Article
Multidisciplinary Sciences
Linhua Wang, Mirjana Maletic-Savatic, Zhandong Liu
Summary: Spatially resolved transcriptomics is a new technique for mapping transcriptional information within tissues. In this study, the authors present MIST, a computational tool that detects molecular regions and denoises missing gene expression values using region-specific imputation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Faisal Abedin, Nabin Kandel, Suren A. Tatulian
Summary: The study identified peptide fragments P3 and P6 as having strong inhibitory effects on A beta(1-42) aggregation, potentially providing therapeutic strategies for Alzheimer's disease treatment by inhibiting A beta fibrillogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Seokjin Haam, Jae-Ho Han, Hyun Woo Lee, Young Wha Koh
Summary: This study identified a 17-gene expression signature related to tumor nonimmune microenvironment that could predict brain metastasis in lung adenocarcinoma after surgical resection. This signature, with 11 genes associated with extracellular matrix remodeling, showed high predictive power in four machine learning classifiers, especially in early-stage lung adenocarcinoma. Immunohistochemical expression of these genes corresponded with NanoString tests, indicating their potential as biological markers for predicting brain metastasis.
Article
Pharmacology & Pharmacy
Yi Zhang, Ning Sun, Meng Zhang, Qian Ding, Qian Wang, Yuguang Liang, Huan He, Yuxin Yang, Chunyan Guo
Summary: The Fuyou formula and its major components can alleviate precocious puberty by inhibiting the effects of estrogen through transcriptional regulation of target genes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Muhammad Kamran, Aodan Laighneach, Farhana Bibi, Gary Donohoe, Naveed Ahmed, Asim Ur Rehman, Derek W. Morris
Summary: This study identifies associations between SORCS3 and various brain-related disorders and traits, and reveals that SNPs related to neurodevelopment and cognitive function are associated with SORCS3. The study also shows that the SORCS3 gene-set contributes significantly to the heritability of schizophrenia, bipolar disorder, intelligence, and education attainment. Furthermore, functional annotation reveals the enrichment of synapse-related ontologies in the SORCS3 gene-set.
Article
Biology
Fengyu Zhang, Yanhong Sun, Yihao Zhang, Wenting Shen, Shujing Wang, Qi Ouyang, Chunxiong Luo
Summary: Zhang et al. create an oscillator circuit that can be orthogonally controlled by two inducers in Escherichia coli and by systematically tuning the concentration of the inducers, the amplitude and period can be modulated independently. This design allows the oscillator to be modularized and used in more complex circuit designs, which can be a valuable contribution to the Synthetic Biology field.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biophysics
Bowen Li, Mei Wang, Yuhua Liu, Yongsheng Zhou, Lin Tang, Pengyue You, Yi Deng
Summary: The osteogenesis of SIS scaffolds was enhanced through structural optimization and resveratrol functionalization. SIS scaffolds with a fabrication concentration of 1% showed superior osteogenic properties. Covalent immobilization of RSV onto SIS scaffolds improved their osteogenic properties. In vivo experiments demonstrated enhanced vascular and new bone tissue formation with RSV/SIS scaffolds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Cell Biology
Tao Liu, Wan Xiang, Zhizhuang Chen, Gang Wang, Rui Cao, Fenfang Zhou, Zhe Meng, Yongwen Luo, Liang Chen
Summary: This study found that hypoxia is elevated in ccRCC and may be an independent risk factor for prognosis in ccRCC patients. The study also revealed that PLOD2 is transcriptionally activated by HIF1A, interacts with EGFR, and ultimately promotes the malignant progression of ccRCC by activating the AKT signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Wen Wang, Dandan Li, GuiRong Quan, Xuefei Wang, Zhumei Xi
Summary: This study showed that removing 4 leaves above the cluster (LR2) significantly increased reducing sugar, soluble sugar, total anthocyanin, and citric acid contents in grape berries during ripening, and enhanced the transcript abundance of most sugar unloading-related genes at harvest. Genes such as VvHT3, VvHT5, VvSUC11, VvSUC12, VvSS, and VvcwINV were positively correlated with both reducing sugar and soluble sugar contents, indicating their role in hexose accumulation in grape berries.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Horticulture
Ziwen Su, Juan Yan, Binbin Zhang, Meng Sun, Zhixiang Cai, Zhijun Shen, Ruijuan Ma, Mingliang Yu
Summary: Bagging is a crucial cultivation measure that affects the quality of peach fruit by regulating exposure to light. This study investigated the effects of bagging on the content of phenolic compounds in peach fruit and identified the most sensitive compounds to bagging treatment. The study also explored the regulatory role of bagging on phenolic synthetic-related genes. The results showed that bagging affected the accumulation of different phenolics in different peach cultivars and light intensity played a significant role in the accumulation of anthocyanins and other phenolic substances in peach fruit. Additionally, the expression of structural genes and transcription factors related to phenolic synthesis was regulated by bagging and light conditions. These findings provide a foundation for understanding the regulation mechanism of light on the synthesis of phenolic compounds in peach fruit.
