Review
Otorhinolaryngology
Tengku Mohamed Izam Tengku Kamalden, Khairunnisak Misron
Summary: This study evaluates the clinical trends and radiological stratification of malignant otitis externa (MOE) using HRCT and TPBS. Most patients were found to be in Phase III (36.7%), followed by Phase V (24.5%), Phase II (18.4%), Phase IV (16.3%), and Phase I (4.1%). A treatment algorithm was developed based on the institution's experience, with a low mortality rate mainly in advanced phases of the disease (Phases IV and V).
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Adi Brenner, Oren Cavel, Genady Shendler, Michal Dekel, Ophir Handzel, Rani Abu Eta, Yahav Oron, Nidal Muhanna, Omer J. Ungar
Summary: This study aimed to identify the earliest sites and spread patterns of bony erosions in skull base osteomyelitis and correlate the radiological findings with clinical/laboratory data. The study found that edema and irregularity or dehiscence of the anterior external auditory canal wall were the most common early CT findings associated with skull base osteomyelitis caused by malignant otitis externa.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Otorhinolaryngology
Jose Luis Trevino Gonzalez, Laura Lisset Reyes Suarez, Jesus Eduardo Hernandez de Leon
Summary: Malignant otitis externa is an infection affecting the external auditory canal and skull base, most commonly caused by Pseudomonas aeruginosa in diabetic, elderly, and immunocompromised individuals. Clinical manifestations include persistent ear pain, chronic otorrhea, and facial nerve palsy. Diagnosis involves CT scan and Technetium-99m, while treatment requires individualized approach and strict diabetes control, with surgical management recommended for refractory cases.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanna E. Vuohijoki, Christopher J. Constable, Antti O. Sohlberg
Summary: Bone single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging can be improved by using anatomical information derived from CT imaging during SPECT reconstruction. This study compared two anatomically guided SPECT reconstruction methods (AMAP and KEM) with the commonly used OSEM method in terms of lesion quantitation and detectability. The accuracy and detectability were significantly better with AMAP and KEM compared to OSEM at all contrast levels. The differences between AMAP and KEM were minimal and likely clinically insignificant.
NUCLEAR MEDICINE COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhe Wen, Hongming Zhuang, Jigang Yang
Summary: The purpose of this study was to determine if the image acquisition time for the salivagram can be shortened without significantly reducing the sensitivity in detecting aspiration. It was found that evidence of aspiration could be detected within the first 40 minutes of dynamic imaging, therefore the originally described 60-minute protocol can be safely shortened to 40 or even 30 minutes.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Masaya Kawaguchi, Hiroki Kato, Yoshifumi Noda, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Fuminori Hyodo, Masayuki Matsuo
Summary: Accurate preoperative diagnosis is crucial for malignant skin tumors (MSTs) due to the different clinical management required for each histological subtype. Radiological imaging plays a significant role in evaluating the extent of local invasion, nodal involvement, and distant metastasis in MSTs. Recent studies have identified characteristic radiological features that aid in the differential diagnosis of MSTs, such as configuration, intratumoral homogeneity, signal intensity, cyst formation, and hemorrhage. Clinical data, including age, gender, and site of occurrence, are also important for determining the histological subtype of MSTs.
INSIGHTS INTO IMAGING
(2022)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Krystyna Pyrzynska, Krzysztof Kilian, Mateusz Pegier
Summary: This paper provides a brief overview of the application of porphyrin ligands in tumor diagnostics, including the chelation of metallic radioisotopes to form radiopharmaceuticals and the evaluation of metabolic changes in the human body through SPECT and PET. The chelation reactions are discussed in terms of the conditions, kinetics, and complex stability.
