Article
Medicine, General & Internal
Jae-Hui Kim, Jong-Woo Kim, Chul-Gu Kim
Summary: This study revealed a trend in the selection of ranibizumab and aflibercept for initial treatment of neovascular AMD and PCV, with ranibizumab preferred in older patients and those with type 3 MNV, and aflibercept highly preferred in patients with PCV. The variance in patient characteristics and efficacy of the two agents may have influenced this trend.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yinchen Shen, Hanying Wang, Xiaoyin Xu, Chong Chen, Shaopin Zhu, Lu Cheng, Junwei Fang, Kun Liu, Xun Xu
Summary: This study investigated the relationship between serum metabolome and treatment response to anti-VEGF therapy in nAMD and PCV patients. The study found that metabolites such as LPC and diacylglycerophosphocholine impact the response to conbercept treatment, with LPC 18:0 identified as a potential biomarker to discriminate responders from non-responders. The findings suggest that metabolites may be useful for guiding treatment options in nAMD and PCV.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Hideo Akiyama
Summary: Loading phase treatment with intravitreal brolucizumab may improve visual acuity and reduce exudative changes in eyes with nAMD associated with type 1 CNV, but careful monitoring for brolucizumab-related intraocular inflammation is necessary.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Xinyuan Zhang, Bingjie Qiu, Zhizhong Gong, Xiaosi Chen, Yanhong Wang, Yao Nie
Summary: This study investigates the differential regulation of lipid metabolism mediated by apolipoproteins in polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD). The results suggest that lipid profiles and apolipoproteins are differentially regulated in PCV, nAMD, and their subtypes, indicating different pathogenicity contributes to the different phenotypes of PCV and nAMD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Huiying Zhou, Xinyu Zhao, Youxin Chen
Summary: The study found significant differences in plasma concentrations of multiple cytokines between nAMD and PCV patients and controls, suggesting potential involvement in the pathogenesis of the diseases. The measurement of leukemia inhibitory factor in plasma may serve as a differentiating factor between nAMD and PCV.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Soo Chang Cho, JoonHee Cho, Kyu Hyung Park, Se Joon Woo
Summary: The study found that the incidence rate of massive submacular haemorrhage was significantly higher in patients with polypoidal choroidal vasculopathy compared to those with typical neovascular age-related macular degeneration. The number of photodynamic therapies, cluster type of polypoidal lesion, and number of anti-VEGF injections were significantly associated with the risk of massive submacular haemorrhage.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Voraporn Chaikitmongkol, Malgorzata Ozimek, Titipol Srisomboon, Direk Patikulsila, Samantha Fraser-bell, Jay Chhablani, Janejit Choovuthayakorn, Nawat Watanachai, Paradee Kunavisarut, Patricio J. Rodriguez-Valdes, David Lozano-Rechy, Marco Lupidi, Mayss Al-Sheikh, Adrian T. Fung, Catharian Busch, Hemal Mehta, Pierre-Henry Gabrielle, Dinah Zur, Dan Ramon, Apisara Sangkaew, Thammasin Ingviya, Atchara Amphornprut, Zafer Cebeci, Aude Couturier, Thais Sousa Mendes, Ermete Giancipoli, Matias Iglicki, Alessandro Invernizzi, Ines Lains, Matus Rehak, Anna Sala-Puigdollers, Mali Okada, Anat Loewenstein, Neil M. Bressler
Summary: The study aimed to determine the prevalence of probable polypoidal choroidal vasculopathy (PCV) among white patients with neovascular age-related macular degeneration (nAMD) using non-indocyanine green angiography (ICGA) criteria. The results showed that the prevalence of probable PCV was 23.4% in white individuals with nAMD, and it was more commonly found in non-Hispanic white individuals.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jae Hui Kim, Jong Woo Kim, Chul Gu Kim
Summary: This study investigated the incidence, risk factors, and impact on visual outcomes of SRH in patients with nAMD and PCV who discontinued treatment. SRH development led to poor visual prognosis in those who stopped treatment, and type 3 MNV had a relatively high risk of SRH occurrence.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Ki Won Jin, Jae Hui Kim, Jun Young Park, Sang Jun Park, Kyu Hyung Park, Joo Yong Lee, Se Joon Woo
Summary: This study evaluated the long-term outcomes of ranibizumab (RBZ) vs. aflibercept (AFL) in treatment-naive eyes with typical neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV). The results showed no significant difference in visual outcomes and number of injections between the two treatments over the course of 4 years.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Qingyan Liu, Shuo Sun, Zhengwei Yang, Yan Shao, Xiaorong Li
Summary: This study identified a novel biomarker related to both nAMD and PCV by analyzing the aqueous humor proteome alterations. The study also revealed the important role of immune response activation in both nAMD and PCV. The level alteration of the SAA4 protein may serve as a common biomarker of nAMD and PCV.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biology
Kan Xing Wu, Natalie Jia Ying Yeo, Chun Yi Ng, Florence Wen Jing Chioh, Qiao Fan, Xianfeng Tian, Binxia Yang, Gunaseelan Narayanan, Hui Min Tay, Han Wei Hou, N. Ray Dunn, Xinyi Su, Chui Ming Gemmy Cheung, Christine Cheung
Summary: Research on PCV patients discovered that blood endothelial cells react differently under different flow speeds, and that inhibiting elevated hyaluronidase-1 in PCV patients can improve cell mechanosensitivity and repair barrier permeability.