SCIENTIA HORTICULTURAE
(2024)
Article
Environmental Sciences
Kirill Azarin, Alexander Usatov, Tatiana Minkina, Andrey Plotnikov, Alexandra Kasyanova, Aleksei Fedorenko, Nadezhda Duplii, Evgeniy Vechkanov, Vishnu D. Rajput, Saglara Mandzhieva, Saud Alamri
Summary: The study compared the effects of bulk and nano-ZnO on barley seedlings and found dose-dependent reduction in root and shoot length and weight, as well as Zn accumulation in plant parts. The antioxidant defense system was activated to prevent oxidative stress, but constant exposure to high concentrations of ZnO depleted the plant's energy resources, negatively impacting growth and development. The results could be useful in predicting risks associated with the further transfer of nano-ZnO to the environment.
Article
Plant Sciences
Yao Cheng, Hanbing Liu, Xuejiao Tong, Zaimin Liu, Xin Zhang, Yingtong Chen, Fengzhi Wu, Xinmei Jiang, Xihong Yu
Summary: The study found that shading had a significant impact on the growth, antioxidant enzyme activity, araloside content, and related gene expression of Aralia elata plants. The optimal growth and leaf biomass were achieved under 40% shading conditions. Overall, optimizing field growing conditions is crucial for obtaining the highest yield of bioactive components, which may be part of a defense response.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Agronomy
Xiaoxi Guan, Changling Sui, Kecui Luo, Zhifeng Chen, Chaoyang Feng, Xiufen Dong, Boping Zeng, Xian Dong, Xiaofang Liu
Summary: In this study, the effect of exogenous auxin on cadmium stress in tomato plants was investigated. The results showed that NAA improved root growth and enhanced antioxidant enzyme activities, reducing oxidative damage caused by cadmium. Transcriptome analysis revealed that NAA activated a large number of genes related to defense response and response to auxin in shoots and roots, suggesting that NAA-mediated response to cadmium stress involves the regulation of defense response genes and oxidoreductase activity in shoots and roots.
Article
Multidisciplinary Sciences
Evangeline M. Foster, Marco Fernandes, Adria Dangla-Valls, Philip Hublitz, Menelaos Pangalos, Simon Lovestone, Elena M. Ribe, Noel J. Buckley
Summary: This study identifies the important role of glycosylated CLU in facilitating Aβ toxicity in human neurons. The loss of these proteins reduces both cell death and neurite damage, which are key consequences of Aβ toxicity in Alzheimer's disease. Transcriptome analysis also reveals the downregulation of extracellular matrix-related genes in CLU exon 2 -/- neurons.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Siying Zhang, Zhonghui Qiao, Zihan Zhao, Jiao Guo, Kaiwen Lu, Kevin H. Mayo, Yifa Zhou
Summary: The study compared the polysaccharides derived from mycelium and culture of Penicillium oxalicum, revealing differences in chemical structures and inhibitory effects on galectins. These findings provide insights into the structure-activity relationships of polysaccharides as galectin inhibitors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Clinical Neurology