Article
Radiology, Nuclear Medicine & Medical Imaging
Haytham Derbel, Mahdi Krichen, Julia Chalaye, Laetitia Saccenti, William van der Sterren, Anne-Hilde Muris, Lionel Lerman, Athena Galletto, Youssef Zaarour, Alain Luciani, Hicham Kobeiter, Vania Tacher
Summary: This study evaluated the anatomical and volumetric predictability of CBCT-based VPP software for SPECT/CT imaging results in HCC patients undergoing TARE. The results showed that the CBCT-based VPP software accurately and reliably predicted the anatomical and volumetric results of Tc-99m-MAA SPECT/CT in HCC patients during TARE.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Nasim Vahidfar, Saeed Farzanefar, Hojjat Ahmadzadehfar, Eoin N. Molloy, Elisabeth Eppard
Summary: This literature review provides a brief overview of the role of nuclear medicine in the diagnosis of obstetric and gynecological cancers. Nuclear medicine has proven to be reliable in diagnostic imaging in nuclear medicine and cancer treatment. [F-18]FDG PET/CT imaging plays a crucial role in investigating gynecological cancer.
Article
Medicine, Research & Experimental
Soon Young Kwon, Kyung Ju Chun, Hong Kwon Kil, Kyoung Ho Oh, Chulhan Kim, Su Jin Jang, Min-Su Km
Summary: This study evaluated the clinical efficacy and safety of botulinum toxin (BTX) injection for chronic parotitis, showing initial improvement in symptoms at 1 month post-injection, but a slight increase at 6 months. However, all subjective symptoms were determined to be better than before injection at the 6-month mark.
Article
Medicine, General & Internal
Ikuya Miyamoto, Ryoichi Tanaka, Shintaro Kogi, Genki Yamaya, Tadashi Kawai, Yu Ohashi, Noriaki Takahashi, Mitsuru Izumisawa, Hiroyuki Yamada
Summary: Radiation therapy plays a significant role in managing head and neck malignancies. Osteoradionecrosis (ORN) can occur as a complication, characterized by bone marrow sclerosis and bone resorption, leading to chronic trismus and pathological fractures. Neurological symptoms may indicate tumor recurrence, but diagnostic imaging is challenging.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Filippo Cademartiri, Antonella Meloni, Laura Pistoia, Giulia Degiorgi, Alberto Clemente, Carmelo De Gori, Vincenzo Positano, Simona Celi, Sergio Berti, Michele Emdin, Daniele Panetta, Luca Menichetti, Bruna Punzo, Carlo Cavaliere, Eduardo Bossone, Luca Saba, Riccardo Cau, Ludovico La Grutta, Erica Maffei
Summary: The photon-counting detector (PCD) is a new technology that provides significant benefits for cardiac and coronary artery imaging. Compared with conventional CT, PCCT has improved capabilities such as multi-energy capability, increased spatial resolution, reduced radiation exposure, and optimized use of contrast agents. It also overcomes limitations of traditional CCT/CCTA, such as reducing artifacts and enabling more precise assessment of stenosis and plaque characteristics. PCCT also has potential applications in characterizing myocardial tissue using a double-contrast agent.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
JiaQian Shi, Hang Wu, Zheng Dong, XianXian Liang, QuanHui Liu, Wusheng Zhu, ChangSheng Zhou, MengJie Lu, Jia Liu, XiaoQin Su, GuangMing Lu, XiaoQing Cheng
Summary: The study showed that ASPECTS-NWU is a quantitative predictor of malignant cerebral edema after large-vessel occlusion. CTA-ASPECTS-NWU performed better than NECT-ASPECTS-NWU and was independently predictive of MCE with a higher AUC. A multivariable logistic regression model incorporating CTA-ASPECTS-NWU, collateral score, and age demonstrated the predictive power of CTA-ASPECTS-NWU for MCE.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taisuke Murata, Hajime Yokota, Ryuhei Yamato, Takuro Horikoshi, Masato Tsuneda, Ryuna Kurosawa, Takuma Hashimoto, Joji Ota, Koichi Sawada, Takashi Iimori, Yoshitada Masuda, Yasukuni Mori, Hiroki Suyari, Takashi Uno
