Article
Pharmacology & Pharmacy
Manna Semere Gebreyesus, Eric H. Decloedt, Catherine A. Cluver, Nicole G. M. Hunfeld, Holmfridur Helgadottir, Einar S. Bjornsson, Roeland E. Wasmann, Paolo Denti
Summary: This study investigated the pharmacokinetics of esomeprazole during pregnancy and found that the clearance rate in pregnant participants was lower compared to non-pregnant due to the inhibition of CYP2C19.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Leandro De Oliveira, James M. Roberts, Arundhathi Jeyabalan, Kasey Blount, Christopher W. Redman, Lucilla Poston, Paul T. Seed, Lucy C. Chappell, Marcos Augusto Bastos Dias
Summary: The implementation of a risk stratification model based on biomarkers and clinical factors did not lead to reductions in preterm deliveries. Further training and development of additional risk stratification methods are needed before adopting this intervention into clinical practice.
Article
Pharmacology & Pharmacy
Leni van Doorn, Niels Heersche, Femke M. de Man, Peter de Bruijn, Ivo Bijl, Esther Oomen-de Hoop, Ferry A. L. M. Eskens, Ate van der Gaast, Ron H. J. Mathijssen, Sander Bins
Summary: The study found that esomeprazole has an effect on the pharmacokinetics of capecitabine, but does not negatively influence capecitabine exposure. Additionally, esomeprazole significantly prolongs the half-life of capecitabine.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Anna Maria Nuzzo, Domenica Giuffrida, Laura Moretti, Paola Re, Giorgio Grassi, Guido Menato, Alessandro Rolfo
Summary: This study compared the expression of anti-angiogenic sFlt1 and pro-angiogenic PlGF in placenta and maternal blood in GDM, GDM-PE, CTRL, and PE cases. The results showed higher sFlt1/PlGF values in GDM-PE maternal blood, decreased PlGF gene expression in GDM, PE, and GDM-PE placentae, and increased PlGF protein levels in GDM and GDM-PE placentae. Additionally, sFlt1 gene expression was higher in PE placentae, while sFlt1 protein expression was lower in GDM-PE placentae. These findings suggest a potential link between sFlt1 overproduction and PE onset in GDM pregnancies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Alvaro Santana-Garrido, Claudia Reyes-Goya, Pablo Espinosa-Martin, Luis Sobrevia, Luis M. Beltran, Carmen M. Vazquez, Alfonso Mate
Summary: This study investigates the role of the NADPH oxidase system in a rodent model of preeclampsia. The results suggest that NADPH oxidase mediates oxidative stress and inflammation in the placenta and kidney, providing important insights into the pathogenesis and potential treatment of preeclampsia.
Article
Medicine, Research & Experimental
Sarah M. Davis, Vignesh N. Hariharan, Agnes Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova
Summary: Preeclampsia is a potentially lethal pregnancy complication driven by overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1). Researchers have found that injecting specific siRNA can reduce placental sFLT1 and improve symptoms. They also discovered that modifying siRNA chemically can enhance its effectiveness and safety, providing a framework for further development of this therapeutic approach.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Rebekka Vogtmann, Mian Bao, Monia Vanessa Dewan, Alina Riedel, Rainer Kimmig, Ursula Felderhoff-Mueser, Ivo Bendix, Torsten Ploesch, Alexandra Gellhaus
Summary: Fetal adaptations to harmful intrauterine environments due to pregnancy disorders such as preeclampsia (PE) can negatively program the offspring's metabolism, resulting in long-term metabolic changes. In this study, researchers examined the consequences of sFLT1 overexpression in transgenic mice with PE/FGR on the offspring's metabolic phenotype. The results showed that sFLT1 overexpression led to growth-restricted fetuses with altered liver development and metabolic gene expression. The postnatal follow-up revealed increased weight gain and abnormal hormone levels in male PE offspring, suggesting adverse metabolic pre-programming specifically targeting males.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shengyi Gu, Chenchen Zhou, Jindan Pei, Yuelin Wu, Sheng Wan, Xiaobo Zhao, Junhao Hu, Xiaolin Hua
Summary: Preeclampsia (PE) is a common condition in pregnant women, and dysfunction of the placenta plays a key role in its pathogenesis. Excessive placental autophagy is involved in the development of PE, but treatment with esomeprazole can inhibit autophagy in the placenta and alleviate PE symptoms.
