Article
Endocrinology & Metabolism
Anna Mikolajczak, Nada A. Sallam, Radha D. Singh, Taylor B. Scheidl, Emma J. Walsh, Sebastian Larion, Carol Huang, Jennifer A. Thompson
Summary: This study demonstrated that accelerated adipogenesis during the perinatal period predisposes offspring to hypertrophic adipocyte dysfunction later in life, compromising the buffering function of subcutaneous fat depot.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Isadora C. C. Furigo, Laura Dearden
Summary: As global obesity rates continue to rise, the number of pregnancies complicated by maternal obesity has also increased. Maternal obesity not only has negative health outcomes for both the mother and the baby during pregnancy and birth, but also increases the risk of developing obesity, diabetes, and cardiovascular disease in later life. Animal models have shown that offspring of obese mothers tend to have increased food intake, suggesting potential changes in the control of food intake. This review examines the development of the hypothalamus, the impact of maternal obesity on its structure and function in offspring, and the factors that may mediate permanent changes in hypothalamic function in individuals exposed to an obese in utero environment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jerod M. Rasmussen, Jetro J. Tuulari, Saara Nolvi, Paul M. Thompson, Harri Merisaari, Maria Lavonius, Linnea Karlsson, Sonja Entringer, Pathik D. Wadhwa, Hasse Karlsson, Claudia Buss
Summary: Using an international dataset, researchers found a link between maternal overweight/obesity during pregnancy and the development of fetal hypothalamus in newborns. These findings can contribute to future prevention strategies for childhood obesity.
Review
Nutrition & Dietetics
Amanda Renae Purcell, Sarah Jean Glastras
Summary: The global rise in obesity among women of reproductive age raises concerns about the health of their offspring. There is a strong connection between an obesogenic maternal environment and metabolic dysfunction in the offspring. Research efforts need to focus on alleviating the intergenerational onset of obesity and metabolic dysfunction.
Article
Immunology
Maria Angela Guzzardi, Thomas H. A. Ederveen, Francesca Rizzo, Alessandro Weisz, Maria Carmen Collado, Filippo Muratori, Gabriele Gross, Wynand Alkema, Patricia Iozzo
Summary: Maternal gestational obesity is associated with offspring's neurodevelopment and cognitive disorders, partially due to alterations in gut microbiota composition. The abundance of specific bacteria like Bifidobacterium and Veillonella in early life may impact cognitive development, with potential implications for primary prevention of neurodevelopmental disorders. Maternal overweight influences bacterial colonization and reasoning skills development in preschool-aged children.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Cell Biology
Philipp Kasper, Saida Breuer, Thorben Hoffmann, Christina Vohlen, Ruth Janoschek, Lisa Schmitz, Sarah Appel, Gregor Fink, Christoph Huenseler, Alexander Quaas, Muenevver Demir, Sonja Lang, Hans-Michael Steffen, Anna Martin, Christoph Schramm, Martin Buerger, Esther Mahabir, Tobias Goeser, Joerg Doetsch, Eva Hucklenbruch-Rother, Inga Bae-Gartz
Summary: Maternal exercise can reduce the risk of hepatic metabolic dysfunction in obese dams and their offspring, by regulating AMPK and other key hepatic metabolic processes, leading to improved metabolic health.
Review
Pediatrics
Brigid Gregg, Lindsay Ellsworth, Gregory Pavela, Kruti Shah, Paige K. Berger, Elvira Isganaitis, Sheri VanOmen, Ellen W. Demerath, David A. Fields
Summary: This article highlights the lack of research on postnatal programming mechanisms and the importance of bioactive compounds in breast milk for infant health. The presence of newly discovered substances in breast milk is associated with maternal metabolic phenotypes and offspring growth and body composition.
Review
Cell Biology
Nanshuo Cai, Yifan Wu, Yan Huang
Summary: With the global increase in the elderly population, understanding the mechanisms of aging and aging-related disorders has become crucial. Mice have emerged as prevalent animal models for aging studies due to their genetic similarity, physiological structure, short lifespan, and ease of reproduction. This review discusses common and emerging mouse models used in the study of accelerated aging and chronic diseases, aiming to provide a reference for future research in fundamental and translational studies.