Jonathan Voeglein, Nicolai Franzmeier, John C. Morris, Marianne Dieterich, Eric McDade, Mikael Simons, Oliver Preische, Anna Hofmann, Jason Hassenstab, Tammie L. Benzinger, Anne Fagan, James M. Noble, Sarah B. Berman, Neill R. Graff-Radford, Bernardino Ghetti, Martin R. Farlow, Jasmeer P. Chhatwal, Stephen Salloway, Chengjie Xiong, Celeste M. Karch, Nigel Cairns, Richard J. Perrin, Gregory Day, Ralph Martins, Raquel Sanchez-Valle, Hiroshi Mori, Hiroyuki Shimada, Takeshi Ikeuchi, Kazushi Suzuki, Peter R. Schofield, Colin L. Masters, Alison Goate, Virginia Buckles, Nick C. Fox, Patricio Chrem, Ricardo Allegri, John M. Ringman, Igor Yakushev, Christoph Laske, Mathias Jucker, Gunter Hoglinger, Randall J. Bateman, Adrian Danek, Johannes Levin
Summary: Autosomal dominant Alzheimer's disease (ADAD) has distinct neurological examination findings that are useful for estimating prognosis and guiding clinical care and therapeutic trial designs.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Patrick H. Luckett, Charlie Chen, Brian A. Gordon, Julie Wisch, Sarah B. Berman, Jasmeer P. Chhatwal, Carlos Cruchaga, Anne M. Fagan, Martin R. Farlow, Nick C. Fox, Mathias Jucker, Johannes Levin, Colin L. Masters, Hiroshi Mori, James M. Noble, Stephen Salloway, Peter R. Schofield, Adam M. Brickman, William S. Brooks, David M. Cash, Michael J. Fulham, Bernardino Ghetti, Clifford R. Jack, Jonathan Voeglein, William E. Klunk, Robert Koeppe, Yi Su, Michael Weiner, Qing Wang, Daniel Marcus, Deborah Koudelis, Nelly Joseph-Mathurin, Lisa Cash, Russ Hornbeck, Chengjie Xiong, Richard J. Perrin, Celeste M. Karch, Jason Hassenstab, Eric McDade, John C. Morris, Tammie L. S. Benzinger, Randall J. Bateman, Beau M. Ances
Summary: This study analyzed 19 biomarkers of Alzheimer's disease using hierarchical clustering and feature selection, and found that amyloid and tau measures were the primary predictors. Emerging biomarkers of neuronal integrity and inflammation showed weaker predictive ability.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Antoinette O'Connor, Emily Abel, Andrea Lessa Benedet, Teresa Poole, Nicholas Ashton, Philip Simon John Weston, Amanda J. Heslegrave, Natalie Ryan, Suzie Barker, James M. Polke, Kaj Blennow, Henrik Zetterberg, Nick C. Fox
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric McDade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen
Summary: This study found that plasma GFAP levels increase a decade before symptom onset in AD and are associated with Aβ load, neurodegeneration, and cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Antoinette O'Connor, Helen Rice, Josephine Barnes, Natalie S. Ryan, Kathy Y. Liu, Ricardo Francisco Allegri, Sarah Berman, John M. Ringman, Carlos Cruchaga, Martin R. Farlow, Jason Hassenstab, Jae-Hong Lee, Richard J. Perrin, Chengjie Xiong, Brian Gordon, Allan Levey, Alison Goate, Neil Graff-Radford, Johannes Levin, Mathias Jucker, Tammie Benzinger, Eric McDade, Hiroshi Mori, James M. Noble, Peter R. Schofield, Ralph N. Martins, Stephen Salloway, Jasmeer Chhatwal, John C. Morris, Randall Bateman, Rob Howard, Suzanne Reeves, Nick C. Fox
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biology
Peter R. Millar, Brian A. Gordon, Patrick H. Luckett, Tammie L. S. Benzinger, Carlos Cruchaga, Anne M. Fagan, Jason J. Hassenstab, Richard J. Perrin, Suzanne E. Schindler, Ricardo F. Allegri, Gregory S. Day, Martin R. Farlow, Hiroshi Mori, Georg Nuebling, Randall J. Bateman, John C. Morris, Beau M. Ances
Summary: Estimates of 'brain-predicted age' quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic Alzheimer disease (AD) but has not been well explored in presymptomatic AD. Prior studies have typically modeled BAG with structural MRI, but more recently other modalities, including functional connectivity (FC) and multimodal MRI, have been explored.