CELL AND TISSUE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Bianca R. Fato, Sally Beard, Natalie K. Binder, Tu'uhevaha J. Kaitu'u-Lino, Kenji Onda, Natalie J. Hannan
Summary: The study demonstrated that both esomeprazole MH and MTH could reduce key factors associated with preeclampsia, but esomeprazole MH was more efficacious in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Natalie K. Binder, Yeukai T. M. Mangwiro, Sally Beard, Natasha Pritchard, Elif Kadife, Bianca R. Fato, Emerson Keenan, Fiona C. Brownfoot, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan
Summary: Esomeprazole, a proton pump inhibitor, shows potential therapeutic effects in the treatment of pregnancy-induced hypertension, and may work via the nitric oxide pathway. Further research is needed to fully understand its mechanism of action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Brooke Armistead, Leena Kadam, Emily Siegwald, Fergus P. McCarthy, John C. Kingdom, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia is a severe hypertensive disorder of pregnancy caused by placental villi pathology leading to widespread maternal endothelial dysfunction. Modulating trophoblast differentiation pathway through PPAR gamma-GCM1 axis may reduce excessive sFLT1 production and improve clinical outcomes. Pharmacological manipulation of PPAR gamma activity shows potential to rescue the antiangiogenic state of preeclampsia.
Article
Medicine, Research & Experimental
Shan Jing, Yue Zhu, Wenfang Liu, Kexu Yang, Lili Hu, Dan Deng, Chunyan Lu, Yang Lin
Summary: The study demonstrates that IR-ESO effectively inhibits gastric acid secretion and its PK and PD are influenced by CYP2C19 genotypes. The AUC(inf) and percentage changes in 24-h integrated gastric acidity from baseline for IR-ESO/ESO are within the range of 80.00-125.00%, with significant differences between different CYP2C19 genotypes.
ADVANCES IN THERAPY
(2021)
Article
Obstetrics & Gynecology
Anna Peguero, Ignacio Herraiz, Alfredo Perales, Juan Carlos Melchor, Inigo Melchor, Beatriz Marcos, Cecilia Villalain, Raigam Martinez-Portilla, Edurne Mazarico, Eva Meler, Sandra Hernandez, Isabel Matas, Maria Del Rio, Alberto Galindo, Francesc Figueras
Summary: The study aimed to determine whether using an algorithm based on maternal levels of placental growth factor in women with late preterm preeclampsia to evaluate the best time for delivery reduced the progression to preeclampsia with severe features without increasing adverse perinatal outcomes. The use of this algorithm resulted in a lower rate of progression to preeclampsia with severe features and reduced maternal complications without worsening neonatal outcomes. This suggests a potential benefit for using this algorithm in making decisions about the timing of delivery for women with late preterm preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Melinda Matyas, Monica Hasmasanu, Ciprian N. Silaghi, Gabriel Samasca, Iulia Lupan, Kovacs Orsolya, Gabriela Zaharie
Summary: The study reveals that early preeclampsia increases the risk of complications in preterm neonates and is correlated with hematological changes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Anadeijda J. E. M. C. Landman, Marjon A. de Boer, Laura Visser, Tobias A. J. Nijman, Marieke A. C. Hemels, Christiana N. Naaktgeboren, Marijke C. van der Weide, Ben W. Mol, Judith O. E. H. van Laar, Dimitri N. M. Papatsonis, Mireille N. Bekker, Joris van Drongelen, Marielle G. van Pampus, Marieke Sueters, David P. van der Ham, J. Marko Sikkema, Joost J. Zwart, Anjoke J. M. Huisjes, Marloes E. van Huizen, Gunilla Kleiverda, Janine Boon, Maureen T. M. Franssen, Wietske Hermes, Harry Visser, Christianne J. M. de Groot, Martijn A. Oudijk
Summary: The study aimed to evaluate the effectiveness of low-dose aspirin compared to placebo in preventing preterm birth in women with a previous spontaneous preterm birth. The results showed that low-dose aspirin did not significantly reduce the preterm birth rate. However, a modest reduction in preterm birth with aspirin cannot be ruled out. Further research is needed to determine the potential benefits of low-dose aspirin in women with a previous spontaneous preterm birth.