Article
Ophthalmology
Jae Hui Kim, Jong Woo Kim, Chul Gu Kim, Dong Won Lee
Summary: Approximately 27.9% of cases with prechoroidal cleft eventually regressed, resulting in relatively favorable visual outcomes. Neovascular age-related macular degeneration accompanied by prechoroidal cleft had a worse visual prognosis, requiring more caution.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Xinyu Zhao, Lihui Meng, Mingyue Luo, Weihong Yu, Hanyi Min, Rongping Dai, Adrian Koh, Youxin Chen
Summary: This study found that delayed treatment due to the COVID-19 pandemic resulted in compromised visual function and a higher rate of sub-macular scar formation in patients, while non-delayed cases maintained stable visual acuity with favorable anatomical outcomes. Regular follow-up for nAMD and PCV patients is crucial, and effective measures by hospitals during pandemics are necessary to provide timely treatment for chronic diseases.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Review
Ophthalmology
Voraporn Chaikitmongkol, Min Sagong, Timothy Y. Y. Lai, Gavin S. W. Tan, Nor Fariza Ngah, Masahito Ohji, Paul Mitchell, Chang-Hao Yang, Paisan Ruamviboonsuk, Ian Wong, Taiji Sakamoto, Anand Rajendran, Youxin Chen, Dennis S. C. Lam, Chi-Chun Lai, Tien Yin Wong, Chui Ming Gemmy Cheung, Andrew Chang, Adrian Koh
Summary: T&E regimens are effective and safe for nAMD and PCV, reducing the number of visits and overall burden for clinicians and patients.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Medicine, General & Internal
Kenji Yamashiro, Yasuo Yanagi, Hideki Koizumi, Hidetaka Matsumoto, Chui Ming Gemmy Cheung, Fumi Gomi, Tomohiro Iida, Akitaka Tsujikawa
Summary: Previous studies have shown inconsistent classification and understanding of pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV). This study summarizes previous research and proposes a refined conceptual framework for future studies on PNV, PCV, and neovascular age-related macular degeneration (nAMD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Sophie Thornton, Sarah E. Coupland, Heinrich Heimann, Rumana Hussain, Carl Groenewald, Andrzej Kacperek, Bertil Damato, Azzam Taktak, Antonio Eleuteri, Helen Kalirai
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Rumana Hussain, Gabriela Czanner, Azzam Taktak, Bertil Damato, Anna Praidou, Heinrich Heimann
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)
Article
Biology
Antonio Eleuteri, Alda Cunha Rola, Helen Kalirai, Rumana Hussain, Joseph Sacco, Bertil E. Damato, Heinrich Heimann, Sarah E. Coupland, Azzam F. G. Taktak
Summary: This study presents a cost-utility analysis method for liver screening in UM patients, validated through data analysis. Results demonstrate the potential cost savings and effectiveness of the method in avoiding unnecessary medical scans.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Ophthalmology
Rodolfo Hernandez, Charlotte Kennedy, Katie Banister, Beatriz Goulao, Jonathan Cook, Sobha Sivaprasad, Ruth Hogg, Augusto Azuara-Blanco, Heinrich Heimann, Maria Dimitrova, Richard Gale, Mia Porteous, Craig R. Ramsay, Usha Chakravarthy, Graham S. Scotland
Summary: The study evaluated the cost-effectiveness of non-invasive monitoring tests for detecting neovascular age-related macular degeneration and found that spectral domain optical coherence tomography (SD-OCT) was the most effective method, generating higher quality-adjusted life-years and lower health and social care costs per patient compared to other individual tests. The early treatment of the second eye following confirmation of SD-OCT positive findings is expected to maintain better visual acuity and quality of life while reducing overall healthcare costs over patients' lifetimes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Health Care Sciences & Services
Katie Banister, Jonathan A. Cook, Graham Scotland, Augusto Azuara-Blanco, Beatriz Goulao, Heinrich Heimann, Rodolfo Hernandez, Ruth Hogg, Charlotte Kennedy, Sobha Sivaprasad, Craig Ramsay, Usha Chakravarthy
Summary: Neovascular age-related macular degeneration is a major cause of sight loss, and early detection and treatment are crucial. Current practice involves monitoring the unaffected eye of patients with the disease in one eye, but the diagnostic accuracy of non-invasive tests is unclear. This study aims to determine the diagnostic monitoring performance, cost-effectiveness, and predictive factors of developing the disease in the second eye of patients with unilateral neovascular age-related macular degeneration.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Article
