Article
Cell Biology
Ruixue Ai, Xu-Xu Zhuang, Alexander Anisimov, Jia-Hong Lu, Evandro F. Fang
Summary: Recognition and clearance of damaged mitochondria are crucial for maintaining brain health and preventing Alzheimer's disease. A study has identified two potential compounds, kaempferol and rhapontigenin, that can induce mitophagy and reduce Alzheimer's-related pathologies in animal models. This research provides a promising approach for developing therapeutic interventions for Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Ye Jian, Shunling Yuan, Jialun Yang, Yong Lei, Xuan Li, Wenfeng Liu
Summary: Abnormalities in autophagy are associated with Alzheimer's disease, and exercise can improve this condition by activating the AdipoR1/AMPK/TFEB signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jinman Liu, Xue Zuo, Mingjun Huang, Jiansong Fang, Weirong Li, Qing Shi, Qi Wang, Yong Liang
Summary: This study investigates the potential effects of Gomisin B on cognitive dysfunction in APP/PS1 transgenic mice and finds that it significantly improves cognitive function. The simultaneous administration of OST and Gomisin B shows enhanced therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Sandra Espinoza, Felipe Grunenwald, Wileidy Gomez, Felipe Garcia, Lorena Abarzua-Catalan, Sebastian Oyarce-Pezoa, Maria Fernanda Hernandez, Bastian Cortes, Markus Uhrig, Daniela P. Ponce, Claudia Duran-Aniotz, Claudio Hetz, Carol D. SanMartin, Victor H. Cornejo, Fernando Ezquer, Valentina Parra, Maria Isabel Behrens, Patricio A. Manque, Diego Rojas-Rivera, Rene L. Vidal, Ute Woehlbier, Melissa Nassif
Summary: This study investigated the cell-specific expression of Rubicon in postmortem brain samples from AD patients and 5xFAD mice and its impact on amyloid beta burden. Increased Rubicon levels were found in AD-hiPSCs and postmortem samples. In AD transgenic mice lacking Rubicon, intensified amyloid beta burden was observed. In neuroblastoma cells, the absence of Rubicon led to increased APP/amyloid beta secretion.
Article
Medicine, Research & Experimental
Xuerui Wang, Zequn Yin, Peichang Cao, Shihong Zheng, Yuanli Chen, Maoyun Yu, Chenzhong Liao, Zhongyuan Zhang, Yajun Duan, Jihong Han, Shuang Zhang, Xiaoxiao Yang
Summary: Alzheimer's disease (AD) is the most common neurodegenerative disease in aging population. The traditional Chinese medicine NaoXinTong Capsule (NXT) has been shown to improve spatial memory impairment and cognitive decline in AD mice by reducing p-Tau levels and A beta accumulation in the brain. This neuroprotective effect is achieved by inhibiting inflammatory cytokines and mediators, thereby suggesting the potential application of NXT for AD treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Qiqi Xin, Weili Shi, Yan Wang, Rong Yuan, Yu Miao, Keji Chen, Weihong Cong
Summary: The study demonstrates that Pantao Pill (PTP) significantly improves cognitive impairment by regulating autophagy, apoptosis, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Fengjin Hao, Yueqin Feng
Summary: This study demonstrated that CBD may improve the pathological process of Alzheimer's disease by enhancing immune system response and autophagy pathway, as shown through transcriptome sequencing.
Review
Neurosciences
Parul Goel, Sasanka Chakrabarti, Kapil Goel, Karanpreet Bhutani, Tanya Chopra, Sharadendu Bali
Summary: Regulated cell death (RCD) is an ordered set of changes in gene expression and protein activity that plays a crucial role in normal development and tissue homeostasis. In Alzheimer's disease (AD), a neurodegenerative disease, aberrant activation of RCD pathways results in pathological changes and cell death. This review explores the process of RCD, its dysregulation in response to different stressors, and its role in the pathogenesis of AD, including the correlation with amyloid-beta and Tau proteins.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Rong Jiang, Xiao-Dong Chi, Yulong Jing, Bin Wang, Shao Li
Summary: This study investigated the effect of NgR in the perforant path on neuronal morphology and function in APP/PS1 transgenic mice. The results showed that reducing NgR expression improved damaged morphology and decreased neuronal numbers in APP/PS1 mice, and also enhanced dendritic complexity and postsynaptic protein density. The downregulation of M1 phenotypes of microglial gene expression in the hippocampus of TG-shNgR mice suggests that NgR plays a critical role in microglial phenotype polarization.