Article
Endocrinology & Metabolism
Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, Susana Pereira, Hugo Rocha, Tiago Bordeira Gaspar, Fatima Gartner, Rossana Correia, Maria Joao Martins, Tiago Guimaraes, Sandra Martins, Paulo J. Oliveira, Antonio Ascensao, Jose Magalhaes
Summary: The study shows that gestational exercise can delay the metabolic changes in GDM mothers and protect offspring from the adverse effects of maternal diet. Gestational exercise reduces hepatic triglycerides accumulation and improves liver mitochondrial respiration capacity in offspring.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Pharmacology & Pharmacy
Zhengjie Lu, Yu Guo, Dan Xu, Hao Xiao, Yongguo Dai, Kexin Liu, Liaobin Chen, Hui Wang
Summary: Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways, multiple organs, and multiple targets. Its mechanisms involve direct ways such as oxidative stress, epigenetic modification, and metabolic activation, and it may also be indirectly caused by placental dysfunction. Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming, functional homeostasis changes, and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels of maternal-derived glucocorticoids.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Endocrinology & Metabolism
Marina Galleazzo Martins, Zachary Silver, Kiara Ayoub, Lindsay Hyland, Barbara Woodside, Ana Carolina Inhasz Kiss, Alfonso Abizaid
Summary: Gestational diabetes is associated with negative outcomes for both mothers and offspring. This study found that maternal hyperglycemia, combined with exposure to an obesogenic diet, leads to adult metabolic alterations in offspring, particularly in females, with increased hypothalamic expression of POMC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rebekka Vogtmann, Mian Bao, Monia Vanessa Dewan, Alina Riedel, Rainer Kimmig, Ursula Felderhoff-Mueser, Ivo Bendix, Torsten Ploesch, Alexandra Gellhaus
Summary: Fetal adaptations to harmful intrauterine environments due to pregnancy disorders such as preeclampsia (PE) can negatively program the offspring's metabolism, resulting in long-term metabolic changes. In this study, researchers examined the consequences of sFLT1 overexpression in transgenic mice with PE/FGR on the offspring's metabolic phenotype. The results showed that sFLT1 overexpression led to growth-restricted fetuses with altered liver development and metabolic gene expression. The postnatal follow-up revealed increased weight gain and abnormal hormone levels in male PE offspring, suggesting adverse metabolic pre-programming specifically targeting males.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Joshua Scheys, Jennifer DelProposto, Carey Lumeng, Ernesto Bernal-Mizrachi, Emilyn U. Alejandro
Summary: Maternal high-fat diet before and during pregnancy may predispose female offspring to insulin resistance in adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Erika Chavira-Suarez, Carlos Alberto Ibanez, Diana Catalina Castro-Rodriguez, Luis Antonio Reyes-Castro, Marina Gisela Ramirez-Leal, Lucia Alba Martinez-Mota, Elena Zambrano
Summary: Maternal obesity has negative effects on the metabolic function of offspring, and its impact on skeletal muscle programming and aging has been poorly studied. This study evaluated the effects of maternal obesity on muscle strength, adiposity, and metabolism in offspring from a rat model. The results showed that maternal obesity can lead to metabolic dysfunctions in male offspring during aging, while adiposity-related muscle strength loss and fatty acid alterations were observed in female offspring.
JOURNAL OF BIOSCIENCES
(2023)
Review
Developmental Biology
Lawrence P. Reynolds, Wellison J. S. Diniz, Matthew S. Crouse, Joel S. Caton, Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward
Summary: Developmental programming refers to the long-term changes in gene expression caused by stressors during development, which can affect organ structure and function. Maternal nutrition plays a crucial role in the developmental program. Future research should focus on the effects of developmental programming on the offspring's life course and subsequent generations, as well as utilizing the positive aspects of developmental programming.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2023)