Oncology
Stephen L. Brown, Peter Fisher, Laura Hope-Stone, Bertil Damato, Heinrich Heimann, Rumana Hussain, M. Gemma Cherry
Summary: Persistent or emerging post-treatment symptoms and functional limitations are probable risk factors for late-occurring fear of cancer recurrence in uveal melanoma survivors. Monitoring symptoms and functional limitations assists in identifying at-risk survivors and targeting preventive interventions.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Ophthalmology
Katharina Eibenberger, Rumana Hussain, Yamini Krishna, Sarah E. Coupland, Heinrich Heimann
Article
Ophthalmology
R. N. Hussain, A. Chiu, B. Pittam, A. Taktak, B. E. Damato, A. Kacperek, D. Errington, P. Cauchi, V Chadha, J. Connolly, S. Salvi, P. Rundle, V Cohen, A. Arora, M. Sagoo, O. Bekir, K. Kopsidas, H. Heimann
Summary: This study aimed to understand the variation in referral patterns for uveal melanoma patients treated with proton therapy in the UK, and conducted a retrospective analysis of patients treated at the Clatterbridge Proton service. The results showed variations in phenotypic characteristics of tumors treated at different centers, indicating the need for standardized referral criteria.
Review
Ophthalmology
J. Pearman, H. Shah, A. Diafas, H. Heimann, R. Hussain
Summary: Idiopathic scleroma is a yellow, hyperautofluorescent, hyperechogenic scleral lesion that has no signs of active inflammation. These characteristics help differentiate it from other more sinister causes of amelanotic fundal lesions.
Review
Ophthalmology
R. N. Hussain, B. Damato, H. Heimann
Summary: The majority of choroidal tumors can be accurately diagnosed using clinical examination and non-invasive imaging techniques. However, biopsies may be required for diagnostic clarity in certain cases, such as small melanocytic or indeterminate lesions, choroidal metastases, or rarer conditions like uveal lymphoma. There is also an increasing use of biopsy techniques for prognostication in uveal melanoma. This review explores the main indications and surgical techniques for tumor acquisition, as well as an optimized approach to improve successful yield for histological and genetic analysis.
Article
Ophthalmology
Keri McLean, Rumana Hussain, Heinrich Heimann
Summary: This study retrospectively analyzed the medical records and imaging data of 17 patients with retinal astrocytomas (RA). The study found that RA has characteristic clinical, demographic, and imaging features that can help differentiate it from other non-pigmented fundal lesions.
Article
Ophthalmology
Alexander Wallace, Yamini Krishna, Sarah E. Coupland, Heinrich Heimann, Asterios Diafas, Rumana N. Hussain
Summary: This study reports a previously unrecognized clinical feature of choroidal melanoma, termed tumor-associated retinal pigmentation (TARP), which represents tumor-associated macrophages. This feature is associated with choroidal melanomas of high metastatic-risk clinical and genetic characteristics.
Article
Ophthalmology
Katharina Eibenberger, Heinrich Heimann, Leandro Gatchalian, Andrzej Kacperek, Rumana Hussain
Summary: This study evaluated the functional outcomes and ocular side effects of patients receiving proton beam radiotherapy (PBR) for the treatment of iris melanoma. The results demonstrate that PBR is a successful treatment option for patients with IM, showing a high tumor control rate and relatively low complication profile.
Article
Ophthalmology
Stephen L. Brown, Laura Hope-Stone, Rumana N. Hussain, Heinrich Heimann, Nicola van der Voort, M. Gemma Cherry
Summary: Phantom eye symptoms, such as phantom visual sensations (PVS) and phantom eye pain (PEP), are common in patients who have undergone enucleation and can cause psychological distress. This cohort study examines the prevalence and course of these symptoms over a 24-month period.
Article
Ophthalmology
Tunde Peto, Rebecca N. Evans, Barnaby C. Reeves, Simon Harding, Savita Madhusudhan, Andrew Lotery, Susan Downes, Konstantinos Balaskas, Clare C. Bailey, Alexander Foss, Faruque Ghanchi, Yit Yang, Dawn Phillips, Chris A. Rogers, Alyson Muldrew, Barbra Hamill, Usha Chakravarthy
Summary: The study aimed to describe the frequency of long-term morphologic features and their relationships with visual function. The results showed that the presence of intralesional macular atrophy and hyperreflective material were strongly associated with visual outcomes after 7 years of follow-up.
OPHTHALMOLOGY RETINA
(2022)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
