Article
Infectious Diseases
Kuan-Jen Chen, Yen-Po Chen, Yi-Hsing Chen, Laura Liu, Nan-Kai Wang, An-Ning Chao, Wei-Chi Wu, Yih-Shiou Hwang, Hung-Da Chou, Eugene Yu-Chuan Kang, Yen-Ting Chen, Ming-Hui Sun, Chi-Chun Lai
Summary: This study investigates the infection sources and antibiotic susceptibilities of Klebsiella pneumoniae in patients with endogenous K. pneumoniae endophthalmitis in Northern Taiwan. Pyogenic liver abscess was identified as the major infection source, and K. pneumoniae showed high susceptibility to ceftazidime and amikacin.
Article
Emergency Medicine
Genevieve S. Pentecost, Jacob Kesterson
Summary: Invasive Liver Abscess Syndrome, caused by Klebsiella pneumoniae, is a manifestation of systemic infection. Although common in Southeast Asia, it is uncommon in the United States. This article presents a case of pyogenic liver abscess and associated endogenous endophthalmitis in a patient presenting to the emergency department.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Biology
Dragos Serban, Alina Popa Cherecheanu, Ana Maria Dascalu, Bogdan Socea, Geta Vancea, Daniela Stana, Gabriel Catalin Smarandache, Alexandru Dan Sabau, Daniel Ovidiu Costea
Summary: This review documents the emerging hypervirulent Klebsiella pneumoniae endogenous endophthalmitis in terms of incidence, microbiological characterization, risk factors, management, and outcomes. It highlights the importance of early diagnosis and preservation of visual function in patients with this condition.
Article
Surgery
Fang Li, Wenfei Zheng, Jian Yu, Linyan Zhao
Summary: This case involves a patient with a Klebsiella pneumoniae liver abscess with infections spreading to the meninges and eyes. Diagnosis was made through ultrasound and CT scans, with treatment including percutaneous catheter drainage and antibiotics. Despite initial improvement, the patient eventually died due to severe pneumonia complications.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Jae Jung Lee, Seung Baek Hong, Nam Kyung Lee, Young Joo Park, So Hee Kim, Sung Who Park, Iksoo Byon, Suk Kim
Summary: This study investigated the CT characteristics of endogenous endophthalmitis (EE) associated with Klebsiella pneumoniae (K. pneumoniae)-related pyogenic liver abscess (PLA). It found that diabetes mellitus (DM), involvement of the left or both hepatic lobes, and the adjacent vessels on CT were significant predictors of EE. These findings provide valuable information for early diagnosis of EE.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Yunjiang Chen, Yanchun Gong, Bei Song, Yueling Du, Kaiyu Cai
Summary: This article reviews a case of Klebsiella pneumoniae-induced pyogenic liver abscess complicated with endogenous endophthalmitis and summarizes the characteristics, causes, and complications of pyogenic liver abscess based on the literature review. It is suggested that liver puncture drainage and empirical use of antibiotics should be performed promptly for patients with pyogenic liver abscess, especially those with poor glycemic control, to avoid serious complications such as endogenous endophthalmitis.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Ophthalmology
Yun Zhou, Yixin Zhang, Yueru Tian, Mengjun Zhu, Xing Wang, Jun Shen, Ying Li
Summary: The purpose of this study was to investigate the clinical features and molecular characteristics of endogenous Klebsiella pneumoniae endophthalmitis (EKPE). Clinical data was collected retrospectively, and K. pneumoniae isolates from EKPE patients were characterized. Results showed that administration of systemic antibiotics and eye treatment within 24 hours of symptom onset was associated with better visual outcomes. Avirulent carbapenem-resistant K. pneumoniae strains were found to cause EKPE.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Infectious Diseases
Jian Lin, Yize Huang, Li Qian, Xiaolong Pan, Youliang Song
Summary: We report a case of community-acquired liver abscess and endogenous endophthalmitis caused by a genotype ST25 serotype K2 (ST25-K2) hypervirulent Klebsiella pneumoniae (HvKp) strain. This case indicates that genotype ST25-K2 HvKp strains can cause community-acquired liver abscess combined with endogenous endophthalmitis.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Ophthalmology
Ji Hwan Lee, Hee Suk Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee
Summary: Endogenous Klebsiella pneumoniae endophthalmitis (EKE) usually has a poor visual prognosis, and early diagnosis with fair initial visual acuity would be crucial in saving vision.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Microbiology
Kuan-Jen Chen, Ming-Hui Sun, Yen-Po Chen, Yi-Hsing Chen, Nan-Kai Wang, Laura Liu, An-Ning Chao, Wei-Chi Wu, Yih-Shiou Hwang, Chi-Chun Lai
Summary: This study retrospectively analyzed the data of 37 patients with endogenous fungal endophthalmitis and found that diabetes was the most common risk factor. Yeasts were more commonly detected than mold, and Candida spp. were the most common fungal isolates. Retinal detachment was a common complication, and better initial visual acuity was associated with superior visual outcomes.
Article
Infectious Diseases
Yingsha Chen, Shuaibing Ying, Lushun Jiang, Shaohua Dong, Jinyao Dai, Xuehang Jin, Wei Yu, Yunqing Qiu
Summary: This study aimed to identify risk factors and establish nomograms to predict the risk and prognosis of bloodstream infections caused by Klebsiella pneumoniae. The results showed that gastric tube indwelling and the use of multiple types of antibiotics were independent risk factors for carbapenem-resistant K. pneumoniae (CRKP) infections. Additionally, urinary catheterization was found to be an independent risk factor for 30-day mortality, while the use of ceftazidime/avibactam showed a favorable prognosis. The nomograms were able to predict the risk and mortality of BSI-KP patients.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Multidisciplinary Sciences
Xin Liu, Qinzhu Bai, Xiande Song
Summary: This study investigated the clinical and CT features, as well as visual prognostic factors, of pars plana vitrectomy for retained posterior segment intraocular foreign body. The results showed that CT was highly sensitive in detecting IOFB and its locations were consistent with those found during PPV. The size of the IOFB removed by PPV was associated with initial visual acuity and endophthalmitis. Poor visual prognostic factors included relative afferent pupillary defect, initial visual acuity less than 0.1, and the presence of endophthalmitis.
SCIENTIFIC REPORTS
(2023)
Review
Microbiology
Jie Zhu, Tao Wang, Liang Chen, Hong Du
Summary: The review summarizes the virulence factors associated with hypervirulent Klebsiella pneumoniae to understand its molecular pathogenesis and provide new strategies for improving the prevention, diagnosis, and treatment of infections caused by hvKP.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shaoqi Sun, Lin Shu, Xiyang Lu, Qinghui Wang, Marina Tisma, Chenguang Zhu, Jiping Shi, Frank Baganz, Gary J. Lye, Jian Hao
Summary: The study demonstrates an efficient way of producing 1,2-propanediol from glycerol via an endogenous pathway of K. pneumoniae. Key enzymes for 1,2-propanediol synthesis were identified, and optimal process parameters were determined for maximal production in the strain.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Ying Zhou, Yang Yang, Xiaobin Li, Dongxing Tian, Wenxiu Ai, Weiwen Wang, Bingjie Wang, Barry N. Kreiswirth, Fangyou Yu, Liang Chen, Xiaofei Jiang
Summary: In this study, the native CRISPR system of K. pneumoniae was used to successfully cure multidrug-resistant IncFII plasmids through conjugation-mediated delivery of the CRISPR-Cas3 system. The work demonstrated that CRISPR-mediated plasmid curing could re-sensitize drug-resistant K. pneumoniae to multiple antibiotics.
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)