Summary: This study developed a deep learning-based approach using NAC images and CTAC images for training to obtain accurate AC images in brain-perfusion SPECT. Experimental results showed that this approach had higher accuracy than conventional Chang's AC method.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-Hung Chen, Kai-Ping Chang, Sung-Chao Chu, Tzu-Chen Yen, Ling-Yi Wang, Joseph Tung-Chieh Chang, Cheng-Lung Hsu, Shu-Hang Ng, Shu-Hsin Liu, Sheng-Chieh Chan
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun-Han Lue, Yi-Feng Wu, Shu-Hsin Liu, Tsung-Cheng Hsieh, Keh-Shih Chuang, Hsin-Hon Lin, Yu -Hung Chen
ACADEMIC RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-Hung Chen, Hwa-Tsung Chen, Ming-Che Lee, Shu-Hsin Liu, Ling-Yi Wang, Kun-Han Lue, Sheng-Chieh Chan
ANNALS OF NUCLEAR MEDICINE
(2020)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yu-Hung Chen, Yung-Hsiang Hsu, Hwa-Tsung Chen, Bee-Song Chang, Shu-Hsin Liu
CLINICAL NUCLEAR MEDICINE
(2020)
Article
Multidisciplinary Sciences
Yu-Hung Chen, Tso-Fu Wang, Sung-Chao Chu, Chih-Bin Lin, Ling-Yi Wang, Kun-Han Lue, Shu-Hsin Liu, Sheng-Chieh Chan
Article
Medicine, General & Internal
Kun-Han Lue, Yi-Feng Wu, Hsin-Hon Lin, Tsung-Cheng Hsieh, Shu-Hsin Liu, Sheng-Chieh Chan, Yu-Hung Chen
Summary: This study found that the baseline F-18-FDG PET radiomic feature RLNGLRLM can independently predict survival outcomes in patients with diffuse large B-cell lymphoma (DLBCL). A prognostic stratification model based on this feature was proposed, which may help tailor therapeutic strategies for DLBCL patients.
Article
Medicine, General & Internal
Yu-Hung Chen, Sung-Chao Chu, Ling-Yi Wang, Tso-Fu Wang, Kun-Han Lue, Chih-Bin Lin, Bee-Song Chang, Dai-Wei Liu, Shu-Hsin Liu, Sheng-Chieh Chan
Summary: Total TLG and age were found to be independent risk factors for unfavorable survival outcomes in nodal metastatic NSCLC patients. Models based on independent prognosticators outperformed the AJCC staging system, suggesting potential for refining risk stratification and tailored therapeutic strategies in this patient group.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun-Han Lue, Sung-Chao Chu, Ling-Yi Wang, Yen-Chang Chen, Ming-Hsun Li, Bee-Song Chang, Sheng-Chieh Chan, Yu-Hung Chen, Chih-Bin Lin, Shu-Hsin Liu
Summary: In this study, the diagnostic value of F-18-FDG PET-derived features for predicting pathological lymph node metastasis in lung adenocarcinoma patients was evaluated. The primary tumor entropy and visual interpretation of regional nodes via F-18-FDG PET were found to independently predict pathological regional lymph node metastasis.
ANNALS OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Kun-Han Lue, Chun-Hou Huang, Tsung-Cheng Hsieh, Shu-Hsin Liu, Yi-Feng Wu, Yu-Hung Chen
Summary: This study aimed to explore the prognostic power of combining systemic inflammation markers and tumor glycolytic heterogeneity in stratifying patients with advanced EGFR-mutated lung adenocarcinoma. The results showed that the integrated model of these two biomarkers could be used to improve risk stratification and guide personalized treatment strategies for patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-Hung Chen, Yen-Chang Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Ling-Yi Wang, Ming-Hsun Li, Chih-Bin Lin
Summary: This study investigated the correlation between glycolytic heterogeneity and histopathology in resectable lung adenocarcinoma. The results showed that entropy significantly correlated with aggressive histopathological characteristics. Entropy-based models outperformed the traditional staging system in predicting survival outcomes, and provided further stratification in different tumor grades.
ANNALS OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-Hung Chen, Kun-Han Lue, Sung-Chao Chu, Bee-Song Chang, Chih-Bin Lin
Summary: This study investigated whether combining primary tumor and metastatic nodal glycolytic heterogeneity on F-18-FDG PET improves prognostic prediction in NSCLC with locoregional disease. The results showed that combined entropy and age independently predicted overall survival and progression-free survival. The models based on combined entropy outperformed the traditional staging system and showed prognostic value in different subgroups.
