Article
Ophthalmology
Mert Simsek, Onur Inam, Emine Sen, Ufuk Elgin
Summary: This study found that patients with XFS had decreased choroidal vascularity in the macular and peripapillary regions, while unaffected fellow eyes may show vascular changes in the peripapillary choroid.
Article
Multidisciplinary Sciences
Jihei Sara Lee, Sungeun Park, Sung Sik Kim, Chan Yun Kim, Wungrak Choi, Sang Yeop Lee, Hyoung Won Bae
Summary: This study aimed to investigate the presence of peripapillary choroidal microvasculature dropout (MvD) in eyes with optic neuritis and its association with longitudinal changes in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIP) thicknesses. Optical coherence tomography angiography (OCTA) was used to evaluate 48 eyes with optic neuritis, and MvD was found in 41.7% of the eyes. MvD was most commonly found in the temporal quadrant, and eyes with MvD had significantly lower peripapillary retinal vessel density in the temporal quadrant. At 6 months follow-up, eyes with MvD showed thinner GCIP in multiple sectors. The presence of MvD was significantly associated with thinner global GCIP thickness at 6 months follow-up.
Article
Ophthalmology
Ji-Ah Kim, Eun Ji Lee, Tae-Woo Kim
Summary: This study aimed to investigate the influence of peripapillary retinoschisis (PRS) on visual field (VF) test results in patients with primary open angle glaucoma (POAG). The results showed that PRS had no short-term effect on VF sensitivity, and VF testing can still be used for evaluating glaucomatous damage.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaolin Xie, Binyao Chen, Jianling Yang, Chukai Huang, Kunliang Qiu, Ce Zheng, Mingzhi Zhang
Summary: This study provided normative SD-OCT data on the pRNFL grayscale value profile in nonglaucomatous eyes. Lower average pRNFL grayscale value was independently correlated to older age, longer axial length, lower RPE grayscale value, and lower ImageQ. These determinants should be considered when interpreting pRNFL grayscale value in glaucoma assessment.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Hua Zhong, Qingqing Dong, Qing Cun, Guangyu He, Yijin Tao, Keyao Song, Yunqing Lu, Qin Zhu, Xi Chen, Qin Chen
Summary: This study identified a positive correlation between peripapillary vessel density (pVD) and visual field mean sensitivity (VFMS) in healthy myopic eyes. This correlation was particularly strong in highly myopic eyes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Anna Lee, Joong Won Shin, Jin Yeong Lee, Min Su Baek, Michael S. Kook
Summary: Identifying biomarkers associated with functional impairment is important in monitoring glaucoma patients. This retrospective study found that OAG eyes with choroidal microvasculature dropout (CMvD) have stronger vasculature-function relationships compared to those without CMvD. Vessel density parameters may serve as useful biomarkers for disease progression in early-stage OAG patients.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Filippo Tatti, Claudio Iovino, Giuseppe Demarinis, Emanuele Siotto Pintor, Marco Pellegrini, Oliver Beale, Kiran Kumar Vupparaboina, Mohammed Abdul Rasheed, Giuseppe Giannaccare, Jay Chhablani, Enrico Peiretti
Summary: The aim of this study was to evaluate choroidal vascularity in unilateral central serous chorioretinopathy (CSC) using en face optical coherence tomography (OCT) images. The study included 40 eyes of 20 CSC patients and 20 eyes of 10 healthy individuals. The results showed no significant differences in choroidal vascularity index (CVI) between different layers of the choroid in CSC-affected eyes and fellow eyes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Olivia Xerri, Federico Bernabei, Elise Philippakis, Cyril Burin-Des-Roziers, Pierre-Olivier Barale, Olivier Laplace, Claire Monin, Dominique Bremond-Gignac, Gilles Guerrier, Sophie Valleix, Antoine Brezin, Pierre-Raphael Rothschild
Summary: Highly myopic patients with Stickler syndrome exhibit distinct clinical and SD-OCT features compared to matched controls, including greater choroidal thickness, lower peripapillary atrophy area, and lower prevalence of posterior staphyloma. These findings could be significant for the development and progression of myopic maculopathy in patients with Stickler syndrome.
Article
Neurosciences
Mazaya Mahmud, Amin Ahem, Mae-Lynn Catherine Bastion, Rokiah Omar, Azmawati Mohammed Nawi, Norsyariza Razak, Adib Mohd Satali, Safinaz Mohd Khialdin, Norshamsiah Md Din
Summary: This study evaluated the choroidal and photoreceptor thickness in highly myopic eyes and found that photoreceptor thickness, age, and axial length are significant predictors of poorer visual acuity. It also found that thinner choroidal thickness does not directly correlate with poorer vision.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Ji-Ah Kim, Hanbit Yoon, Dayun Lee, MoonHyun Kim, JoonHee Choi, Eun Ji Lee, Tae-Woo Kim
Summary: Myopia is a risk factor for glaucoma, and diagnosing glaucoma in myopic eyes is challenging due to distorted optic disc and macular structures. This study developed a deep learning system using macular vertical OCT scans to detect glaucoma in myopic eyes and compared its diagnostic power with circumpapillary OCT scans. The results showed that the vertical scans had a higher ability to diagnose glaucoma in eyes with large myopic parapapillary atrophy than the circumpapillary scans.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Kaho Akiyama, Hitomi Saito, Shiroaki Shirato, Aiko Iwase, Koichiro Sugimoto, Takashi Fujishiro, Hiroshi Murata, Rei Sakata, Megumi Honjo, Makoto Aihara
Summary: This study evaluated the diagnostic ability of OCTA and the relationship between circumpapillary vessel density (cpVD) and macular vessel density (mVD) with visual field sensitivity in early glaucomatous (EG) eyes. The results showed significant correlations between cpVD and mVD with visual field sensitivity, indicating their potential for diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Kendra L. Hong, Bruce Burkemper, Anna L. Urrea, Brenda R. Chang, Jae C. Lee, Vivian H. LeTran, Zhongdi Chu, Xiao Zhou, Benjamin Y. Xu, Brandon J. Wong, Brian J. Song, Xuejuan Jiang, Ruikang K. Wang, Rohit Varma, Grace M. Richter
Summary: The study found that hdVAD is higher in early glaucoma patients and may be helpful in detecting early focal damage, but its diagnostic ability is less robust in advanced glaucoma. Combining hdVAD with gRNFL can improve the diagnostic accuracy of glaucoma.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: There is a correlation between visual acuity and VF parameters or OCT parameters in glaucoma patients, and as glaucoma progresses, visual acuity decreases.
CURRENT EYE RESEARCH
(2021)
Article
Ophthalmology
Shiqi Xie, Koju Kamoi, Tae Igarashi-Yokoi, Kengo Uramoto, Hiroyuki Takahashi, Noriko Nakao, Kyoko Ohno-Matsui
Summary: The study identified four common structural abnormalities in eyes with pathologic myopia, with corresponding visual field defects. The presence of these abnormalities suggests a possibility of functional damage.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Scott R. Shuldiner, Michael Boland, Pradeep Y. Ramulu, C. Gustavo De Moraes, Tobias Elze, Jonathan Myers, Louis Pasquale, Sarah Wellik, Jithin Yohannan
Summary: This study assessed the prediction of rapid glaucoma progression using machine learning algorithms based on initial visual field tests. The results showed that age and reliability metrics in the initial visual field were the most strongly associated variables with rapid progression. Incorporating additional clinical data may improve the accuracy of predicting patients most likely to rapidly progress.
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)