Review
Developmental Biology
Bridget M. Arman, Natalie K. Binder, Natasha de Alwis, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan
Summary: Preterm birth is a major cause of neonatal morbidity and mortality worldwide. Current therapies for preterm birth have limited effectiveness. This review explores the potential of repurposing drugs with known safety profiles to prevent or treat preterm birth.
Letter
Obstetrics & Gynecology
Natasha Pritchard, Susan Walker, Anthea Lindquist
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Lisa Hui, Melvin B. Marzan, Daniel L. Rolnik, Stephanie Potenza, Natasha Pritchard, Joanne M. Said, Kirsten R. Palmer, Clare L. Whitehead, Penelope M. Sheehan, Jolyon Ford, Ben W. Mol, Susan P. Walker
Summary: This retrospective multicenter cohort study examined the impact of COVID-19 vaccination during pregnancy on perinatal outcomes. The study found that vaccinated pregnant women had a lower risk of stillbirth and preterm birth, without any adverse effects on fetal growth or development. Vaccine coverage was influenced by social determinants of health.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Natasha L. Pritchard, Richard Hiscock, Susan P. Walker, Stephen Tong, Anthea C. Lindquist
Summary: Obese mothers have heavier fetuses but lower rates of small for gestational age infants. However, their infants may be growth-restricted at a higher birthweight centile, leading to an increased risk of stillbirth. This study aimed to quantify the birthweight centile at which the risk of stillbirth in infants born to obese women equaled that of small for gestational age infants born to healthy-weight women, and to clarify the relationship between maternal body mass index, infant size, and stillbirth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Developmental Biology
Natalie K. Binder, Natasha de Alwis, Sally Beard, Elif Kadife, Alesia Harper, Tuuhevaha J. Kaitu'u-Lino, Fiona C. Brownfoot, Natalie J. Hannan
Summary: The anti-inflammatory drug sulfasalazine has been identified as a potential therapeutic for the treatment of preeclampsia, as it effectively mitigates endothelial dysfunction and promotes vasodilation. However, in a mouse model, sulfasalazine had limited effects on blood pressure and fetal growth.
Article
Medicine, General & Internal
Amber C. Kennedy, Beverley Vollenhoven, Richard Hiscock, Catharyn P. Stern, Susan Walker, Jeanie L. Y. C. Cheong, Jon Quach, Roxanne Hastie, David Wilkinson, John McBain, Lyle Gurrin, Vivien MacLachlan, Franca Agresta, Susan Baohm, Stephen Tong, Anthea Lindquist
Summary: This study examined the school-age developmental and educational outcomes for children conceived via in vitro fertilisation (IVF) compared to spontaneously conceived children. The researchers found that there was no difference in outcomes between the two groups. These findings provide reassurance for parents and clinicians involved in IVF.
Review
Infectious Diseases
Kevin Meesters, Tinsae Alemayehu, Sofia Benou, Danilo Buonsenso, Eric H. Decloedt, Veshni Pillay-Fuentes Lorente, Kevin J. Downes, Karel Allegaert
Summary: Effective antimicrobial exposure is essential to treat infections and prevent antimicrobial resistance in low and middle income countries (LMIC). However, specific data on the pharmacokinetics of antimicrobials in children living in LMIC settings are scarce. This article outlines the effects of growth, maturation, and comorbidities on pharmacokinetics in LMIC children.