NUCLEAR MEDICINE COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun-Han Lue, Yu-Hung Chen, Yi-Feng Wu, Shu-Hsin Liu
Summary: This study investigated the influence of different dichotomization methods on the survival prediction of lymphoma patients based on total metabolic tumor volume (TMTV) measured from F-18-FDG PET. The results showed that the optimal TMTV cutoff point for predicting progression-free survival and overall survival varied among different dichotomization methods, but the prognostic significance of TMTV remained consistent.
NUCLEAR MEDICINE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yu-Hung Chen, Kun-Han Lue, Chih-Bin Lin, Kuang-Chi Chen, Sheng-Chieh Chan, Sung-Chao Chu, Bee-Song Chang, Yen-Chang Chen
Summary: This study found that the entropy-based radiogenomic features are more reliable than median-based features, and PET-based glycolytic entropy is insensitive to image matrix size change and significantly associated with tumor metabolic volume and cancer staging. These findings suggest that radiogenomic and glycolytic entropy can serve as ideal biomarkers for NSCLC research and clinical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Yu-Hung Chen, Shu-Hsin Liu, Ming-Che Lee, Hwa-Tsung Chen
JOURNAL OF NUCLEAR MEDICINE
(2019)
Article
Medicine, General & Internal
Ching-Chun Ho, Yu-Hung Chen, Shu-Hsin Liu, Hwa-Tsung Chen, Ming-Che Lee
TZU CHI MEDICAL JOURNAL
(2019)
Article
Otorhinolaryngology
Jason Lee, Alia Tayara, James D. Warren, Boris Kuyeb, Elizabeth McKee, Alexander Velazquez, Oishika Paul, Andrea F. Lewis
Summary: The purpose of the study was to understand the impact of COVID-19 on facial trauma incidence and etiology in Mississippi. The research found a significant increase in facial trauma caused by family members during the pandemic, which may be related to the reported increase in domestic violence. Additionally, there were notable changes in the etiology and insurance payor of facial trauma cases during the COVID-19 pandemic.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Sheila Moran, Cassidy Anderson, Risha Sheni, Monica Azmy, Daniel T. Li, Anthony M. Loizides, Christina J. Yang
Summary: This retrospective study found that a family history of eczema and a dairy-free diet may be associated with an increased risk of future diagnosis of EoE in children with aerodigestive dysfunction.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Robert Brinton Fujiki, Amanda Edith Fujiki, Susan L. Thibeault
Summary: This study examined the number of therapy sessions required for patients with EILO/ILO to sufficiently improve their symptoms. The results showed that patients with comorbid behavioral health diagnosis, higher vocal handicap index score, and reduced physical activity due to EILO/ILO symptoms required more therapy sessions. Patients with secondary environmental triggers also required more sessions. Only a small percentage of patients returned for additional therapy sessions after discharge, and they were mostly from affluent neighborhoods.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Brian W. Herrmann, Salina H. Goff, Juri Boguniewicz, Sarah A. Gitomer
Summary: This retrospective case series analyzed nHiB H. influenzae meningitis cases diagnosed at Children's Hospital Colorado from 2000 to 2020. The results showed that nHiB H. influenzae can cause both transient and permanent postmeningitic hearing loss. The use of steroids may offer otoprotection in nHiB H. influenzae meningitis. Further research is needed to better understand hearing outcomes after nHiB H. influenzae meningitis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
M. Kovacs, J. Uzsaly, G. Bodzai, I. Pap, B. Lippai, T. Dergez, A. Nemeth, I. Gerlinger, I. Szanyi, P. Bako
Summary: The pathophysiology and treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) are still debated. A randomized controlled trial showed no significant differences in hearing improvement between different treatments, but identified clinical factors such as vertigo, cardiovascular comorbidity, and initial hearing loss severity as significant predictors of hearing outcomes.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Roee Noy, Yotam Shkedy, Nadeem Habashi, Salem Billan, Jacob Cohen
Summary: Salvage cordectomy offers favorable larynx preservation rates and oncological outcomes for recurrent glottic cancer amenable to conservative surgery. Smoking, advanced age, and advanced tumor stages are associated with salvage cordectomy failure.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Pietro De Luca, Ignazio La Mantia, Federico Maria Gioacchini, Massimo Re, Marco Radici, Angelo Camaioni, Arianna Di Stadio
