Article
Ophthalmology
Juliane Mehlan, Johannes Steinberg, Vasyl Druchkiv, Toam Katz, Stephan Johannes Linke
Summary: The study aims to explore intereye asymmetry in normal and keratoconic individuals and proposes using asymmetry parameters to improve the diagnosis of keratoconus. The results show that in addition to existing parameters, thickness, elevation, and high-order corneal wavefront asymmetry parameters can be used for diagnosis.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Matheus Ivan Schmitz Vieira, Alessandro Adad Jammal, Carlos Eduardo Leite Arieta, Monica Alves, Jose Paulo Cabral de Vasconcellos
Summary: This study compared corneal parameters and indices among healthy children, ocular allergy, and keratoconus using the OCULUS Pentacam Scheimpflug topography system. Differentiation was observed in terms of corneal parameters between the three groups, with certain parameters found to be useful for discriminating between different diseases.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Hyunmin Ahn, Na Eun Kim, Jae Lim Chung, Young Jun Kim, Ikhyun Jun, Tae-im Kim, Kyoung Yul Seo
Summary: An AI model using basic ophthalmologic examination results has the potential to recommend corneal topography for keratoconus.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Kaili Yang, Qi Fan, Liyan Xu, Yuwei Gu, Chenjiu Pang, Shengwei Ren
Summary: This study aimed to explore the characteristics of unilateral post-LASIK keratectasia (KE) and the accuracy of corneal tomographic and biomechanical parameters in detecting KE and distinguishing fellow eyes from control eyes. The results showed that the fellow eyes of patients with unilateral KE had significantly higher posterior evaluation (PE) values than control eyes, indicating a potential disease indicator. In addition, posterior radius of curvature, anterior evaluation, and Corvis biomechanical index-laser vision correction were sensitive indicators for distinguishing KE from control eyes. Therefore, long-term follow-up of patients after LASIK and vigilance for early KE are necessary.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Ophthalmology
Robert Herber, Janine Lenk, Lutz E. Pillunat, Frederik Raiskup
Summary: This study compares the repeatability and agreement of corneal parameters measured by swept-source optical coherence tomography (SS-OCT) and rotating Scheimpflug camera (RSC) in normal and keratoconus eyes. The results show that SS-OCT has highly repeatable measurements in both normal and keratoconus eyes, with better repeatability compared to RSC.
Article
Ophthalmology
Alexandra Bograd, Isabelle Himmel, Isabel B. Pfister, Theo G. Seiler, Beatrice E. Frueh, Christoph Tappeiner
Summary: The purpose of this study was to assess the feasibility and reliability of biometric measurements taken with the Eyestar 900 device in keratoconus eyes compared to the Pentacam HR and IOLMaster 700 devices. The results showed that the Eyestar 900 demonstrated high repeatability and good correlation with the other devices, particularly in terms of corneal topography and axial length measurements.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jianqin Shen, Huiyan Li, Yanhong Chen, Lan Liu, Hongguang Cui
Summary: This study investigated the impact of drooping eyelid on corneal topographic and tomographic alterations in patients with congenital ptosis. It found that the whole corneal contour is remodeled to be flatter in ptosis eyes, and the position of the upper eyelid is closely associated with corneal irregularity.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Omar M. Said, Mahmoud Kamal, Sara Tawfik, Ahmed Tamer Sayed Saif
Summary: This study compared the measurements of K, CCT, and TCT obtained by Optovue AS-OCT and Wavelight Oculyzer Pentacam HR in keratoconus (KC) eyes and normal eyes. The results showed significant differences between the two groups in terms of BCVA, intraocular pressure, and CCT. There were also significant differences in TCT measurements between the groups using Pentacam HR and AS-OCT. Both imaging techniques provided accurate identification of KC eyes and healthy ones, but there was a significant difference in K readings.