Article
Clinical Neurology
Ellen Grober, Kellen K. Petersen, Richard B. Lipton, Jason Hassenstab, John C. Morris, Brian A. Gordon, Ali Ezzati
Summary: This study used the SOMI system to identify individuals with subtle cognitive impairment among those who appear to be cognitively normal. The results showed that participants with retrieval impairment (SOMI-1) had a higher incidence of cognitive impairment, and the risk increased even more for those with storage impairment (SOMI-3/4), after adjusting for demographics and APOE ε4 status. Additionally, the study found that SOMI remained a significant predictor of incident cognitive impairment even after considering biomarkers of β-amyloid, tau pathology, and neurodegeneration.
Article
Clinical Neurology
Rebecca E. Green, Jodie Lord, Marzia A. Scelsi, Jin Xu, Andrew Wong, Sarah Naomi-James, Alex Handy, Lachlan Gilchrist, Dylan M. Williams, Thomas D. Parker, Christopher A. Lane, Ian B. Malone, David M. Cash, Carole H. Sudre, William Coath, David L. Thomas, Sarah Keuss, Richard Dobson, Cristina Legido-Quigley, Nick C. Fox, Jonathan M. Schott, Marcus Richards, Petroula Proitsi
Summary: By analyzing the associations between blood metabolites and brain volume, hippocampal volume, and amyloid-beta status among the participants of Insight 46, this study identifies key metabolites related to brain health and preclinical pathology, providing insights into early disease mechanisms and potential intervention strategies.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Antoinette O'Connor, David M. Cash, Teresa Poole, Pawel J. Markiewicz, Maggie R. Fraser, Ian B. Malone, Jieqing Jiao, Philip S. J. Weston, Shaney Flores, Russ Hornbeck, Eric McDade, Michael Schoell, Brian A. Gordon, Randall J. Bateman, Tammie L. S. Benzinger, Nick C. Fox
Summary: Cortical tau accumulation is a crucial pathological event in Alzheimer's disease, and understanding the timing and pattern of tau deposition can help track the disease progression. This study used data from participants in AD cohort studies to investigate if tau PET can detect early changes in presymptomatic carriers and found that there were regional differences in tau accumulation prior to symptom onset, particularly in posterior regions.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Editorial Material
Clinical Neurology
Christopher R. S. Belder, Jonathan M. Schott, Nick C. Fox
Article
Biochemistry & Molecular Biology
Erik C. B. Johnson, Shijia Bian, Rafi U. Haque, E. Kathleen Carter, Caroline M. Watson, Brian A. Gordon, Lingyan Ping, Duc M. Duong, Michael P. Epstein, Eric McDade, Nicolas R. Barthelemy, Celeste M. Karch, Chengjie Xiong, Carlos Cruchaga, Richard J. Perrin, Aliza P. Wingo, Thomas S. Wingo, Jasmeer P. Chhatwal, Gregory S. Day, James M. Noble, Sarah B. Berman, Ralph Martins, Neill R. Graff-Radford, Peter R. Schofield, Takeshi Ikeuchi, Hiroshi Mori, Johannes Levin, Martin Farlow, James J. Lah, Christian Haass, Mathias Jucker, John C. Morris, Tammie L. S. Benzinger, Blaine R. Roberts, Randall J. Bateman, Anne M. Fagan, Nicholas T. Seyfried, Allan Levey
Summary: Alzheimer's disease pathology, characterized by aggregation of Aβ peptide into plaques and tau protein into neurofibrillary tangles, develops years before cognitive symptoms. By analyzing cerebrospinal fluid proteomics in individuals with autosomal dominant AD, researchers identified protein changes associated with Aβ plaques and their temporal evolution over six decades. These proteomic measurements were able to differentiate mutation carriers from noncarriers before symptom onset better than traditional Aβ and tau measures. Understanding the multifaceted landscape of AD pathology and its progression is crucial for developing precise therapeutic interventions and biomarkers.
