Article
Acoustics
Kazuyo Ito, Theresa H. Lye, Yee Shan Dan, Jason D. G. Yu, Ronald H. Silverman, Jonathan Mamou, Quan Hoang
Summary: The aim of this study was to develop an algorithm based on eyewall curvature and axial length to automate the detection of staphyloma locations using ultrasound. The algorithm successfully quantified the non-uniformity of eye shape and achieved high diagnostic performance in binary classification. This method can be used as a screening tool for clinician-free staphyloma detection.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Ophthalmology
Lillian Liu, Yuxin Fang, Tae Igarashi-Yokoi, Hiroyuki Takahashi, Kyoko Ohno-Matsui
Summary: Choroidal thinning and scleral protrusion are hallmark features of staphyloma edges in eyes with pathologic myopia, observed in over 95% of cases. Larger angles at the staphyloma edge are significant predictors of retinal thinning, while the presence of staphyloma can be detected using Optos pseudocolor fundus photography.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Lillian Liu, Yuxin Fang, Tae Igarashi-Yokoi, Hiroyuki Takahashi, Kyoko Ohno-Matsui
Summary: Using ultra-widefield optical coherence tomography imaging, morphologic features along posterior staphyloma edges in eyes with pathologic myopia were investigated. Choroidal thinning and scleral protrusion were hallmark features of staphyloma edges, with larger angles being significant predictors of retinal thinning.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Fen Nie, Junyi Ouyang, Wenquan Tang, Lijia Luo, Mengdan Cao, Lurong Zhang, Dengming Zhou, Ke Liu, Daijin Ma, Xuanchu Duan
Summary: PS group showed differences in ACD, lens thickness, and SE compared to NPS group. Reduced choriocapillaris perfusion, SFCT, and retinal layer thickness were observed in the PS group. Multivariate regression analysis indicated that disc tilt ratio and SFCT were significant predictors of PS.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Physiology
Haoru Li, Qingxin Wang, Yucheng Liu, Xin Wang, Qing He, Yanhui Chen, Ruihua Wei
Summary: This study investigated the characteristics of macular structures and microcirculation in eyes with posterior staphyloma (PS) and explored the factors related to PS in high myopia. Thinner retinal and choroid thickness were observed in patients with PS, and they also had significantly lower subfoveal scleral thickness. The density of retinal deep vascular complex and choriocapillaris perfusion area were also significantly lower in the PS group. Factors such as subfoveal scleral thickness, retinal and choroid thickness, and choriocapillaris perfusion area were found to be significantly correlated with PS.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Ophthalmology
Kai Yuan Tey, Qiu Ying Wong, Yee Shan Dan, Andrew S. H. Tsai, Daniel S. W. Ting, Marcus Ang, Gemmy Chiu Ming Cheung, Shu Yen Lee, Tien Yin Wong, Quan V. Hoang, Chee Wai Wong
Summary: This study found that in highly myopic eyes, myopic traction maculopathy and posterior staphyloma are independently associated with myopic macular degeneration.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Jianping Xiong, Ran Du, Shiqi Xie, Hongshuang Lu, Changyu Chen, Tae Lgarashi-Yokoi, Kengo Uramoto, Yuka Onishi, Takeshi Yoshida, Koju Kamoi, Kyoko Ohno-Matsui
Summary: The purpose of this study was to determine the prevalence, characteristics, and causes of papillary and peripapillary hemorrhages (PPHs) in eyes with pathologic myopia (PM). The study found that the prevalence of PPHs in PM eyes was 4.05%, with the most common type and location being the conus type and the temporal side. Axial elongation, mild myopic maculopathy, and potential glaucoma were found to be risk factors for recurrences.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, General & Internal
Jose M. Ruiz-Moreno, Mariluz Puertas, Ignacio Flores-Moreno, Elena Almazan-Alonso, Maria Garcia-Zamora, Jorge Ruiz-Medrano
Summary: The purpose of this study was to examine the bilaterality and symmetry of posterior staphyloma in high myopic eyes. The results showed that 92.8% of the eyes had posterior staphyloma, and 85.6% of the patients had it in both eyes. Patients with bilateral posterior staphyloma showed higher myopic severity and incidence of severe pathologic myopia compared to those with unilateral posterior staphyloma.
Article
Biotechnology & Applied Microbiology
Hua Rong, Lin Liu, Yuling Liu, Wanzeng Fu, He Xu, Danyang Yu, Di Wu, Bei Du, Xuejun Zhang, Bin Zhang, Ruihua Wei
Summary: The morphology of eyeballs with posterior staphyloma (PS) was quantified using Zernike decomposition, and the association between Zernike coefficients and existing PS classification was explored. PS eyeballs had significantly increased Zernike coefficients compared to highly myopic eyeballs, including vertical and horizontal tilt, oblique astigmatism, defocus, vertical and horizontal coma, and higher order aberrations. Higher order aberrations (HOA) was the most effective parameter in PS classification. The geometrical meaning of the Zernike components showed great accordance with PS classification.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Ophthalmology
Reina Saito, Kosei Shinohara, Noriko Tanaka, Hiroyuki Takahashi, Takeshi Yoshida, Kyoko Ohno-Matsui
Summary: The relationship between dome-shaped maculas (DSMs) and posterior staphylomas in highly myopic eyes is investigated, with DSMs tending to occur in eyes with a large expansion of the posterior fundus. The lack of staphylomas in 45% of eyes with a DSM suggests that DSMs form independently from posterior staphylomas.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Songhomitra Panda-Jonas, Leonard Holbach, Jost B. Jonas
Summary: The study found that the thickness and density of the choriocapillaris decrease gradually from the posterior pole to the periphery of the fundus, and are not significantly associated with axial length. These findings may be important for understanding high myopia and pathologic myopia.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Feihui Zheng, Jacqueline Chua, Yin Ci Sim, Bingyao Tan, Marco Yu, Qiu Ying Wong, Yee Shan Dan, Rachel S. Chong, Chui Ming Gemmy Cheung, Marcus Ang, Shu Yen Lee, Tien Yin Wong, Leopold Schmetterer, Chee Wai Wong, Quan Hoang
Summary: This study evaluated the relationship between macular sensitivity and retinal perfusion density in eyes with myopic macular degeneration. The results showed that macular sensitivity decreased with increasing severity of MMD and was significantly associated with deep retinal PD.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Caixia Lin, Yawen Bai, Yuxin Fang, Xiaoxia Li, Yuhan Wang, Ke Yang, Liya Qiao
Summary: This study retrospectively analyzed the clinical outcomes of posterior chamber phakic intraocular lens (pIOL) implantation for non-pathological and pathological myopia. The results showed that pIOL implantation had comparable results in terms of predictability, efficacy, safety, and adverse events for both non-pathological and pathological myopia patients at 6 months after surgery. No vision-threatening complications occurred during the follow-up.
Article
Ophthalmology
Santiago Delgado-Tirado, Alberto Lopez-Miguel, Yazmin Baez-Peralta, Lucia Gonzalez-Buendia, Itziar Fernandez, Jorge L. Alio, Miguel J. Maldonado, Rosa M. Coco-Martin
Summary: The study aimed to assess monochromatic higher order aberrations in highly myopic eyes with staphyloma, revealing significant differences in patients aged <= 45 years between groups with and without dome-shaped macula.
Article
Medicine, General & Internal
Do Yeon Kim, Yu Cheol Kim
Summary: Treatment of macular hole retinal detachment in patients with pathologic myopia may require multiple surgeries, but intravitreal silicone oil injection before surgery in aphakic eyes could be an alternative option.
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)