Article
Biotechnology & Applied Microbiology
Yiyong Xian, Yu Zhao, Ling Sun, Xiaoyu Zhang, Lan Ding, Zesheng Liu, Yuan Li, Yanlan Ding, Lin Jiang, Xingtao Zhou, Yang Shen
Summary: This study compared the differences in corneal biomechanics between keratoconus and normal eyes. It found that corneal biomechanical parameters differed between eyes with forme fruste keratoconus and normal eyes. Additionally, in the keratoconus group, bilateral differences in corneal biomechanical parameters were significantly increased, which may aid in the early detection of keratoconus.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Kitti Kormanyos, Klaudia Kovacs, Orsolya Nemeth, Gabor Toth, Gabor Laszlo Sandor, Anita Csorba, Cecilia Nora Czako, Laszlo Modis, Achim Langenbucher, Zoltan Zsolt Nagy, Gergely Varga, Laszlo Gopcsa, Gabor Mikala, Nora Szentmary
Summary: The study analyzed corneal stromal properties in subjects with monoclonal gammopathy using Pentacam and in vivo confocal cornea microscopy. The results showed that corneal light scattering and keratocyte hyperreflectivity were significantly higher in subjects with monoclonal gammopathy compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Shiva Mehravaran, Iman Dehzangi, Md Mahmudur Rahman
Summary: This study utilized a large number of Pentacam files from a population-based cohort to investigate elevation symmetry of the corneal surface. Using Python for data processing and machine learning algorithms for analysis, the most common pattern observed was a monochrome circle, with other discernible patterns including tilt, cone, and four-leaf.
Article
Chemistry, Multidisciplinary
Emily Sanchez-Real, Diego Otuna-Hernandez, Alisson Fajardo-Cabrera, Rosemary Davies-Alcivar, Mario Madrid-Perez, Carolina Cadena-Morejon, Diego Almeida-Galarraga, Cesar Guevara, Andres Tirado-Espin, Fernando Villalba-Meneses
Summary: This study analyzed the effect of increasing intraocular pressure on eyes with different severity of keratoconus using patient-specific models. The findings revealed differences in corneal deformation and stress between normal eyes and eyes with keratoconus, highlighting the importance of biomechanics in ophthalmology. Further research is needed to confirm the role of these differences in the diagnosis of keratoconus.
APPLIED SCIENCES-BASEL
(2023)
Article
Ophthalmology
Jie Li, Bi Ning Zhang, Vishal Jhanji, Xiaochuan Wang, Dewei Li, Xianli Du
Summary: This study aims to investigate the hereditability of corneal tomographic and biomechanical parameters in keratoconus. Data from a control group and a study group were analyzed to assess the associations between KC and various factors through clinical examinations and collection of relevant indices.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Ali H. Al-Timemy, Nebras H. Ghaeb, Zahraa M. Mosa, Javier Escudero
Summary: This study introduces a novel method based on corneal topographic maps for improving the diagnosis accuracy of keratoconus (KCN) using deep network classifiers and transfer learning strategy. The results show the significant improvement in accuracy by utilizing ensemble classifiers, with networks learning features that align with clinical knowledge.
COGNITIVE COMPUTATION
(2022)
Article
Multidisciplinary Sciences
Seung Min Lee, Kang Hyun Kim, Hyun Goo Kang, Eun Young Choi, Junwon Lee, Min Kim
Summary: Coats' disease is a retinal vascular disorder that usually affects only one eye, but recent studies have found vascular abnormalities in the unaffected eye. This retrospective study used various imaging tools to investigate the peripheral vascular features and macular vascular structure of the unaffected fellow eyes in patients with unilateral Coats' disease. The findings suggest that there may be subtle vascular abnormalities in the peripheral regions of the unaffected eyes, while the macular microvasculature remains unaffected.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Jaeryung Kim, Dae-Young Park, Hosung Bae, Do Young Park, Dongkyu Kim, Choong-Kun Lee, Sukhyun Song, Tae-Young Chung, Dong Hui Lim, Yoshiaki Kubota, Young-Kwon Hong, Yulong He, Hellmut G. Augustin, Guillermo Oliver, Gou Young Koh