Article
Neurosciences
Nicole S. McKay, Brian A. Gordon, Russ C. Hornbeck, Aylin Dincer, Shaney Flores, Sarah J. Keefe, Nelly Joseph-Mathurin, Clifford R. Jack, Robert Koeppe, Peter R. Millar, Beau M. Ances, Charles D. Chen, Alisha Daniels, Diana A. Hobbs, Kelley Jackson, Deborah Koudelis, Parinaz Massoumzadeh, Austin McCullough, Michael L. Nickels, Farzaneh Rahmani, Laura Swisher, Qing Wang, Ricardo F. Allegri, Sarah B. Berman, Adam M. Brickman, William S. Brooks, David M. Cash, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Christian la Fougere, Nick C. Fox, Michael Fulham, Bernardino Ghetti, Neill Graff-Radford, Takeshi Ikeuchi, William Klunk, Jae-Hong Lee, Johannes Levin, Ralph Martins, Colin L. Masters, Jonathan McConathy, Hiroshi Mori, James Noble, Gerald Reischl, Christopher Rowe, Stephen Salloway, Raquel Sanchez-Valle, Peter R. Schofield, Hiroyuki Shimada, Mikio Shoji, Yi Su, Kazushi Suzuki, Jonathan Voeglein, Igor Yakushev, Carlos Cruchaga, Jason Hassenstab, Celeste Karch, Eric McDade, Richard J. Perrin, Chengjie Xiong, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger
Summary: The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration that studies autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations in three genes. Non-carrier siblings from ADAD families can be recruited for case-control studies. The predictable age of onset in ADAD allows for mapping candidate AD biomarkers during the preclinical phase. This study provides valuable data for understanding early disease stages of both ADAD and sporadic AD, as well as for research in healthy aging.
NATURE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Sarah-Naomi James, Emily N. Manning, Mathew Storey, Jennifer M. Nicholas, William Coath, Sarah E. Keuss, David M. Cash, Christopher A. Lane, Thomas Parker, Ashvini Keshavan, Sarah M. Buchanan, Aaron Wagen, Mathew Harris, Ian Malone, Kirsty Lu, Louisa P. Needham, Rebecca Street, David Thomas, John Dickson, Heidi Murray-Smith, Andrew Wong, Tamar Freiberger, Sebastian J. Crutch, Nick C. Fox, Marcus Richards, Frederik Barkhof, Carole H. Sudre, Josephine Barnes, Jonathan M. Schott
Summary: This study investigates the associations between normal-appearing white matter microstructural integrity, brain health, cognition, demographics, genetics, and cardiovascular health in cognitively normal adults in their seventies. The results show that measures of brain health, cognition, demographics, genetics, and cardiovascular health are associated with the microstructural integrity of normal-appearing white matter. Additionally, sex, blood pressure, and cardiovascular health in females were found to have an impact on white matter integrity.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
William Coath, Marc Modat, M. Jorge J. Cardoso, Pawel J. A. Markiewicz, Christopher A. D. Lane, Thomas D. Parker, Ashvini M. Keshavan, Sarah M. E. Buchanan, Sarah E. J. Keuss, Matthew J. Harris, Ninon Burgos, John Dickson, Anna L. Barnes, David L. Thomas, Daniel B. Beasley, Ian B. Malone, Andrew Wong, Kjell A. Erlandsson, Benjamin A. Thomas, Michael Scholl, Sebastien Ourselin, Marcus C. Richards, Nick C. M. Fox, Jonathan M. M. Schott, David M. Cash
Summary: The Centiloid scale aims to harmonize Aβ PET measures across different analysis methods. This study investigated the Centiloid transformation with PET/MRI data, finding that the transformation is valid but further understanding of the effects of acquisition or biological factors on using white matter as a reference is needed.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Article
Clinical Neurology
Julie K. K. Wisch, Ganesh M. Babulal, Kalen Petersen, Peter R. R. Millar, Enbal Shacham, Stephen Scroggins, Anna H. H. Boerwinkle, Shaney Flores, Sarah Keefe, Brian A. A. Gordon, John C. C. Morris, Beau M. M. Ances
Summary: This article presents a practical guide for applying geospatial methods to a neuroimaging cohort, aiming to evaluate the impact of the environment on the brain. The authors used structural magnetic resonance imaging data from 239 city-dwelling participants in St. Louis, Missouri, and compared them to population-level estimates from the American Community Survey to identify neighborhoods associated with altered brain structure. They observed a relationship between neighborhoods and brain health, suggesting the potential for neighborhood-based interventions.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)