Summary: In this study, the effect of nasal packaging using Fitostimoline (R) gauze on nasal outcomes after septoplasty and FESS surgery was evaluated. The results showed that the use of Fitostimoline (R) gauze improved healing of nasal mucosa and reduced discomfort during tampon removal.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Anna Frants, Antonios N. Varelas, Alexa M. Franco, W. Matthew White, Minas S. Constantinides, Philip J. Miller, Judy W. Lee
Summary: This article introduces DESS as a new educational format to increase the comfort of residents with the surgical evaluation and intraoperative planning of rhinoplasty. Through DESS, residents display significant improvement in their comfort with facial nasal analysis and overall surgical preparation.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Zhengcai Lou, Zihan Lou, Tian Lv, Zhengnong Chen
Summary: This study compared the operation time, graft success, audiometric outcomes, and complications of the over-under technique using temporalis fascia and cartilage grafts for repairing large perforations. The results showed that both techniques had similar graft success rates and hearing outcomes, but the temporalis fascia graft technique prolonged the operation time and increased the risk of re-perforation and graft atelectasis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Ciaran Lane, Maxwell Wright, Janice Linton, Neerav Goyal
Summary: This study systematically reviewed the data on surgical closure of enlarged tracheoesophageal fistula after laryngectomy and compared different reconstruction techniques. The results showed that using vascularized tissue for reconstruction had a higher success rate compared to primary closure.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
John Q. Odom, Andrew R. Mangan, Anna Celeste Gibson, Michael Larson, John L. Dornhoffer, Robert A. Saadi
Summary: Granulomatosis with polyangiitis is often associated with otolaryngologic complaints, and in rare cases, patients may experience facial nerve palsy. It is important for healthcare professionals to recognize facial nerve palsy as a potential presentation of granulomatosis with polyangiitis.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
R. Bar, A. Mattei, R. Haddad, A. Giovanni
Summary: Office-based flexible interventional laryngoscopy under local anesthesia is a safe and well-tolerated procedure, suitable for various ambulatory and office-based settings.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Do Hyun Kim, Soo Whan Kim, Sung Won Kim, Gulnaz Stybayeva, Se Hwan Hwang
Summary: This systematic review and meta-analysis compared the effects of cryotherapy and radiofrequency neurolysis in treating rhinitis-related symptoms caused by ablation of the posterior nasal nerves. The results showed that both cryotherapy and radiofrequency neurolysis significantly improved rhinitis-related symptoms and quality of life. Radiofrequency neurolysis was found to be more effective than cryotherapy in reducing total nasal symptom scores.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Mengdie Gao, Liyu Cheng, Qingcui Wang, Qingwen Yang, Xiaoyi Wang, Yanru Li, Rong Hu, Wen Xu
Summary: This study investigates the clinical characteristics, diagnosis, and prognosis of patients with laryngeal tuberculosis (LTB) combined with respiratory tuberculosis. The study found that LTB commonly affects middle-aged men and presents with symptoms such as hoarseness, abnormal sensation of pharyngeal, and pharyngalgia. The lesions mainly involve multiple subregions, primarily the glottis, and can also involve the pharynx. Half of the patients were complicated with pulmonary tuberculosis (PTB), and chest CT was superior to X-ray in detecting pulmonary lesions. Most patients showed significant improvement in symptoms and morphology of the pharyngeal and laryngeal mucosa after regular anti-tuberculosis treatment.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Alfonso Scarpa, Emilio Avallone, Mario Carucci, Giovanni Salzano, Giuseppe Chiarella, Claudia Cassandro, Pasquale Viola, Filippo Ricciardiello, Massimo Ralli, Pietro De Luca, Francesco Antonio Salzano
Summary: This study assessed the efficacy and safety of low-dose intratympanic gentamicin for vertigo attacks in Meniere's disease. The treatment significantly reduced vertigo attacks without causing hearing deterioration. The method primarily affected vestibular function while preserving cochlear integrity. These findings suggest that a low-dose, clinical symptomatology-based gentamicin treatment regimen could be an effective and safe strategy for managing unilateral Meniere's disease.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2024)