Article
Neurosciences
Francesca E. Mowry, Francisco Espejo-Porras, Shijie Jin, Zainuddin Quadri, Limin Wu, Marcela Bertolio, Rachel Jarvis, Caroline Reynolds, Rashed Alananzeh, Erhard Bieberich, Yongjie Yang
Summary: This study found that elevated levels of ceramide, a sphingolipid, in AD patients may contribute to the sex-specific differences in amyloid pathology. Chronic inhibition of nSMase had a greater impact on female AD mice, reducing amyloid pathology and improving cognitive function. These findings suggest that ceramide and exosome pathways play a crucial role in the progression of female-specific amyloid pathology in AD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Mei Wang, Chao-qun Zhu, Ling Zeng, Lin Cheng, Ling Ma, Ming Zhang, Yuan-zhen Zhang
Summary: SIRT3 acts as a pivotal protective factor in testicular Leydig cells injury, and melatonin regulates the cross-talk between autophagy and apoptosis by SIRT3, ameliorating cadmium-induced testicular injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yang Liu, Wen Guo, Si-Lu Hong
Summary: This study found that aerobic exercise can improve neuronal apoptosis and spatial memory in aging mice, and its mechanism may be related to the regulation of the DAPK1 pathway.
Article
Multidisciplinary Sciences
Luming Zhou, Guiping Kong, Ilaria Palmisano, Maria Teresa Cencioni, Matt Danzi, Francesco De Virgiliis, Jessica S. Chadwick, Greg Crawford, Zicheng Yu, Fred De Winter, Vance Lemmon, John Bixby, Radhika Puttagunta, Joost Verhaagen, Constandina Pospori, Cristina Lo Celso, Jessica Strid, Marina Botto, Simone Di Giovanni
Summary: Aging is associated with increased prevalence of axonal injuries, and the underlying mechanisms remain unclear. This study found that T cell signaling is enriched in mice before and after sciatic nerve injury (SNI), and this signaling promotes immune cell recruitment and axonal injury through the activation of specific proteins. Inhibition of T cell recruitment facilitates axonal regeneration.
Article
Immunology
Jiawei Zhang, Yaling Zheng, Yao Zhao, Yaxuan Zhang, Yu Liu, Fang Ma, Xiuzhe Wang, Jianliang Fu
Summary: Andrographolide can significantly alleviate cognitive impairments, reduce amyloid-β deposition, inhibit microglial activation, and decrease the secretion of proinflammatory factors in APP/PS1 mice. Furthermore, transcriptome sequencing analysis revealed that Andro could significantly decrease the expression of various genes associated with inflammation in APP/PS1 mice, which was further validated by qRT-PCR. Our results suggest that Andro might be a potential therapeutic drug for AD by regulating neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Nenad Bogdanovic, Per Nilsson
Summary: Alzheimer's disease is characterized by impaired protein homeostasis leading to amyloid-beta peptide amyloidosis. In this study, the researchers compared AD postmortem brain tissue with brains from App knock-in mice and found that p62 levels were increased in both. Additionally, the App knock-in mice exhibited inhibited autophagy, especially when A beta pathology was increased. These findings suggest that the App knock-in mouse models can help understand the correlation between A beta and autophagy.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Developmental Biology
M. A. Gilbert, B. Lin, J. Peterson, W. Jang, J. E. Schwob
GENE EXPRESSION PATTERNS
(2015)
Article
Multidisciplinary Sciences
Nikolai Schnittke, Daniel B. Herrick, Brian Lin, Jesse Peterson, Julie H. Coleman, Adam I. Packard, Woochan Jang, James E. Schwob
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Review
Neurosciences
James E. Schwob, Woochan Jang, Eric H. Holbrook, Brian Lin, Daniel B. Herrick, Jesse N. Peterson, Julie Hewitt Coleman
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Virology
Jesse N. Peterson, Brian Lin, Jong Shin, Paul J. Phelan, Philip Tsichlis, James E. Schwob, Peter A. Bullock
JOURNAL OF VIROLOGY
(2017)
Article
Multidisciplinary Sciences
Daniel B. Herrick, Brian Lin, Jesse Peterson, Nikolai Schnittke, James E. Schwob
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Geriatrics & Gerontology
Yuanxin Chen, Victor V. Dyakin, Craig A. Branch, Babak Ardekani, Dunsheng Yang, David N. Guilfoyle, Jesse Peterson, Corrinne Peterhoff, Stephen D. Ginsberg, Anne M. Cataldo, Ralph A. Nixon
NEUROBIOLOGY OF AGING
(2009)
Article
Cell & Tissue Engineering
Elena H. Chartoff, Diane Damez-Werno, Kai C. Sonntag, Linda Hassinger, Daniel E. Kaufmann, Jesse Peterson, Donna McPhie, Anne M. Cataldo, Bruce M. Cohen
STEM CELLS INTERNATIONAL
(2011)
Article
Neurosciences
Julie H. Coleman, Brian Lin, Jonathan D. Louie, Jesse Peterson, Robert P. Lane, James E. Schwob
JOURNAL OF NEUROSCIENCE
(2019)
Article
Cell & Tissue Engineering
Jesse Peterson, Brian Lin, Camila M. Barrios-Camacho, Daniel B. Herrick, Eric H. Holbrook, Woochan Jang, Julie H. Coleman, James E. Schwob
Article
Cell & Tissue Engineering
Brian Lin, Julie H. Coleman, Jesse N. Peterson, Matthew J. Zunitch, Woochan Jang, Daniel B. Herrick, James E. Schwob