Article
Acoustics
C. A. Cluver, L. Bergman, J. Bergkvist, H. Imberg, L. Geerts, D. R. Hall, B. W. Mol, S. Tong, S. P. Walker
Summary: This study assessed whether coexisting fetal growth restriction (FGR) influences pregnancy latency and maternal and perinatal outcomes in women with preterm pre-eclampsia. The results showed that FGR is associated with shorter pregnancy latency, more emergency Cesarean deliveries, fewer successful inductions of labor, and increased rates of neonatal morbidity and mortality.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Psychiatry
Alexandra Roddy Mitchell, Hannah Gordon, Anthea Lindquist, Susan P. Walker, Caroline S. E. Homer, Anna Middleton, Catherine A. Cluver, Stephen Tong, Roxanne Hastie
Summary: Depression among perinatal women in low- and middle-income countries is common, with a prevalence of 24.7%. The highest prevalence is found in lower-middle-income countries, and intimate partner violence, HIV, and natural disasters are associated with higher rates of depression.
Editorial Material
Physiology
Lina Bergman, Carlos Alonso Escudero, Catherine Cluver, Roxanne Hastie, Pablo Torres-Vergara
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Obstetrics & Gynecology
Emma Bokstrom-Res, Henrik Zetterberg, Kaj Blennow, Roxanne Hastie, Sonja Schell, Catherine Cluver, Lina Bergman
Summary: In this study, the correlation between cognitive function assessment scores and plasma concentrations of neurofilament light chain (NfL), tau, and glial fibrillary acidic protein (GFAP) was investigated in women with pre-eclampsia. The results showed a negative correlation between impaired cognitive function and increased plasma concentrations of NfL in women with eclampsia and pre-eclampsia complicated by pulmonary edema. However, no correlation was found between NfL concentrations and cognitive impairment in pre-eclampsia cases without pulmonary edema, HELLP or neurological complications, or normotensive pregnancies.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2023)
Review
Medicine, General & Internal
James Hong, Jessica Atkinson, Alexandra Roddy Mitchell, Stephen Tong, Susan P. Walker, Anna Middleton, Anthea Lindquist, Roxanne Hastie
Summary: This systematic review and meta-analysis found that elective induction of labor at 39 weeks of gestation improved maternal labor-related and neonatal outcomes, including a reduced likelihood of perineal injury, macrosomia, and low 5-minute Apgar score after birth. However, among nulliparous women, induction of labor was associated with an increased likelihood of shoulder dystocia compared with expectant management. These findings suggest that elective induction of labor at 39 weeks may be safe and beneficial for some women, but potential risks should be discussed with nulliparous women.
Article
Chemistry, Analytical
Vanessa Louw, Fiona Brownfoot, Catherine Cluver, Eric Decloedt, Tracy Kellermann
Summary: A robust LC-MS/MS method was developed and validated to simultaneously quantitate sulfasalazine and sulfapyridine in human placenta. The method was applied to a pilot clinical trial to investigate the placental exposure of these analytes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Letter
Medicine, General & Internal
Catherine Cluver, Christianne de Groot, Ben W. Mol, Kellie E. Murphy, Jane E. Norman, Rodolfo Pacagnella, Kirsten Palmer, Liona C. Poon, Daniel L. Rolnik, Catherine Y. Spong, Sarah J. Stock, Shakila Thangaratinam, Stephen Tong, Corine Verhoeven, Lan N. Vuong, Sue P. Walker, Liu Xiaohua
Article
Endocrinology & Metabolism
Lucy A. Bartho, Manju Kandel, Susan P. Walker, Catherine A. Cluver, Roxanne Hastie, Lina Bergman, Natasha Pritchard, Ping Cannon, Tuong-Vi Nguyen, Georgia P. Wong, Teresa M. MacDonald, Emerson Keenan, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: This study evaluated the biomarker potential of circulating chemerin to predict preeclampsia. The results showed that circulating chemerin was increased in women with early-onset preeclampsia, established preeclampsia, and preceding preeclampsia diagnosis. RARRES2, the gene coding chemerin, was dysregulated in placenta complicated by preeclampsia. Chemerin may have potential as a biomarker for preeclampsia but would need to be combined with other biomarkers.