, Hyung-Suk Yoo, Manjosh Uppal, David J. Granville, Joanne A. Matsubara
Summary: Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in the elderly and is associated with abnormal blood vessel growth. This study explored the relationship between the protease Granzyme B (GzmB) and the antiangiogenic factors Thrombospondin (TSP)-1 and TSP-2 in eyes with neovascular AMD. The study found that TSP-1 and TSP-2 are substrates of GzmB and that the proteolysis of these factors by GzmB may contribute to neovascular AMD-related choroidal neovascularization (CNV).
LABORATORY INVESTIGATION
(2023)
Article
Immunology
Paul Roumeliotis, Sherilyn K. D. Houle, Ajit Johal, Bertrand Roy, Wendy Boivin
Summary: The Public Health Agency of Canada recommends that 80% of high-risk persons, including adults aged =65 years and 18-64 years with certain comorbidities, be vaccinated against influenza. An online survey conducted during the 2022-2023 influenza season showed that only 47.3% of the Canadian residents received the influenza vaccination. There is a gap in education regarding the importance of influenza vaccination among people at risk of influenza complications.
Article
Dermatology
Wendy A. Boivin, Huijun Jiang, Oliver B. Utting, David W. C. Hunt
EXPERIMENTAL DERMATOLOGY
(2006)
Article
Biochemistry & Molecular Biology
David W. C. Hunt, Wendy A. Boivin, Lindsay A. Fairley, Miroslava M. Jovanovic, Diane E. King, Ruth A. Salmon, Oliver B. Utting
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2006)