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Cardiac & Cardiovascular Systems
Hyunsoo Cho, Jaeryung Kim, Ji Hoon Ahn, Young-Kwon Hong, Taija Makinen, Dae-Sik Lim, Gou Young Koh
CIRCULATION RESEARCH
(2019)
Article
Multidisciplinary Sciences
Jaeryung Kim, Jang Ryul Park, Jeongwoon Choi, Intae Park, Yoonha Hwang, Hosung Bae, Yongjoo Kim, WooJhon Choi, Jee Myung Yan, Sangyeul Han, Tae-Young Chung, Pilhan Kim, Yoshiaki Kubota, Hellmut G. Augustin, Wang-Yuhl Oh, Gou Young Koh
Article
Ophthalmology
Jaeryung Kim, Dong Hui Lim, Kyungdo Han, Se Woong Kang, Don -Il Ham, Sang Jin Kim, Tae -Young Chung
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Jaeryung Kim, Sung-Ho Choi, Dong Hui Lim, Chan Min Yang, Gil-Joong Yoon, Tae-Young Chung
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2019)
Article
Multidisciplinary Sciences
Jaeryung Kim, Dong Hui Lim, Sun Hyup Han, Tae-Young Chung
Article
Medicine, Research & Experimental
Simone Ragusa, Borja Prat-Luri, Alejandra Gonzalez-Loyola, Sina Nassiri, Mario Leonardo Squadrito, Alan Guichard, Sabrina Cavin, Nikolce Gjorevski, David Barras, Giancarlo Marra, Matthias P. Lutolf, Jean Perentes, Emily Corse, Roberta Bianchi, Laureline Wetterwald, Jaeryung Kim, Guillermo Oliver, Mauro Delorenzi, Michele De Palma, Tatiana Petrova
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Ophthalmology
Jaeryung Kim, Sung-Ho Choi, Dong Hui Lim, Gil-Joong Yoon, Tae-Young Chung
Article
Ophthalmology
Geun Woo Lee, Jae Hui Kim, Se Woong Kang, Jaeryung Kim
Article
Multidisciplinary Sciences
Sera Park, Dae-Young Park, Jaeryung Kim, Kyung In Woo, Yoon-Duck Kim, Jisang Han, Tae-Young Chung, Hoon-Suk Cha, Dong Hui Lim
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Jorge Andrade, Chenyue Shi, Ana S. H. Costa, Jeongwoon Choi, Jaeryung Kim, Anuradha Doddaballapur, Toshiya Sugino, Yu Ting Ong, Marco Castro, Barbara Zimmermann, Manuel Kaulich, Stefan Guenther, Kerstin Wilhelm, Yoshiaki Kubota, Thomas Braun, Gou Young Koh, Ana Rita Grosso, Christian Frezza, Michael Potente
Summary: Andrade et al. demonstrate that FOXO1 regulates mitochondrial metabolism to produce the metabolite S-2HG, promoting a quiescent endothelial state. S-2HG inhibits cell cycle progression and vascular expansion, highlighting its role as a key metabolite in regulating endothelial quiescence.
NATURE CELL BIOLOGY
(2021)
Article
Ophthalmology
George D. Kymionis, Jaeryung Kim, Myrsini Petrelli, Michael A. Grentzelos, Kattayoon Hashemi, Georges Wagnieres
Summary: The study found that the higher the RI of the IOL, the higher the external surface reflections, with IOLs made of high RI materials having over three times higher reflectivity compared to those with low RI. Ultraviolet or blue light filtering did not show significant correlation with external reflectance.
JOURNAL OF REFRACTIVE SURGERY
(2021)
Article
Multidisciplinary Sciences
Alejandra Gonzalez-Loyola, Esther Bovay, Jaeryung Kim, Tania Wyss Lozano, Amelie Sabine, Francois Renevey, Silvia Arroz-Madeira, Alexis Rapin, Tomasz P. Wypych, Giorgia Rota, Stephan Durot, Dominique Velin, Benjamin Marsland, Greta Guarda, Mauro Delorenzi, Nicola Zamboni, Sanjiv A. Luther, Tatiana V. Petrova
Summary: Inactivation of Foxc2 in adult lymphatic endothelium leads to a stepwise intestine-to-lung systemic failure, compromising gut epithelial barrier and promoting dysbiosis. The loss of Foxc2 skewed the specialization of lymphatic endothelial subsets, resulting in populations with mixed identities and emergence of lymph node-like endothelial cells.
Article
Medicine, Research & Experimental
Jaeryung Kim, Kaweh Mansouri
Summary: This article introduces a potential strategy to investigate and treat POAG related to collector channels.
MEDICAL HYPOTHESES
(2022)
Article
Ophthalmology
Marta Zola, Jaeryung Kim, Myrsini Petrelli, Lydia Schmutz, Kattayoon Hashemi, George Kymionis
OPHTHALMOLOGY AND THERAPY
(2020)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)